P:referred pain

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pChart

Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 704
Hot Single Events 58
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for referred pain. They are ordered first by their pain relevance and then by number of times they were reported for referred pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29 92.60
2 INT132701 Adarb1 Negative_regulation of Gene_expression of Fos 1 0.01 0.73 1.07 90.44
3 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32 68.24
4 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21 5.00
5 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06 5.00
6 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 5.00
7 INT197470 Binding of Sostdc1 and Hbtq 1 0.00 0.87 0.87 5.00
8 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61 5.00
9 INT353861 Binding of Mgp and Phdlc1 1 0.01 5.09 0.16 5.00
10 INT353865 Binding of CHI3L1 and Lepr 1 0.00 1.88 0.03 5.00
11 INT197466 Dpcd Positive_regulation of Sostdc1 1 0.00 0 0 5.00
12 INT197467 Binding of Dpcd and Memor1 1 0.00 0.12 0 5.00
13 INT197469 Binding of Dpcd and Hbtq 1 0.00 0 0 5.00
14 INT197468 Dpcd Positive_regulation of Hbtq 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for referred pain. They are ordered first by their pain relevance and then by number of times they were reported in referred pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT71350 Positive_regulation of Tpnr1 3 0.01 3.92 4.08 100.00
2 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 99.86
3 INT4729 Positive_regulation of PPT1 19 0.67 7.11 17.83 99.80
4 INT116737 Localization of Mif 63 0.81 52.97 28.11 99.48
5 INT232323 Regulation of SMCP 1 0.23 3.07 3.06 99.12
6 INT113961 Regulation of PPT1 6 0.26 3.87 6.09 98.88
7 INT165258 Binding of BC013712 1 0.06 0.85 1.02 98.84
8 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 98.28
9 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 98.08
10 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 97.84
11 INT80394 Localization of Vom1r68 2 0.05 0.19 0.64 97.60
12 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 97.52
13 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 97.12
14 INT130440 Phosphorylation of GRIN2B 2 0.79 2.93 1.79 94.64
15 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08 94.64
16 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95 94.64
17 INT153959 Phosphorylation of GRIN1 8 0.80 4.07 6.18 94.64
18 INT163895 Positive_regulation of Phosphorylation of GRIN2B 1 0.09 0.99 0.48 94.64
19 INT163896 Positive_regulation of Phosphorylation of GRIN1 1 0.67 0.55 0.29 94.64
20 INT246297 Positive_regulation of RGS1 1 0.01 0.78 0.78 94.52
21 INT269142 Positive_regulation of Mia1 1 0.34 0.98 0.71 93.48
22 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 93.20
23 INT11937 Localization of Il6 228 0.81 139.83 64.39 92.88
24 INT112054 Negative_regulation of Negative_regulation of DMD 12 0.44 5.02 0.45 92.88
25 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 92.72
26 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51 92.64
27 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 92.28
28 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 92.20
29 INT45266 Negative_regulation of Nenf 3 0.38 2.46 3.59 91.84
30 INT155507 Binding of EFNB1 2 0.35 0.74 0.43 91.84
31 INT2541 Binding of Calca 200 0.48 67.14 134.62 91.40
32 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59 91.28
33 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 90.84
34 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 90.04
35 INT137961 Localization of Ppt1 1 0.64 2.89 3.09 89.44
36 INT84079 Positive_regulation of MDH2 2 0.45 0.18 0.92 89.28
37 INT99088 Gene_expression of HPT 5 0.59 9.1 6.72 88.96
38 INT87623 Gene_expression of PPT1 9 0.75 5.32 7.65 88.64
39 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 88.48
40 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 87.20
41 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 87.20
42 INT4895 Positive_regulation of Gene_expression of Tac4 16 0.69 2.46 11.51 87.20
43 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88 87.00
44 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 86.56
45 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 86.52
46 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 86.52
47 INT97848 Positive_regulation of Localization of Trpv1 18 0.50 7.66 13.36 86.52
48 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 86.32
49 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 86.12
50 INT53460 Gene_expression of tn 13 0.66 7.97 5.2 86.08
51 INT4887 Gene_expression of Tac4 70 0.77 11.66 40.97 84.88
52 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 84.60
53 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 84.40
54 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 83.80
55 INT74237 Positive_regulation of Ppt1 3 0.49 2.92 2.32 83.08
56 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 82.48
57 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 81.84
58 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 81.08
59 INT163891 Positive_regulation of Phosphorylation of MECOM 1 0.00 0.4 0.29 78.48
60 INT163897 Negative_regulation of Phosphorylation of GRIN2B 1 0.08 0.39 0.28 77.92
61 INT163894 Phosphorylation of MECOM 1 0.00 0.4 0.28 77.92
62 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 77.52
63 INT246298 Localization of RGS1 1 0.02 1.72 1.6 75.96
64 INT37615 Gene_expression of ESCO1 6 0.72 1.1 4.15 75.00
65 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 75.00
66 INT22956 Gene_expression of Mpg 2 0.68 1.48 0.25 71.56
67 INT182847 Regulation of Binding of Il10 2 0.41 1.26 1.15 69.20
68 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 69.04
69 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 69.04
70 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14 69.04
71 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 69.04
72 INT103289 Binding of Il10 15 0.35 13.67 7.42 68.76
73 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 68.72
74 INT138457 Gene_expression of Hbtq 13 0.02 1.68 2 67.52
75 INT197463 Positive_regulation of Gene_expression of Hbtq 1 0.01 0.57 0.9 67.52
76 INT232317 Gene_expression of C12orf39 4 0.75 2.21 2.16 66.84
77 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 64.48
78 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 64.40
79 INT174341 Localization of Mpg 1 0.30 1.12 0.36 64.08
80 INT350 Localization of Th 79 0.80 10.26 41.17 64.08
81 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 63.36
82 INT163893 Positive_regulation of Phosphorylation of EPHB1 1 0.49 0.43 0.27 63.12
83 INT163892 Phosphorylation of EPHB1 1 0.80 0.42 0.27 63.12
84 INT84080 Localization of MDH2 2 0.55 0.57 0.45 60.32
85 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 59.44
86 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87 58.96
87 INT53459 Negative_regulation of Gene_expression of tn 2 0.42 0.85 1.13 58.24
88 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28 58.20
89 INT7134 Localization of KNG1 127 0.79 65.73 67.97 57.76
90 INT120518 Gene_expression of Trg@ 1 0.47 0.3 0.49 57.12
91 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 55.92
92 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83 53.72
93 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37 52.00
94 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 51.36
95 INT269144 Gene_expression of Mia1 8 0.59 11.84 6.16 49.36
96 INT233945 Positive_regulation of Expi 5 0.04 2.53 3.46 46.88
97 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 46.72
98 INT2649 Regulation of Calca 433 0.62 146.05 330.95 44.08
99 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 43.60
100 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 40.08
101 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08 38.32
102 INT246299 Negative_regulation of RGS1 1 0.01 0.85 0.81 37.04
103 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 29.76
104 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 29.04
105 INT63365 Gene_expression of Spg21 21 0.65 12.9 7.37 28.80
106 INT132700 Positive_regulation of Trpc1 6 0.39 4.33 3.89 27.44
107 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48 27.36
108 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84 27.36
109 INT165578 Regulation of Positive_regulation of Grin2b 3 0.41 1.07 0.74 27.36
110 INT48338 Gene_expression of Ahsg 2 0.52 0.25 1.16 26.80
111 INT89363 Positive_regulation of Ahsg 2 0.11 1.11 0.63 26.80
112 INT165579 Regulation of Gene_expression of Ahsg 1 0.01 0.25 0.26 26.80
113 INT165577 Positive_regulation of Gene_expression of Ahsg 1 0.04 0.25 0.26 26.80
114 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 26.40
115 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 26.40
116 INT20210 Localization of Ngf 69 0.79 46.22 38.57 25.52
117 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 25.00
118 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43 25.00
119 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 25.00
120 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 25.00
121 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88 25.00
122 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 25.00
123 INT9200 Gene_expression of ITPA 8 0.65 0.86 2.18 25.00
124 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 25.00
125 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08 22.56
126 INT72949 Binding of Mif 31 0.46 23.12 11.65 22.40
127 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 17.76
128 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 17.76
129 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 17.76
130 INT125884 Positive_regulation of CHI3L1 15 0.62 34.04 4.43 17.28
131 INT125885 Positive_regulation of Gene_expression of CHI3L1 8 0.49 10.8 2.64 17.28
132 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 16.08
133 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 15.32
134 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 15.20
135 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 12.00
136 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 10.32
137 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 9.68
138 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 8.60
139 INT126177 Positive_regulation of Atf3 14 0.70 14.34 5.56 7.84
140 INT269145 Positive_regulation of Gene_expression of Mia1 1 0.34 0.98 1.23 7.84
141 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 7.76
142 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.84
143 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.84
144 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
145 INT292 Localization of Penk 876 0.81 88.44 669.14 5.00
146 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 5.00
147 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 5.00
148 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 5.00
149 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
150 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
151 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
152 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 5.00
153 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
154 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
155 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
156 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
157 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 5.00
158 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
159 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
160 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
161 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
162 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 5.00
163 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
164 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
165 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
166 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
167 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
168 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
169 INT74826 Gene_expression of Slc1a2 131 0.78 61.83 100.84 5.00
170 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 5.00
171 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
172 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 5.00
173 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
174 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
175 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
176 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
177 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
178 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
179 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
180 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
181 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 5.00
182 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 5.00
183 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
184 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 5.00
185 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
186 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
187 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
188 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
189 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
190 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
191 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
192 INT74827 Positive_regulation of Gene_expression of Slc1a2 52 0.70 26.54 50.63 5.00
193 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 5.00
194 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
195 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
196 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
197 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
198 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 5.00
199 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
200 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
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