P:psychological dependence

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Pain Term
Category Condition
Synonyms None
Pain Specific No
Documents 105
Hot Single Events 52
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for psychological dependence. They are ordered first by their pain relevance and then by number of times they were reported for psychological dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27 100.00
2 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27 100.00
3 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92 85.20
4 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4 85.20
5 INT150754 GTS Negative_regulation of Gene_expression of Prkaca 1 0.32 0.08 0.65 79.52
6 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58 77.56
7 INT150755 GTS Negative_regulation of Phosphorylation of Atf6b 1 0.13 0.08 0.64 75.96
8 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12 73.64
9 INT112608 DNAJC15 Regulation of Gene_expression of Fos 1 0.02 0.14 1.12 73.64
10 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58 64.56
11 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62 25.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for psychological dependence. They are ordered first by their pain relevance and then by number of times they were reported in psychological dependence. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.84
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 99.72
3 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 99.72
4 INT99076 Regulation of Gene_expression of FosB 7 0.62 1.34 7.32 99.66
5 INT57379 Positive_regulation of Phosphorylation of Creb1 79 0.69 28.24 30.25 99.52
6 INT118675 Positive_regulation of Phosphorylation of Camk4 5 0.66 1.58 2.93 99.52
7 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 99.38
8 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 98.80
9 INT127556 Positive_regulation of Cdk5 35 0.70 19.6 5.95 98.48
10 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 98.20
11 INT5533 Binding of Oxt 43 0.48 8.69 18.35 97.92
12 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7 97.84
13 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 97.72
14 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 97.40
15 INT114394 Negative_regulation of Positive_regulation of Nlrp1a 4 0.42 1.09 7.37 95.68
16 INT325976 Negative_regulation of Gene_expression of Ifi30 1 0.19 0.56 2.78 95.68
17 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 95.32
18 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 94.72
19 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37 94.04
20 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 93.60
21 INT325973 Positive_regulation of Gene_expression of Ifi30 1 0.21 0.49 2.68 93.08
22 INT325971 Gene_expression of Ifi30 1 0.01 0.48 2.63 91.80
23 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68 91.52
24 INT131572 Negative_regulation of Phosphorylation of Mdk 4 0.15 1.67 1.71 91.52
25 INT325974 Gene_expression of Ifi30 1 0.27 0.48 2.6 91.48
26 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18 91.04
27 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 90.88
28 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 90.88
29 INT127555 Negative_regulation of Cdk5 59 0.59 50.2 8.45 90.56
30 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 90.52
31 INT85075 Phosphorylation of Mdk 22 0.61 10.29 5.55 90.32
32 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16 90.16
33 INT90727 Negative_regulation of Gene_expression of FosB 4 0.54 0.5 3.37 90.00
34 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33 90.00
35 INT325972 Negative_regulation of Binding of Slc6a1 1 0.02 0.52 2.38 89.64
36 INT325975 Binding of Slc6a1 1 0.02 0.52 2.37 89.64
37 INT75754 Phosphorylation of DYT10 6 0.80 2.67 4.79 89.48
38 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 89.32
39 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 89.00
40 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 88.52
41 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18 88.40
42 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07 88.40
43 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 88.36
44 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 87.76
45 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 86.76
46 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 86.76
47 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 86.00
48 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 85.48
49 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 84.56
50 INT121866 Localization of Creb1 13 0.73 1.95 4.48 81.92
51 INT121867 Positive_regulation of Localization of Creb1 2 0.60 0.43 1.2 81.92
52 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 80.08
53 INT150753 Negative_regulation of Gene_expression of Prkaca 1 0.41 0.08 0.65 79.36
54 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11 78.48
55 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 78.08
56 INT77619 Gene_expression of Prkaca 43 0.75 8.55 14.13 78.00
57 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 77.56
58 INT23784 Gene_expression of FAIM3 25 0.55 2.89 17.14 77.48
59 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 76.56
60 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17 76.24
61 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 76.24
62 INT62089 Phosphorylation of FAIM3 14 0.63 0.62 10.05 75.44
63 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 75.40
64 INT142240 Positive_regulation of Phosphorylation of Atf6b 6 0.49 1.54 3.87 75.24
65 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 75.12
66 INT112905 Phosphorylation of Cdk5 15 0.82 2.78 2.3 75.00
67 INT127557 Positive_regulation of Phosphorylation of Cdk5 2 0.50 0.43 0.56 75.00
68 INT190499 Regulation of OAS1 2 0.04 0.99 0.1 75.00
69 INT135120 Phosphorylation of Atf6b 13 0.61 4.01 8.03 74.76
70 INT58083 Positive_regulation of DYT10 10 0.67 3.66 7.12 74.52
71 INT89830 Positive_regulation of Gphn 4 0.45 0.81 2.61 74.52
72 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 74.04
73 INT121871 Localization of Camk4 9 0.81 4.67 3.84 72.00
74 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 71.80
75 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 69.68
76 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72 69.48
77 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 69.32
78 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29 69.16
79 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 65.04
80 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8 64.16
81 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 63.56
82 INT18995 Binding of CEL 23 0.47 14.46 4.5 63.04
83 INT1438 Localization of Pomc 360 0.81 101.26 116.47 62.52
84 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18 62.40
85 INT30638 Positive_regulation of Gene_expression of Dbi 17 0.69 4.63 8.28 62.00
86 INT109280 Negative_regulation of Phosphorylation of Creb1 29 0.59 11.81 10.37 61.04
87 INT82572 Negative_regulation of Prkg2 4 0.14 0.82 3.03 56.08
88 INT121869 Negative_regulation of Calm1 2 0.57 0 1.83 52.48
89 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 52.20
90 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3 52.20
91 INT62577 Negative_regulation of Creb1 55 0.59 19.68 18.1 49.28
92 INT102023 Regulation of Creb1 51 0.62 16.29 16.71 49.28
93 INT234289 Binding of Swd1 1 0.03 5.79 0.23 49.16
94 INT14516 Positive_regulation of CRTAC1 14 0.37 4.6 6.01 46.32
95 INT123554 Transcription of Dbi 5 0.72 1.13 1.13 43.36
96 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 31.52
97 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 31.52
98 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 25.00
99 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39 25.00
100 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63 25.00
101 INT109279 Regulation of Phosphorylation of Creb1 14 0.62 4.06 8.96 25.00
102 INT121870 Positive_regulation of Gene_expression of Camk4 24 0.70 15.63 5.83 25.00
103 INT121865 Regulation of Gene_expression of Camk4 8 0.54 2.65 3.23 25.00
104 INT121868 Regulation of Localization of Creb1 1 0.23 0 0.66 25.00
105 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 22.80
106 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
107 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
108 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
109 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 5.00
110 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
111 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
112 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
113 INT114 Binding of Oprl1 139 0.48 23 103.35 5.00
114 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
115 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
116 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
117 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
118 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
119 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 5.00
120 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 5.00
121 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
122 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 5.00
123 INT11764 Positive_regulation of ENG 78 0.61 27.65 33.69 5.00
124 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
125 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
126 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 5.00
127 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
128 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
129 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
130 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
131 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
132 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
133 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
134 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
135 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
136 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
137 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
138 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
139 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
140 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
141 INT7674 Regulation of ENG 42 0.30 11.41 14.44 5.00
142 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78 5.00
143 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
144 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
145 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
146 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 5.00
147 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 5.00
148 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 5.00
149 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03 5.00
150 INT34268 Binding of WAS 14 0.47 4.41 8.67 5.00
151 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61 5.00
152 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 5.00
153 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57 5.00
154 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 5.00
155 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 5.00
156 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61 5.00
157 INT23375 Binding of ENG 17 0.47 6.02 6.46 5.00
158 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 5.00
159 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79 5.00
160 INT37834 Negative_regulation of Positive_regulation of CPP 14 0.58 6.22 5.69 5.00
161 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
162 INT83014 Binding of Adora2a 13 0.48 5.57 5.33 5.00
163 INT111100 Gene_expression of Dusp1 18 0.76 14.81 5.21 5.00
164 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 5.00
165 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
166 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
167 INT75562 Regulation of FosB 8 0.52 2.38 4.07 5.00
168 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95 5.00
169 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
170 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
171 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
172 INT74632 Transcription of Oxt 11 0.64 3.93 3.56 5.00
173 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47 5.00
174 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
175 INT101959 Regulation of Rorb 10 0.14 5.18 3.17 5.00
176 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 5.00
177 INT100544 Positive_regulation of Fabp1 16 0.38 6.81 2.63 5.00
178 INT254118 Negative_regulation of Gene_expression of Adora2a 3 0.42 2.54 2.43 5.00
179 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 5.00
180 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29 5.00
181 INT172622 Localization of EP300 8 0.65 2.56 1.72 5.00
182 INT99077 Transcription of FosB 2 0.50 1.04 1.67 5.00
183 INT186144 Positive_regulation of Transcription of Oxt 3 0.29 2.07 1.65 5.00
184 INT16153 Gene_expression of Cenpj 7 0.77 2.56 1.42 5.00
185 INT147607 Binding of TERT 16 0.48 12.36 1.31 5.00
186 INT169643 Binding of Ods 3 0.18 2.89 1.15 5.00
187 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 5.00
188 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
189 INT265696 Negative_regulation of Transcription of Oxt 2 0.39 0.57 1.11 5.00
190 INT34586 Positive_regulation of Negative_regulation of HSD11B1 6 0.49 4.39 1.05 5.00
191 INT226221 Binding of Dusp1 1 0.04 0.92 0.68 5.00
192 INT27492 Gene_expression of Swd1 4 0.50 2.07 0.68 5.00
193 INT215149 Binding of Sbds 5 0.22 0.44 0.48 5.00
194 INT197012 Regulation of Gene_expression of LDLR 4 0.40 1.31 0.4 5.00
195 INT120210 Negative_regulation of Hcrtr1 3 0.58 1.17 0.34 5.00
196 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34 5.00
197 INT274379 Negative_regulation of Binding of SERPINE1 1 0.03 0.91 0.33 5.00
198 INT118610 Localization of BPHL 6 0.57 6.88 0.33 5.00
199 INT125419 Positive_regulation of Cyp4a3 5 0.18 2.05 0.27 5.00
200 INT215152 Regulation of Sbds 2 0.16 0.11 0.27 5.00
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