P:opiate

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pChart

Pain Term
Category Drug class
Synonyms Opiates
Pain Specific Yes
Documents 18430
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for opiate. They are ordered first by their pain relevance and then by number of times they were reported for opiate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98 100.00
2 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57 100.00
3 INT32937 Binding of Pgrmc1 and Dtnb 1 0.20 0 1.61 100.00
4 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64 100.00
5 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44 100.00
6 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44 100.00
7 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28 100.00
8 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64 100.00
9 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2 100.00
10 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05 100.00
11 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96 100.00
12 INT60047 Oprl1 Negative_regulation of Phosphorylation of Syn1 1 0.05 0.17 1.05 100.00
13 INT43409 Regulation of Binding of Oprl1 and P9Ehs1 1 0.01 0 0.71 100.00
14 INT43408 Binding of Oprl1 and P9Ehs1 1 0.01 0 0.71 100.00
15 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08 100.00
16 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08 100.00
17 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14 100.00
18 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68 100.00
19 INT42861 Negative_regulation of Binding of Penk and Oprl1 1 0.45 0 0.94 100.00
20 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1 100.00
21 INT71070 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Cck 1 0.26 0 1.24 100.00
22 INT40186 Binding of Oprl1 and Srms 1 0.01 0 0.52 100.00
23 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 100.00
24 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55 100.00
25 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68 100.00
26 INT55460 Binding of OPRM1 and HERPUD1 1 0.11 0 0.4 100.00
27 INT30483 Binding of Oprl1 and Acyp2-ps1 1 0.02 0 0.58 100.00
28 INT33349 Binding of IFNA1 and Oprl1 1 0.09 0.08 0.52 100.00
29 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63 100.00
30 INT63279 Binding of Oprl1 and Gpm6a 1 0.01 0 0.47 100.00
31 INT45521 Oprl1 Positive_regulation of Localization of LH 1 0.24 0 0.77 100.00
32 INT5990 Positive_regulation of Oprl1 Positive_regulation of Localization of Prl 1 0.17 0 0.59 100.00
33 INT40610 Binding of Prkaca and Oprl1 1 0.02 0.09 0.8 100.00
34 INT33059 Dsp Negative_regulation of Localization of LH 1 0.18 0 0.8 100.00
35 INT31534 Binding of Sst and Oprl1 2 0.16 0.53 1.74 100.00
36 INT42765 Binding of PDYN and Oprl1 1 0.00 0 0.87 100.00
37 INT44589 Negative_regulation of Oprl1 Positive_regulation of Gh1 1 0.22 0.53 0.87 100.00
38 INT46008 OPRM1 Regulation of Localization of PRL 1 0.14 0 0.44 100.00
39 INT44590 Oprl1 Positive_regulation of Gh1 1 0.23 0.53 0.87 100.00
40 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 0.03 0 1.63 100.00
41 INT12754 Binding of Oprl1 and U 1 0.00 0.08 0.51 100.00
42 INT12755 Binding of Oprl1 and ERVK-5 1 0.00 0.08 0.51 100.00
43 INT24378 Penk Regulation of Oprl1 1 0.10 0 1.29 100.00
44 INT40180 Regulation of Binding of Oprl1 and Scn7a 1 0.02 0 0.67 100.00
45 INT40179 Binding of Oprl1 and Scn7a 1 0.03 0 0.67 100.00
46 INT30503 OPRM1 Regulation of Localization of Prl 1 0.00 0 0.67 100.00
47 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63 100.00
48 INT40321 Oprl1 Regulation of Localization of LH 1 0.18 0 0.59 100.00
49 INT1583 PENK Negative_regulation of Binding of PENK and POMC 1 0.08 0 0.83 100.00
50 INT1582 Binding of PENK and POMC 1 0.16 0 0.83 100.00
51 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97 100.00
52 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1 100.00
53 INT27451 OPRM1 Positive_regulation of Localization of Lhb 1 0.01 0.1 0.41 100.00
54 INT6768 Oprl1 Regulation of Localization of Prl 2 0.12 0 1.55 100.00
55 INT46022 tp Positive_regulation of SERPINB1 1 0.04 0 1.26 100.00
56 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84 100.00
57 INT46021 tp Positive_regulation of Oprl1 1 0.22 0 1.26 100.00
58 INT25837 Binding of Dbp and Oprl1 1 0.10 0 1.05 100.00
59 INT123465 Oprl1 Positive_regulation of ATP5G3 1 0.22 0 0.57 100.00
60 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07 100.00
61 INT71000 Positive_regulation of Adarb1 Positive_regulation of Odc1 1 0.01 0 1 100.00
62 INT43388 OPRM1 Positive_regulation of Localization of PLOD1 1 0.27 0 0.34 100.00
63 INT34535 Regulation of Binding of Penk and Oprl1 1 0.05 0 1.02 100.00
64 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22 100.00
65 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99 100.00
66 INT29137 ENG Regulation of POMC 1 0.00 0 0.28 100.00
67 INT29139 ENG Regulation of Oprl1 1 0.00 0 0.28 100.00
68 INT29140 POMC Regulation of Oprl1 1 0.00 0 0.27 100.00
69 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98 100.00
70 INT30268 Binding of Gnrh1 and Crh 1 0.45 0.65 0.57 100.00
71 INT30267 Binding of Crh and Gnrhr 1 0.33 0.65 0.57 100.00
72 INT18125 Binding of OPRM1 and Penk 1 0.54 0 0.4 100.00
73 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58 100.00
74 INT142490 Avp Regulation of Oxt 1 0.09 0.74 1.4 100.00
75 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42 100.00
76 INT30525 Acyp2-ps1 Regulation of Oprl1 1 0.04 0.15 0.33 100.00
77 INT26338 Binding of OPRM1 and Prl 1 0.02 0.37 0.47 100.00
78 INT30524 Crh Regulation of Oprl1 1 0.15 0.15 0.33 100.00
79 INT1619 Binding of Gad1 and Oprl1 1 0.14 0 1.13 100.00
80 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 0.16 0 1.13 100.00
81 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99 100.00
82 INT30523 Pomc Regulation of Oprl1 1 0.06 0.15 0.33 100.00
83 INT42780 Negative_regulation of Scn4a Negative_regulation of Positive_regulation of Prl 1 0.11 0 0.69 100.00
84 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7 100.00
85 INT783 Prss12 Positive_regulation of Positive_regulation of Oprl1 1 0.05 0 0.7 100.00
86 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63 100.00
87 INT3433 Vip Positive_regulation of Positive_regulation of Oprl1 1 0.26 0 0.53 100.00
88 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73 100.00
89 INT82393 Binding of OPRM1 and MAPRE2 1 0.06 0.1 0.17 100.00
90 INT82392 Binding of OPRM1 and VPS11 1 0.25 0.1 0.17 100.00
91 INT57391 Binding of Tspo and Oprl1 1 0.18 0.16 0.49 100.00
92 INT22273 Nts Regulation of Oprl1 1 0.09 0 0.51 100.00
93 INT64106 Oprl1 Positive_regulation of Localization of Gnrh1 1 0.03 0 0.88 100.00
94 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36 100.00
95 INT17601 Binding of POMC and Oprl1 1 0.01 0 1.2 100.00
96 INT21331 Binding of Adarb1 and Gm5195 1 0.00 0.26 1.08 100.00
97 INT21329 Binding of Man2a2 and Gm5195 1 0.00 0.26 1.06 100.00
98 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03 100.00
99 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1 100.00
100 INT21330 Binding of Htr1f and Gm5195 1 0.00 0.26 0.99 100.00
101 INT30422 Penk Regulation of Ins1 1 0.06 0 0.85 100.00
102 INT30425 Penk Regulation of Sst 1 0.20 0 0.84 100.00
103 INT41108 Adarb1 Positive_regulation of Localization of Ins1 1 0.03 0 0.81 100.00
104 INT53225 Qrfp Positive_regulation of Localization of LH 1 0.06 0 0.74 100.00
105 INT62898 Binding of Oprl1 and Dsp 1 0.35 0 0.52 100.00
106 INT60022 Oprl1 Positive_regulation of Localization of Rhd 1 0.18 0.1 0.44 100.00
107 INT55263 Binding of Cck and Pigt 1 0.05 0 0.41 100.00
108 INT100514 Binding of Oprl1 and Tbpl1 1 0.02 0 0.22 100.00
109 INT108598 Positive_regulation of Oprl1 Positive_regulation of Phosphorylation of P2ry2 1 0.10 0 0.13 100.00
110 INT34497 Binding of Oprl1 and Ache 1 0.40 0 0.1 100.00
111 INT55459 Binding of OPRM1 and TYR 1 0.08 0 0.1 100.00
112 INT29803 Binding of Rtcd1 and Rbm39 1 0.00 0.14 0.59 99.98
113 INT17528 Prl Regulation of Gh 2 0.28 1.28 0.73 99.98
114 INT47221 Prl Regulation of Localization of Gh 1 0.28 0.27 0.46 99.98
115 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64 99.98
116 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34 99.92
117 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05 99.90
118 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58 99.90
119 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68 99.84
120 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15 99.84
121 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2 99.84
122 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97 99.80
123 INT116450 POMC Negative_regulation of Localization of LHB 1 0.08 0 0.1 99.80
124 INT116449 POMC Negative_regulation of Localization of PLOD1 1 0.11 0 0.1 99.80
125 INT79383 Pde1b Regulation of Oprd1 1 0.02 0 0.34 99.78
126 INT82391 Binding of MAPRE2 and VPS11 1 0.07 0.1 0.17 99.76
127 INT33113 Binding of Abpa and pcp 1 0.02 0.09 0.37 99.72
128 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85 99.70
129 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59 99.66
130 INT60536 Gnrh1 Positive_regulation of Localization of Prl 2 0.22 1.12 0.6 99.64
131 INT60537 Gnrh1 Positive_regulation of Localization of FSHR 1 0.00 0.19 0.6 99.64
132 INT60538 Gnrh1 Positive_regulation of Localization of LHB 1 0.00 0.19 0.59 99.64
133 INT21513 Negative_regulation of GNRH1 Negative_regulation of Lhb 1 0.05 0.14 0.32 99.60
134 INT106243 Oprm1 Regulation of Gene_expression of IL8 1 0.00 0 0.45 99.54
135 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18 99.48
136 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 99.48
137 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05 99.48
138 INT30265 Binding of Pomc and Gnrh1 1 0.29 0.33 0.29 99.46
139 INT30264 Binding of Pomc and Gnrhr 1 0.22 0.32 0.29 99.46
140 INT14374 Zmat3 Positive_regulation of Localization of Prl 1 0.03 0 0.45 99.44
141 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14 99.40
142 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55 99.40
143 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01 99.36
144 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83 99.36
145 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31 99.36
146 INT43454 Pomc Regulation of Localization of Avp 2 0.24 0.89 0.94 99.32
147 INT31389 Negative_regulation of Binding of PRCP and Abpa 1 0.02 0.09 0.72 99.30
148 INT35690 Dpp6 Regulation of Jmjd1c 1 0.17 0 0.33 99.28
149 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19 99.26
150 INT46339 Ptgds Regulation of Localization of Lh 1 0.25 0 0.29 99.26
151 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44 99.22
152 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16 99.22
153 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96 99.16
154 INT30501 Sst Negative_regulation of Localization of Gh 1 0.01 0 0.38 99.14
155 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91 99.14
156 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65 99.12
157 INT31640 POMC Regulation of POMC Regulation of GCG 1 0.19 0.38 0.58 99.10
158 INT42043 Binding of Gnrh1 and MCG 1 0.01 0.26 0.35 99.10
159 INT42042 Binding of Gnrhr and MCG 1 0.01 0.26 0.35 99.10
160 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61 99.08
161 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81 99.08
162 INT19261 Binding of LH and Gnrh1 2 0.43 0.09 0.96 99.08
163 INT63703 Regulation of TRH Positive_regulation of Prl 1 0.07 0 0.23 99.08
164 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46 99.04
165 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46 99.04
166 INT42040 Pomc Regulation of Positive_regulation of Gnrh1 1 0.28 0.46 0.56 99.00
167 INT42041 Pomc Regulation of Gnrh1 1 0.17 0.46 0.56 99.00
168 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71 98.98
169 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14 98.98
170 INT40742 Pomc Regulation of Localization of Gh1 1 0.37 0 0.86 98.98
171 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97 98.96
172 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7 98.96
173 INT784 Prss12 Positive_regulation of Gh1 1 0.06 0 0.7 98.96
174 INT40770 Binding of Penk and Acyp2-ps1 1 0.41 0 0.43 98.96
175 INT70811 Penk Negative_regulation of Binding of Tyr 1 0.01 0 0.6 98.96
176 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2 98.92
177 INT139189 Binding of Daxx and Fadd 1 0.03 0.27 0.57 98.90
178 INT72017 Binding of Adora2a and Ptprg 2 0.07 0 0.77 98.86
179 INT19819 Penk Regulation of Gene_expression of Ins1 1 0.05 0 1.27 98.84
180 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73 98.82
181 INT30263 Binding of Gnrh1 and Penk 1 0.13 0.33 0.29 98.78
182 INT30266 Binding of Penk and Gnrhr 1 0.10 0.32 0.29 98.78
183 INT31391 Binding of PRCP and Abpa 1 0.03 0.16 1.42 98.72
184 INT777 Prss12 Positive_regulation of Prl 1 0.19 0 1.33 98.68
185 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7 98.68
186 INT117053 Slc3a1 Regulation of Positive_regulation of Mzb1 1 0.42 0 0.19 98.68
187 INT117054 Slc3a1 Regulation of Mzb1 1 0.25 0 0.19 98.68
188 INT31531 Mif-ps1 Regulation of TYR 1 0.11 0 0.49 98.66
189 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61 98.64
190 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21 98.60
191 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73 98.58
192 INT43118 Binding of Pla2g1b and Phax 1 0.03 0 0.15 98.56
193 INT42779 Scn4a Positive_regulation of Localization of Gnrhr 1 0.10 0 0.66 98.52
194 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82 98.40
195 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75 98.40
196 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75 98.40
197 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73 98.40
198 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73 98.40
199 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 98.36
200 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67 98.34

Single Events

The table below shows the top 200 pain related interactions that have been reported for opiate. They are ordered first by their pain relevance and then by number of times they were reported in opiate. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
2 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 100.00
3 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
4 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
5 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
6 INT443 Localization of POMC 1020 0.81 284.52 443.17 100.00
7 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
8 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 100.00
9 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 100.00
10 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
11 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
12 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
13 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
14 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 100.00
15 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 100.00
16 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
17 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 100.00
18 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 100.00
19 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 100.00
20 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 100.00
21 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 100.00
22 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 100.00
23 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 100.00
24 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
25 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 100.00
26 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 100.00
27 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
28 INT1308 Localization of Pomc 457 0.81 66.83 217.5 100.00
29 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 100.00
30 INT2366 Binding of Cck 192 0.48 30.64 163.46 100.00
31 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
32 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41 100.00
33 INT1376 Binding of Trh 121 0.48 20 69.86 100.00
34 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 100.00
35 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
36 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 100.00
37 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 100.00
38 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07 100.00
39 INT287 Localization of Cck 518 0.81 86.84 364.04 100.00
40 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
41 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57 100.00
42 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 100.00
43 INT3948 Regulation of Cck 291 0.62 58.07 255.88 100.00
44 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 100.00
45 INT292 Localization of Penk 876 0.81 88.44 669.14 100.00
46 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 100.00
47 INT6437 Binding of YY1 154 0.47 26.3 90.46 100.00
48 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 100.00
49 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 100.00
50 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 100.00
51 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62 100.00
52 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 100.00
53 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 100.00
54 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 100.00
55 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 100.00
56 INT60046 Positive_regulation of Syn1 16 0.70 2 13.9 100.00
57 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 100.00
58 INT1463 Binding of Pomc 129 0.48 15.89 56.27 100.00
59 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 100.00
60 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 100.00
61 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 100.00
62 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 100.00
63 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 100.00
64 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 100.00
65 INT6765 Localization of Oprl1 49 0.81 5.11 28.87 100.00
66 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 100.00
67 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 100.00
68 INT1612 Regulation of Binding of Oprl1 19 0.62 2.34 12.45 100.00
69 INT339 Regulation of Trh 156 0.62 39.27 83.55 100.00
70 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 100.00
71 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72 100.00
72 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 100.00
73 INT6762 Binding of Srms 56 0.31 6.62 30.27 100.00
74 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24 100.00
75 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 100.00
76 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
77 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 100.00
78 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
79 INT6299 Regulation of Localization of Lhb 104 0.61 8.98 48.79 100.00
80 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 100.00
81 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 100.00
82 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97 100.00
83 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 100.00
84 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 100.00
85 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28 100.00
86 INT24780 Binding of Ap1m1 20 0.29 4.75 25.05 100.00
87 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 100.00
88 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 100.00
89 INT1782 Regulation of Gh1 125 0.62 22 55.74 100.00
90 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 100.00
91 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 100.00
92 INT12734 Regulation of Binding of Oprl1 10 0.62 2.23 7.71 100.00
93 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75 100.00
94 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 100.00
95 INT462 Regulation of Pomc 157 0.62 41.67 67.27 100.00
96 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 100.00
97 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 100.00
98 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 100.00
99 INT685 Regulation of AVP 124 0.62 34.9 39.91 100.00
100 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 100.00
101 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
102 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 100.00
103 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69 100.00
104 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
105 INT26632 Binding of Acyp2-ps1 12 0.42 0.66 6.16 100.00
106 INT13209 Regulation of Binding of Trh 19 0.62 2.84 16.26 100.00
107 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97 100.00
108 INT4153 Binding of Insrr 109 0.40 17.99 72.15 100.00
109 INT1898 Regulation of Crh 220 0.62 61.33 102.64 100.00
110 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 100.00
111 INT8248 Binding of Adra2a 43 0.48 6.72 22.17 100.00
112 INT1530 Regulation of Gh 382 0.61 115.96 112.47 100.00
113 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 100.00
114 INT18571 Binding of HERPUD1 6 0.48 0 3.17 100.00
115 INT5426 Negative_regulation of RTCA 58 0.51 12.34 25.74 100.00
116 INT42971 Binding of Hivep3 14 0.42 3.92 8.99 100.00
117 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01 100.00
118 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48 100.00
119 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 100.00
120 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 100.00
121 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 100.00
122 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39 100.00
123 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 100.00
124 INT76649 Gene_expression of TRIM54 12 0.22 1.91 5.55 100.00
125 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 100.00
126 INT54706 Regulation of Adrbk1 11 0.62 0.89 10.69 100.00
127 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 100.00
128 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 100.00
129 INT1491 Regulation of Rtcd1 33 0.53 5.17 13.4 100.00
130 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 100.00
131 INT14419 Negative_regulation of Localization of Trh 40 0.59 2.04 17.42 100.00
132 INT2156 Positive_regulation of Positive_regulation of LH 33 0.69 3.18 14.33 100.00
133 INT8153 Regulation of Localization of Cck 52 0.62 11.22 54.83 100.00
134 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 100.00
135 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23 100.00
136 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26 100.00
137 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3 100.00
138 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 100.00
139 INT8089 Binding of Gnrh1 47 0.48 10.04 13.99 100.00
140 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 100.00
141 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 100.00
142 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 100.00
143 INT1510 Binding of PDYN 94 0.48 4.68 56.44 100.00
144 INT1975 Regulation of Regulation of Prl 32 0.59 5.78 18.53 100.00
145 INT1321 Localization of Oprl1 18 0.76 1.74 9.56 100.00
146 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03 100.00
147 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 100.00
148 INT7017 Regulation of Npr1 45 0.52 3.38 20.05 100.00
149 INT1597 Negative_regulation of Binding of Oprl1 11 0.59 1.38 6.62 100.00
150 INT1617 Positive_regulation of Binding of Oprl1 10 0.59 0.63 9.79 100.00
151 INT28326 Positive_regulation of Negative_regulation of Oprl1 6 0.44 2.01 3.78 100.00
152 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 100.00
153 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 100.00
154 INT32936 Binding of Dtnb 3 0.41 0 3.41 100.00
155 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52 100.00
156 INT2160 Negative_regulation of Negative_regulation of LH 22 0.58 4.58 11.53 100.00
157 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57 100.00
158 INT4803 Transcription of Penk 435 0.72 59.09 182.4 100.00
159 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 100.00
160 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 100.00
161 INT4030 Positive_regulation of Regulation of LH 6 0.50 0.96 4.66 100.00
162 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 100.00
163 INT2278 Regulation of Localization of Gast 81 0.62 16.93 30.64 100.00
164 INT16879 Binding of Crh 72 0.48 21.65 28.43 100.00
165 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
166 INT3117 Regulation of Oxt 103 0.61 17.93 32.28 100.00
167 INT6764 Regulation of Regulation of Oprl1 5 0.45 0.58 5.28 100.00
168 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 100.00
169 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3 100.00
170 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 100.00
171 INT33996 Positive_regulation of Negative_regulation of Oprl1 4 0.53 1.34 2.68 100.00
172 INT451 Regulation of Oxt 142 0.62 22.07 69.42 100.00
173 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 100.00
174 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 100.00
175 INT605 Regulation of Acot1 61 0.62 10.7 26.34 100.00
176 INT7282 Regulation of Localization of Sst 58 0.62 1.92 34.83 100.00
177 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11 100.00
178 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 100.00
179 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32 100.00
180 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 100.00
181 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37 100.00
182 INT14368 Regulation of Gene_expression of Gnrhr 13 0.61 3.23 8.45 100.00
183 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 100.00
184 INT10557 Regulation of Positive_regulation of LH 13 0.62 2.76 9.58 100.00
185 INT8526 Negative_regulation of Positive_regulation of Fos 26 0.59 5.99 17.52 100.00
186 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 100.00
187 INT1252 Binding of Ache 46 0.48 9.94 10.25 100.00
188 INT8989 Binding of Npr1 25 0.36 5.52 14.58 100.00
189 INT2157 Positive_regulation of Gene_expression of LH 24 0.69 6.07 8.67 100.00
190 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34 100.00
191 INT1416 Transcription of POMC 40 0.72 10.71 15.38 100.00
192 INT5118 Regulation of SST 97 0.62 34.35 51.74 100.00
193 INT1512 Binding of Prl 73 0.48 26.22 20.63 100.00
194 INT1156 Binding of CCK 27 0.48 8.71 20.58 100.00
195 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 100.00
196 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 100.00
197 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 100.00
198 INT21067 Regulation of Regulation of PRL 11 0.60 2 5.31 100.00
199 INT12117 Regulation of Negative_regulation of Oprl1 6 0.44 1.49 2.82 100.00
200 INT2330 Regulation of CB 78 0.10 20.46 32.6 100.00
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