P:topical agent

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pChart

Pain Term
Category Drug class
Synonyms Topical Agents
Pain Specific No
Documents 222
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for topical agent. They are ordered first by their pain relevance and then by number of times they were reported for topical agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08 22.84
2 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04 22.84
3 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08 22.64
4 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
5 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73 5.00
6 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 5.00
7 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 5.00
8 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31 5.00
9 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21 5.00
10 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21 5.00
11 INT325470 MMP3 Positive_regulation of MMP9 1 0.17 0.9 0.2 5.00
12 INT307755 TNF Regulation of Gene_expression of IL8 1 0.02 0.5 0.14 5.00
13 INT307769 TNF Regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 5.00
14 INT307771 TNF Negative_regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 5.00
15 INT313913 Binding of Il23a and Il23r 1 0.24 0.43 0.13 5.00
16 INT313914 Binding of Il12a and Il23r 1 0.14 0.44 0.13 5.00
17 INT347577 Binding of MUC1 and MUC16 1 0.25 0.42 0 5.00
18 INT316101 Binding of HIST1H4PS1 and ANGPTL5 1 0.01 0.28 0 5.00
19 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0 5.00
20 INT348334 Gml Positive_regulation of Micrl 1 0.01 0.51 0 5.00
21 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for topical agent. They are ordered first by their pain relevance and then by number of times they were reported in topical agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT316210 Positive_regulation of TEAD4 1 0.01 0.87 0.37 99.84
2 INT316211 Negative_regulation of TEAD4 2 0.01 1.24 0.09 99.84
3 INT198453 Negative_regulation of MUC5AC 12 0.58 12.96 1.38 99.00
4 INT217429 Positive_regulation of SLC9A6 22 0.38 42.17 0.67 97.40
5 INT316212 Binding of SPRN 1 0.12 0.38 0.1 95.88
6 INT217425 Regulation of Localization of SLC9A6 1 0.25 1.87 0.09 95.76
7 INT217431 Positive_regulation of Localization of SLC9A6 1 0.27 7.38 0.12 95.12
8 INT192975 Localization of SLC9A6 7 0.43 14.24 0.24 94.68
9 INT6437 Binding of YY1 154 0.47 26.3 90.46 94.40
10 INT274290 Binding of Fhl1 3 0.03 1.16 0.1 94.20
11 INT16214 Localization of F13A1 36 0.74 21.8 4.87 93.80
12 INT316209 Regulation of TEAD4 1 0.00 0.39 0.2 93.56
13 INT36162 Phosphorylation of ras 5 0.70 3.87 0.72 91.48
14 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 90.96
15 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 89.60
16 INT95641 Regulation of Fbn1 3 0.45 3.67 0.91 88.72
17 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 85.28
18 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 82.56
19 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 80.52
20 INT22080 Regulation of ras 40 0.53 36.24 4.44 77.76
21 INT81688 Binding of ras 32 0.41 30.13 4.02 76.32
22 INT209354 Gene_expression of SLC9A6 15 0.58 37.52 0.29 75.68
23 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 75.12
24 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86 74.76
25 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 74.32
26 INT111962 Regulation of Bld 1 0.14 0.69 0.23 71.64
27 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 71.24
28 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 69.80
29 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 63.12
30 INT49025 Positive_regulation of TYR 14 0.69 7.15 5.84 59.92
31 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 59.08
32 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 59.08
33 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 58.36
34 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 54.56
35 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 54.56
36 INT133423 Positive_regulation of Micrl 2 0.18 2.51 0.28 53.84
37 INT68692 Regulation of HTT 8 0.60 4.06 0.89 52.40
38 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21 52.00
39 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 49.28
40 INT323220 Transcription of ZC3H15 1 0.04 0.95 0 47.48
41 INT209356 Regulation of SLC9A6 2 0.39 5.61 0.14 47.20
42 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 44.32
43 INT4146 Binding of SHBG 49 0.47 31 4.71 43.28
44 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 42.80
45 INT173021 Localization of MUC5AC 14 0.70 10.73 0.91 40.68
46 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 39.52
47 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05 38.44
48 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 38.00
49 INT102056 Protein_catabolism of Tenc1 14 0.84 6.29 2.14 37.76
50 INT58755 Binding of PAM 6 0.34 3.09 0.97 35.16
51 INT323218 Gene_expression of ZC3H15 1 0.05 2.59 0.07 34.60
52 INT323216 Localization of ZC3H15 1 0.06 0.1 0 33.76
53 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 25.00
54 INT28507 Regulation of ANPEP 4 0.26 1.84 0.5 25.00
55 INT95640 Transcription of Fbn1 1 0.53 0.21 0.08 25.00
56 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 24.44
57 INT173014 Positive_regulation of Gene_expression of MUC5AC 10 0.45 4.82 0.94 24.44
58 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 21.60
59 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 17.04
60 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 16.32
61 INT209355 Binding of SLC9A6 8 0.42 14.9 0.09 14.56
62 INT217426 Positive_regulation of Binding of SLC9A6 1 0.27 2.04 0 14.56
63 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 11.96
64 INT217428 Positive_regulation of Gene_expression of SLC9A6 3 0.29 4.99 0 6.80
65 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
66 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
67 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
68 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
69 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
70 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
71 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
72 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
73 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
74 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
75 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
76 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
77 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
78 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
79 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
80 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
81 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
82 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
83 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
84 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
85 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
86 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
87 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
88 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 5.00
89 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
90 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
91 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
92 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
93 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
94 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
95 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
96 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
97 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
98 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
99 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
100 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
101 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
102 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
103 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
104 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
105 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
106 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
107 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
108 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 5.00
109 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
110 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
111 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
112 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
113 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 5.00
114 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 5.00
115 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
116 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 5.00
117 INT34487 Localization of MMP2 56 0.81 31.41 23.61 5.00
118 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 5.00
119 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
120 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
121 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
122 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
123 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
124 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
125 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
126 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 5.00
127 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
128 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
129 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
130 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
131 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 5.00
132 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
133 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
134 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
135 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
136 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
137 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
138 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
139 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
140 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
141 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
142 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
143 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
144 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
145 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
146 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 5.00
147 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
148 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
149 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 5.00
150 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
151 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
152 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 5.00
153 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
154 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
155 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
156 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 5.00
157 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 5.00
158 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
159 INT63169 Positive_regulation of Gene_expression of Selp 35 0.69 21.95 7.16 5.00
160 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 5.00
161 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 5.00
162 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 5.00
163 INT9951 Gene_expression of ANGPTL5 45 0.53 37.2 6.44 5.00
164 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
165 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14 5.00
166 INT95616 Gene_expression of Thpo 48 0.78 21.51 5.88 5.00
167 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 5.00
168 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
169 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 5.00
170 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
171 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 5.00
172 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 5.00
173 INT100059 Gene_expression of MUC4 30 0.75 31.58 4.95 5.00
174 INT60066 Positive_regulation of NPEPPS 17 0.22 11.99 4.83 5.00
175 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
176 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8 5.00
177 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
178 INT112458 Localization of Selenbp2 4 0.04 1.1 4.74 5.00
179 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66 5.00
180 INT160565 Gene_expression of Il23r 6 0.56 10.01 4.51 5.00
181 INT80696 Positive_regulation of Thpo 16 0.70 13.75 4.49 5.00
182 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
183 INT88571 Positive_regulation of Tcas1 4 0.34 2.08 4.42 5.00
184 INT28030 Binding of Otc 5 0.37 2.72 4.3 5.00
185 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84 5.00
186 INT60415 Regulation of NPEPPS 13 0.27 5.81 3.78 5.00
187 INT68695 Gene_expression of HTT 63 0.77 44.54 3.69 5.00
188 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 5.00
189 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
190 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 5.00
191 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
192 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 5.00
193 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
194 INT163269 Binding of Il23a 11 0.44 7.2 3.14 5.00
195 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87 5.00
196 INT61645 Negative_regulation of Gc 15 0.51 10.44 2.71 5.00
197 INT120515 Gene_expression of Otc 13 0.66 4.33 2.6 5.00
198 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 5.00
199 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 5.00
200 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29 5.00
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