P:nalbuphine

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 637
Hot Single Events 79
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for nalbuphine. They are ordered first by their pain relevance and then by number of times they were reported for nalbuphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6320 Binding of Rbm39 and Scq1 1 0.03 0 1.92 99.76
2 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07 96.60
3 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27 96.60
4 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29 91.16
5 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 61.60
6 INT70836 Positive_regulation of OPRK1 Positive_regulation of Binding of CRYGS 1 0.03 0.09 0.36 26.52
7 INT243276 Hrh4 Positive_regulation of Hrh3 1 0.25 0.78 0.52 5.00
8 INT243273 Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 5.00
9 INT243280 Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 5.00
10 INT243278 Positive_regulation of Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29 5.00
11 INT243274 Positive_regulation of Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29 5.00
12 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28 5.00
13 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28 5.00
14 INT281609 Foxo3 Positive_regulation of Transcription of Trim63 1 0.29 0 0 5.00
15 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0 5.00
16 INT281608 Foxo4 Positive_regulation of Transcription of Trim63 1 0.27 0 0 5.00
17 INT281607 Foxo1 Positive_regulation of Transcription of Trim63 1 0.27 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for nalbuphine. They are ordered first by their pain relevance and then by number of times they were reported in nalbuphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51411 Negative_regulation of EDAR 8 0.41 1.05 5.49 100.00
2 INT7035 Regulation of CGA 87 0.45 29.04 28.45 100.00
3 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 99.98
4 INT153119 Positive_regulation of KCNJ1 1 0.27 0.06 1.22 99.98
5 INT141434 Positive_regulation of SUCLG1 2 0.49 0.74 1.18 99.90
6 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 99.76
7 INT12837 Binding of SIGMAR1 57 0.48 5.31 15.49 99.64
8 INT90020 Gene_expression of SUCLG1 8 0.75 1.61 8.34 99.52
9 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12 99.48
10 INT54294 Localization of Spnb4 9 0.78 0 18.64 99.38
11 INT80779 Positive_regulation of Hbb-ar 10 0.41 2.48 3.29 99.32
12 INT65694 Positive_regulation of Bw86 1 0.18 0 1.23 99.28
13 INT6319 Binding of Scq1 1 0.11 0 3.51 99.26
14 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31 99.24
15 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 99.12
16 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 98.88
17 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 98.88
18 INT6437 Binding of YY1 154 0.47 26.3 90.46 98.88
19 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 98.72
20 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 98.62
21 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 98.52
22 INT12111 Negative_regulation of Hbb-ar 11 0.37 6.63 4.22 98.52
23 INT36886 Transcription of Myc 6 0.69 3.16 2.86 98.48
24 INT71848 Positive_regulation of Transcription of Myc 1 0.67 0.16 1.11 98.48
25 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 98.36
26 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 98.36
27 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 98.16
28 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 98.08
29 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 98.00
30 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 97.84
31 INT52233 Transcription of Jun 37 0.66 6.39 11.15 97.68
32 INT61570 Positive_regulation of Transcription of Jun 10 0.35 1.62 3.45 97.68
33 INT1160 Positive_regulation of Rbm39 122 0.57 28.19 90.28 97.42
34 INT28174 Negative_regulation of CCHCR1 8 0.57 4.41 1.92 97.24
35 INT28175 Localization of CCHCR1 1 0.73 0.17 0.9 97.24
36 INT5219 Negative_regulation of DBP 43 0.57 23.35 4.26 97.24
37 INT28173 Localization of DBP 8 0.73 3.4 1.83 97.24
38 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61 97.08
39 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23 96.80
40 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78 96.60
41 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 96.60
42 INT21185 Binding of Ptprg 213 0.47 13.49 157.75 96.32
43 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 96.28
44 INT58625 Gene_expression of Ugt2b1 19 0.77 1.95 7.05 96.00
45 INT58626 Positive_regulation of Gene_expression of Ugt2b1 3 0.50 0.07 1.45 96.00
46 INT12717 Binding of Pck1 85 0.47 12.49 54.81 95.68
47 INT20976 Binding of CRYGS 39 0.46 5.4 20.09 94.96
48 INT82919 Negative_regulation of KRT75 2 0.36 0.15 0.77 94.96
49 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 94.72
50 INT52945 Regulation of Cet1 1 0.21 0 1.9 94.48
51 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 94.32
52 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 93.72
53 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39 93.56
54 INT273123 Binding of Hp 1 0.25 3.56 10.9 93.40
55 INT54297 Regulation of Localization of Spnb4 3 0.44 0 4.36 93.36
56 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91 92.52
57 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08 91.84
58 INT12315 Gene_expression of Nr3c2 37 0.75 19.28 11.97 91.16
59 INT56658 Gene_expression of Spnb4 7 0.58 5.6 2.22 91.04
60 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 90.28
61 INT56589 Positive_regulation of Localization of Spnb4 2 0.49 0 2.81 90.24
62 INT54295 Negative_regulation of Localization of Spnb4 2 0.57 0 2.21 89.60
63 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 89.16
64 INT273124 Positive_regulation of Negative_regulation of Hp 1 0.26 0.54 0.91 89.16
65 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 88.48
66 INT5743 Localization of NA 104 0.59 14.35 35.29 88.12
67 INT39632 Regulation of Localization of NA 8 0.20 1.52 1.81 88.12
68 INT56657 Negative_regulation of Positive_regulation of Spnb4 1 0.41 0 1.71 86.40
69 INT56656 Positive_regulation of Spnb4 3 0.49 1.09 1.92 86.40
70 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 86.40
71 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 86.24
72 INT71846 Regulation of Positive_regulation of Fn1 1 0.14 0.13 1.25 86.20
73 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03 85.68
74 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01 83.80
75 INT192968 Positive_regulation of Gene_expression of Hp 2 0.28 1.34 1.44 83.80
76 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 83.52
77 INT27387 Binding of Aecp 4 0.34 5.09 1 83.52
78 INT53536 Gene_expression of Bw86 8 0.30 0.89 5.21 82.36
79 INT113709 Positive_regulation of SNORD50A 1 0.22 0 0.93 81.52
80 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 78.48
81 INT21186 Negative_regulation of Binding of Ptprg 28 0.44 1.78 27.04 78.44
82 INT273125 Positive_regulation of Localization of Hp 1 0.26 0.45 0.78 78.04
83 INT273127 Localization of Hp 1 0.39 0.45 0.77 78.04
84 INT35212 Negative_regulation of Atp2b1 1 0.51 0 0.96 77.84
85 INT64748 Regulation of Binding of Pck1 4 0.44 0.45 3.15 75.84
86 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89 73.08
87 INT12110 Regulation of Hbb-ar 5 0.17 0.85 3.82 72.96
88 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 70.80
89 INT29142 Positive_regulation of Binding of Pck1 10 0.67 1.48 7.6 69.92
90 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 68.80
91 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 62.32
92 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9 61.60
93 INT351285 Localization of AP1M2 1 0.07 0.79 1.89 60.32
94 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 58.28
95 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28 57.12
96 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 55.92
97 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36 54.72
98 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 50.24
99 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 50.00
100 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 50.00
101 INT1703 Regulation of PCa 52 0.52 23.65 20.6 50.00
102 INT139613 Binding of pr 16 0.47 5.52 8.46 50.00
103 INT161480 Regulation of Positive_regulation of PCA 1 0.23 0.05 0 50.00
104 INT26602 Negative_regulation of HAGH 1 0.09 0 0.11 43.20
105 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 42.16
106 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 39.72
107 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 25.00
108 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 25.00
109 INT6933 Gene_expression of ANTXRL 15 0.10 4.77 6.84 25.00
110 INT70837 Positive_regulation of Binding of CRYGS 10 0.45 0.63 4.64 25.00
111 INT70840 Regulation of Positive_regulation of OPRK1 1 0.09 0.09 0.5 25.00
112 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 23.96
113 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 20.52
114 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 6.40
115 INT47044 Positive_regulation of ORM1 5 0.68 0.58 4.46 6.40
116 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
117 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
118 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
119 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
120 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
121 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
122 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 5.00
123 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
124 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
125 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
126 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
127 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
128 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
129 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
130 INT19511 Localization of Il6 212 0.81 118.17 67.67 5.00
131 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
132 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
133 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
134 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
135 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 5.00
136 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 5.00
137 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
138 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
139 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
140 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
141 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
142 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
143 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
144 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
145 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
146 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 5.00
147 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
148 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 5.00
149 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 5.00
150 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 5.00
151 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
152 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09 5.00
153 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
154 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
155 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
156 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
157 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 5.00
158 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
159 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 5.00
160 INT18930 Positive_regulation of Hrh1 20 0.63 7.77 12.96 5.00
161 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
162 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 5.00
163 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93 5.00
164 INT26534 Regulation of Akt1 34 0.61 14.47 11.86 5.00
165 INT9954 Negative_regulation of Hrh1 16 0.52 13.04 11.76 5.00
166 INT173272 Phosphorylation of Fig4 45 0.48 13.85 11.42 5.00
167 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
168 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
169 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07 5.00
170 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
171 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98 5.00
172 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
173 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23 5.00
174 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 5.00
175 INT10228 Positive_regulation of PCS 49 0.67 28.72 7 5.00
176 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
177 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07 5.00
178 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 5.00
179 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
180 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 5.00
181 INT187133 Protein_catabolism of TIMP1 19 0.73 11.3 5.51 5.00
182 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41 5.00
183 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
184 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26 5.00
185 INT49319 Regulation of Hrh2 5 0.45 2.31 5.04 5.00
186 INT112883 Gene_expression of Hspg2 22 0.65 6.54 4.95 5.00
187 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
188 INT115927 Negative_regulation of Hspg2 27 0.57 4.16 4.53 5.00
189 INT239217 Gene_expression of Agtrap 47 0.78 48.8 4.44 5.00
190 INT74365 Positive_regulation of Alox5 19 0.47 11.03 4.04 5.00
191 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54 5.00
192 INT122997 Phosphorylation of Rps6kb1 46 0.72 9.92 3.43 5.00
193 INT25990 Positive_regulation of Pla2g5 11 0.69 4.93 3.32 5.00
194 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 5.00
195 INT135316 Gene_expression of Hrh3 9 0.74 5.66 3.14 5.00
196 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08 5.00
197 INT228677 Negative_regulation of Phosphorylation of Rps6kb1 24 0.51 3.88 2.97 5.00
198 INT12237 Positive_regulation of Lipg 19 0.60 11.09 2.92 5.00
199 INT77226 Phosphorylation of Eif4ebp1 36 0.09 6.39 2.91 5.00
200 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78 5.00
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