P:methotrexate

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pChart

Pain Term
Category Drug
Synonyms Amethopterin
Pain Specific No
Documents 2507
Hot Single Events 200
Hot Interactions 80

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for methotrexate. They are ordered first by their pain relevance and then by number of times they were reported for methotrexate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 100.00
2 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88 100.00
3 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69 100.00
4 INT338940 Fpgs Positive_regulation of Mtx1 1 0.32 0.32 0.47 100.00
5 INT115812 Binding of Slc22a8 and Mtx1 1 0.08 0.17 0.65 100.00
6 INT115811 Binding of Slc22a6 and Mtx1 1 0.02 0.17 0.65 100.00
7 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64 100.00
8 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45 100.00
9 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44 100.00
10 INT210263 Mtx1 Regulation of Gene_expression of LYZ 1 0.00 0.33 0.32 100.00
11 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92 100.00
12 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92 100.00
13 INT338941 Binding of Ggh and Mtx1 1 0.30 0.47 0.27 100.00
14 INT278688 MTX1 Negative_regulation of Positive_regulation of SOAT1 1 0.04 0.69 0.54 100.00
15 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62 100.00
16 INT194914 Mtx1 Regulation of Gene_expression of Nfasc 1 0.00 0.71 0.58 100.00
17 INT278691 MTX1 Negative_regulation of DHFR 1 0.02 0.57 0.49 100.00
18 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74 100.00
19 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73 100.00
20 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83 100.00
21 INT278696 MTX1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83 100.00
22 INT285341 Mtx1 Regulation of Gene_expression of Tnf 1 0.03 0.78 0.22 100.00
23 INT285340 Mtx1 Regulation of Tnf 1 0.03 0.78 0.22 100.00
24 INT285342 Mtx1 Regulation of Il10 1 0.03 0.78 0.22 100.00
25 INT285343 Mtx1 Regulation of Il6 1 0.04 0.78 0.22 100.00
26 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27 100.00
27 INT181976 TNF Regulation of Transcription of Gpi1 1 0.00 0.64 0.26 100.00
28 INT181977 TNF Regulation of Gene_expression of Gpi1 1 0.00 0.64 0.25 100.00
29 INT346266 MTX1 Regulation of IL17A 1 0.08 1.33 0.89 100.00
30 INT232417 Binding of Mtx1 and Ifx 1 0.04 0.99 0.86 100.00
31 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96 99.88
32 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56 99.84
33 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35 99.84
34 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61 99.80
35 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4 99.66
36 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73 99.28
37 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43 98.24
38 INT105917 Binding of SLC22A6 and SLC22A8 2 0.31 0.34 1.67 97.56
39 INT194857 Positive_regulation of Adora2a Positive_regulation of Gene_expression of Vegfa 1 0.23 0.74 0.67 96.72
40 INT264331 Olr614 Regulation of IgG-2a 1 0.00 0.53 0.29 95.68
41 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91 95.36
42 INT138862 ABCC2 Negative_regulation of ABCC4 1 0.63 0.24 0.9 95.28
43 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87 94.80
44 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 93.80
45 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78 93.44
46 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52 93.36
47 INT194916 Kitl Positive_regulation of Gene_expression of Mmp1a 1 0.00 0.85 0.52 93.36
48 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52 93.36
49 INT194919 Kitl Positive_regulation of Gene_expression of VEGFA 1 0.01 0.85 0.52 93.36
50 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 93.28
51 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78 92.96
52 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61 92.08
53 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94 90.92
54 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56 90.92
55 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56 90.92
56 INT210258 Wnt2 Regulation of Gene_expression of Tff3 1 0.03 0 0.05 90.88
57 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05 90.88
58 INT264330 Olr614 Negative_regulation of IgG-2a 1 0.00 1.07 0.51 90.84
59 INT264325 Olr614 Negative_regulation of Igh-6 1 0.01 0.54 0.26 90.84
60 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 89.60
61 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 89.60
62 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17 89.48
63 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79 89.28
64 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75 88.28
65 INT204090 Binding of KIR2DL2 and KIR2DS1 1 0.03 0.41 0.29 87.60
66 INT204089 Binding of KIR2DL3 and KIR2DS1 1 0.03 0.41 0.29 87.60
67 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39 86.72
68 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31 86.60
69 INT264328 Olr614 Negative_regulation of Gene_expression of IL-17 1 0.01 0.71 0.39 86.40
70 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 85.76
71 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 85.64
72 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28 85.28
73 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 84.68
74 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4 83.92
75 INT231750 LOC690550 Negative_regulation of Jak3 1 0.02 1.3 0.52 82.84
76 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 81.60
77 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05 81.60
78 INT264332 Olr614 Negative_regulation of Regulation of Igh-6 1 0.01 1.04 0.48 81.52
79 INT231751 Binding of Il2rg and Jak3 1 0.03 1.56 0.67 80.32
80 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78 80.16
81 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 79.68
82 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14 78.40
83 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08 77.64
84 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08 77.64
85 INT327995 Positive_regulation of TRPV1 Positive_regulation of Tnfrsf1a 1 0.16 0.63 0.46 77.60
86 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8 77.44
87 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 77.28
88 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43 77.28
89 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08 77.24
90 INT194577 Binding of BTG3 and BDNF-AS 1 0.01 0.31 0.46 77.12
91 INT254578 Binding of TNF and Tst 1 0.02 1.57 0.13 76.88
92 INT47600 Ccno Regulation of MBD2 1 0.00 0.22 0.24 76.76
93 INT194578 Binding of HOXA10 and BTG3 1 0.00 0.66 0.24 76.12
94 INT209957 Binding of CD8A and RDBP Positive_regulation of CD8A 1 0.01 0.3 0.71 75.76
95 INT353730 Binding of FCGR2A and FCGR3A 1 0.33 0.5 0.41 75.64
96 INT124088 Rab38 Negative_regulation of Mapk14 1 0.00 0.89 0.42 75.28
97 INT209956 Binding of CD8A and RDBP 1 0.01 0.3 0.7 74.92
98 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 74.68
99 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96 74.56
100 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 0.11 0.64 0.4 74.40
101 INT207440 Binding of HDLBP and PLA2G7 1 0.06 1.25 0.58 74.28
102 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 74.08
103 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69 73.76
104 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74 73.28
105 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56 72.12
106 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 71.64
107 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18 71.44
108 INT78368 IGKV2D-29 Positive_regulation of PKIB 1 0.07 0.26 0.35 70.32
109 INT264324 Olr614 Regulation of IL-17 1 0.02 2.3 1.03 69.92
110 INT302819 Regulation of S1pr1 Positive_regulation of Ptger2 1 0.02 0.35 0.22 68.28
111 INT302835 S1pr1 Positive_regulation of Ptger2 1 0.03 0.3 0.2 68.28
112 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 68.16
113 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23 67.76
114 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 67.32
115 INT184291 Binding of AGER and Crp 1 0.01 1.23 0.46 66.96
116 INT207438 Binding of OLR1 and ERAL1 1 0.08 0.5 0.25 66.80
117 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33 65.36
118 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 64.96
119 INT182367 IgG Regulation of Vim 1 0.00 0.99 0.11 64.72
120 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7 64.52
121 INT207437 Binding of PLA2G7 and ERAL1 1 0.14 3.64 1.11 64.04
122 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43 63.96
123 INT182368 IgG Regulation of Cast 1 0.01 0.99 0.11 63.92
124 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47 63.36
125 INT316674 Binding of CRP and SFTPD 1 0.16 2.02 0.59 63.04
126 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 62.44
127 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 62.28
128 INT232386 Binding of CD22 and SYCP3 1 0.37 0.86 0.16 61.32
129 INT155220 ABCG2 Positive_regulation of Abcc2 1 0.23 0.54 0.76 61.08
130 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 60.40
131 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38 59.60
132 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 59.44
133 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 59.20
134 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 58.92
135 INT214691 Binding of CGA and CGB 1 0.01 0.7 0.17 58.36
136 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03 57.16
137 INT221685 Binding of pr and FRTS 1 0.00 0.15 0.03 56.64
138 INT353741 Binding of IGHE and Aia1 1 0.00 1.16 1.06 56.24
139 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11 56.12
140 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03 56.08
141 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12 55.44
142 INT221683 Binding of Mki67 and FRTS 1 0.01 1.18 0.11 55.20
143 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 54.64
144 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 54.64
145 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19 52.76
146 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18 52.76
147 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2 52.68
148 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2 52.40
149 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09 51.92
150 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03 51.92
151 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49 51.88
152 INT315066 AKT1 Negative_regulation of PAR4 1 0.39 1.8 0.03 51.24
153 INT264326 IL-17 Positive_regulation of Gene_expression of Il6 1 0.13 0.83 0.43 50.64
154 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29 50.40
155 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98 50.40
156 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94 50.40
157 INT194856 Positive_regulation of Adora2b Negative_regulation of Positive_regulation of Mmp13 1 0.01 0.73 0.85 50.00
158 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49 50.00
159 INT227547 Hspa9 Regulation of Gene_expression of Rnpep 1 0.02 0.31 0.08 50.00
160 INT227546 Hspa9 Regulation of Rnpep 1 0.01 0.31 0.08 50.00
161 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07 49.12
162 INT211115 Positive_regulation of Binding of LTBR and TNF 1 0.01 0.31 0.39 49.12
163 INT171903 Binding of TNF and Lifr 1 0.01 0.35 0.22 49.00
164 INT180565 HEYL Positive_regulation of Negative_regulation of COL1A1 1 0.01 0 0.03 49.00
165 INT180571 HEYL Positive_regulation of Protein_catabolism of COL1A1 1 0.01 0 0.03 49.00
166 INT334314 Tlr4 Positive_regulation of Gene_expression of Dusp1 1 0.01 0.37 0.19 48.72
167 INT315068 Binding of AKT1 and PAR4 1 0.34 4.41 0 48.08
168 INT327992 TRPV1 Positive_regulation of Gene_expression of ROS1 1 0.28 0.35 0.6 47.44
169 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98 47.28
170 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63 47.28
171 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 46.68
172 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 46.68
173 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76 45.92
174 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76 45.92
175 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94 45.28
176 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62 45.28
177 INT198700 Binding of DSG3 and Pv 1 0.15 1.45 0.18 42.96
178 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55 41.84
179 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 41.40
180 INT173942 Binding of DMD and Atp6v1e1 1 0.00 0 0.13 41.28
181 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 40.48
182 INT299763 Binding of APC and CTLA4 Positive_regulation of Ido1 1 0.11 0.31 0.14 39.52
183 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11 39.52
184 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07 38.72
185 INT264338 Binding of IL-17 and Positive_regulation of Localization of TNF 1 0.04 1.71 0.67 36.56
186 INT264329 Binding of IL-17 and Positive_regulation of Localization of Ccl2 1 0.13 1.65 0.64 36.56
187 INT264334 Binding of IL-17 and Positive_regulation of Localization of Csf3 1 0.13 1.64 0.63 36.56
188 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62 36.56
189 INT231797 Glrb Regulation of Negative_regulation of TNF 1 0.02 1.49 0.25 35.80
190 INT315061 PAR4 Positive_regulation of Gene_expression of TNF 1 0.10 1.95 0 34.80
191 INT239502 Binding of Emp2 and Aes 1 0.14 0.06 0 31.68
192 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06 31.36
193 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65 31.12
194 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58 31.12
195 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 30.32
196 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96 30.32
197 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 29.84
198 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69 29.84
199 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57 29.36
200 INT334009 Binding of CCL25 and CCR9 1 0.40 0.96 0.4 29.28

Single Events

The table below shows the top 200 pain related interactions that have been reported for methotrexate. They are ordered first by their pain relevance and then by number of times they were reported in methotrexate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 100.00
2 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 100.00
3 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 100.00
4 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 100.00
5 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
6 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 100.00
7 INT137400 Regulation of Mtx1 16 0.52 9.19 9.45 100.00
8 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 100.00
9 INT334310 Gene_expression of Mtx1 1 0.16 3.88 5.79 100.00
10 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
11 INT22285 Negative_regulation of Mtx1 16 0.49 7.84 8.98 100.00
12 INT182320 Binding of MTX1 14 0.18 8.5 7.65 100.00
13 INT24232 Localization of Mtx1 24 0.65 8.06 7.99 100.00
14 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 100.00
15 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87 100.00
16 INT239495 Negative_regulation of Gene_expression of Mtx1 3 0.36 1.55 3.24 100.00
17 INT60568 Negative_regulation of Mtx1 5 0.38 3.6 2.87 100.00
18 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 100.00
19 INT227515 Regulation of Gene_expression of Mtx1 5 0.38 4.34 3.24 100.00
20 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
21 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
22 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 100.00
23 INT60569 Binding of Mtx1 5 0.42 0.82 2.45 100.00
24 INT28862 Positive_regulation of Mtx1 3 0.38 2.49 1.77 100.00
25 INT108890 Regulation of Mtx1 1 0.24 0.67 2.74 100.00
26 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73 100.00
27 INT21728 Binding of Slc19a1 2 0.22 0.56 1.5 100.00
28 INT211120 Negative_regulation of Binding of MTX1 2 0.18 0.64 1.6 100.00
29 INT232486 Positive_regulation of Gene_expression of Mtx1 3 0.42 0.96 1.41 100.00
30 INT87360 Binding of ABCC1 6 0.47 1.71 2.38 100.00
31 INT194898 Regulation of Gene_expression of Nfasc 1 0.03 4.51 2.93 100.00
32 INT99911 Localization of MTX1 5 0.45 3.81 3.07 100.00
33 INT238653 Regulation of MTX1 2 0.30 1.71 1.42 100.00
34 INT211131 Regulation of Gene_expression of MTX1 3 0.21 1.45 1.97 100.00
35 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 100.00
36 INT168284 Localization of Slc22a8 1 0.78 0.1 0.82 100.00
37 INT211132 Positive_regulation of Gene_expression of MTX1 4 0.23 2.71 2.94 100.00
38 INT120598 Negative_regulation of ABCC4 4 0.59 0.49 1.6 100.00
39 INT72684 Binding of Slc21a4 1 0.48 0.37 1.52 100.00
40 INT194894 Regulation of Binding of Mtx1 1 0.05 3.07 1.8 100.00
41 INT69703 Gene_expression of TXN 20 0.71 3.57 2.01 100.00
42 INT117267 Transcription of MTX1 2 0.52 2.45 1.31 100.00
43 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 100.00
44 INT138864 Binding of ABCC4 1 0.36 0.38 0.93 100.00
45 INT113864 Binding of ABCC2 5 0.36 0.38 1.25 100.00
46 INT168285 Negative_regulation of Localization of Slc22a8 1 0.36 0 0.44 100.00
47 INT338936 Negative_regulation of Localization of Mtx1 2 0.30 1.08 0.64 100.00
48 INT103553 Positive_regulation of Positive_regulation of MTX1 1 0.01 0.53 0.69 100.00
49 INT24234 Positive_regulation of Localization of Mtx1 2 0.34 0.32 0.77 100.00
50 INT17779 Negative_regulation of Got1 12 0.40 3.5 6.08 100.00
51 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 100.00
52 INT182323 Regulation of Binding of MTX1 2 0.19 1.32 0.53 100.00
53 INT62882 Negative_regulation of Binding of Mtx1 1 0.37 0.7 0.38 100.00
54 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 100.00
55 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 100.00
56 INT260860 Positive_regulation of Negative_regulation of Mtx1 1 0.42 0.26 0.35 100.00
57 INT110588 Phosphorylation of Mtx1 1 0.55 0.07 0.89 100.00
58 INT104185 Negative_regulation of ABCC2 7 0.57 0.64 1.5 100.00
59 INT59181 Negative_regulation of Positive_regulation of DHFR 1 0.43 0.24 0.34 100.00
60 INT59178 Negative_regulation of Positive_regulation of GRHPR 1 0.10 0.24 0.34 100.00
61 INT340441 Positive_regulation of Binding of MTX1 1 0.17 1.7 0.72 100.00
62 INT117266 Positive_regulation of Transcription of MTX1 1 0.45 0.73 0.62 100.00
63 INT21013 Regulation of Gene_expression of IL36RN 4 0.11 1.71 2.11 100.00
64 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 100.00
65 INT194912 Regulation of Binding of Csf2 3 0.10 3.03 1.41 100.00
66 INT211135 Positive_regulation of Localization of MTX1 2 0.23 2.14 2.14 100.00
67 INT227522 Regulation of Hspa9 4 0.39 1.85 0.66 100.00
68 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82 100.00
69 INT91176 Regulation of Localization of GSTA2 2 0.33 1.04 1.31 100.00
70 INT232487 Regulation of Positive_regulation of Mtx1 1 0.13 0 0.24 100.00
71 INT13354 Transcription of TNF 108 0.72 85.81 42.32 100.00
72 INT221213 Negative_regulation of Hspa9 7 0.34 2.79 1.18 100.00
73 INT108170 Gene_expression of Tyms 6 0.69 1.97 0.71 100.00
74 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 100.00
75 INT14778 Gene_expression of FCGR3A 25 0.75 16.25 3.86 100.00
76 INT194900 Phosphorylation of Mtx1 1 0.10 1.15 0.56 100.00
77 INT181269 Positive_regulation of Gene_expression of USE1 3 0.24 1.43 1.18 100.00
78 INT211134 Positive_regulation of Localization of USE1 1 0.06 1.23 1.18 100.00
79 INT15557 Regulation of Localization of Alb 13 0.50 5.71 2.91 100.00
80 INT227511 Binding of Hspa9 2 0.30 0.28 0.19 100.00
81 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 100.00
82 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 100.00
83 INT3841 Gene_expression of FCGR3B 117 0.75 58.99 28.87 100.00
84 INT334304 Protein_catabolism of Mtx1 1 0.21 0.38 0.39 100.00
85 INT323789 Transcription of Mtx1 1 0.04 0.06 0.08 100.00
86 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 99.98
87 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 99.98
88 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 99.98
89 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 99.98
90 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 99.98
91 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 99.98
92 INT194846 Positive_regulation of Positive_regulation of Il10 9 0.57 5.07 3.71 99.98
93 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37 99.98
94 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 99.98
95 INT211136 Localization of USE1 3 0.11 2.67 1.57 99.98
96 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 99.96
97 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.92
98 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.92
99 INT120596 Gene_expression of ABCC4 11 0.78 2.51 3.76 99.92
100 INT135436 Gene_expression of Hspa9 31 0.62 14.75 5.2 99.92
101 INT108805 Binding of Slc22a8 3 0.18 0.44 0.97 99.92
102 INT115809 Binding of Slc22a6 1 0.03 0.17 0.65 99.92
103 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34 99.92
104 INT227521 Regulation of Gene_expression of Hspa9 2 0.36 2.25 0.92 99.90
105 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.88
106 INT21613 Gene_expression of Pla2g1b 25 0.68 9.05 6.39 99.88
107 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63 99.88
108 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 99.84
109 INT138863 Positive_regulation of Gene_expression of ABCC4 1 0.49 0.64 1.84 99.84
110 INT153109 Gene_expression of Dao 7 0.78 2.54 4.26 99.84
111 INT1282 Negative_regulation of Dao 4 0.59 3.08 3.2 99.84
112 INT239496 Gene_expression of Aes 4 0.52 1.45 0.76 99.84
113 INT239497 Binding of Aes 8 0.29 3.61 0.84 99.84
114 INT59010 Positive_regulation of Regulation of Crp 2 0.27 2.11 1.09 99.84
115 INT72053 Localization of GSTA2 15 0.78 6.12 2.78 99.84
116 INT7678 Localization of Alb 142 0.81 80.93 22.49 99.84
117 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 99.84
118 INT334311 Negative_regulation of Gene_expression of Dao 1 0.28 0.81 0.37 99.84
119 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.82
120 INT194854 Regulation of Positive_regulation of Il10 3 0.37 2.55 1.44 99.80
121 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 99.78
122 INT61400 Positive_regulation of Positive_regulation of Ik 2 0.22 1.56 1.95 99.78
123 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07 99.78
124 INT162020 Negative_regulation of Gene_expression of HIST1H2BG 1 0.24 0.16 0.28 99.78
125 INT57182 Negative_regulation of Dhfr 2 0.55 0.37 0.16 99.78
126 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 99.76
127 INT95101 Binding of SLC22A8 6 0.48 0.75 5.07 99.76
128 INT104134 Binding of SLC22A6 3 0.34 0.52 2.75 99.76
129 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43 99.76
130 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 99.76
131 INT55335 Binding of Cpox 49 0.34 15.48 18.46 99.76
132 INT117598 Regulation of ACR 118 0.26 41.25 48.01 99.74
133 INT95099 Gene_expression of SLC22A8 14 0.67 1.59 5.14 99.74
134 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28 99.74
135 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 99.72
136 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 99.72
137 INT102694 Localization of CREM 4 0.27 1.6 1.8 99.72
138 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 99.72
139 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 99.70
140 INT113987 Localization of IK 29 0.23 16.73 8.25 99.70
141 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 99.70
142 INT156427 Localization of FOXC1 2 0.73 1.36 1.07 99.70
143 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12 99.70
144 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 99.70
145 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 99.70
146 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 99.70
147 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12 99.70
148 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19 99.70
149 INT118305 Negative_regulation of Gene_expression of IL18 7 0.39 6.52 2.05 99.70
150 INT254724 Negative_regulation of DHFR 2 0.42 3.92 1.39 99.68
151 INT26962 Negative_regulation of IgG-2a 12 0.42 6.07 5.31 99.68
152 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 99.68
153 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 99.68
154 INT274040 Localization of Pml 1 0.24 0.77 0.27 99.66
155 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 99.64
156 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.64
157 INT258404 Positive_regulation of Gene_expression of ACR 4 0.28 1.08 2.24 99.64
158 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.64
159 INT304045 Transcription of PTEN 2 0.51 4.12 1.4 99.64
160 INT136074 Regulation of ELOVL1 5 0.23 3.6 0.49 99.64
161 INT86222 Binding of SLC22A11 2 0.48 0.1 0.63 99.64
162 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 99.64
163 INT139829 Negative_regulation of Gene_expression of AGER 2 0.57 3.76 1.3 99.64
164 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73 99.64
165 INT189395 Positive_regulation of Gene_expression of MFI2 2 0.15 1.4 0.24 99.64
166 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 99.62
167 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 99.62
168 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7 99.62
169 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63 99.62
170 INT328754 Positive_regulation of TMX1 1 0.20 2.19 0.31 99.60
171 INT227424 Binding of Prep 6 0.35 2.61 1.39 99.60
172 INT95102 Localization of SLC22A8 3 0.75 0.69 4.24 99.58
173 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 99.58
174 INT59180 Positive_regulation of DHFR 1 0.70 0.24 0.33 99.58
175 INT59179 Positive_regulation of GRHPR 5 0.14 2.57 1.09 99.58
176 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 99.56
177 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 99.54
178 INT123213 Negative_regulation of SLC22A8 2 0.35 1.43 1.05 99.54
179 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 99.54
180 INT90829 Negative_regulation of SLC22A6 3 0.40 0.75 1.22 99.54
181 INT55874 Binding of GPM6A 20 0.34 4.2 13.63 99.54
182 INT546 Binding of ALB 311 0.48 85.98 60.14 99.52
183 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78 99.52
184 INT1850 Binding of OXA1L 77 0.48 7.61 15.22 99.52
185 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.50
186 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.50
187 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.50
188 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 99.50
189 INT61399 Positive_regulation of Ik 21 0.22 10.17 8.75 99.50
190 INT189392 Gene_expression of MFI2 6 0.57 7.69 1.45 99.50
191 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 99.50
192 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 99.50
193 INT274041 Binding of Pml 1 0.12 0.77 0.27 99.50
194 INT231694 Negative_regulation of IGKV2-19 14 0.03 7.09 2.64 99.48
195 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 99.48
196 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13 99.48
197 INT278714 Regulation of Phosphorylation of STAT1 1 0.21 0.81 0.62 99.48
198 INT181970 Positive_regulation of Transcription of Gpi1 1 0.04 1.1 0.44 99.46
199 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 99.46
200 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 99.46
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