P:postherpetic neuralgia

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Pain Term
Category Disorder
Synonyms None
Pain Specific Yes
Documents 1036
Hot Single Events 57
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for postherpetic neuralgia. They are ordered first by their pain relevance and then by number of times they were reported for postherpetic neuralgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07 99.20
2 INT107269 Binding of HLA-A and NCR3 1 0.35 1.42 1.1 99.20
3 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1 99.20
4 INT107263 Binding of HLA-DRB1 and NCR3 1 0.40 1.42 1.1 99.20
5 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1 98.80
6 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1 98.44
7 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1 98.44
8 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67 61.96
9 INT109739 Binding of ITPA and Pcyt1b 1 0.16 0.72 1.6 38.08
10 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
11 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
12 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55 5.00
13 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55 5.00
14 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45 5.00
15 INT208990 Binding of CALM1 and Trpv1 1 0.10 0.07 1.29 5.00
16 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
17 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
18 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83 5.00
19 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71 5.00
20 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6 5.00
21 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54 5.00
22 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48 5.00
23 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1 5.00
24 INT208979 Binding of Itpr3 and Trpc3 1 0.00 0.33 0.09 5.00
25 INT208989 Binding of CALM1 and Fig4 1 0.01 0 0.07 5.00
26 INT208988 Binding of CALM1 and Itpr3 1 0.01 0.15 0.05 5.00
27 INT208982 Negative_regulation of Binding of Itpr3 and Trpc3 1 0.00 0.17 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for postherpetic neuralgia. They are ordered first by their pain relevance and then by number of times they were reported in postherpetic neuralgia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT81280 Binding of Atp9a 20 0.47 11.14 3.24 100.00
2 INT155150 Gene_expression of Spic 5 0.26 1.21 0.86 100.00
3 INT278362 Negative_regulation of Hps5 2 0.21 15.71 4.44 99.92
4 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 99.80
5 INT19330 Binding of HLA-A 99 0.48 76.26 22.85 99.76
6 INT11072 Binding of HELT 4 0.31 3.81 0.89 99.72
7 INT107272 Binding of GPA33 1 0.24 1.37 0.76 99.52
8 INT68369 Transcription of TNC 13 0.72 8.69 4.42 99.52
9 INT78798 Regulation of LUM 2 0.60 2.56 2.87 99.36
10 INT60122 Negative_regulation of MADD 3 0.11 2.23 0.93 99.32
11 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 99.32
12 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.14
13 INT18621 Binding of ABAT 28 0.36 9.88 18.04 99.12
14 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 98.84
15 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81 98.80
16 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 98.68
17 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 98.44
18 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 98.44
19 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47 98.36
20 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 98.32
21 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 98.00
22 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 97.92
23 INT14501 Gene_expression of CST3 28 0.75 25.77 5.16 97.56
24 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 97.44
25 INT278318 Gene_expression of Hps5 10 0.37 4.24 1.27 97.44
26 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 97.44
27 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 96.92
28 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 96.72
29 INT154730 Regulation of Slc6a5 3 0.43 1.91 1.56 96.72
30 INT56651 Binding of HLA-DRB1 58 0.48 52.25 13.68 95.76
31 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 95.24
32 INT4880 Regulation of MME 17 0.61 7.78 8.2 93.04
33 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 91.48
34 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 91.48
35 INT94876 Gene_expression of LY6G6E 1 0.01 1.82 0.48 91.48
36 INT19823 Negative_regulation of Pbrgcsf1 12 0.36 7.37 2.13 91.16
37 INT2405 Negative_regulation of SGCA 15 0.57 6.04 2.45 90.48
38 INT127428 Negative_regulation of Ptger1 8 0.42 5.26 4.15 90.40
39 INT127427 Negative_regulation of Ptgdr 1 0.17 1.66 1.12 90.40
40 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41 90.36
41 INT222892 Binding of CACNA2D2 2 0.23 2.78 2.42 90.12
42 INT19824 Negative_regulation of Abr 3 0.59 0.88 0.84 89.96
43 INT7531 Positive_regulation of Eef1a1 29 0.62 8.16 15.41 89.92
44 INT278328 Negative_regulation of Gene_expression of Hps5 1 0.20 1.1 0.39 89.84
45 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85 88.16
46 INT339019 Negative_regulation of Gm4010 1 0.01 0.78 0.64 87.68
47 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 86.80
48 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 86.24
49 INT106781 Negative_regulation of Ylpm1 5 0.49 5.36 2.95 85.92
50 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 84.48
51 INT546 Binding of ALB 311 0.48 85.98 60.14 84.08
52 INT36616 Positive_regulation of Binding of ALB 8 0.67 3 2.07 84.08
53 INT169076 Localization of MRVI1 1 0.68 1.94 0.35 82.04
54 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 81.20
55 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2 80.28
56 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 80.08
57 INT26705 Transcription of ADRA1D 6 0.67 3.99 2.74 80.08
58 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 79.84
59 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41 79.84
60 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 78.16
61 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 76.84
62 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 76.40
63 INT328985 Negative_regulation of Negative_regulation of Hps5 1 0.03 1.07 0.39 75.52
64 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59 75.20
65 INT280447 Negative_regulation of Positive_regulation of MOCS1 1 0.00 0.75 0.69 75.20
66 INT232187 Gene_expression of DFNB31 1 0.06 1.32 0.29 75.08
67 INT6437 Binding of YY1 154 0.47 26.3 90.46 75.00
68 INT25647 Negative_regulation of Binding of YY1 10 0.57 1.47 6.77 75.00
69 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 74.96
70 INT114017 Gene_expression of CD200 10 0.75 2.38 0.88 74.64
71 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 73.20
72 INT90097 Localization of PTGS2 15 0.69 6.14 6.63 72.80
73 INT151520 Negative_regulation of Slc6a9 5 0.58 1.86 1.86 72.72
74 INT166486 Negative_regulation of Gene_expression of Slc6a9 1 0.42 1.27 1.29 72.72
75 INT166487 Negative_regulation of Gene_expression of Slc6a5 1 0.48 1.27 1.29 72.72
76 INT166484 Negative_regulation of Slc6a5 1 0.35 1.26 1.28 72.72
77 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5 70.72
78 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 69.12
79 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 69.12
80 INT166485 Gene_expression of Slc6a5 2 0.64 1.51 1.36 69.04
81 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 68.64
82 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 68.48
83 INT166488 Gene_expression of Slc6a9 2 0.77 1.45 6.46 67.84
84 INT264641 Binding of AES 25 0.42 18.56 6.98 65.08
85 INT123787 Gene_expression of Bid 25 0.66 16 6.35 64.72
86 INT397 Localization of SST 232 0.81 58.05 101.19 63.40
87 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 63.12
88 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94 62.56
89 INT278341 Positive_regulation of Hps5 8 0.38 5.47 0.62 62.28
90 INT103828 Negative_regulation of Gene_expression of TRPV1 23 0.59 13.63 13.81 61.04
91 INT95585 Negative_regulation of Pde12 18 0.43 8.32 11.23 61.00
92 INT180535 Gene_expression of BPI 4 0.52 3.61 0.91 60.04
93 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 59.52
94 INT202602 Positive_regulation of PTPN5 4 0.29 3.34 1.83 59.44
95 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 58.16
96 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74 58.16
97 INT262375 Binding of Fmod 1 0.20 12.37 10.1 57.20
98 INT52180 Binding of Aes 38 0.42 23.16 6.7 55.92
99 INT42277 Gene_expression of GIPC1 6 0.25 2.06 1.61 54.64
100 INT84703 Negative_regulation of Nqo1 8 0.38 7.1 4.05 52.08
101 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 50.00
102 INT2893 Localization of Oxt 219 0.80 28.96 79.43 50.00
103 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 50.00
104 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 50.00
105 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 50.00
106 INT116783 Protein_catabolism of IL8 3 0.86 1.11 0.16 50.00
107 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 48.68
108 INT152221 Gene_expression of PRODH 7 0.58 11.03 0.79 46.64
109 INT50130 Positive_regulation of Ptger3 13 0.67 5.23 6.47 45.96
110 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 44.00
111 INT278331 Localization of Hps5 3 0.34 4.14 0.34 41.20
112 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3 38.20
113 INT4958 Gene_expression of Pcyt1b 18 0.65 3.4 5.66 38.08
114 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 33.84
115 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27 30.68
116 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 29.92
117 INT71895 Negative_regulation of Gapdh 2 0.39 1.36 1.69 27.92
118 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 27.28
119 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 25.00
120 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 25.00
121 INT112758 Binding of Ppard 7 0.37 3.6 2.87 20.00
122 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78 17.84
123 INT262373 Positive_regulation of Fmod 1 0.20 0.89 0.77 16.08
124 INT3439 Localization of Abat 1017 0.78 112.39 727.06 14.20
125 INT32165 Binding of CALM1 92 0.48 24.19 29.57 13.72
126 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 10.56
127 INT109164 Phosphorylation of Abat 5 0.39 0 0.51 8.88
128 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22 8.16
129 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 7.56
130 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
131 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
132 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
133 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
134 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
135 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
136 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
137 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
138 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
139 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
140 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
141 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 5.00
142 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
143 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
144 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 5.00
145 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
146 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
147 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 5.00
148 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 5.00
149 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
150 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
151 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
152 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
153 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 5.00
154 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
155 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
156 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
157 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
158 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 5.00
159 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 5.00
160 INT1032 Regulation of Ca2 202 0.52 54.91 53.03 5.00
161 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 5.00
162 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
163 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
164 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 5.00
165 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
166 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 5.00
167 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
168 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
169 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 5.00
170 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45 5.00
171 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
172 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
173 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
174 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
175 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
176 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 5.00
177 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
178 INT96511 Negative_regulation of Positive_regulation of Trpv1 35 0.59 10.95 19.79 5.00
179 INT106097 Localization of pr 20 0.62 12.01 19.46 5.00
180 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8 5.00
181 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72 5.00
182 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 5.00
183 INT7339 Localization of CALM1 46 0.75 16.15 16.47 5.00
184 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 5.00
185 INT86790 Gene_expression of P2rx6 34 0.74 14.04 15.92 5.00
186 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
187 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 5.00
188 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
189 INT99116 Binding of Cacna2d3 15 0.48 7.33 13.58 5.00
190 INT39564 Negative_regulation of Gene_expression of Ptger2 50 0.42 30.9 12.97 5.00
191 INT19799 Binding of Ca2 71 0.48 13.69 12.92 5.00
192 INT174844 Binding of Fig4 81 0.41 18.03 12.87 5.00
193 INT83601 Binding of CNR2 30 0.47 7.79 12.37 5.00
194 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
195 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
196 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56 5.00
197 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4 5.00
198 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
199 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
200 INT45812 Protein_catabolism of Gabrg1 12 0.79 1.93 8.76 5.00
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