P:vanilloid receptor subtype 1

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Pain Term
Category Molecule
Synonyms Capsaicin Receptor; Osm-9-like TRP Channel 1, Transient Receptor Potential Cation Channel Subfamily V Member 1, Transient Receptor Potential Vanilloid 1a, Transient Receptor Potential Vanilloid 1b
Pain Specific Yes
Documents 79
Hot Single Events 120
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for vanilloid receptor subtype 1. They are ordered first by their pain relevance and then by number of times they were reported for vanilloid receptor subtype 1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92 100.00
2 INT125353 Binding of Sst and Trpv1 1 0.36 0.5 0.79 100.00
3 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32 99.76
4 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74 97.20
5 INT282665 Binding of Gfap and Ticam1 1 0.01 0 0.69 95.28
6 INT282664 Binding of Aif1 and Gfap 1 0.06 0 0.69 95.28
7 INT147385 Binding of TRPV1 and TRPV2 1 0.37 0 0.15 87.04
8 INT147386 Regulation of Binding of TRPV1 and TRPV2 1 0.45 0 0.15 87.04
9 INT334526 Trpv1 Positive_regulation of Gene_expression of Sema3a 1 0.31 0.92 0.55 85.32
10 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05 83.40
11 INT103178 Mastl Positive_regulation of Localization of Calca 1 0.13 0.36 0.81 77.04
12 INT117908 Em Regulation of Localization of Pax3 1 0.00 0.07 1.03 68.04
13 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79 66.28
14 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4 58.48
15 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14 21.64
16 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14 21.20
17 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14 21.20
18 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13 21.20
19 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75 10.24
20 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14 5.00
21 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2 5.00
22 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
23 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29 5.00
24 INT334537 Sema3a Negative_regulation of Gene_expression of Plxna1 1 0.08 3.76 1 5.00
25 INT276864 Positive_regulation of Gpr65 Positive_regulation of Prkaca 1 0.16 0.74 0.97 5.00
26 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92 5.00
27 INT334529 Pax3 Positive_regulation of Gene_expression of Ngf 1 0.03 0.31 0.91 5.00
28 INT225690 KNG1 Positive_regulation of TRPV1 1 0.42 0.7 0.83 5.00
29 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83 5.00
30 INT276865 Regulation of Trpv1 Regulation of Gene_expression of Gpr65 1 0.25 0.62 0.76 5.00
31 INT106999 F2 Positive_regulation of PAR4 3 0.06 1.83 0.72 5.00
32 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72 5.00
33 INT334533 Binding of Foxq1 and Ngf 1 0.05 0.8 0.38 5.00
34 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22 5.00
35 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22 5.00
36 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13 5.00
37 INT334524 Sema3a Regulation of Foxq1 1 0.04 1.61 0.13 5.00
38 INT229393 Negative_regulation of PRSS1 Negative_regulation of Gene_expression of IL8 1 0.00 0.86 0.11 5.00
39 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 0.34 0.65 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for vanilloid receptor subtype 1. They are ordered first by their pain relevance and then by number of times they were reported in vanilloid receptor subtype 1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 100.00
2 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 100.00
3 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 100.00
4 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 100.00
5 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 100.00
6 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 100.00
7 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 100.00
8 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77 100.00
9 INT81251 Gene_expression of Trpv2 78 0.78 28.27 41.76 100.00
10 INT96406 Regulation of Trpv2 14 0.62 7.45 12.04 100.00
11 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 100.00
12 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 100.00
13 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 100.00
14 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16 100.00
15 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 100.00
16 INT67275 Gene_expression of L2 6 0.66 1.9 2.63 100.00
17 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88 100.00
18 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59 100.00
19 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 100.00
20 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4 100.00
21 INT105306 Regulation of Gene_expression of P2rx2 7 0.21 6.92 5.22 100.00
22 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 100.00
23 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2 100.00
24 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 100.00
25 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 100.00
26 INT94357 Positive_regulation of Transcription of Trpv1 11 0.50 3.63 5.05 100.00
27 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 100.00
28 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47 100.00
29 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 100.00
30 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28 100.00
31 INT13051 Regulation of Kcnma1 12 0.12 2.09 5.06 100.00
32 INT101494 Regulation of Positive_regulation of Trpv1 18 0.62 6.57 12.9 100.00
33 INT92839 Regulation of P2rx2 36 0.45 13.19 15.38 100.00
34 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 100.00
35 INT129161 Binding of TRPM8 7 0.48 1.32 2.48 100.00
36 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.76
37 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.76
38 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 99.74
39 INT81249 Positive_regulation of Trpv2 21 0.70 8.13 12.36 99.70
40 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.64
41 INT626 Localization of CALCA 289 0.81 125.39 221.15 99.48
42 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56 99.44
43 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 99.28
44 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 99.04
45 INT81664 Positive_regulation of Gene_expression of Pnoc 12 0.68 2.51 9.75 99.04
46 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 99.04
47 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8 98.90
48 INT99865 Binding of Trpv2 4 0.48 1.13 2.25 98.82
49 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 98.80
50 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 98.76
51 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 98.76
52 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 98.76
53 INT87976 Regulation of Gene_expression of Cnr1 9 0.58 6.87 7.51 98.76
54 INT108007 Regulation of Gene_expression of Cnr2 2 0.44 0.39 1.17 98.76
55 INT100729 Localization of F2RL1 7 0.75 5.29 3.37 98.74
56 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4 98.60
57 INT124028 Localization of Trpv2 6 0.80 2.04 3.96 98.52
58 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 98.40
59 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 98.36
60 INT79797 Positive_regulation of TRPC3 4 0.38 0.12 0.58 98.28
61 INT148025 Localization of Pik3cg 1 0.58 0.69 2.34 97.32
62 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 97.12
63 INT108986 Gene_expression of Sit1 1 0.01 0.66 1.08 96.84
64 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 96.20
65 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 95.60
66 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97 95.52
67 INT105217 Regulation of Pou4f1 8 0.60 6.15 3.88 95.28
68 INT148027 Localization of Pik3c3 1 0.24 0.34 1.17 95.20
69 INT4723 Transcription of Tac1 26 0.71 8.33 11.18 94.08
70 INT26058 Gene_expression of SH3BP5 12 0.23 2.81 4.88 94.04
71 INT13348 Negative_regulation of Mastl 11 0.36 3.33 7.28 94.00
72 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 93.76
73 INT78234 Positive_regulation of Gene_expression of P2rx2 18 0.69 12.86 12.75 93.72
74 INT26061 Positive_regulation of Gene_expression of SH3BP5 2 0.13 1.28 1.25 93.72
75 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 93.40
76 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 93.08
77 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28 92.84
78 INT98522 Gene_expression of Accn3 68 0.78 26.95 28.6 92.04
79 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 91.48
80 INT140799 Positive_regulation of Gene_expression of Accn3 6 0.68 5.44 5.06 91.48
81 INT100124 Gene_expression of Accn3 38 0.78 30.02 23.63 91.48
82 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01 91.48
83 INT125187 Positive_regulation of Transcription of Trpv1 9 0.69 8.98 5.77 91.48
84 INT165084 Transcription of Accn3 3 0.70 3.4 3.01 91.48
85 INT276842 Positive_regulation of Transcription of Accn3 2 0.49 3.32 2.93 91.48
86 INT125191 Regulation of Transcription of Trpv1 6 0.45 4.54 2.62 91.48
87 INT276839 Regulation of Transcription of Accn3 1 0.29 1.22 1.06 91.48
88 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 90.88
89 INT146054 Positive_regulation of Gpr68 2 0.57 2 1.44 90.72
90 INT146057 Positive_regulation of Gpr4 2 0.60 2.26 1.95 90.48
91 INT104707 Gene_expression of Em 16 0.65 3.95 22.19 90.24
92 INT146058 Positive_regulation of Gpr132 2 0.48 2.26 1.95 90.24
93 INT146053 Positive_regulation of Gpr65 2 0.61 12.11 13.38 89.88
94 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 89.72
95 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 89.56
96 INT141253 Regulation of Transcription of Trpv1 7 0.62 3.54 3.62 88.40
97 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 87.04
98 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 86.64
99 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 86.56
100 INT92108 Gene_expression of Tubb3 3 0.12 1.94 1.97 86.24
101 INT9378 Regulation of Positive_regulation of TRPV1 9 0.45 2.36 4.26 85.80
102 INT73155 Positive_regulation of Positive_regulation of Ngf 11 0.70 5.11 6.7 85.36
103 INT89053 Positive_regulation of Phosphorylation of Trpv1 16 0.70 8.89 9.39 85.12
104 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 84.72
105 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16 84.48
106 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04 84.00
107 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 83.80
108 INT4891 Transcription of Calca 81 0.72 35.27 53.75 83.40
109 INT154842 Positive_regulation of Phosphorylation of Cpox 1 0.13 0.07 1.05 83.40
110 INT92040 Localization of Em 10 0.57 3.1 7.19 83.12
111 INT8534 Localization of Pax3 85 0.59 28.71 82.82 83.08
112 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 82.52
113 INT88651 Phosphorylation of Cpox 5 0.41 2.92 4.04 82.52
114 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32 82.28
115 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62 82.28
116 INT153189 Gene_expression of Sema3a 19 0.75 14.37 4.21 81.92
117 INT146056 Localization of Prelid1 1 0.03 1.36 0.98 81.80
118 INT25475 Positive_regulation of TRPC6 7 0.64 0.3 0.55 81.52
119 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 80.64
120 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 80.64
121 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 79.80
122 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2 79.80
123 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 79.40
124 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 79.20
125 INT146055 Gene_expression of Gpr68 3 0.63 8.12 6.99 78.92
126 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 78.80
127 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 78.80
128 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 78.80
129 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 78.80
130 INT81250 Transcription of Trpv2 7 0.64 1.54 4.27 77.72
131 INT5008 Localization of Calca 204 0.81 80.35 125.16 77.04
132 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 75.68
133 INT11485 Localization of KCNMA1 7 0.09 1.81 2.6 75.68
134 INT11487 Positive_regulation of Localization of KCNMA1 4 0.06 1.5 2.31 75.68
135 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 75.44
136 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47 75.00
137 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 75.00
138 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62 75.00
139 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 75.00
140 INT101501 Phosphorylation of TRPV1 31 0.82 9.26 17.27 75.00
141 INT118489 Negative_regulation of Binding of TRPV1 4 0.57 0 0.37 75.00
142 INT144944 Positive_regulation of Negative_regulation of TRPV1 3 0.46 0.84 1.89 75.00
143 INT148026 Positive_regulation of Pik3cg 4 0.45 0.54 1.46 75.00
144 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3 74.32
145 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49 74.32
146 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 74.28
147 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 70.72
148 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 70.24
149 INT221545 Binding of Sema3a 2 0.33 1.4 0.53 69.68
150 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98 69.08
151 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 68.96
152 INT138350 Regulation of Phosphorylation of Trpv1 6 0.58 1.87 3.16 68.68
153 INT70555 Regulation of Pax3 13 0.35 3.62 12.05 67.88
154 INT6934 Binding of OPRD1 51 0.48 7.72 25.73 64.48
155 INT68581 Transcription of Pnoc 4 0.70 1.21 3.54 63.92
156 INT96825 Positive_regulation of Transcription of Pnoc 1 0.49 0.41 0.47 63.92
157 INT116490 Positive_regulation of Localization of TRPV1 9 0.68 3.86 5.67 63.68
158 INT56805 Localization of SH3BP5 2 0.70 0.42 1.25 63.08
159 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 59.80
160 INT100125 Negative_regulation of Accn3 11 0.59 5.85 4.32 58.52
161 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 58.32
162 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 55.48
163 INT790 Gene_expression of Mastl 22 0.68 4.56 10.23 54.24
164 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 48.96
165 INT153190 Negative_regulation of Sema3a 7 0.56 7.94 1.76 42.64
166 INT158486 Negative_regulation of Gene_expression of Sema3a 4 0.41 2.49 0.57 42.64
167 INT48437 Positive_regulation of SH3BP5 4 0.20 2.41 3.09 38.08
168 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24 28.88
169 INT196155 Binding of Nrp1 5 0.16 2.38 0.69 28.88
170 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99 25.00
171 INT66024 Negative_regulation of Gene_expression of Itgam 9 0.59 5.5 4.38 24.64
172 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 24.04
173 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 24.04
174 INT276855 Positive_regulation of Gene_expression of Gpr65 1 0.61 17.04 16.96 21.84
175 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94 21.48
176 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 21.44
177 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 21.00
178 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 15.96
179 INT176649 Negative_regulation of Localization of Cd4 5 0.32 2.41 0.51 15.96
180 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 15.36
181 INT160562 Localization of Cd4 49 0.71 27.58 6.78 15.36
182 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 14.16
183 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 12.00
184 INT62821 Negative_regulation of Gene_expression of VCAM1 21 0.54 12.24 4.41 12.00
185 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 11.40
186 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 11.40
187 INT148968 Gene_expression of Gpbar1 29 0.56 11.9 5.66 5.56
188 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
189 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
190 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
191 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
192 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
193 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
194 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
195 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
196 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
197 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
198 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
199 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
200 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
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