P:spinal-cord stimulation

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Pain Term
Category Treatment
Synonyms Spinal Cord Stimulation
Pain Specific No
Documents 758
Hot Single Events 79
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for spinal-cord stimulation. They are ordered first by their pain relevance and then by number of times they were reported for spinal-cord stimulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95 100.00
2 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4 100.00
3 INT320600 TNS3 Regulation of CEBPZ 1 0.29 1.96 0.74 99.40
4 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29 75.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for spinal-cord stimulation. They are ordered first by their pain relevance and then by number of times they were reported in spinal-cord stimulation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4 100.00
2 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88 100.00
3 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97 100.00
4 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 100.00
5 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98 100.00
6 INT104508 Regulation of Gene_expression of Nkx1-1 9 0.30 4.55 7.36 100.00
7 INT146019 Regulation of Transcription of Nkx1-1 1 0.18 0.41 0.72 100.00
8 INT146018 Positive_regulation of Transcription of Nkx1-1 1 0.31 0.41 0.72 100.00
9 INT2910 Regulation of Abat 169 0.62 36.95 153.53 100.00
10 INT140436 Binding of TWIST1 5 0.39 2.34 0.47 100.00
11 INT163028 Negative_regulation of Negative_regulation of IFNAR1 1 0.05 0.86 0.73 100.00
12 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 100.00
13 INT102354 Localization of TWIST1 3 0.75 0.17 0.15 100.00
14 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 99.98
15 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.98
16 INT126539 Negative_regulation of Transcription of Trpv1 9 0.59 1.52 1.8 99.98
17 INT74465 Negative_regulation of Nkx1-1 22 0.46 8.51 13.63 99.98
18 INT146020 Negative_regulation of Transcription of Nkx1-1 1 0.28 0.39 0.75 99.98
19 INT4776 Localization of TAC1 82 0.78 16.89 45.21 99.98
20 INT8049 Regulation of Nts 18 0.53 6.15 10.39 99.98
21 INT3948 Regulation of Cck 291 0.62 58.07 255.88 99.98
22 INT5118 Regulation of SST 97 0.62 34.35 51.74 99.98
23 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 99.92
24 INT3439 Localization of Abat 1017 0.78 112.39 727.06 99.92
25 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 99.88
26 INT17271 Positive_regulation of CDNF 11 0.28 2.69 5.03 99.88
27 INT49191 Gene_expression of IFNAR1 14 0.41 9.96 3.84 99.86
28 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77 99.84
29 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 99.84
30 INT160556 Gene_expression of TNS3 4 0.60 2.94 1.77 99.84
31 INT58595 Transcription of Nkx1-1 7 0.47 2.53 3.54 99.84
32 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 99.84
33 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.82
34 INT146091 Negative_regulation of IFNAR1 6 0.25 9.12 4.86 99.82
35 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 99.76
36 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.68
37 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.68
38 INT94357 Positive_regulation of Transcription of Trpv1 11 0.50 3.63 5.05 99.68
39 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 99.52
40 INT167902 Binding of ALDH3A2 1 0.33 0.93 0.56 99.50
41 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 99.48
42 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.48
43 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.46
44 INT1352 Localization of Acot1 728 0.80 73.01 296.01 99.32
45 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 99.20
46 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 99.16
47 INT19575 Negative_regulation of Positive_regulation of Abat 14 0.43 2.07 11.05 99.08
48 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.00
49 INT443 Localization of POMC 1020 0.81 284.52 443.17 98.92
50 INT12123 Negative_regulation of Lynx1 2 0.03 0.31 0.8 98.92
51 INT16562 Negative_regulation of Positive_regulation of Gabbr1 5 0.43 2.67 3.24 98.46
52 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19 98.46
53 INT242259 Negative_regulation of Positive_regulation of CEBPZ 4 0.48 1.44 0.59 98.32
54 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 98.26
55 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 98.08
56 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 97.96
57 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.72
58 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 96.80
59 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 96.08
60 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81 96.08
61 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84 96.04
62 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 95.76
63 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 94.80
64 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 94.32
65 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 93.96
66 INT49041 Transcription of Tacr1 25 0.72 12.52 12.8 93.96
67 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 93.48
68 INT2330 Regulation of CB 78 0.10 20.46 32.6 91.20
69 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 91.12
70 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 90.48
71 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 90.36
72 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 88.64
73 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 88.32
74 INT7580 Positive_regulation of Mbp 54 0.70 23.37 17.14 87.88
75 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 86.24
76 INT2217 Positive_regulation of Positive_regulation of Ins1 21 0.69 7.66 6.32 86.24
77 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 85.12
78 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 84.56
79 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 82.24
80 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 80.00
81 INT158016 Positive_regulation of VEGFC 7 0.49 6.58 2.18 79.84
82 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 79.84
83 INT11745 Protein_catabolism of Cst7 3 0.39 0.81 2.08 76.16
84 INT15821 Positive_regulation of Myo9b 1 0.53 0 1.05 74.32
85 INT15820 Regulation of Positive_regulation of Myo9b 1 0.47 0 0.68 74.16
86 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 70.48
87 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 61.68
88 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 50.28
89 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 50.00
90 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 50.00
91 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 50.00
92 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0 50.00
93 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 49.64
94 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 38.52
95 INT121909 Regulation of FAIM3 3 0.22 1.06 2.42 26.68
96 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 12.80
97 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 12.80
98 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72 8.56
99 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
100 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
101 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
102 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
103 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
104 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
105 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
106 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 5.00
107 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
108 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
109 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
110 INT23784 Gene_expression of FAIM3 25 0.55 2.89 17.14 5.00
111 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
112 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
113 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
114 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 5.00
115 INT36173 Positive_regulation of Gs 17 0.43 7.48 8.19 5.00
116 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
117 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
118 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 5.00
119 INT19086 Negative_regulation of COL1A1 32 0.38 16.77 5.98 5.00
120 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 5.00
121 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
122 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 5.00
123 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
124 INT100912 Regulation of Kdm5d 52 0.32 20.39 4.72 5.00
125 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
126 INT19965 Positive_regulation of COL1A1 23 0.45 14.49 4.38 5.00
127 INT82876 Regulation of IFNAR1 6 0.26 6.69 3.73 5.00
128 INT142084 Positive_regulation of Kdm5d 22 0.29 5.88 3.17 5.00
129 INT33057 Binding of Dsp 9 0.36 4.05 2.66 5.00
130 INT269719 Positive_regulation of Localization of FAIM3 1 0.17 0.22 2.36 5.00
131 INT269718 Localization of FAIM3 1 0.25 0.22 2.35 5.00
132 INT104006 Binding of Kdm5d 26 0.26 8.09 2.07 5.00
133 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07 5.00
134 INT89240 Gene_expression of VEGFC 23 0.75 15.94 2.03 5.00
135 INT232662 Localization of MS 1 0.03 0.57 1.95 5.00
136 INT232666 Negative_regulation of AK1 1 0.02 2.52 1.88 5.00
137 INT133826 Negative_regulation of Kdm5d 15 0.16 7.88 1.83 5.00
138 INT175535 Gene_expression of GPC3 5 0.29 4.17 1.74 5.00
139 INT80784 Regulation of BCS1L 9 0.39 7.63 1.47 5.00
140 INT24736 Positive_regulation of SERPINA5 17 0.49 9.55 1.47 5.00
141 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 5.00
142 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 5.00
143 INT232665 Gene_expression of WIPF3 1 0.06 1.85 1.14 5.00
144 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 5.00
145 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13 5.00
146 INT280858 Localization of IFNAR1 5 0.39 4.5 1.09 5.00
147 INT9551 Regulation of AK1 2 0.03 1.38 1.03 5.00
148 INT232664 Regulation of Positive_regulation of AK1 1 0.02 0.91 0.95 5.00
149 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 5.00
150 INT26295 Positive_regulation of mea 4 0.49 1.08 0.91 5.00
151 INT157846 Gene_expression of BCS1L 13 0.50 15.89 0.83 5.00
152 INT170625 Binding of SERPINA5 8 0.32 8.42 0.69 5.00
153 INT103015 Positive_regulation of Tms 3 0.34 0.46 0.68 5.00
154 INT89520 Regulation of COL1A1 8 0.32 3.21 0.66 5.00
155 INT151157 Negative_regulation of SERPINA5 5 0.23 3.68 0.64 5.00
156 INT89239 Negative_regulation of Gene_expression of VEGFC 2 0.39 1.11 0.59 5.00
157 INT77562 Regulation of TNS3 5 0.39 1 0.55 5.00
158 INT37179 Negative_regulation of TNS3 2 0.45 0.63 0.4 5.00
159 INT36176 Negative_regulation of Gs 4 0.18 0.96 0.31 5.00
160 INT308015 Phosphorylation of IFNAR1 1 0.27 1.11 0.28 5.00
161 INT111676 Phosphorylation of MYH14 5 0.48 2.14 0.28 5.00
162 INT332658 Gene_expression of Laptm4a 1 0.01 0.48 0.25 5.00
163 INT332665 Negative_regulation of ALDH1B1 1 0.02 0.1 0.15 5.00
164 INT212357 Binding of TNS3 2 0.31 0.53 0.15 5.00
165 INT170624 Localization of SERPINA5 3 0.40 0.79 0.12 5.00
166 INT320601 Negative_regulation of Negative_regulation of TNS3 1 0.33 0.36 0.1 5.00
167 INT36175 Positive_regulation of Negative_regulation of Gs 2 0.20 0.23 0.1 5.00
168 INT129058 Binding of Arid3a 2 0.34 0.95 0.09 5.00
169 INT332664 Positive_regulation of GUCY2D 1 0.01 0.13 0.07 5.00
170 INT263610 Gene_expression of Arid3a 1 0.16 0 0.03 5.00
171 INT263611 Negative_regulation of Gene_expression of Arid3a 1 0.10 0 0.03 5.00
172 INT320602 Regulation of Gene_expression of TNS3 1 0.35 0.44 0 5.00
173 INT320211 Negative_regulation of Binding of Kdm5d 1 0.16 0.2 0 5.00
174 INT320603 Negative_regulation of Binding of TNS3 1 0.33 0.09 0 5.00
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