P:tolerance

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pChart

Pain Term
Category Response
Synonyms None
Pain Specific No
Documents 13278
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for tolerance. They are ordered first by their pain relevance and then by number of times they were reported for tolerance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97 100.00
2 INT152361 Binding of Ifng and T2dm2 1 0.00 0.86 0.37 100.00
3 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43 100.00
4 INT166413 Gprasp1 Regulation of D2Mit212 1 0.15 0.31 1.26 100.00
5 INT79021 Regulation of Binding of Jun and Fos 2 0.50 0.66 1.5 100.00
6 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43 100.00
7 INT323491 Olfr781 Positive_regulation of Localization of Ins1 1 0.01 0.87 0.4 100.00
8 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03 100.00
9 INT32396 Oxt Negative_regulation of Pomc 1 0.45 0 0.67 100.00
10 INT317259 Pyy Positive_regulation of Ins1 1 0.02 0.33 0.12 100.00
11 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16 100.00
12 INT271902 Binding of KCNK1 and Jun 1 0.12 0.08 0.53 100.00
13 INT94240 Binding of Cp and Ins1 1 0.02 0.7 0.58 100.00
14 INT285748 PRL Positive_regulation of Positive_regulation of C6orf25 1 0.01 1.01 0.31 100.00
15 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 100.00
16 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 100.00
17 INT339647 Binding of IFN1@ and Carg1 1 0.01 0.75 0.2 100.00
18 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8 99.96
19 INT199194 Ros1 Negative_regulation of Aldh2 1 0.07 0.27 0.3 99.96
20 INT199190 Ros1 Positive_regulation of Aldh2 1 0.08 0.27 0.3 99.96
21 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85 99.92
22 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45 99.92
23 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76 99.80
24 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5 99.78
25 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52 99.62
26 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02 99.60
27 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47 99.56
28 INT115272 Neu1 Positive_regulation of Coq10a 1 0.43 0.41 1.35 99.48
29 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73 99.44
30 INT178969 Slc7a2 Regulation of Ins1 1 0.01 0.56 0.05 99.44
31 INT306238 Tead1 Regulation of Ins1 1 0.00 1.04 0.05 99.44
32 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65 99.40
33 INT325653 Positive_regulation of Binding of Nab1 and Gopc 1 0.05 0.63 0.09 99.36
34 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53 99.32
35 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51 99.32
36 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46 99.32
37 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47 99.32
38 INT251426 Gnat3 Negative_regulation of Aldh2 1 0.22 0 0.35 99.28
39 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81 99.28
40 INT251393 Gnat3 Positive_regulation of Gnat3 Negative_regulation of Aldh2 1 0.10 0 0.05 99.28
41 INT325654 Binding of Nab1 and Gopc 1 0.04 0.63 0.09 99.22
42 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77 99.20
43 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24 99.16
44 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29 99.12
45 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29 99.12
46 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29 99.12
47 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15 99.12
48 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15 99.12
49 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15 99.12
50 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14 99.12
51 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98 99.08
52 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53 99.08
53 INT40728 SST Regulation of IRG1 1 0.11 0.36 0.38 99.04
54 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14 98.96
55 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 98.96
56 INT317531 Regulation of Binding of Grin1 and Mors1 1 0.08 0.06 1.05 98.94
57 INT317534 Regulation of Binding of Camk2a and Grin1 1 0.20 0.06 1.05 98.94
58 INT147913 Phosphorylation of Camk2a Positive_regulation of Binding of Lpl 1 0.10 0 0.77 98.92
59 INT115271 Neu1 Positive_regulation of Coq10a 1 0.01 0.41 1.35 98.88
60 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33 98.76
61 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13 98.72
62 INT304346 MIR133B Regulation of Gene_expression of MIR206 1 0.05 0.78 0.07 98.72
63 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34 98.64
64 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11 98.64
65 INT168865 Cd38 Regulation of Wdtc1 1 0.03 0.12 1.35 98.64
66 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05 98.64
67 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28 98.52
68 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 98.50
69 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01 98.48
70 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14 98.48
71 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05 98.44
72 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21 98.42
73 INT317535 Binding of Grin1 and Mors1 1 0.07 0.06 1.04 98.42
74 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21 98.40
75 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45 98.38
76 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72 98.32
77 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46 98.28
78 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 98.28
79 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9 98.24
80 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64 98.24
81 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64 98.24
82 INT255260 Binding of Cd47 and Tsp1 1 0.20 1.42 0.67 98.20
83 INT199191 Negative_regulation of Sod2 Positive_regulation of Ros1 1 0.08 0 0.19 98.20
84 INT255261 Tsp1 Positive_regulation of Binding of Cd47 1 0.27 0.5 0.23 98.20
85 INT251427 Gnat3 Positive_regulation of Aldh2 1 0.26 0 0.05 98.20
86 INT253148 Ins1 Regulation of Phosphorylation of Tbc1d4 1 0.09 0.42 0.09 98.16
87 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16 98.04
88 INT26812 SST Regulation of Localization of OXT 1 0.40 0.57 1.37 98.04
89 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 98.00
90 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15 98.00
91 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39 98.00
92 INT150350 Oprk1 Regulation of Pat 1 0.22 0.38 0.81 97.92
93 INT150348 Oprd1 Regulation of Pat 1 0.01 0.38 0.81 97.92
94 INT298730 PROC Positive_regulation of Gene_expression of Ngf 1 0.00 0.6 0.74 97.84
95 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9 97.84
96 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18 97.76
97 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46 97.72
98 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33 97.70
99 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82 97.68
100 INT345966 Binding of Arid1a and al44 1 0.00 1.56 0.05 97.68
101 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05 97.68
102 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62 97.60
103 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85 97.52
104 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11 97.52
105 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 97.48
106 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 97.44
107 INT199189 Binding of Aldh2 and Ros1 1 0.06 0.3 0.88 97.36
108 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35 97.36
109 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02 97.32
110 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02 97.32
111 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02 97.32
112 INT332638 Gip Regulation of Glp1r 1 0.02 0.47 0.05 97.26
113 INT211744 Binding of Gopc and Mors1 1 0.10 0.2 1.48 97.20
114 INT339493 Binding of Irak1 and Irak3 1 0.02 0.17 0.41 97.12
115 INT298729 PROC Positive_regulation of Set 1 0.00 0.76 0.55 97.08
116 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23 97.08
117 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 97.04
118 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64 96.96
119 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07 96.96
120 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06 96.96
121 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28 96.96
122 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27 96.96
123 INT114921 Binding of Oprm1 and Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.06 0.05 0.54 96.96
124 INT114930 Binding of Oprm1 and Crebbp Positive_regulation of Positive_regulation of Creb1 1 0.06 0 0.51 96.96
125 INT114931 Binding of Oprm1 and Creb1 Positive_regulation of Positive_regulation of Creb1 1 0.16 0 0.51 96.96
126 INT314134 Negative_regulation of Nos2 Positive_regulation of Ucp3 1 0.36 0.45 0.05 96.96
127 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7 96.92
128 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57 96.88
129 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44 96.84
130 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05 96.84
131 INT330433 ALDOA Positive_regulation of esterase 1 0.00 0.46 0.17 96.76
132 INT330430 ALDOA Positive_regulation of Pcyt2 1 0.01 0.47 0.17 96.76
133 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32 96.68
134 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67 96.56
135 INT251420 Aldh3a1 Regulation of Gene_expression of Gnat3 1 0.09 0.08 0.28 96.56
136 INT18325 Grem2 Positive_regulation of Ins1 1 0.02 0.9 0.88 96.56
137 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2 96.44
138 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11 96.40
139 INT166414 Gprasp1 Regulation of Negative_regulation of Cnr1 1 0.37 0.3 0.75 96.36
140 INT124160 Binding of Rgs9 and Mors1 1 0.23 0.28 0.9 96.32
141 INT123052 Gpbar1 Regulation of Phosphorylation of Grk4 1 0.37 0 0.94 96.28
142 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94 96.28
143 INT123049 Grk4 Regulation of Phosphorylation of Gpbar1 1 0.37 0 0.94 96.28
144 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94 96.28
145 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94 96.28
146 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94 96.28
147 INT234724 Binding of NPC1 and Cxcl1 1 0.00 0.33 0.21 96.28
148 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8 96.28
149 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71 95.96
150 INT253135 Ins1 Regulation of Il6 1 0.13 0.42 0.09 95.96
151 INT180344 CYP2A6 Regulation of AMELX 1 0.01 2.01 0.05 95.88
152 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05 95.88
153 INT180348 CYP2A6 Regulation of AIRE 1 0.01 2.01 0.05 95.88
154 INT317538 Binding of Neu3 and Mors1 1 0.00 0 1.51 95.76
155 INT267158 Binding of IRS1 and SHMT2 1 0.02 0.46 0.05 95.68
156 INT292816 Binding of KCNJ11 and FTO 1 0.46 0.49 0.05 95.64
157 INT350020 ARID1B Regulation of Positive_regulation of Tnf 1 0.04 1.78 0.16 95.60
158 INT296324 NFE2L2 Regulation of GSTK1 1 0.01 0.91 0.14 95.60
159 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24 95.52
160 INT50793 Oprd1 Regulation of Phosphorylation of Oprd1 1 0.00 0 0.8 95.52
161 INT123987 RGS17 Positive_regulation of Rgs20 1 0.13 0 1.09 95.48
162 INT249833 Binding of CHI3L1 and GOPC 1 0.06 1.11 0.15 95.48
163 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05 95.48
164 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74 95.40
165 INT203040 Binding of PDCD1 and PDCD1LG2 3 0.40 4.86 0.98 95.36
166 INT203056 Binding of Cd274 and PDCD1LG2 1 0.13 1.61 0.57 95.36
167 INT203041 Binding of CD274 and PDCD1LG2 1 0.03 1.61 0.57 95.36
168 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32 95.32
169 INT91306 Binding of Npff and Npffr1 1 0.23 0.17 0.6 95.32
170 INT350013 ARID1B Regulation of Positive_regulation of NFKB1 1 0.00 1.77 0.16 95.28
171 INT131889 gr Regulation of Gene_expression of Grin1 1 0.02 0 1.01 95.24
172 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25 95.04
173 INT114928 Positive_regulation of Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.16 0.05 0.54 95.04
174 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 0.02 0.07 1.49 94.80
175 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49 94.80
176 INT93783 Racgap1 Positive_regulation of Gnptab 1 0.02 0.07 1.49 94.80
177 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65 94.80
178 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14 94.76
179 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31 94.72
180 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96 94.72
181 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96 94.72
182 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05 94.72
183 INT251430 Gnat3 Positive_regulation of Gucy1b2 1 0.04 0.48 0.42 94.68
184 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25 94.68
185 INT304349 Binding of HBN1 and MIR133B 1 0.00 0.29 0.07 94.68
186 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15 94.68
187 INT251424 Positive_regulation of Gnat3 Positive_regulation of Gucy1b2 1 0.02 0.2 0.15 94.68
188 INT203055 Binding of PDCD1 and Cd274 1 0.40 0.8 0.29 94.64
189 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43 94.56
190 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42 94.52
191 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14 94.40
192 INT203046 Binding of PDCD1 and CD274 2 0.40 3.97 0.68 94.36
193 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17 94.24
194 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38 94.20
195 INT292815 Binding of CDC123 and FTO 1 0.50 0.48 0.05 94.20
196 INT330855 Binding of Ins1 and Tgs1 1 0.02 0.86 0.09 94.16
197 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08 94.08
198 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07 94.08
199 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55 94.08
200 INT127738 Binding of Crygb and Pnoc 2 0.49 0.1 0.99 93.76

Single Events

The table below shows the top 200 pain related interactions that have been reported for tolerance. They are ordered first by their pain relevance and then by number of times they were reported in tolerance. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
2 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
3 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 100.00
4 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 100.00
5 INT3214 Localization of Ins1 527 0.80 196.9 79.26 100.00
6 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 100.00
7 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 100.00
8 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
9 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 100.00
10 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 100.00
11 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 100.00
12 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 100.00
13 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
14 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 100.00
15 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 100.00
16 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 100.00
17 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78 100.00
18 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
19 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 100.00
20 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 100.00
21 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 100.00
22 INT287 Localization of Cck 518 0.81 86.84 364.04 100.00
23 INT251636 Gene_expression of Csf2rb2 1 0.33 9.64 8.34 100.00
24 INT88293 Localization of Mors1 25 0.39 2.18 28.72 100.00
25 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
26 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 100.00
27 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 100.00
28 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
29 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 100.00
30 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 100.00
31 INT99539 Positive_regulation of Slc1a2 25 0.67 5.46 23.38 100.00
32 INT95145 Negative_regulation of Positive_regulation of Ean5 1 0.10 4.85 4.16 100.00
33 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 100.00
34 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 100.00
35 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33 100.00
36 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14 100.00
37 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 100.00
38 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75 100.00
39 INT2699 Binding of Cpe 40 0.48 7.07 33.64 100.00
40 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 100.00
41 INT34263 Positive_regulation of Mastl 8 0.35 1.36 4.35 100.00
42 INT251633 Positive_regulation of Csf2rb2 1 0.26 2.64 2.44 100.00
43 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 100.00
44 INT59352 Positive_regulation of Fosb 16 0.58 1.89 10.09 100.00
45 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 100.00
46 INT191974 Regulation of Ide 16 0.38 9.54 2.52 100.00
47 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
48 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
49 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 100.00
50 INT111258 Regulation of Rgs9 11 0.54 1.81 8.9 100.00
51 INT1376 Binding of Trh 121 0.48 20 69.86 100.00
52 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 100.00
53 INT73709 Binding of Mastl 11 0.40 3.39 6.76 100.00
54 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
55 INT97777 Positive_regulation of CNBP 7 0.37 9.85 1.09 100.00
56 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43 100.00
57 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
58 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 100.00
59 INT1463 Binding of Pomc 129 0.48 15.89 56.27 100.00
60 INT96529 Positive_regulation of Fbln5 1 0.11 1.09 2.35 100.00
61 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
62 INT135673 Positive_regulation of Slc1a3 23 0.57 5.45 21.45 100.00
63 INT109150 Negative_regulation of Tubgcp2 4 0.38 2.04 5.12 100.00
64 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 100.00
65 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
66 INT339 Regulation of Trh 156 0.62 39.27 83.55 100.00
67 INT18400 Localization of Glp1r 97 0.80 11.96 24.32 100.00
68 INT5587 Regulation of Fos 191 0.62 40.81 99.7 100.00
69 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 100.00
70 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06 100.00
71 INT6437 Binding of YY1 154 0.47 26.3 90.46 100.00
72 INT3546 Binding of Oxt 54 0.48 9.75 10.81 100.00
73 INT13290 Binding of Atxn2l 34 0.18 1.86 28.16 100.00
74 INT111262 Regulation of Gnb5 8 0.51 4.18 4.34 100.00
75 INT64192 Regulation of Gtf2a2 3 0.19 0.87 6.36 100.00
76 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 100.00
77 INT251639 Positive_regulation of Gene_expression of Csf2rb2 1 0.21 1.73 1.66 100.00
78 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 100.00
79 INT87932 Positive_regulation of Gene_expression of Cnr1 28 0.69 8.86 16.38 100.00
80 INT113961 Regulation of PPT1 6 0.26 3.87 6.09 100.00
81 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 100.00
82 INT28946 Binding of Prl 8 0.48 1.67 2.92 100.00
83 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 100.00
84 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 100.00
85 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85 100.00
86 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 100.00
87 INT353480 Negative_regulation of Tol1 1 0.01 2.4 0.47 100.00
88 INT18489 Binding of Man2a2 59 0.48 11.27 29.38 100.00
89 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23 100.00
90 INT355101 Negative_regulation of Transcription of Hdl1 1 0.02 1.61 0.38 100.00
91 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17 100.00
92 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55 100.00
93 INT158772 Negative_regulation of Regulation of Ptges 1 0.03 0.07 1.81 100.00
94 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84 100.00
95 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69 100.00
96 INT126101 Regulation of Map3k14 2 0.44 0.77 3.38 100.00
97 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 100.00
98 INT2774 Binding of Crp 241 0.48 195.89 44.39 100.00
99 INT123466 Binding of T2dm2 21 0.37 34.87 2.91 100.00
100 INT246851 Negative_regulation of Gene_expression of H6PD 1 0.02 2.67 0.33 100.00
101 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 100.00
102 INT135675 Positive_regulation of Negative_regulation of Slc1a3 4 0.45 0.38 5.87 100.00
103 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24 100.00
104 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 100.00
105 INT251643 Localization of Csf2rb2 1 0.28 0.75 0.86 100.00
106 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8 100.00
107 INT64738 Regulation of Dpp6 1 0.01 0 1.79 100.00
108 INT12416 Regulation of Atxn2l 8 0.07 0.25 7.42 100.00
109 INT64736 Regulation of Regulation of Atxn2l 1 0.01 0 1.78 100.00
110 INT50338 Binding of Gt(pU21)50Imeg 1 0.05 0 1.64 100.00
111 INT105198 Positive_regulation of Negative_regulation of GTS 3 0.26 0.58 4.18 100.00
112 INT105195 Positive_regulation of Negative_regulation of Slc1a1 2 0.40 0.48 3.4 100.00
113 INT112253 Positive_regulation of Regulation of Rgs9 2 0.41 0.29 2.51 100.00
114 INT67078 Binding of Ifng 7 0.48 4.84 2.73 100.00
115 INT173693 Localization of Gopc 249 0.65 70.49 38.81 100.00
116 INT96482 Positive_regulation of Hal 1 0.36 0 0.9 100.00
117 INT191978 Positive_regulation of Gene_expression of Ide 16 0.63 6.8 0.65 100.00
118 INT50633 Regulation of Gene_expression of Glul 12 0.60 1.64 6.59 100.00
119 INT155137 Regulation of Gene_expression of Phospho2 1 0.10 0.53 1.31 100.00
120 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 100.00
121 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 100.00
122 INT112252 Regulation of Rgs7 3 0.38 0 2.62 100.00
123 INT112251 Regulation of Rgs6 3 0.41 0 2.61 100.00
124 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18 100.00
125 INT3484 Localization of Fglu 5 0.02 0.55 1.36 100.00
126 INT10299 Regulation of Localization of Fglu 1 0.01 0.37 1.03 100.00
127 INT124920 Positive_regulation of Negative_regulation of Slc1a2 4 0.58 0.06 4.69 100.00
128 INT15011 Positive_regulation of Gpi1 29 0.47 12.47 13.48 100.00
129 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 100.00
130 INT55335 Binding of Cpox 49 0.34 15.48 18.46 100.00
131 INT68978 Regulation of Positive_regulation of Hpse 6 0.45 1.88 4.02 100.00
132 INT53196 Binding of Cd4 44 0.47 27.28 5.85 100.00
133 INT240954 Localization of Ffar1 5 0.73 1.98 0.47 100.00
134 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3 100.00
135 INT79020 Regulation of Binding of Fos 3 0.45 1.2 2.1 100.00
136 INT17593 Regulation of Jun 37 0.60 5.5 14.35 100.00
137 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38 100.00
138 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81 100.00
139 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
140 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 100.00
141 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72 100.00
142 INT207279 Localization of ZNF236 1 0.04 1.98 0.38 100.00
143 INT52250 Positive_regulation of Regulation of CALCA 1 0.48 0.08 1.43 100.00
144 INT147527 Regulation of Gene_expression of PPT1 1 0.44 1.17 1.69 100.00
145 INT159397 Regulation of Regulation of PPT1 1 0.26 0.54 0.76 100.00
146 INT87623 Gene_expression of PPT1 9 0.75 5.32 7.65 100.00
147 INT236143 Transcription of Hdl1 2 0.06 1.85 0.41 100.00
148 INT169482 Negative_regulation of Positive_regulation of Sema6a 1 0.42 0.2 1.32 100.00
149 INT112247 Positive_regulation of Regulation of Rgs7 1 0.42 0 1.52 100.00
150 INT112249 Positive_regulation of Regulation of Rgs6 1 0.46 0 1.52 100.00
151 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 100.00
152 INT2229 Positive_regulation of Man2a2 50 0.69 7.47 30.33 100.00
153 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89 100.00
154 INT5939 Regulation of Gene_expression of Oxt 27 0.51 2.84 9.1 100.00
155 INT230470 Regulation of Imgt1 1 0.00 0.65 0.17 100.00
156 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 100.00
157 INT44381 Regulation of Eeq1 2 0.21 1.23 1.19 100.00
158 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14 100.00
159 INT9128 Regulation of Gene_expression of Cck 27 0.62 6.55 19.45 100.00
160 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23 100.00
161 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 100.00
162 INT302547 Negative_regulation of Gene_expression of Imgt1 1 0.03 2.92 0.16 100.00
163 INT44841 Positive_regulation of Regulation of Oxt 1 0.50 0 0.9 100.00
164 INT251637 Positive_regulation of Localization of Csf2rb2 1 0.19 0.48 0.31 100.00
165 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4 100.00
166 INT2415 Binding of MAOA 26 0.47 13.26 11.86 100.00
167 INT2581 Regulation of Binding of Ins1 7 0.61 2.05 2.08 100.00
168 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 100.00
169 INT70530 Binding of NPR1 3 0.17 0.71 0.65 100.00
170 INT92144 Positive_regulation of Positive_regulation of Hspa1b 2 0.43 1.35 0.35 100.00
171 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59 100.00
172 INT130466 Regulation of Negative_regulation of Tubgcp2 2 0.30 0.55 1.24 100.00
173 INT182666 Negative_regulation of DLAT 2 0.38 9.01 1.16 100.00
174 INT242954 Regulation of Localization of Ffar1 1 0.32 1.11 0.13 100.00
175 INT1510 Binding of PDYN 94 0.48 4.68 56.44 100.00
176 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82 100.00
177 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 100.00
178 INT111358 Regulation of Localization of Cnr1 3 0.39 0.09 4.53 100.00
179 INT264900 Regulation of Localization of Mors1 1 0.14 0 1.49 100.00
180 INT219648 Gene_expression of Hd 16 0.27 8.78 0.68 100.00
181 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 100.00
182 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55 100.00
183 INT221427 Positive_regulation of FOXP3 6 0.45 2.74 0.83 100.00
184 INT353486 Negative_regulation of Positive_regulation of Tol1 1 0.01 0.45 0.1 100.00
185 INT353485 Positive_regulation of Tol1 1 0.02 0.44 0.1 100.00
186 INT15470 Regulation of CPP 42 0.48 26.1 18.25 100.00
187 INT11905 Protein_catabolism of EPO 6 1.00 2.36 2 100.00
188 INT125237 Negative_regulation of Gene_expression of CD40LG 16 0.54 9.9 3.27 100.00
189 INT170603 Negative_regulation of Gene_expression of CD40 5 0.32 2.18 0.78 100.00
190 INT97130 Negative_regulation of CD40 5 0.35 1.96 0.63 100.00
191 INT988 Positive_regulation of Negative_regulation of Trh 3 0.50 0 2.39 100.00
192 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 100.00
193 INT246825 Regulation of Positive_regulation of Irs1 1 0.45 0.47 0.09 100.00
194 INT240850 Regulation of Irs1 2 0.47 0.64 0.09 100.00
195 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13 100.00
196 INT310903 Positive_regulation of GIT1 1 0.04 0.57 0.7 100.00
197 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 100.00
198 INT39415 Gene_expression of HBN1 33 0.43 19.31 0.93 100.00
199 INT302548 Gene_expression of Imgt1 1 0.05 1.46 0.08 100.00
200 INT310904 Transcription of GIT1 1 0.05 0.8 0.58 100.00
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