Y:1975

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 1975. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 1975. They are ordered first by their pain relevance and then by number of times they were reported in 1975. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 1975 Documents TM Confidence Disease Relevance Pain Relevance
1 INT1151 Binding of CCK and GAST 7 2 0.49 0.73 3.08
2 INT3576 Sst Negative_regulation of Localization of Gh1 6 2 0.23 0 2.13
3 INT3573 Tf Negative_regulation of Localization of Gh1 1 4 0.36 0 1.49
4 INT3575 Sst Regulation of Localization of Gnrhr 2 1 0.24 0 1.24
5 INT3570 Trh Regulation of Localization of Gnrhr 2 1 0.26 0.3 0.75
6 INT544 Binding of ALB and GC 1 1 0.13 0 0.55
7 INT1006 Sst Negative_regulation of Ggh 1 1 0.24 0 0.52
8 INT3571 Sst Regulation of Negative_regulation of Gh1 1 1 0.24 0 0.42
9 INT4382 RIPK2 Regulation of INS 1 1 0.12 0.58 0.36
10 INT4381 RIPK2 Positive_regulation of Localization of INS 1 1 0.13 0.53 0.34
11 INT4339 Binding of OLAH and Cea 1 1 0.00 0.79 0.29
12 INT3569 Trh Negative_regulation of Positive_regulation of Gh1 1 1 0.20 0 0.27
13 INT3577 Tf Negative_regulation of Positive_regulation of Gh1 1 1 0.49 0 0.27
14 INT3574 Trh Negative_regulation of Localization of Gh1 1 1 0.15 0 0.27
15 INT3572 Sst Negative_regulation of Positive_regulation of Gh1 1 1 0.32 0 0.27
16 INT3592 INS Positive_regulation of AVP 1 1 0.05 0.28 0.2
17 INT3591 Negative_regulation of INS Positive_regulation of AVP 1 1 0.04 0.28 0.2
18 INT3562 Trh Positive_regulation of Klkb1 1 1 0.10 0 0.1
19 INT4262 IL8 Positive_regulation of Localization of Adh1 1 1 0.12 0 0.09
20 INT4542 LOC689866 Regulation of Prl 1 1 0.01 0.1 0.08
21 INT4580 Positive_regulation of Thra Positive_regulation of Babr 1 1 0.00 0 0.07
22 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 1 0.52 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in 1975. They are ordered first by their pain relevance and then by number of times they were reported in 1975. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 1975 Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 35 2431 0.81 378.96 952.2
2 INT155 Positive_regulation of Prl 29 1233 0.70 317.93 457.82
3 INT1045 Localization of LH 11 1211 0.81 87.04 456.25
4 INT443 Localization of POMC 1 1020 0.81 284.52 443.17
5 INT157 Positive_regulation of Localization of Prl 8 790 0.70 104.54 374.78
6 INT439 Localization of Gnrh1 3 976 0.81 100.96 363.25
7 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
8 INT876 Localization of Gh1 13 843 0.80 67.75 340.82
9 INT162 Regulation of Prl 18 794 0.62 165.01 322.24
10 INT477 Localization of Avp 2 813 0.81 131.58 300.4
11 INT161 Regulation of Localization of Prl 10 615 0.62 65.37 298.66
12 INT3579 Localization of Oxt 3 555 0.81 43.35 292.44
13 INT1893 Localization of Gh 1 1041 0.79 340.23 256.58
14 INT1005 Localization of Sst 1 385 0.81 26.31 244.56
15 INT1902 Gene_expression of Cck 2 348 0.78 70.33 241.92
16 INT1212 Binding of Oprl1 5 312 0.48 28.6 225.15
17 INT767 Localization of Gnrhr 8 565 0.80 106.68 214.57
18 INT156 Negative_regulation of Prl 12 542 0.59 131.97 192.24
19 INT528 Gene_expression of Prl 7 693 0.78 217.18 192.2
20 INT2085 Positive_regulation of LH 20 441 0.70 60.15 191.02
21 INT159 Negative_regulation of Localization of Prl 12 416 0.59 55.34 171.8
22 INT867 Gene_expression of IFNA1 4 930 0.78 594.85 168.03
23 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
24 INT1114 Localization of Ins1 3 748 0.80 192.95 165.48
25 INT3448 Positive_regulation of Gh 3 521 0.69 180.03 161.18
26 INT1044 Negative_regulation of Localization of LH 3 358 0.59 25.95 151.31
27 INT880 Positive_regulation of Localization of Gh1 4 304 0.70 14.79 150.23
28 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
29 INT812 Localization of INS 2 1026 0.81 515.6 145.31
30 INT425 Localization of PRL 5 455 0.81 189.64 144.8
31 INT2379 Positive_regulation of Localization of LH 3 349 0.70 27.86 144.53
32 INT1047 Negative_regulation of LH 6 314 0.59 53.71 135.89
33 INT416 Regulation of LH 8 253 0.62 31.48 125.55
34 INT4259 Positive_regulation of Npr1 4 262 0.70 49.37 123.11
35 INT2106 Regulation of Localization of LH 2 279 0.62 22.37 122.77
36 INT1026 Binding of Lbp 1 207 0.48 150.96 119.16
37 INT1793 Localization of CGA 7 379 0.81 67.38 114.69
38 INT90 Localization of Gast 2 400 0.81 137.67 113
39 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
40 INT3038 Gene_expression of INS 6 1583 0.78 1174.16 107.01
41 INT915 Positive_regulation of PRL 4 342 0.70 141.96 104.31
42 INT874 Positive_regulation of Gh1 6 244 0.70 27.17 97.98
43 INT1760 Gene_expression of PTGER2 1 524 0.57 226.94 96.4
44 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
45 INT214 Localization of AVP 1 370 0.81 208.51 91.09
46 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
47 INT1472 Positive_regulation of Ins1 2 349 0.69 146.2 86.36
48 INT875 Regulation of Localization of Gh1 4 166 0.62 12.87 84.97
49 INT4289 Positive_regulation of Localization of Gnrh1 1 202 0.70 12.3 84.01
50 INT1309 Positive_regulation of Localization of Gnrhr 3 152 0.69 24.25 81.56
51 INT403 Localization of Trh 1 241 0.81 28.55 81.45
52 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
53 INT2431 Positive_regulation of Mpo 2 275 0.70 211.99 78.47
54 INT4358 Positive_regulation of Localization of Avp 1 195 0.70 30.79 77.58
55 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
56 INT881 Negative_regulation of Localization of Gh1 6 164 0.58 15.1 75.28
57 INT1080 Negative_regulation of Ache 1 343 0.59 108.51 72.4
58 INT2123 Positive_regulation of Gnrh1 3 209 0.70 24.2 68.97
59 INT1046 Gene_expression of LH 3 180 0.77 29.75 66.87
60 INT253 Regulation of PRL 3 184 0.62 47.27 65.79
61 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
62 INT46 Localization of Ren 21 233 0.81 46.15 62.44
63 INT1169 Negative_regulation of Bche 5 322 0.59 149.22 61.27
64 INT546 Binding of ALB 4 311 0.48 85.98 60.14
65 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
66 INT1794 Regulation of Localization of CGA 3 136 0.57 13.39 59.07
67 INT3920 Localization of Ldha 2 241 0.81 83.08 58.72
68 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
69 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
70 INT1200 Negative_regulation of Ins1 5 274 0.58 155.17 56.14
71 INT1782 Regulation of Gh1 2 125 0.62 22 55.74
72 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
73 INT314 Positive_regulation of Ren 12 212 0.70 66.68 55.56
74 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
75 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
76 INT251 Regulation of INS 2 398 0.62 232.47 55.04
77 INT1027 Gene_expression of Lbp 1 132 0.77 106.7 54.16
78 INT2276 Regulation of Ins1 2 234 0.61 103.78 54.05
79 INT1032 Regulation of Ca2 1 202 0.52 54.91 53.03
80 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
81 INT1781 Negative_regulation of Gh1 4 127 0.59 16.94 51.77
82 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
83 INT4345 Gene_expression of Gtf3a 2 157 0.67 80.75 48.47
84 INT1197 Negative_regulation of Localization of POMC 1 109 0.59 28.29 48.02
85 INT1977 Negative_regulation of Positive_regulation of Prl 4 98 0.59 17.06 47.88
86 INT654 Localization of REN 12 250 0.81 75.12 47.86
87 INT375 Positive_regulation of REN 8 293 0.70 152.46 47.55
88 INT873 Gene_expression of Gh1 2 130 0.76 26.15 46.75
89 INT531 Gene_expression of GH1 1 376 0.75 193.45 46.24
90 INT1028 Positive_regulation of Lbp 2 102 0.69 67.86 46.05
91 INT619 Positive_regulation of Positive_regulation of Prl 2 116 0.70 22.69 45.06
92 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
93 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
94 INT935 Localization of Gtf3a 1 124 0.70 35.72 43.3
95 INT613 Gene_expression of Alb 1 268 0.78 149.84 42.78
96 INT30 Gene_expression of Gast 1 158 0.78 99 41.45
97 INT918 Positive_regulation of Localization of PRL 2 90 0.70 23.97 40.3
98 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
99 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
100 INT115 Negative_regulation of Maoa 1 65 0.59 16.27 38.66
101 INT4449 Positive_regulation of NA 2 179 0.55 40.26 37.82
102 INT3971 Positive_regulation of Alb 4 175 0.70 98.46 36.45
103 INT390 Positive_regulation of Agt 2 170 0.70 61.47 36.08
104 INT49 Negative_regulation of Ren 6 129 0.59 37.48 35.62
105 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
106 INT2296 Positive_regulation of Gene_expression of Prl 1 137 0.70 36.96 35.39
107 INT1163 Negative_regulation of Rbm39 1 64 0.29 16.8 34.74
108 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
109 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
110 INT1116 Regulation of Ren 3 103 0.62 27.66 33.26
111 INT3117 Regulation of Oxt 3 103 0.61 17.93 32.28
112 INT1159 Negative_regulation of Agt 4 133 0.59 40.14 31.67
113 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
114 INT1158 Regulation of Agt 3 106 0.61 29.4 30.29
115 INT50 Negative_regulation of Localization of Ren 9 87 0.59 14.94 30.22
116 INT660 Negative_regulation of REN 5 194 0.59 82.06 29.46
117 INT1196 Positive_regulation of Positive_regulation of POMC 1 51 0.70 15.99 28.58
118 INT2532 Negative_regulation of Cebpz 5 98 0.00 53.06 28.57
119 INT4459 Positive_regulation of Arc 4 74 0.69 33.61 28.29
120 INT1166 Negative_regulation of Dbh 3 56 0.59 12.54 28.26
121 INT97 Negative_regulation of Adrb1 1 102 0.59 32.44 26.9
122 INT3760 Positive_regulation of ALB 2 142 0.70 87.46 26.7
123 INT3559 Negative_regulation of Localization of Gnrhr 2 73 0.58 18.89 26.41
124 INT605 Regulation of Acot1 1 61 0.62 10.7 26.34
125 INT276 Regulation of Ache 1 83 0.62 16.75 25.99
126 INT1030 Localization of Lbp 1 52 0.74 38.92 24.91
127 INT2140 Regulation of REN 2 104 0.62 28.24 24.49
128 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
129 INT4465 Gene_expression of CEL 1 116 0.77 98.35 23.58
130 INT250 Regulation of GHRH 3 65 0.61 17.46 23.19
131 INT956 Negative_regulation of PRL 4 94 0.59 42.72 23.01
132 INT4369 Gene_expression of Ldha 1 157 0.76 88.12 22.45
133 INT4612 Positive_regulation of Localization of CGA 1 64 0.64 8.51 22.39
134 INT1644 Regulation of FSHR 2 77 0.55 15.62 21.49
135 INT4535 Localization of PROC 2 106 0.73 76.24 21.1
136 INT3593 Gene_expression of ADRA1D 1 70 0.75 29.48 20.87
137 INT1792 Positive_regulation of CGA 2 123 0.70 64.73 20.79
138 INT955 Gene_expression of GHRH 1 126 0.78 59.91 20.74
139 INT1334 Negative_regulation of Binding of Oprl1 2 29 0.59 3.03 20.62
140 INT1156 Binding of CCK 1 27 0.48 8.71 20.58
141 INT4260 Negative_regulation of Positive_regulation of Npr1 1 29 0.43 4.39 19.57
142 INT756 Gene_expression of C3 1 138 0.75 100.6 19.2
143 INT2960 Regulation of Dbh 1 32 0.47 10.32 18.94
144 INT4420 Positive_regulation of GOT1 1 103 0.64 88.4 18.38
145 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
146 INT48 Positive_regulation of Localization of Ren 5 69 0.70 12.47 18.03
147 INT2158 Negative_regulation of Positive_regulation of LH 1 41 0.58 4.52 17.75
148 INT1578 Negative_regulation of Localization of PRL 1 52 0.59 20.62 17.18
149 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
150 INT653 Negative_regulation of Localization of REN 8 67 0.59 20.33 16.7
151 INT1000 Localization of Ggh 4 31 0.75 2.74 16.41
152 INT1020 Negative_regulation of BCHE 1 109 0.59 44.86 16.4
153 INT1261 Localization of Adh1 8 63 0.81 19.36 16.09
154 INT4616 Regulation of Maoa 1 40 0.62 6.09 15.94
155 INT4242 Negative_regulation of Positive_regulation of Gh1 1 26 0.58 1.47 15.75
156 INT4340 Positive_regulation of Localization of Ldha 2 46 0.70 14.52 15.66
157 INT1154 Negative_regulation of CCK 1 24 0.59 9.3 15.32
158 INT1850 Binding of OXA1L 2 77 0.48 7.61 15.22
159 INT95 Positive_regulation of Adrb1 1 34 0.62 11.95 14.41
160 INT655 Positive_regulation of Localization of REN 5 86 0.70 32.41 13.56
161 INT4298 Positive_regulation of Positive_regulation of Gh1 1 30 0.50 1.79 13.32
162 INT711 Positive_regulation of PIK3C2A 1 83 0.70 76.87 13.18
163 INT1148 Positive_regulation of ecs 1 38 0.48 25.27 13.1
164 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
165 INT635 Negative_regulation of MAOB 1 51 0.59 24.5 12.66
166 INT1827 Gene_expression of Aap 1 11 0.67 9.37 12.66
167 INT541 Positive_regulation of MBP 1 31 0.67 28.56 12.24
168 INT4460 Regulation of Mpo 1 44 0.62 31.16 12.11
169 INT1190 Positive_regulation of F2 1 53 0.70 46.41 11.64
170 INT481 Regulation of Localization of Ren 3 37 0.62 5.95 11.61
171 INT3597 Positive_regulation of Pla2g1b 1 37 0.63 17.94 11.41
172 INT373 Regulation of Ldha 1 37 0.61 17.86 11.41
173 INT661 Gene_expression of REN 1 100 0.78 48.21 11.36
174 INT686 Negative_regulation of Sct 1 35 0.59 9.59 11.32
175 INT152 Negative_regulation of MBD2 1 31 0.38 3.95 11.31
176 INT141 Binding of Th 4 21 0.48 3.53 11.04
177 INT3546 Binding of Oxt 1 54 0.48 9.75 10.81
178 INT4498 Gene_expression of F2 1 83 0.65 57.4 10.8
179 INT4605 Negative_regulation of Gene_expression of INS 1 220 0.58 139.66 10.75
180 INT1180 Gene_expression of Ren 2 63 0.77 27.33 10.51
181 INT4297 Negative_regulation of CFP 1 21 0.42 12.7 10.29
182 INT1372 Regulation of Localization of REN 1 50 0.62 5.76 9.81
183 INT4391 Gene_expression of SERPINA1 1 47 0.78 41.43 9.7
184 INT4494 Regulation of GCG 2 41 0.45 18.38 9.68
185 INT1648 Regulation of LHB 2 21 0.61 3.32 9.6
186 INT2059 Positive_regulation of Negative_regulation of Prl 1 24 0.70 5.7 9.37
187 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
188 INT1168 Binding of PROC 1 62 0.38 44.15 9.04
189 INT4534 Regulation of PROC 2 38 0.33 19.81 8.99
190 INT3755 Positive_regulation of GBE1 1 29 0.40 8.99 8.91
191 INT591 Negative_regulation of Serpinc1 1 44 0.57 31.73 8.82
192 INT4563 Positive_regulation of Regulation of Prl 1 20 0.70 4.2 8.1
193 INT4487 Positive_regulation of Positive_regulation of PRL 1 27 0.70 8.06 8.09
194 INT4457 Regulation of Arc 1 27 0.60 14.96 7.83
195 INT573 Negative_regulation of C3 1 60 0.59 41.37 7.78
196 INT1150 Gene_expression of ecs 1 42 0.59 29.38 7.73
197 INT4606 Regulation of Gene_expression of INS 1 67 0.61 54.69 7.53
198 INT4299 Positive_regulation of Gene_expression of Gh1 1 27 0.50 5.24 7.31
199 INT4438 Negative_regulation of Localization of Adh1 4 18 0.59 6.23 6.95
200 INT3757 Positive_regulation of Gene_expression of ALB 1 45 0.69 23.73 6.85
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