P:reflex sympathetic dystrophy

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Pain Term
Category Disorder
Synonyms Complex Regional Pain Syndrome
Pain Specific Yes
Documents 1085
Hot Single Events 132
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for reflex sympathetic dystrophy. They are ordered first by their pain relevance and then by number of times they were reported for reflex sympathetic dystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16 100.00
2 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75 91.20
3 INT118257 Binding of ENPP1 and SUGT1 1 0.00 0.87 0.16 75.00
4 INT96782 FAM176C Regulation of Gene_expression of COL1A1 1 0.32 0.05 0 50.00
5 INT339287 Binding of Cxcr2 and Cxcl1 1 0.29 0.48 0.24 24.48
6 INT335405 Binding of Arntl and Npas2 1 0.28 1.82 1.61 5.00
7 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56 5.00
8 INT296950 Tacr1 Negative_regulation of Gene_expression of Cck 1 0.30 0.94 1.11 5.00
9 INT230019 Binding of HLA-B and ERAL1 1 0.00 2.23 1.1 5.00
10 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04 5.00
11 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83 5.00
12 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82 5.00
13 INT335403 Binding of Hspg2 and Npas2 1 0.04 0.93 0.82 5.00
14 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
15 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55 5.00
16 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36 5.00
17 INT339294 Il1 Positive_regulation of Gene_expression of Cxcl1 1 0.06 0.53 0.3 5.00
18 INT339292 Il1 Positive_regulation of Gene_expression of Ptger2 1 0.02 0.4 0.2 5.00
19 INT310113 Binding of SET and TP53INP2 1 0.15 0.05 0.08 5.00
20 INT310110 SET Positive_regulation of Localization of POMT1 1 0.08 0 0.05 5.00
21 INT310114 Binding of ENOSF1 and TP53INP2 1 0.04 0 0 5.00
22 INT310115 Binding of NOVA2 and SET 1 0.12 0 0 5.00
23 INT310112 Binding of NOVA2 and TP53INP2 1 0.07 0 0 5.00
24 INT339288 Binding of Hprt1 and Il1 1 0.09 0.05 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for reflex sympathetic dystrophy. They are ordered first by their pain relevance and then by number of times they were reported in reflex sympathetic dystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 100.00
2 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 100.00
3 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 100.00
4 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 100.00
5 INT138695 Positive_regulation of Mks1 1 0.01 2.16 1.03 100.00
6 INT84646 Binding of PDHA1 2 0.32 1.36 0.8 100.00
7 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 100.00
8 INT958 Negative_regulation of ATRX 6 0.58 2.92 1.25 100.00
9 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 100.00
10 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 100.00
11 INT24020 Positive_regulation of HPS1 6 0.44 6.14 1.08 100.00
12 INT148892 Binding of HPS1 13 0.37 19.21 3.35 100.00
13 INT167588 Localization of HPS1 3 0.65 1.24 0.9 100.00
14 INT148891 Positive_regulation of Binding of HPS1 1 0.07 0.37 0.22 100.00
15 INT109297 Negative_regulation of WSN 3 0.05 2.13 1.31 100.00
16 INT161394 Binding of Mks1 2 0.02 1.52 0.62 100.00
17 INT215301 Binding of PQBP1 9 0.27 10.36 0.59 100.00
18 INT146303 Binding of PHGDH 7 0.36 4.7 1.42 99.98
19 INT3364 Binding of SGCG 87 0.47 31.93 17.24 99.98
20 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.88
21 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.88
22 INT89425 Positive_regulation of HLA-DRB3 2 0.59 2.38 0.42 99.88
23 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.88
24 INT1148 Positive_regulation of ecs 38 0.48 25.27 13.1 99.84
25 INT35269 Localization of SGCG 38 0.78 14.68 9.01 99.84
26 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 99.82
27 INT242107 Positive_regulation of SYNM 8 0.38 2.82 2.39 99.78
28 INT34358 Binding of MME 13 0.37 7.25 5.14 99.72
29 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 99.58
30 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 99.52
31 INT89426 Binding of HLA-DRB3 2 0.41 1.77 1.32 99.42
32 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78 99.42
33 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19 99.42
34 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 99.28
35 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.28
36 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67 99.28
37 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44 99.28
38 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.20
39 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 99.16
40 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 99.16
41 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 98.92
42 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 98.92
43 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 98.74
44 INT198136 Positive_regulation of BCL2A1 7 0.67 5.72 5.05 98.68
45 INT103298 Binding of CALCR 5 0.47 6.03 2.15 98.60
46 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91 98.60
47 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57 98.60
48 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 98.32
49 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37 98.28
50 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 98.04
51 INT53683 Negative_regulation of Gene_expression of ITGB2 10 0.57 9.11 3.2 98.04
52 INT67333 Negative_regulation of ITGB2 10 0.41 6.92 3.06 98.04
53 INT53684 Negative_regulation of Gene_expression of ITGAM 23 0.59 14.36 5.66 98.04
54 INT71732 Negative_regulation of ITGAM 3 0.41 2 1 98.04
55 INT4528 Negative_regulation of Sell 12 0.58 4.76 4.22 98.04
56 INT104300 Negative_regulation of Gene_expression of Sell 8 0.58 3.46 1.91 98.04
57 INT163028 Negative_regulation of Negative_regulation of IFNAR1 1 0.05 0.86 0.73 98.04
58 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 98.00
59 INT127565 Positive_regulation of ENC1 2 0.39 11.67 11.82 98.00
60 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89 98.00
61 INT7134 Localization of KNG1 127 0.79 65.73 67.97 98.00
62 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 97.84
63 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 97.84
64 INT87434 Gene_expression of Sell 38 0.77 21.95 8.51 97.84
65 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.28
66 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29 97.04
67 INT146091 Negative_regulation of IFNAR1 6 0.25 9.12 4.86 96.92
68 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 96.92
69 INT8518 Localization of Ifng 53 0.81 36.68 24.13 96.60
70 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 96.24
71 INT291559 Negative_regulation of NMS 1 0.19 0.33 0.1 95.72
72 INT626 Localization of CALCA 289 0.81 125.39 221.15 95.68
73 INT4776 Localization of TAC1 82 0.78 16.89 45.21 95.68
74 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 95.16
75 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64 95.04
76 INT163709 Regulation of Negative_regulation of COL1A1 1 0.29 0.93 0.34 95.04
77 INT149761 Negative_regulation of MAS1 5 0.29 1.91 1.95 94.88
78 INT72884 Positive_regulation of Tenc1 13 0.42 14.01 7.67 94.72
79 INT195203 Binding of Tenc1 14 0.32 13.97 8.28 94.48
80 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 93.92
81 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 93.92
82 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 93.16
83 INT55343 Localization of Ros1 39 0.60 34.51 12.5 92.64
84 INT297020 Positive_regulation of CLTC 5 0.36 3.38 0.41 92.16
85 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 92.12
86 INT131783 Localization of Nociq1 2 0.60 1.46 1.08 91.24
87 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76 91.20
88 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53 91.20
89 INT163998 Gene_expression of CTSC 9 0.65 11.24 1.69 91.12
90 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52 90.72
91 INT163787 Gene_expression of Nlrp1a 1 0.77 4 3.24 90.72
92 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 90.72
93 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 90.48
94 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 90.32
95 INT17821 Gene_expression of Pls1 4 0.32 2.19 1.96 90.04
96 INT51445 Binding of B3GAT1 9 0.47 4.64 3.95 89.80
97 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95 89.64
98 INT398 Localization of AGT 45 0.78 16.97 11.54 89.44
99 INT69034 Regulation of Casp1 3 0.27 3.56 1.36 88.72
100 INT135984 Regulation of Ptn 3 0.44 2.07 1.67 88.60
101 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 88.24
102 INT267750 Binding of Casp1 4 0.35 1.53 1.02 88.04
103 INT68744 Localization of Cxcl1 18 0.80 8.65 8.6 87.12
104 INT344613 Negative_regulation of Gene_expression of CLTC 2 0.31 1.19 0.37 86.12
105 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 85.76
106 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26 85.72
107 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52 85.68
108 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 85.52
109 INT112536 Regulation of Regulation of Mrpl40 1 0.00 1.58 1.3 84.92
110 INT112537 Regulation of Mrpl40 1 0.00 1.58 1.3 84.92
111 INT178818 Regulation of Gene_expression of Il18 3 0.40 2.98 0.68 84.56
112 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 84.56
113 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 83.20
114 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53 83.20
115 INT138997 Gene_expression of Dyt1 2 0.67 1.91 0.37 83.20
116 INT125106 Gene_expression of PRKRA 2 0.13 2.35 0.3 83.20
117 INT165571 Gene_expression of ATP1A3 1 0.09 1.22 0.24 83.20
118 INT165572 Gene_expression of SGCE 1 0.09 1.22 0.24 83.20
119 INT165570 Gene_expression of THAP1 2 0.08 2.13 0.24 83.20
120 INT210527 Positive_regulation of Gene_expression of Tenc1 14 0.38 6.37 2.45 83.04
121 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12 82.64
122 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 81.96
123 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41 81.96
124 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 81.80
125 INT69304 Negative_regulation of Il10 47 0.59 36.88 19.79 81.64
126 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 81.60
127 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 81.60
128 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73 81.40
129 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 81.36
130 INT96116 Transcription of COL1A1 10 0.44 4.57 1.81 81.00
131 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 80.64
132 INT16562 Negative_regulation of Positive_regulation of Gabbr1 5 0.43 2.67 3.24 80.48
133 INT315282 Positive_regulation of Naa15 1 0.09 1.32 1.26 79.76
134 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 79.56
135 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 79.16
136 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34 79.08
137 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 78.72
138 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 78.72
139 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 78.68
140 INT89046 Positive_regulation of P2RX2 15 0.67 7.25 7.52 78.60
141 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7 78.08
142 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 78.00
143 INT87861 Gene_expression of Il18 33 0.78 30.44 18.42 77.96
144 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19 77.52
145 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71 77.36
146 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 76.92
147 INT91158 Regulation of Ros1 26 0.25 17 4.23 76.08
148 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 75.32
149 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 75.00
150 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 75.00
151 INT13354 Transcription of TNF 108 0.72 85.81 42.32 75.00
152 INT51014 Transcription of IL2 42 0.71 21.56 12.7 75.00
153 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 75.00
154 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16 75.00
155 INT17451 Positive_regulation of Tst 23 0.67 8.85 9.52 75.00
156 INT163783 Transcription of Casp1 1 0.58 0.88 0.73 75.00
157 INT163784 Transcription of Nlrp1a 1 0.68 0.83 0.73 75.00
158 INT163785 Positive_regulation of Transcription of Casp1 1 0.42 0.89 0.73 75.00
159 INT163782 Positive_regulation of Transcription of Nlrp1a 1 0.50 0.89 0.73 75.00
160 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 75.00
161 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19 75.00
162 INT163786 Regulation of Gene_expression of Il18 1 0.28 0.88 0.74 75.00
163 INT163788 Negative_regulation of Regulation of Il18 1 0.27 0.87 0.73 75.00
164 INT148151 Regulation of Il18 7 0.28 5.4 3.5 75.00
165 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45 75.00
166 INT82886 Positive_regulation of Mip 7 0.49 3.61 1.89 75.00
167 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 75.00
168 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3 75.00
169 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03 75.00
170 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 75.00
171 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 75.00
172 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54 75.00
173 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 75.00
174 INT93916 Positive_regulation of IFNAR1 7 0.25 5.58 1.09 75.00
175 INT17544 Negative_regulation of Gene_expression of NPY 3 0.42 1.97 1.05 75.00
176 INT90201 Binding of Trp53inp1 1 0.00 0.81 0.81 75.00
177 INT52740 Binding of ACLS 5 0.31 3 0.54 75.00
178 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82 74.04
179 INT152906 Regulation of Gene_expression of Cxcl1 10 0.44 5.83 2.69 74.04
180 INT9191 Localization of EDN1 94 0.81 57.01 14.78 72.04
181 INT274527 Regulation of SYNM 3 0.20 2.68 2.7 71.92
182 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 69.88
183 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1 69.88
184 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 69.20
185 INT73755 Localization of Scn10a 2 0.81 1.82 1.76 69.04
186 INT96443 Gene_expression of KNCN 4 0.56 2.49 2.22 67.60
187 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 67.56
188 INT96073 Localization of Casp1 11 0.78 4.91 1.29 66.72
189 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 66.24
190 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 66.00
191 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 65.72
192 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 63.32
193 INT156694 Binding of SET 10 0.36 3.77 2.21 62.24
194 INT12791 Gene_expression of Xdh 12 0.62 7.2 4.54 61.84
195 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 61.28
196 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5 61.04
197 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 60.56
198 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 59.88
199 INT72060 Positive_regulation of Gene_expression of Ros1 127 0.41 76.76 20.91 59.88
200 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 59.20
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