P:sSRI

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pChart

Pain Term
Category Drug class
Synonyms Selective Serotonin Reuptake Inhibitor, Selective Serotonin Reuptake Inhibitors, SSRIs
Pain Specific No
Documents 2522
Hot Single Events 200
Hot Interactions 55

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for sSRI. They are ordered first by their pain relevance and then by number of times they were reported for sSRI. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08 100.00
2 INT276438 Binding of OPN1SW and MYP1 1 0.12 1.21 0.09 100.00
3 INT296169 Binding of Htr4 and Creb1 1 0.49 0.1 0.56 99.98
4 INT305738 Binding of Creb1 and Atf6b 1 0.08 0.34 0.53 99.80
5 INT235884 Htr3a Regulation of Nr3c1 1 0.00 0.63 0.32 99.40
6 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84 99.26
7 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84 99.26
8 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84 99.26
9 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25 98.72
10 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 98.00
11 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31 97.20
12 INT235870 Bdnf Regulation of Gene_expression of Slc6a4 1 0.09 0.77 0.5 96.32
13 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67 96.04
14 INT152867 HTR1A Negative_regulation of Localization of S100b 1 0.46 0 0.75 95.92
15 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12 95.72
16 INT282202 Tcas1 Negative_regulation of NA 1 0.01 0.32 0.34 95.20
17 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74 94.80
18 INT164476 Negative_regulation of Binding of Bche and Frl 1 0.02 0.48 0.51 93.76
19 INT305744 Fst Positive_regulation of Creb1 1 0.12 0.33 0.57 93.68
20 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74 93.52
21 INT305732 Tst Positive_regulation of Creb1 1 0.12 0.33 0.57 93.36
22 INT235868 Creb1 Negative_regulation of Atf6b 1 0.02 0.21 0.4 93.36
23 INT164475 Binding of Bche and Frl 1 0.02 0.48 0.51 93.32
24 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76 92.68
25 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 92.28
26 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76 92.24
27 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 92.08
28 INT296172 Fig4 Positive_regulation of Gene_expression of NOVA2 1 0.04 0 0.22 91.80
29 INT305731 Binding of Bdnf and Creb1 Positive_regulation of BDNF 1 0.11 0.49 0.47 91.56
30 INT305735 Binding of Bdnf and Creb1 1 0.08 0.49 0.47 91.56
31 INT305747 Binding of Bdnf and Creb1 Positive_regulation of Bdnf 1 0.03 0.49 0.47 91.56
32 INT305746 Positive_regulation of Creb1 Positive_regulation of BDNF 1 0.32 0.41 0.47 91.56
33 INT305743 Binding of Bdnf and Positive_regulation of Positive_regulation of Creb1 1 0.11 0.49 0.47 91.56
34 INT305736 Positive_regulation of Creb1 Positive_regulation of Bdnf 1 0.10 0.41 0.46 91.56
35 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53 91.40
36 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51 91.04
37 INT305745 Binding of Bdnf and Positive_regulation of BDNF 1 0.17 0.44 0.44 90.84
38 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14 89.72
39 INT235880 Binding of Mtap2 and Prkaca 1 0.07 0.41 0.38 88.44
40 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85 85.52
41 INT235883 Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15 85.12
42 INT235879 Regulation of Ppp2ca Regulation of Slc6a4 1 0.03 0 0.15 85.12
43 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52 84.84
44 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39 84.32
45 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51 83.76
46 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49 83.44
47 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39 83.12
48 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92 83.04
49 INT149471 Avp Regulation of Gene_expression of Crh 1 0.45 0.6 0.96 83.04
50 INT149474 Avp Regulation of Gene_expression of Oxt 1 0.27 0.6 0.96 83.04
51 INT235882 Creb1 Positive_regulation of Positive_regulation of Bdnf 1 0.11 0.17 0.47 83.04
52 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38 83.04
53 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56 82.92
54 INT149469 Oxt Regulation of Gene_expression of Crh 1 0.45 1.2 1.91 82.84
55 INT343599 Gys1 Regulation of Tst 1 0.01 0 0.75 80.56
56 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94 79.60
57 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37 78.80
58 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37 78.80
59 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37 78.80
60 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81 77.92
61 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 76.64
62 INT192873 Binding of RS1 and Nktcn1 1 0.00 0.8 0.59 74.64
63 INT271194 Binding of Bdnf and Gopc 1 0.03 0.49 0.6 74.24
64 INT271192 Binding of Gopc and Gtf3a 1 0.00 0.49 0.6 74.24
65 INT70422 Binding of Htr1a and Adarb1 1 0.01 0.37 0.81 74.00
66 INT334180 Tdo2 Negative_regulation of Tbpl1 1 0.10 0.16 0.45 73.32
67 INT235881 Prkaca Positive_regulation of Creb1 2 0.10 0.16 0.64 72.48
68 INT223934 HSPG2 Negative_regulation of Gene_expression of Cux1 1 0.03 0 0.53 72.16
69 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51 71.84
70 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95 71.68
71 INT235875 Bdnf Positive_regulation of Phosphorylation of Mapk1 1 0.09 0.38 0.17 70.04
72 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31 69.72
73 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99 68.96
74 INT149473 Avp Positive_regulation of Localization of Pomc 4 0.48 2.64 0.56 68.96
75 INT256042 Negative_regulation of Musk Negative_regulation of Ntrk1 1 0.08 0.48 0.44 68.72
76 INT60627 Crh Positive_regulation of Localization of Mc2r 2 0.11 0.44 0.53 68.48
77 INT149468 Avp Positive_regulation of Localization of Mc2r 1 0.07 0.26 0.21 68.48
78 INT304575 Creb1 Regulation of Gene_expression of Bdnf 1 0.04 1 0.84 67.44
79 INT235872 Phosphorylation of Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.31 67.00
80 INT235886 Ppp2ca Positive_regulation of Slc37a4 1 0.00 0.15 0.3 66.16
81 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35 65.44
82 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35 65.08
83 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35 65.08
84 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88 64.56
85 INT190652 Mdk Positive_regulation of Phosphorylation of Mapk1 2 0.50 0.85 0.33 63.36
86 INT223936 HSPG2 Positive_regulation of Gene_expression of Cux1 1 0.03 0 0.46 61.96
87 INT223935 HSPG2 Positive_regulation of Cux1 1 0.03 0 0.45 60.32
88 INT235874 Camk2a Positive_regulation of Slc6a4 1 0.11 0.14 0.28 60.28
89 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4 58.88
90 INT99440 Fglu Positive_regulation of Localization of Ins1 1 0.01 0.18 0.17 58.32
91 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31 58.24
92 INT253165 SCN10A Positive_regulation of OVGP1 1 0.06 1.34 0.61 57.40
93 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75 55.28
94 INT223928 Cux1 Regulation of Gene_expression of Maoa 1 0.24 0.15 0.57 47.16
95 INT223924 Cux1 Regulation of Gene_expression of Serpina1 1 0.04 0.15 0.57 47.16
96 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 46.24
97 INT167819 IFNA1 Positive_regulation of Fst 1 0.39 0 1.07 45.88
98 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27 43.40
99 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13 43.04
100 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 40.88
101 INT216075 ATD Regulation of Cfp 1 0.07 0.11 0.11 40.28
102 INT334182 Tdo2 Positive_regulation of Gene_expression of Ngf 1 0.07 0.08 0.16 34.64
103 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 31.48
104 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8 26.96
105 INT305737 Binding of Sort1 and Gga2 1 0.19 0.11 0.06 26.92
106 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08 25.00
107 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52 18.20
108 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52 18.20
109 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 18.00
110 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 18.00
111 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 16.16
112 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 16.12
113 INT253897 Binding of Htr1d and Pag1 1 0.30 0.29 0.52 13.56
114 INT253896 Binding of Htr1a and Pag1 1 0.30 0.29 0.49 13.56
115 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 12.88
116 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29 12.36
117 INT282505 Binding of ocd and Slc1a1 1 0.39 4.22 0.4 8.60
118 INT152699 Bdnf Positive_regulation of Ltp 5 0.05 1.22 2.95 8.20
119 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
120 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
121 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25 5.00
122 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 5.00
123 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27 5.00
124 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26 5.00
125 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
126 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74 5.00
127 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 5.00
128 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48 5.00
129 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41 5.00
130 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 5.00
131 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29 5.00
132 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
133 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27 5.00
134 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2 5.00
135 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19 5.00
136 INT321478 Binding of Slc6a2 and Flvcr2 1 0.00 0.41 1.14 5.00
137 INT321476 Binding of Slc6a3 and Slc6a2 1 0.01 0.41 1.14 5.00
138 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13 5.00
139 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13 5.00
140 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11 5.00
141 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04 5.00
142 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04 5.00
143 INT224856 Binding of Bdnf and Eef2 1 0.14 0 1.02 5.00
144 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01 5.00
145 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
146 INT310348 Binding of Tspo and Gabrd 1 0.00 0.43 0.88 5.00
147 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83 5.00
148 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77 5.00
149 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
150 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73 5.00
151 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
152 INT224892 Bdnf Regulation of Localization of Ltp 1 0.03 0.17 0.69 5.00
153 INT224893 Bdnf Regulation of Ltp 1 0.03 0.17 0.69 5.00
154 INT321479 Ubqln1 Regulation of Cfp 1 0.00 0.37 0.67 5.00
155 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66 5.00
156 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
157 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63 5.00
158 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63 5.00
159 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 5.00
160 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
161 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61 5.00
162 INT290594 BDNF Positive_regulation of Localization of S100B 1 0.08 0.6 0.57 5.00
163 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
164 INT343597 Gys1 Regulation of Transcription of Gria2 1 0.00 0 0.55 5.00
165 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
166 INT255463 Binding of Avp and Avpr1a 1 0.06 0.67 0.54 5.00
167 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
168 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
169 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
170 INT240192 RBX1 Negative_regulation of BDNF 1 0.08 0.13 0.52 5.00
171 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51 5.00
172 INT224853 Binding of Bdnf and Eif4e 1 0.10 0 0.5 5.00
173 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5 5.00
174 INT256040 Ngf Regulation of Gene_expression of Ntrk1 1 0.36 0.73 0.5 5.00
175 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49 5.00
176 INT320451 ECT Positive_regulation of Gene_expression of BDNF 1 0.05 1.21 0.49 5.00
177 INT218783 Binding of Faah and Cfp 1 0.04 0.55 0.45 5.00
178 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45 5.00
179 INT355540 Gnptg Positive_regulation of AMELX 1 0.00 2.16 0.44 5.00
180 INT304577 Binding of Arntl and Clock Regulation of Gene_expression of Maoa 1 0.01 0.3 0.44 5.00
181 INT240193 RBX1 Positive_regulation of Gene_expression of BDNF 1 0.10 0 0.43 5.00
182 INT315333 Binding of Cflar and Fadd 1 0.01 0.49 0.42 5.00
183 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42 5.00
184 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
185 INT327562 Binding of MCS and AKR1B10 1 0.00 0.5 0.41 5.00
186 INT224894 Bdnf Positive_regulation of Positive_regulation of IER3 1 0.00 0.36 0.41 5.00
187 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4 5.00
188 INT189300 Atp6v1e1 Regulation of Gene_expression of Prl 1 0.03 0.29 0.39 5.00
189 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
190 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
191 INT245328 Binding of Esr2 and Pgr 1 0.03 0.41 0.37 5.00
192 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36 5.00
193 INT207211 Binding of Creb1 and Crem 2 0.30 1.35 0.36 5.00
194 INT272363 Binding of Adar and Adarb1 3 0.26 0.76 0.36 5.00
195 INT340607 Bdnf Regulation of Gene_expression of Creb1 1 0.36 0.31 0.36 5.00
196 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35 5.00
197 INT355539 Gnptg Positive_regulation of Mmp23 1 0.00 1.18 0.35 5.00
198 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35 5.00
199 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 5.00
200 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for sSRI. They are ordered first by their pain relevance and then by number of times they were reported in sSRI. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 100.00
2 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 100.00
3 INT56775 Binding of Htr2c 16 0.47 3.77 8.74 100.00
4 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 100.00
5 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 100.00
6 INT94132 Binding of ACOT1 7 0.13 2.62 4.04 100.00
7 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 100.00
8 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 100.00
9 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 100.00
10 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 100.00
11 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 100.00
12 INT92732 Gene_expression of Tcas1 2 0.05 0.34 1.83 100.00
13 INT135572 Negative_regulation of Slc18a2 9 0.43 1.25 4.52 100.00
14 INT120865 Regulation of Cyp3a62 5 0.62 0.07 3.4 100.00
15 INT242353 Binding of Tcas1 3 0.03 3.31 2.22 100.00
16 INT119757 Negative_regulation of SSR1 3 0.42 0.38 1.18 100.00
17 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 100.00
18 INT78487 Localization of SSR1 2 0.73 0.95 1.7 100.00
19 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 100.00
20 INT235710 Binding of SSR1 2 0.36 0.86 1.75 100.00
21 INT79136 Transcription of Flvcr2 4 0.39 0.66 3.35 100.00
22 INT95156 Transcription of Sert1 3 0.72 0.3 0.83 100.00
23 INT154727 Regulation of Cyp2b2 2 0.25 0 1.76 100.00
24 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 100.00
25 INT50309 Binding of Il1a 22 0.40 5.4 4.49 100.00
26 INT163272 Gene_expression of SSR1 2 0.65 0.23 0.56 100.00
27 INT79699 Regulation of Cyp2a 1 0.55 0.46 1.62 100.00
28 INT270 Regulation of MAOA 17 0.60 2.58 6.84 100.00
29 INT61011 Regulation of TPH1 4 0.22 1.17 2.09 100.00
30 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53 100.00
31 INT48673 Negative_regulation of IGKV2D-26 4 0.42 0.24 1.59 100.00
32 INT152864 Regulation of Localization of S100b 2 0.52 0 1.66 100.00
33 INT71504 Negative_regulation of Negative_regulation of HTR1A 3 0.57 0.14 1.32 100.00
34 INT9311 Regulation of Ssr1 13 0.60 6.41 6.58 100.00
35 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42 100.00
36 INT133835 Regulation of Cyp2c6 1 0.45 0 0.69 100.00
37 INT326316 Positive_regulation of SSR1 1 0.49 0.41 0.13 100.00
38 INT133526 Regulation of Transcription of HTR1B 1 0.26 0 0.55 100.00
39 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 100.00
40 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 100.00
41 INT62127 Localization of SRI 12 0.45 10.21 1.54 100.00
42 INT133060 Regulation of Bai1 1 0.03 0.74 0.86 100.00
43 INT132501 Positive_regulation of Binding of Cyp2a 1 0.50 0 0.56 100.00
44 INT132503 Negative_regulation of Positive_regulation of Cyp2a 1 0.43 0 0.55 100.00
45 INT219847 Regulation of Ssr1 1 0.44 1.53 0.2 100.00
46 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.98
47 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 99.98
48 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 99.98
49 INT119651 Binding of Slc6a4 12 0.32 4.65 7.07 99.98
50 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61 99.98
51 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 99.98
52 INT323979 Negative_regulation of Negative_regulation of Ghrl 2 0.42 0.98 0.76 99.98
53 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 99.98
54 INT1289 Negative_regulation of Fglu 6 0.01 3.1 1.82 99.98
55 INT146987 Negative_regulation of KIR2DS4 1 0.02 0 3.32 99.96
56 INT116619 Positive_regulation of Positive_regulation of Creb1 25 0.69 8.32 7.3 99.96
57 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 99.92
58 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 99.92
59 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 99.92
60 INT49748 Binding of HTR2C 10 0.47 3.03 4.76 99.92
61 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92 99.92
62 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 99.92
63 INT48050 Regulation of Htr7 2 0.60 0 1.59 99.90
64 INT282201 Localization of Tcas1 1 0.06 0.28 0.23 99.90
65 INT235840 Negative_regulation of Gene_expression of Ppp1r1b 1 0.09 0.19 0.57 99.90
66 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.88
67 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39 99.88
68 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46 99.88
69 INT20072 Positive_regulation of Positive_regulation of HTR2A 5 0.67 2.96 2.33 99.86
70 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 99.84
71 INT81895 Regulation of Positive_regulation of HTR1A 2 0.44 1.37 1.04 99.84
72 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 99.82
73 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91 99.82
74 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 99.82
75 INT86789 Gene_expression of P2rx4 46 0.77 30.66 25.68 99.80
76 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.80
77 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21 99.80
78 INT52403 Negative_regulation of HTR2B 5 0.42 1.79 3.15 99.80
79 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22 99.80
80 INT29280 Negative_regulation of Tcas1 2 0.03 0.77 1.78 99.80
81 INT92971 Binding of Creb1 31 0.47 11.3 6.22 99.80
82 INT5923 Negative_regulation of Rtn4 50 0.36 24.19 27.2 99.78
83 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 99.78
84 INT125242 Localization of RLS 15 0.64 15.87 4.99 99.78
85 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39 99.76
86 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 99.76
87 INT66868 Positive_regulation of Ceacam3 40 0.69 26.61 28.9 99.76
88 INT94007 Binding of Pphn 4 0.31 0.63 0.31 99.76
89 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 99.74
90 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 99.72
91 INT81388 Localization of Xpr1 6 0.55 2.26 2.09 99.72
92 INT107683 Positive_regulation of Negative_regulation of NME1 1 0.49 0.93 0.48 99.72
93 INT107686 Positive_regulation of Negative_regulation of MYC 2 0.49 1.59 0.6 99.72
94 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51 99.72
95 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 99.72
96 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 99.72
97 INT112550 Positive_regulation of Positive_regulation of Pla2g1b 3 0.49 0.48 0.94 99.72
98 INT135102 Positive_regulation of Localization of Prkaca 3 0.17 1.21 0.75 99.70
99 INT50106 Positive_regulation of Localization of CTSB 9 0.33 3.15 1.69 99.68
100 INT22454 Regulation of Crp 213 0.62 160.67 49.24 99.68
101 INT117855 Negative_regulation of Ghrl 29 0.57 17.52 5 99.68
102 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 99.66
103 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 99.66
104 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 99.66
105 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93 99.66
106 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14 99.64
107 INT241581 Regulation of Htr4 6 0.44 1.34 2.19 99.64
108 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 99.64
109 INT54052 Gene_expression of App 33 0.78 25.08 14.7 99.62
110 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63 99.62
111 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93 99.60
112 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28 99.60
113 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 99.60
114 INT296168 Phosphorylation of Htr3a 1 0.06 0 0.26 99.60
115 INT169764 Positive_regulation of Mir16-1 1 0.56 0 0.77 99.58
116 INT59706 Transcription of HTR1B 5 0.69 0.4 3.4 99.58
117 INT71488 Transcription of HTR1A 2 0.69 0.7 1.36 99.58
118 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.56
119 INT61245 Positive_regulation of Cyp2b2 9 0.64 0.41 4.7 99.56
120 INT6791 Binding of NA 55 0.46 5.36 17.59 99.56
121 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18 99.56
122 INT157982 Positive_regulation of Gene_expression of Cyp2b2 1 0.43 0 0.85 99.56
123 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 99.56
124 INT132499 Positive_regulation of Cyp2a 1 0.69 0 1.15 99.56
125 INT29086 Negative_regulation of Sert1 37 0.58 7.49 14.98 99.54
126 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 99.52
127 INT31774 Positive_regulation of Vta1 67 0.44 14.52 71.79 99.52
128 INT181587 Negative_regulation of OPN1SW 12 0.51 4.36 0.89 99.52
129 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 99.52
130 INT246083 Positive_regulation of Cacna1d 1 0.02 0.89 0.22 99.52
131 INT96557 Binding of Bdnf 46 0.47 21.74 24.26 99.50
132 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 99.50
133 INT50105 Localization of CTSB 29 0.78 10.98 5.21 99.50
134 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23 99.48
135 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28 99.48
136 INT253 Regulation of PRL 184 0.62 47.27 65.79 99.48
137 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 99.48
138 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 99.48
139 INT5205 Localization of AR 43 0.80 12.87 4.63 99.48
140 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 99.46
141 INT235845 Positive_regulation of Transcription of Adcy1 1 0.13 0.43 0.44 99.46
142 INT116623 Localization of Prkaca 15 0.73 2.89 3.59 99.46
143 INT143208 Negative_regulation of TPI1 30 0.59 7.54 1.08 99.46
144 INT14264 Binding of Gal 39 0.47 5.7 14.48 99.46
145 INT66303 Regulation of Slc6a4 10 0.45 4.82 10.55 99.44
146 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 99.44
147 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 99.42
148 INT274374 Negative_regulation of Regulation of Enc1 1 0.01 0.73 0.86 99.42
149 INT1682 Negative_regulation of Rem1 28 0.37 7.38 8.4 99.40
150 INT126685 Gene_expression of Rem1 30 0.65 11.21 3.61 99.40
151 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8 99.38
152 INT146988 Gene_expression of KIR2DS4 2 0.12 1.52 0.83 99.38
153 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 99.38
154 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.38
155 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 99.36
156 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 99.36
157 INT46797 Negative_regulation of Cyp3a62 27 0.59 7.06 13.97 99.36
158 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 99.36
159 INT6063 Positive_regulation of Bche 17 0.66 6.07 3.08 99.36
160 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 99.36
161 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 99.36
162 INT196736 Gene_expression of Ppp1r1b 24 0.55 2.01 3.99 99.34
163 INT282488 Negative_regulation of ocd 1 0.43 2.38 0.49 99.34
164 INT57920 Positive_regulation of Prnp 5 0.64 0.7 2.87 99.32
165 INT100728 Positive_regulation of SEMA6A 7 0.67 2.73 3.25 99.32
166 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 99.32
167 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.30
168 INT65423 Negative_regulation of PTPRN 1 0.57 0.08 0.38 99.30
169 INT61241 Gene_expression of Cyp2b2 1 0.56 0 0.92 99.30
170 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 99.30
171 INT200417 Positive_regulation of Binding of Sert1 1 0.17 0.18 0.13 99.30
172 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 99.30
173 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 99.28
174 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99 99.28
175 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37 99.28
176 INT196739 Regulation of Ppp1cc 5 0.19 0 0.63 99.28
177 INT235847 Transcription of Adcy1 2 0.25 0.42 0.5 99.26
178 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66 99.24
179 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36 99.24
180 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 99.22
181 INT83817 Regulation of Enc1 5 0.14 2.37 2.04 99.22
182 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 99.22
183 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 99.20
184 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.20
185 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 99.20
186 INT101711 Positive_regulation of Gene_expression of Tph1 3 0.69 0.84 2.52 99.16
187 INT235831 Negative_regulation of Binding of Sugt1 1 0.01 0.24 0.4 99.16
188 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.14
189 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.14
190 INT107680 Positive_regulation of Protein_catabolism of Pola1 1 0.01 0.91 0.48 99.14
191 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48 99.14
192 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3 99.14
193 INT107681 Positive_regulation of Pola1 1 0.01 0.91 0.47 99.14
194 INT26248 Positive_regulation of Ptprg 12 0.40 1.42 9.48 99.14
195 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84 99.12
196 INT425 Localization of PRL 455 0.81 189.64 144.8 99.12
197 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 99.12
198 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26 99.10
199 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 99.10
200 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24 99.10
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