P:orphanin

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pChart

Pain Term
Category Drug
Synonyms Nociceptin
Pain Specific No
Documents 798
Hot Single Events 200
Hot Interactions 148

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for orphanin. They are ordered first by their pain relevance and then by number of times they were reported for orphanin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 100.00
2 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57 100.00
3 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38 100.00
4 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41 100.00
5 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27 100.00
6 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25 100.00
7 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82 100.00
8 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14 100.00
9 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5 100.00
10 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17 100.00
11 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29 100.00
12 INT104348 Pnoc Negative_regulation of Localization of Gnrh1 1 0.45 0 1.24 100.00
13 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58 100.00
14 INT69788 Binding of Gpr1 and Pnoc 2 0.09 0 1.49 100.00
15 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83 100.00
16 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55 100.00
17 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46 100.00
18 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72 100.00
19 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84 100.00
20 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85 100.00
21 INT94091 Binding of Pnoc and Tbce 1 0.03 0.19 1.19 100.00
22 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83 100.00
23 INT75126 Pnoc Regulation of Localization of Avp 2 0.26 0.24 1.18 100.00
24 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72 100.00
25 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96 100.00
26 INT73398 Binding of Pnoc and Nr1d2 1 0.10 0 1.27 100.00
27 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76 100.00
28 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08 100.00
29 INT104347 Pnoc Regulation of Localization of Gnrh1 1 0.57 0 0.75 100.00
30 INT76508 Pnoc Regulation of Oprl1 1 0.47 0.25 1.32 100.00
31 INT80718 Trpv3 Negative_regulation of Chn1 1 0.01 0.7 0.92 100.00
32 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77 100.00
33 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58 100.00
34 INT72463 NA Positive_regulation of Binding of OPRL1 and PNOC 1 0.04 0 0.91 100.00
35 INT72464 Positive_regulation of Binding of OPRL1 and PNOC 1 0.34 0 0.91 100.00
36 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75 100.00
37 INT128515 Binding of PNOC and Pnoc 1 0.12 0.38 1.14 100.00
38 INT72467 Regulation of Binding of OPRL1 and PNOC 1 0.18 0 0.86 100.00
39 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91 100.00
40 INT79123 Binding of Pnoc and Oprm1 3 0.14 0 0.91 100.00
41 INT81520 Binding of PNOC and Oprl1 1 0.24 0.1 0.75 100.00
42 INT69225 Pnoc Negative_regulation of Car1 1 0.42 0 0.78 100.00
43 INT108073 Pnoc Negative_regulation of Gene_expression of Fos 1 0.32 0.25 0.76 100.00
44 INT119281 Pnoc Regulation of Oprl1 1 0.31 0.29 0.56 100.00
45 INT161387 Binding of PNOC and GTPBP4 1 0.03 1.05 0.59 100.00
46 INT77737 Pnoc Positive_regulation of Localization of Prl 3 0.55 0 1.07 100.00
47 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99 100.00
48 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66 100.00
49 INT75129 Pnoc Negative_regulation of Avp 1 0.13 0 0.54 100.00
50 INT75127 Pnoc Negative_regulation of Oxt 1 0.15 0 0.54 100.00
51 INT104346 Pnoc Regulation of Localization of Glt6d1 1 0.01 0 0.41 100.00
52 INT94089 Binding of Pnoc and Pde6b 1 0.02 0.09 0.57 100.00
53 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07 100.00
54 INT126654 Oprd1 Regulation of Oprm1 1 0.03 0.13 0.52 100.00
55 INT75128 Pnoc Regulation of Localization of Oxt 1 0.19 0 0.57 100.00
56 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25 100.00
57 INT122380 Pnoc Positive_regulation of Oprl1 1 0.36 0.55 0.98 100.00
58 INT87805 Pnoc Negative_regulation of Gene_expression of Fosl1 1 0.33 0 1.08 100.00
59 INT90987 Positive_regulation of Oprl1 Positive_regulation of Binding of Oprl1 1 0.00 0 0.66 100.00
60 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45 100.00
61 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39 100.00
62 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34 100.00
63 INT94092 Pnoc Positive_regulation of Pde6b 1 0.02 0.1 0.44 100.00
64 INT70833 Binding of PDYN and Pnoc 1 0.53 0 0.65 100.00
65 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44 100.00
66 INT71089 Binding of HTR1A and Pnoc 1 0.01 0 0.35 100.00
67 INT116102 Cck Positive_regulation of Negative_regulation of Pnoc 1 0.51 0.41 1.33 100.00
68 INT69226 Regulation of Pnoc Positive_regulation of Oprl1 1 0.19 0 0.63 100.00
69 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77 100.00
70 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77 100.00
71 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08 100.00
72 INT117404 Binding of Pnoc and OR4F4 1 0.00 0.46 0.86 100.00
73 INT72465 PNOC Positive_regulation of OPRL1 1 0.30 0 0.36 100.00
74 INT85559 Binding of Pnoc and Oprl1 1 0.39 0 0.53 100.00
75 INT126951 PNOC Positive_regulation of OPRM1 1 0.21 0.06 0.6 100.00
76 INT83417 Binding of OPRL1 and Oprm1 1 0.01 0 0.89 100.00
77 INT116227 Pnoc Negative_regulation of NAV1 1 0.02 0.1 0.48 100.00
78 INT93558 Binding of Oprl1 and Btd 1 0.00 0 0.37 100.00
79 INT93557 Binding of Pnoc and Btd 1 0.00 0 0.37 100.00
80 INT138072 Chn1 Positive_regulation of Oprl1 1 0.42 1.02 0.95 100.00
81 INT97202 Binding of APLNR and Pnoc 1 0.02 0.27 0.63 100.00
82 INT88215 Binding of PNOC and Pnoc 1 0.01 0.07 0.46 100.00
83 INT121272 PNOC Negative_regulation of Positive_regulation of TRPV1 1 0.27 0 0.66 100.00
84 INT111504 Pnoc Positive_regulation of Binding of Ptprg 1 0.01 0 0.96 100.00
85 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57 100.00
86 INT128541 Pnoc Positive_regulation of Crygb 1 0.21 0 0.29 100.00
87 INT69362 Binding of Pnoc and Rtn4 1 0.01 0 0.31 100.00
88 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31 100.00
89 INT70811 Penk Negative_regulation of Binding of Tyr 1 0.01 0 0.6 100.00
90 INT74252 Binding of Penk and Set 1 0.03 0 0.75 100.00
91 INT143492 OPRL1 Regulation of PNOC 1 0.05 0 0.99 100.00
92 INT85760 Binding of Pnoc and Noc3l 1 0.01 0 0.21 100.00
93 INT98480 Lif Positive_regulation of Pnoc 1 0.18 0.2 0.49 100.00
94 INT98481 Lif Regulation of Regulation of Oprl1 1 0.04 0.16 0.45 100.00
95 INT98482 Lif Positive_regulation of Gene_expression of Pnoc 1 0.16 0.17 0.46 100.00
96 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16 100.00
97 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77 100.00
98 INT81977 Binding of OPRL1 and Galphaqo5 1 0.01 0 0.77 100.00
99 INT81975 Binding of OPRL1 and RASGRP1 1 0.03 0 0.76 100.00
100 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14 100.00
101 INT77736 Pnoc Positive_regulation of Localization of Gnrhr 1 0.24 0 0.23 100.00
102 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61 100.00
103 INT89514 Pnoc Regulation of Gene_expression of Fos 1 0.47 0.98 0.93 100.00
104 INT89515 Pnoc Regulation of Gene_expression of Fosl1 1 0.09 0.98 0.93 100.00
105 INT101966 Pnoc Positive_regulation of Kcnj9 1 0.14 0.26 0.46 100.00
106 INT90544 Efw Negative_regulation of Regulation of Pnoc 1 0.00 0 0.34 100.00
107 INT90543 Npff Negative_regulation of Regulation of Pnoc 1 0.26 0 0.34 100.00
108 INT324694 Tlr4 Positive_regulation of Gene_expression of Pnoc 1 0.05 0.56 0.24 100.00
109 INT77816 Binding of HOAC and Pnoc 1 0.07 0 0.15 100.00
110 INT144589 Binding of YY1 and Oprl1 1 0.04 0.73 0.13 100.00
111 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19 99.92
112 INT91005 Binding of Oprl1 and CCRN4L 1 0.14 0.37 0.85 99.90
113 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 99.76
114 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04 99.76
115 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45 99.56
116 INT108072 Grip2 Positive_regulation of Gene_expression of Fos 1 0.08 0.21 0.82 99.06
117 INT111014 Binding of OPRL1 and Oprd1 1 0.02 0 0.64 98.92
118 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96 98.44
119 INT111509 Pnoc Positive_regulation of Binding of Ptprg 1 0.00 0 0.47 98.32
120 INT109803 Binding of Avp and Oprl1 1 0.07 0.1 0.59 97.56
121 INT109802 Binding of Esr2 and Oprl1 1 0.22 0.1 0.59 97.56
122 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8 97.32
123 INT172239 Binding of NPBWR1 and NPBWR2 1 0.17 0.27 0.44 97.04
124 INT172238 Binding of NPBWR2 and NCOR2 1 0.01 0.27 0.44 97.04
125 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2 96.24
126 INT98484 Lif Regulation of Gene_expression of Gal 1 0.04 0.16 0.47 96.16
127 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85 94.72
128 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69 93.92
129 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66 92.72
130 INT97184 Oprm1 Regulation of Gene_expression of Pomc 1 0.31 0 0.89 90.96
131 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07 90.64
132 INT111505 Positive_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71 90.36
133 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82 90.16
134 INT111506 Negative_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71 89.68
135 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63 89.00
136 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52 88.24
137 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51 86.84
138 INT96307 Binding of Pnoc and Adarb1 1 0.12 0.37 0.77 86.32
139 INT273945 Crh Positive_regulation of Gene_expression of Crem 1 0.20 0.52 0.43 84.48
140 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29 84.28
141 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11 84.20
142 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53 84.04
143 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67 84.00
144 INT153370 LBX1 Positive_regulation of Gene_expression of Slc6a5 1 0.02 0 0.88 83.56
145 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14 83.28
146 INT81035 Binding of Oprl1 and Pomc 1 0.03 0.13 0.47 82.64
147 INT81036 Binding of Oprl1 and Rbm39 1 0.02 0.13 0.47 81.36
148 INT167002 Pnoc Regulation of Gene_expression of Oxt 1 0.10 0.2 0.25 80.68
149 INT106397 Positive_regulation of OPRL1 Positive_regulation of ADRBK1 1 0.46 0.09 0.31 76.88
150 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11 75.00
151 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5 75.00
152 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5 75.00
153 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35 75.00
154 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34 75.00
155 INT104110 Negative_regulation of Adrbk2 Negative_regulation of Oprm1 1 0.00 0 0.71 75.00
156 INT104102 Negative_regulation of Adrbk2 Negative_regulation of Oprl1 1 0.06 0 0.7 75.00
157 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36 75.00
158 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57 75.00
159 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38 75.00
160 INT137569 Comp Negative_regulation of Positive_regulation of Prl 1 0.23 0 0.2 75.00
161 INT137568 Comp Negative_regulation of Regulation of Prl 1 0.17 0 0.2 75.00
162 INT137570 Comp Negative_regulation of Prl 1 0.17 0 0.2 75.00
163 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42 73.00
164 INT106395 DYT10 Positive_regulation of ADRBK2 1 0.44 0 0.42 73.00
165 INT125404 OPRL1 Positive_regulation of Binding of OPRL1 and PTPRM 1 0.03 0.08 0.54 70.72
166 INT125405 PTPRM Positive_regulation of Binding of OPRL1 and PTPRM 1 0.00 0.16 1.07 69.92
167 INT273935 Crem Regulation of Gene_expression of Egr2 1 0.05 0.16 0.26 69.80
168 INT171825 Binding of Prkcg and Ncs1 1 0.00 0.07 0.66 67.28
169 INT171824 Binding of Ncs1 and Aspm 1 0.00 0.07 0.65 67.28
170 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13 60.80
171 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97 51.48
172 INT88971 Binding of Sult4a1 and Atrn 1 0.02 0.54 1.03 50.76
173 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22 50.44
174 INT123052 Gpbar1 Regulation of Phosphorylation of Grk4 1 0.37 0 0.94 41.04
175 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94 41.04
176 INT123049 Grk4 Regulation of Phosphorylation of Gpbar1 1 0.37 0 0.94 41.04
177 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94 41.04
178 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94 41.04
179 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94 41.04
180 INT172247 Binding of NCOR2 and QRFPR 1 0.01 0.12 0.43 40.84
181 INT126075 Binding of Npvf and Npffr2 1 0.35 0 0.19 30.24
182 INT126073 Binding of Npvf and Npffr1 1 0.35 0 0.19 29.44
183 INT126074 Binding of Npff and Npvf 1 0.35 0 0.18 28.08
184 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0 27.68
185 INT98671 ROS1 Positive_regulation of Gene_expression of Penk 1 0.00 0.52 0.25 25.00
186 INT172248 Binding of KNG1 and NCOR2 1 0.02 0.19 0.52 22.32
187 INT172244 Binding of GPR39 and NTSR1 1 0.39 0 0.26 10.52
188 INT172243 Binding of GPR39 and NTS 1 0.09 0 0.23 10.52
189 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
190 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
191 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
192 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
193 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
194 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 5.00
195 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
196 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
197 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
198 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92 5.00
199 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
200 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for orphanin. They are ordered first by their pain relevance and then by number of times they were reported in orphanin. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 100.00
2 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 100.00
3 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 100.00
4 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 100.00
5 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76 100.00
6 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
7 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39 100.00
8 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
9 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
10 INT66417 Localization of Pnoc 34 0.80 1.61 24.48 100.00
11 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
12 INT68970 Positive_regulation of Pnoc 33 0.67 9.29 19.08 100.00
13 INT47876 Binding of Pnoc 20 0.47 4.99 20.01 100.00
14 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 100.00
15 INT68640 Regulation of Pnoc 18 0.54 7.6 17.27 100.00
16 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11 100.00
17 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 100.00
18 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 100.00
19 INT64484 Binding of PNOC 12 0.33 5.51 10.86 100.00
20 INT73351 Negative_regulation of Pnoc 13 0.42 5.71 14.17 100.00
21 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
22 INT78556 Gene_expression of PNOC 11 0.76 2.93 10.58 100.00
23 INT67213 Transcription of Pnoc 18 0.67 4.66 12.17 100.00
24 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41 100.00
25 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 100.00
26 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 100.00
27 INT18573 Regulation of Positive_regulation of Oprl1 11 0.45 0.78 9.91 100.00
28 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
29 INT81664 Positive_regulation of Gene_expression of Pnoc 12 0.68 2.51 9.75 100.00
30 INT65206 Regulation of PNOC 8 0.38 1.61 7.43 100.00
31 INT68971 Localization of Pnoc 10 0.73 2.95 8.43 100.00
32 INT86371 Protein_catabolism of Pnoc 2 0.98 0.79 3.65 100.00
33 INT82811 Negative_regulation of Binding of Pnoc 6 0.37 0 7.04 100.00
34 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52 100.00
35 INT6765 Localization of Oprl1 49 0.81 5.11 28.87 100.00
36 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
37 INT87890 Regulation of Gene_expression of Pnoc 8 0.44 2.45 7.66 100.00
38 INT72804 Negative_regulation of OPRL1 16 0.43 1.79 12.14 100.00
39 INT67214 Transcription of Oprl1 9 0.69 1.8 5.66 100.00
40 INT72474 Positive_regulation of PNOC 9 0.68 1.76 4.84 100.00
41 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9 100.00
42 INT477 Localization of Avp 813 0.81 131.58 300.4 100.00
43 INT122080 Positive_regulation of Crygb 10 0.45 4.32 7.14 100.00
44 INT1321 Localization of Oprl1 18 0.76 1.74 9.56 100.00
45 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
46 INT21223 Positive_regulation of Gene_expression of Oprl1 10 0.70 2.21 9.24 100.00
47 INT69941 Positive_regulation of Gene_expression of Pnoc 9 0.67 1.53 5.16 100.00
48 INT122078 Gene_expression of Crygb 7 0.76 1.25 4.34 100.00
49 INT68581 Transcription of Pnoc 4 0.70 1.21 3.54 100.00
50 INT120807 Binding of NOL3 10 0.45 3.62 3.97 100.00
51 INT87786 Regulation of Gene_expression of Pnoc 3 0.61 3.06 5.66 100.00
52 INT108475 Transcription of PNOC 1 0.52 0.35 2.08 100.00
53 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72 100.00
54 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05 100.00
55 INT138070 Gene_expression of Chn1 1 0.56 4.05 3.79 100.00
56 INT3431 Negative_regulation of Positive_regulation of Oprl1 14 0.46 2.55 9.65 100.00
57 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 100.00
58 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62 100.00
59 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
60 INT138068 Positive_regulation of Chn1 2 0.50 2.45 2.87 100.00
61 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
62 INT76994 Negative_regulation of Gene_expression of Oprl1 3 0.59 0.75 1.73 100.00
63 INT110521 Regulation of Crygb 5 0.28 1.42 2.92 100.00
64 INT121601 Positive_regulation of Localization of Oprl1 1 0.70 1.58 2.22 100.00
65 INT138067 Regulation of Chn1 2 0.20 2.43 2.82 100.00
66 INT110520 Negative_regulation of Crygb 6 0.31 2.32 4.71 100.00
67 INT81665 Positive_regulation of Localization of Pnoc 5 0.60 0.58 4.23 100.00
68 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 100.00
69 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22 100.00
70 INT128511 Negative_regulation of Positive_regulation of Pnoc 2 0.42 0.45 2.26 100.00
71 INT97665 Negative_regulation of Regulation of Pnoc 3 0.43 0.72 2.29 100.00
72 INT46986 Negative_regulation of Negative_regulation of Oprl1 5 0.43 0.13 3.37 100.00
73 INT105279 Negative_regulation of Protein_catabolism of Pnoc 1 0.42 0.09 0.77 100.00
74 INT68014 Negative_regulation of Gene_expression of Pnoc 2 0.41 0.35 0.95 100.00
75 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 100.00
76 INT78557 Positive_regulation of Negative_regulation of Pnoc 2 0.59 0.45 2.59 100.00
77 INT105278 Positive_regulation of Protein_catabolism of Pnoc 1 0.49 0.09 0.71 100.00
78 INT72076 Regulation of Regulation of Pnoc 1 0.32 0.09 2.68 100.00
79 INT121274 Negative_regulation of PNOC 4 0.43 0.22 2.16 100.00
80 INT32910 Positive_regulation of Gene_expression of Oprl1 22 0.70 7.07 19.03 100.00
81 INT70057 Positive_regulation of Binding of Pnoc 1 0.41 0.08 0.76 100.00
82 INT108474 Localization of PNOC 1 0.73 0.14 0.96 100.00
83 INT165180 Positive_regulation of Phosphorylation of Pnoc 1 0.44 0.72 0.73 100.00
84 INT5586 Binding of Fos 47 0.48 12.7 21.33 100.00
85 INT165181 Phosphorylation of Pnoc 1 0.71 0.71 0.73 100.00
86 INT82669 Negative_regulation of Gene_expression of Pnoc 3 0.43 1.19 3.25 100.00
87 INT72471 Negative_regulation of Binding of PNOC 1 0.23 0 0.91 100.00
88 INT77167 Positive_regulation of Dr1 2 0.25 0 0.85 100.00
89 INT5481 Binding of TYR 26 0.47 1.3 7.95 100.00
90 INT87785 Regulation of Regulation of Pnoc 2 0.39 1.85 2.45 100.00
91 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94 100.00
92 INT8157 Binding of Tyr 14 0.09 0.64 5.89 100.00
93 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 100.00
94 INT120747 Negative_regulation of Localization of Pnoc 1 0.37 0 1.42 100.00
95 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 100.00
96 INT78432 Negative_regulation of Gene_expression of Oprl1 6 0.58 3.27 7.24 100.00
97 INT3579 Localization of Oxt 555 0.81 43.35 292.44 100.00
98 INT142898 Positive_regulation of Regulation of Chn1 1 0.25 1.02 1.57 100.00
99 INT72777 Positive_regulation of Positive_regulation of Pnoc 5 0.49 1.07 2.18 100.00
100 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 100.00
101 INT70056 Gene_expression of Chn1 3 0.32 0.47 0.63 100.00
102 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 100.00
103 INT79484 Regulation of Negative_regulation of Pnoc 2 0.37 0.92 1.62 100.00
104 INT29051 Regulation of OPRL1 6 0.60 1.29 5.81 100.00
105 INT122379 Negative_regulation of Regulation of Pnoc 1 0.28 0.49 1.11 100.00
106 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02 100.00
107 INT122332 Binding of Crygb 2 0.48 0 2.55 100.00
108 INT138069 Negative_regulation of Gene_expression of Chn1 1 0.31 1.38 1.28 100.00
109 INT161389 Regulation of Binding of PNOC 1 0.21 1.06 0.59 100.00
110 INT57618 Binding of GTPBP4 9 0.43 1.61 1.87 100.00
111 INT79821 Negative_regulation of Binding of Pnoc 2 0.29 0.44 1.93 100.00
112 INT1463 Binding of Pomc 129 0.48 15.89 56.27 100.00
113 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 100.00
114 INT148598 Regulation of Binding of Pnoc 1 0.15 0.18 1.12 100.00
115 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92 100.00
116 INT127737 Binding of Nags 1 0.01 0.07 0.71 100.00
117 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 100.00
118 INT43552 Negative_regulation of Binding of RTCA 2 0.03 1.15 0.87 100.00
119 INT43557 Binding of RTCA 3 0.17 1.59 1.34 100.00
120 INT138071 Regulation of Gene_expression of Chn1 1 0.20 1.31 1.2 100.00
121 INT161391 Negative_regulation of Binding of NOL3 1 0.34 0.8 0.48 100.00
122 INT132508 Regulation of Binding of Pnoc 1 0.44 0.34 0.45 100.00
123 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 100.00
124 INT53007 Regulation of Gene_expression of Fosl1 6 0.27 1.28 5.06 100.00
125 INT71628 Localization of Odf2l 1 0.03 0.09 0.75 100.00
126 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57 100.00
127 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 100.00
128 INT107259 Phosphorylation of Pnoc 1 0.08 0.19 1.05 100.00
129 INT121273 Negative_regulation of Negative_regulation of PNOC 1 0.43 0 0.6 100.00
130 INT1508 Positive_regulation of Binding of Oprl1 6 0.62 1.38 3.54 100.00
131 INT5098 Negative_regulation of Localization of Sst 70 0.58 3.56 51.17 100.00
132 INT126963 Phosphorylation of PNOC 1 0.61 0.07 0.72 100.00
133 INT116225 Positive_regulation of Regulation of NAV1 1 0.03 0.09 0.64 100.00
134 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 100.00
135 INT116224 Regulation of Negative_regulation of Pnoc 1 0.22 0.09 0.63 100.00
136 INT60924 Regulation of Regulation of Fos 6 0.44 1.04 3.89 100.00
137 INT96174 Regulation of Ppp1r12a 2 0.03 0.37 1.92 100.00
138 INT96175 Binding of Ppp1r12a 1 0.02 0.23 0.87 100.00
139 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 100.00
140 INT6437 Binding of YY1 154 0.47 26.3 90.46 100.00
141 INT7282 Regulation of Localization of Sst 58 0.62 1.92 34.83 100.00
142 INT3057 Gene_expression of Ptgfr 60 0.58 14.54 11.73 100.00
143 INT149980 Transcription of NOL3 1 0.71 0 0.28 100.00
144 INT91193 Regulation of Negative_regulation of cerebral blood flow 1 0.00 0.53 0.28 100.00
145 INT106411 Gene_expression of Sult4a1 2 0.67 0.47 0.23 100.00
146 INT101218 Regulation of Positive_regulation of Pnoc 1 0.40 0 0.52 100.00
147 INT21379 Transcription of Crh 65 0.72 15.64 27.92 100.00
148 INT58097 Transcription of Oxt 18 0.69 1.62 4.6 100.00
149 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 100.00
150 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 100.00
151 INT74251 Negative_regulation of Set 5 0.18 1.87 2.23 100.00
152 INT4867 Positive_regulation of Gene_expression of GAL 17 0.70 6.65 8.28 100.00
153 INT128951 Positive_regulation of NDST1 1 0.33 0.1 0.37 100.00
154 INT3359 Regulation of YY1 32 0.60 8.19 19.2 100.00
155 INT1612 Regulation of Binding of Oprl1 19 0.62 2.34 12.45 100.00
156 INT85739 Negative_regulation of Regulation of Oprl1 2 0.36 0.46 1.98 100.00
157 INT40800 Regulation of Gene_expression of Oprl1 8 0.61 1.82 4.73 100.00
158 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52 100.00
159 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 100.00
160 INT7281 Binding of Sst 42 0.48 5.48 26.57 100.00
161 INT10705 Binding of Il1b 9 0.36 2.8 5.53 100.00
162 INT102029 Regulation of Positive_regulation of Pnoc 1 0.26 0 0.28 100.00
163 INT103213 Negative_regulation of Np4 1 0.41 0.28 0.65 100.00
164 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 100.00
165 INT48654 Negative_regulation of Gene_expression of GAL 5 0.42 2.14 2.56 100.00
166 INT4153 Binding of Insrr 109 0.40 17.99 72.15 99.98
167 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 99.98
168 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 99.98
169 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 99.98
170 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2 99.98
171 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49 99.98
172 INT72472 Positive_regulation of Gene_expression of OPRL1 4 0.68 0.07 3.39 99.98
173 INT77756 Positive_regulation of GTPBP4 16 0.11 2.6 7.29 99.98
174 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 99.98
175 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 99.98
176 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 99.96
177 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 99.96
178 INT58650 Positive_regulation of NOL3 5 0.67 1.75 1.15 99.92
179 INT1005 Localization of Sst 385 0.81 26.31 244.56 99.92
180 INT97485 Localization of ADCYAP1 4 0.78 0.24 2.35 99.92
181 INT48912 Localization of NOS1 52 0.77 24.14 10.92 99.92
182 INT626 Localization of CALCA 289 0.81 125.39 221.15 99.92
183 INT100728 Positive_regulation of SEMA6A 7 0.67 2.73 3.25 99.92
184 INT104345 Negative_regulation of Localization of Glt6d1 1 0.02 0 0.42 99.92
185 INT88626 Positive_regulation of CCRN4L 4 0.49 4.05 2.38 99.90
186 INT88625 Localization of CCRN4L 4 0.78 4.15 2.14 99.90
187 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 99.90
188 INT80717 Gene_expression of Trpv3 20 0.72 10.05 9.96 99.88
189 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 99.88
190 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.84
191 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 99.84
192 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.84
193 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 99.84
194 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 99.84
195 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 99.84
196 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 99.84
197 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 99.84
198 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.84
199 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84 99.84
200 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.82
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