P:nerve block

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pChart

Pain Term
Category Treatment
Synonyms None
Pain Specific Yes
Documents 2591
Hot Single Events 76
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for nerve block. They are ordered first by their pain relevance and then by number of times they were reported for nerve block. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6 99.96
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6 99.96
3 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32 99.18
4 INT45008 Cish Negative_regulation of pcp 1 0.13 0 0.22 90.84
5 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25 89.32
6 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12 26.36
7 INT317261 Binding of Gpr119 and Zglp1 1 0.08 0 0.07 22.08
8 INT317256 Binding of Pyy and Gpr119 1 0.29 0 0.07 22.08
9 INT317253 Binding of Pyy and Zglp1 1 0.12 0 0.07 21.00
10 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23 5.00
11 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65 5.00
12 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5 5.00
13 INT240658 Ngf Positive_regulation of Ngf Positive_regulation of Bdnf 1 0.33 1.67 1.99 5.00
14 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16 5.00
15 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09 5.00
16 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02 5.00
17 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99 5.00
18 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94 5.00
19 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84 5.00
20 INT299987 SPANXB1 Positive_regulation of TRPV1 1 0.20 0.71 0.82 5.00
21 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
22 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67 5.00
23 INT323352 Binding of F8 and VWF 5 0.08 2.22 0.33 5.00
24 INT317251 Npy Positive_regulation of Gpr119 1 0.32 0 0.25 5.00
25 INT323351 Positive_regulation of Binding of F8 and VWF 1 0.03 0.8 0.13 5.00
26 INT317259 Pyy Positive_regulation of Ins1 1 0.02 0.33 0.12 5.00
27 INT317243 Npy Positive_regulation of Tap2 1 0.08 0 0.1 5.00
28 INT317260 Pyy Positive_regulation of Tap2 1 0.09 0 0.1 5.00
29 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07 5.00
30 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07 5.00
31 INT317247 Ffar1 Positive_regulation of Localization of Gpr119 1 0.10 0.12 0.06 5.00
32 INT317249 Gpr119 Positive_regulation of Localization of Ffar1 1 0.10 0.12 0.06 5.00
33 INT317245 Binding of Npy2r and Pyy 1 0.09 0 0.05 5.00
34 INT317255 Pyy Positive_regulation of Localization of Npy 1 0.49 0 0.05 5.00
35 INT317244 Binding of Npy and Pyy 1 0.26 0 0.05 5.00
36 INT317257 Binding of Tap2 and Pyy 1 0.06 0 0.05 5.00
37 INT317242 Binding of Tap2 and Npy 1 0.05 0 0.05 5.00
38 INT317246 Binding of Npy2r and Npy 1 0.08 0 0.05 5.00
39 INT317252 Npy Positive_regulation of Localization of Pyy 1 0.49 0 0.05 5.00
40 INT336288 PYCARD Positive_regulation of SMN1 1 0.13 0 0 5.00
41 INT238270 Binding of VMO1 and MSLNL 1 0.11 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for nerve block. They are ordered first by their pain relevance and then by number of times they were reported in nerve block. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT160554 Gene_expression of BLK 2 0.59 0.1 0.63 100.00
2 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 100.00
3 INT135088 Negative_regulation of Phax 15 0.36 8.93 8.29 100.00
4 INT228328 Positive_regulation of Gene_expression of PYCARD 7 0.34 0.27 1.23 99.98
5 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7 99.98
6 INT89925 Gene_expression of NR1I2 22 0.75 9.63 4.21 99.80
7 INT149654 Negative_regulation of NR1I2 2 0.41 1.19 0.59 99.80
8 INT166936 Positive_regulation of Gene_expression of NR1I2 2 0.43 0.22 0.25 99.80
9 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 99.76
10 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 99.70
11 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31 99.54
12 INT47664 Positive_regulation of Lpn1 1 0.38 0.32 0.36 99.50
13 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 99.48
14 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 99.40
15 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28 99.36
16 INT57592 Negative_regulation of TAs 17 0.33 9.49 4.51 99.26
17 INT271783 Regulation of FES 10 0.39 0.9 0.7 99.22
18 INT36502 Positive_regulation of asp1 10 0.40 6.26 4.45 99.12
19 INT82919 Negative_regulation of KRT75 2 0.36 0.15 0.77 98.60
20 INT80837 Negative_regulation of NOVA2 7 0.42 2.11 2.02 98.36
21 INT22066 Gene_expression of Phax 40 0.78 22.51 25.91 98.24
22 INT102036 Positive_regulation of Dre 12 0.59 4.41 2.4 97.84
23 INT1703 Regulation of PCa 52 0.52 23.65 20.6 97.48
24 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46 97.36
25 INT264629 Localization of Rac1 8 0.72 5.7 0.79 97.28
26 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14 96.56
27 INT7883 Binding of ADRB2 18 0.47 5.49 7.37 96.56
28 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94 96.24
29 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.12
30 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 95.84
31 INT207156 Binding of TKTL1 3 0.22 0.93 0.99 95.64
32 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 95.60
33 INT69133 Negative_regulation of SON 3 0.10 1.79 1.96 95.36
34 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43 95.36
35 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 94.96
36 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 94.80
37 INT36365 Positive_regulation of SK 15 0.41 4.13 3.56 93.60
38 INT46148 Binding of LBR 5 0.31 1.58 0.64 93.44
39 INT39492 Negative_regulation of TNIP1 1 0.42 0.75 0.18 93.04
40 INT133508 Positive_regulation of TKTL1 8 0.60 6.37 4.8 92.96
41 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 92.80
42 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 92.32
43 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 92.32
44 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73 92.28
45 INT70721 Negative_regulation of SRRT 1 0.09 0.19 0.91 91.72
46 INT44578 Binding of Hbb 19 0.48 3.12 4.2 91.04
47 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 90.44
48 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 88.64
49 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 88.36
50 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 87.76
51 INT9015 Positive_regulation of Ptn 6 0.69 3 1.94 86.88
52 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 86.76
53 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 86.16
54 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 85.68
55 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 85.44
56 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 85.04
57 INT10106 Positive_regulation of Msr1 16 0.50 5.86 3.52 85.04
58 INT161811 Positive_regulation of Gene_expression of Msr1 5 0.49 6.38 0.38 85.04
59 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86 84.88
60 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86 84.88
61 INT19823 Negative_regulation of Pbrgcsf1 12 0.36 7.37 2.13 84.40
62 INT19824 Negative_regulation of Abr 3 0.59 0.88 0.84 84.40
63 INT38056 Localization of Crp 71 0.78 53.14 17.03 84.24
64 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33 83.96
65 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 83.20
66 INT2038 Localization of Esr1 104 0.79 40.12 13.27 83.20
67 INT36779 Localization of HBG2 3 0.59 1.57 2 82.84
68 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 82.52
69 INT4204 Positive_regulation of St8sia2 1 0.69 0.19 0.79 82.52
70 INT3842 Positive_regulation of Gsr 14 0.69 3.48 3.55 82.36
71 INT16871 Negative_regulation of Positive_regulation of Gsr 1 0.58 0 0.23 82.36
72 INT16870 Negative_regulation of Gsr 27 0.59 10.28 11.81 82.04
73 INT38283 Positive_regulation of Cebpg 2 0.04 1.96 0.69 81.76
74 INT22431 Negative_regulation of HBG2 20 0.58 6.6 3.33 81.56
75 INT122101 Negative_regulation of Tap2 4 0.25 0.36 0.82 80.68
76 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64 80.32
77 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 80.00
78 INT29377 Negative_regulation of Stresp2 1 0.05 0.28 0.56 79.56
79 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 79.44
80 INT127524 Localization of Zglp1 9 0.53 4.28 1.7 78.96
81 INT280038 Negative_regulation of Localization of Zglp1 3 0.10 1.13 0.55 78.96
82 INT317236 Regulation of Localization of Zglp1 1 0.11 0 0.23 78.96
83 INT101898 Negative_regulation of Gan 1 0.43 0.71 1.14 77.12
84 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 75.64
85 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 75.00
86 INT126675 Negative_regulation of NAT8 2 0.42 1.95 0.33 75.00
87 INT168374 Negative_regulation of Capns1 2 0.50 5.09 1.1 75.00
88 INT168373 Gene_expression of Capns1 4 0.58 4.55 1.34 75.00
89 INT605 Regulation of Acot1 61 0.62 10.7 26.34 75.00
90 INT50669 Negative_regulation of Ptn 15 0.58 5.56 6.88 75.00
91 INT37405 Positive_regulation of Cst7 7 0.49 3.32 2.99 75.00
92 INT34864 Binding of Cp 23 0.47 5.17 1.78 75.00
93 INT165684 Localization of HADH 3 0.73 0.91 0.82 75.00
94 INT81217 Positive_regulation of Copa 1 0.21 0 0.07 74.76
95 INT29376 Negative_regulation of Sr1 1 0.07 0.14 0.28 74.44
96 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51 72.92
97 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 72.36
98 INT14081 Regulation of Cyp2a5 11 0.50 7.91 2.18 72.04
99 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 70.96
100 INT132335 Gene_expression of KCNA1 36 0.77 18.31 13.36 68.40
101 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 68.08
102 INT145450 Localization of Pyy 7 0.79 0.75 1.14 68.08
103 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 65.20
104 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 65.20
105 INT96499 Gene_expression of FES 5 0.65 2.26 0.48 64.80
106 INT271781 Positive_regulation of Gene_expression of FES 1 0.43 0.05 0.06 64.80
107 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03 64.36
108 INT2774 Binding of Crp 241 0.48 195.89 44.39 63.04
109 INT37296 Binding of Esr1 117 0.43 62.51 27.33 63.04
110 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 63.04
111 INT22454 Regulation of Crp 213 0.62 160.67 49.24 62.44
112 INT135133 Binding of NR1I2 7 0.42 1.7 0.29 60.72
113 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 59.48
114 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 59.12
115 INT44772 Negative_regulation of Negative_regulation of LBR 2 0.42 0.38 0.92 58.72
116 INT64792 Positive_regulation of Gene_expression of ITGAM 39 0.69 23.21 6.71 56.60
117 INT316829 Negative_regulation of SYNM 4 0.54 3.31 3.32 56.60
118 INT15179 Positive_regulation of Gene_expression of SELL 18 0.61 14.35 2.84 56.60
119 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 55.48
120 INT2216 Gene_expression of SELL 92 0.77 59.29 17.71 55.48
121 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 54.24
122 INT298578 Negative_regulation of CYB5R3 1 0.25 0.47 0.1 53.68
123 INT3359 Regulation of YY1 32 0.60 8.19 19.2 52.36
124 INT98254 Binding of MAX 1 0.36 0 0.05 51.12
125 INT98252 Binding of SK 3 0.08 0 0.1 50.80
126 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 50.00
127 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 50.00
128 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 50.00
129 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63 50.00
130 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53 50.00
131 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52 50.00
132 INT156827 Localization of MRI1 25 0.65 16.06 8.33 50.00
133 INT82104 Negative_regulation of Gimap1 25 0.54 4.78 6.6 50.00
134 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 50.00
135 INT156189 Positive_regulation of Gene_expression of Ntrk1 11 0.49 2.81 2.89 50.00
136 INT571 Negative_regulation of C2 9 0.43 3.93 1.54 50.00
137 INT27585 Positive_regulation of smc 9 0.58 3.2 1.47 50.00
138 INT28533 Negative_regulation of Cs 3 0.55 0 0.91 50.00
139 INT79726 Binding of Spef1 2 0.05 0.44 0 50.00
140 INT184579 Negative_regulation of SCTR 3 0.03 1.31 0.11 48.48
141 INT291027 Binding of FAM84A 1 0.02 1.12 0.82 47.68
142 INT271782 Positive_regulation of FES 1 0.43 0.17 0 47.40
143 INT98253 Regulation of Pou2f3 2 0.00 0.32 0.29 47.12
144 INT79113 Gene_expression of LOC682801 12 0.12 3.15 5.63 46.92
145 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86 44.68
146 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 44.16
147 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 44.00
148 INT274527 Regulation of SYNM 3 0.20 2.68 2.7 43.72
149 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 42.48
150 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 42.16
151 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33 42.00
152 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 41.36
153 INT70723 Binding of SRRT 1 0.10 0 1.38 40.08
154 INT9310 Negative_regulation of Ssr1 20 0.49 6.55 4.73 39.04
155 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 38.72
156 INT317226 Gene_expression of Gpr119 1 0.53 0.74 1.54 38.48
157 INT317227 Regulation of Gene_expression of Gpr119 1 0.36 0 0.42 38.48
158 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79 36.40
159 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12 35.68
160 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 34.08
161 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 33.84
162 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03 33.28
163 INT88114 Gene_expression of Cd53 20 0.77 10.99 12.38 32.56
164 INT84933 Regulation of Gene_expression of SELL 8 0.39 5.62 0.84 32.00
165 INT5008 Localization of Calca 204 0.81 80.35 125.16 29.16
166 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 29.16
167 INT317219 Regulation of Negative_regulation of Dpp4 1 0.21 0 0.22 26.40
168 INT26477 Regulation of ACE 26 0.45 16.31 4.33 25.72
169 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 25.68
170 INT17150 Regulation of Abpa 2 0.38 1.08 1.29 25.68
171 INT70722 Negative_regulation of Binding of SRRT 1 0.12 0 0.8 25.00
172 INT57397 Binding of Aif1 15 0.28 4.06 3.49 24.64
173 INT119769 Binding of Itgam 27 0.36 6.57 3.29 24.64
174 INT173394 Regulation of Gene_expression of Itgam 2 0.11 1.05 0.91 23.60
175 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05 22.68
176 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68 22.32
177 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82 22.32
178 INT51269 Gene_expression of HIST2H2AA3 16 0.56 10.16 6.55 19.88
179 INT140350 Binding of C2 17 0.36 3.97 4.69 16.56
180 INT29094 Binding of C3 39 0.37 12.65 2.27 16.56
181 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73 16.04
182 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28 15.60
183 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 15.36
184 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 13.36
185 INT246677 Gene_expression of Zglp1 10 0.51 4.26 1.39 12.96
186 INT47186 Localization of SCTR 8 0.50 5.07 1.55 11.60
187 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 11.04
188 INT240355 Gene_expression of srn 1 0.56 1.18 0.07 9.52
189 INT95128 Positive_regulation of KCNA1 8 0.41 4.28 2.19 6.64
190 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 6.20
191 INT22335 Regulation of Negative_regulation of ACE 10 0.44 7.01 1.77 6.20
192 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
193 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
194 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
195 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
196 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
197 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
198 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
199 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 5.00
200 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
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