Y:1977

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 1977. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 1977. They are ordered first by their pain relevance and then by number of times they were reported in 1977. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 1977 Documents TM Confidence Disease Relevance Pain Relevance
1 INT1310 Pomc Regulation of Localization of Prl 9 2 0.40 0.61 4.96
2 INT1390 Trh Positive_regulation of Prl 14 1 0.67 4.42 4.39
3 INT1392 Trh Regulation of Prl 15 2 0.29 2.47 4.29
4 INT1313 Pomc Positive_regulation of Prl 7 1 0.35 0 4.19
5 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 1 0.38 0.16 2.16
6 INT1314 Pomc Regulation of Localization of Gnrhr 2 1 0.16 0.14 1.45
7 INT777 Prss12 Positive_regulation of Prl 1 2 0.19 0 1.33
8 INT221 Chd7 Negative_regulation of Th 1 1 0.02 0 1.04
9 INT775 Nts Positive_regulation of Gnrhr 2 1 0.18 0 1.02
10 INT1415 Binding of OPRM1 and POMC 3 1 0.16 0.3 0.98
11 INT2881 SST Negative_regulation of Positive_regulation of CCK 1 1 0.32 0.1 0.84
12 INT2880 SST Negative_regulation of CCK 1 1 0.32 0.1 0.84
13 INT1312 Pomc Positive_regulation of Gnrhr 2 1 0.11 0.22 0.7
14 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 1 0.11 0 0.7
15 INT778 Tf Positive_regulation of Gh1 1 1 0.14 0 0.7
16 INT784 Prss12 Positive_regulation of Gh1 1 1 0.06 0 0.7
17 INT782 Tf Positive_regulation of Prl 1 1 0.43 0 0.7
18 INT783 Prss12 Positive_regulation of Positive_regulation of Oprl1 1 1 0.05 0 0.7
19 INT780 Prss12 Positive_regulation of Gene_expression of Prl 1 1 0.14 0 0.65
20 INT781 Prss12 Positive_regulation of Gene_expression of Gnrhr 1 1 0.10 0 0.65
21 INT779 Nts Positive_regulation of Gene_expression of Gnrhr 1 1 0.28 0 0.65
22 INT776 Nts Positive_regulation of Gene_expression of Prl 1 1 0.36 0 0.65
23 INT773 Prss12 Positive_regulation of Gnrhr 1 1 0.04 0 0.64
24 INT774 Nts Positive_regulation of Prl 1 1 0.34 0 0.64
25 INT1311 Lct Positive_regulation of Localization of Gnrhr 1 1 0.03 0 0.45
26 INT3727 Abat Regulation of LH 1 1 0.05 0 0.32
27 INT3728 Abat Positive_regulation of Positive_regulation of Prl 1 1 0.15 0 0.31
28 INT1394 Binding of Prl and LH 3 1 0.36 0 0.17
29 INT3751 Binding of GOT1 and PIK3C2A 1 1 0.08 0.68 0.12
30 INT3752 Binding of GOT1 and LDHA 1 1 0.11 0.68 0.12
31 INT1388 Binding of Prl and Gnrh1 3 1 0.35 0.17 0.08
32 INT1387 Binding of Gnrh1 and Trh 1 1 0.29 0 0.08
33 INT1389 Binding of LH and Trh 1 1 0.16 0 0.08
34 INT1393 Negative_regulation of Binding of Prl and Gnrh1 1 1 0.35 0 0.08
35 INT1385 Negative_regulation of Binding of Prl and LH 1 1 0.19 0 0.08
36 INT1386 'Negative_regulation of Binding of ' and Trh 1 1 0.18 0 0.08
37 INT1391 Negative_regulation of Binding of Gnrh1 and Trh 1 1 0.34 0 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported in 1977. They are ordered first by their pain relevance and then by number of times they were reported in 1977. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 1977 Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 3 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 20 2431 0.81 378.96 952.2
3 INT3439 Localization of Abat 1 1017 0.78 112.39 727.06
4 INT2543 Positive_regulation of Calca 3 787 0.70 331.13 592.08
5 INT797 Regulation of Penk 5 812 0.62 111.13 542.24
6 INT155 Positive_regulation of Prl 13 1233 0.70 317.93 457.82
7 INT1045 Localization of LH 1 1211 0.81 87.04 456.25
8 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
9 INT467 Gene_expression of POMC 7 1048 0.78 332.8 394.16
10 INT1395 Negative_regulation of Penk 2 537 0.59 87.33 389.81
11 INT157 Positive_regulation of Localization of Prl 7 790 0.70 104.54 374.78
12 INT287 Localization of Cck 2 518 0.81 86.84 364.04
13 INT439 Localization of Gnrh1 2 976 0.81 100.96 363.25
14 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
15 INT876 Localization of Gh1 6 843 0.80 67.75 340.82
16 INT162 Regulation of Prl 9 794 0.62 165.01 322.24
17 INT161 Regulation of Localization of Prl 7 615 0.62 65.37 298.66
18 INT1352 Localization of Acot1 7 728 0.80 73.01 296.01
19 INT886 Gene_expression of Pomc 2 676 0.78 129.87 295.98
20 INT2365 Positive_regulation of Cck 2 354 0.70 87.8 277.41
21 INT1396 Binding of Penk 7 355 0.48 22.79 269.65
22 INT3948 Regulation of Cck 1 291 0.62 58.07 255.88
23 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
24 INT1212 Binding of Oprl1 8 312 0.48 28.6 225.15
25 INT1308 Localization of Pomc 1 457 0.81 66.83 217.5
26 INT767 Localization of Gnrhr 9 565 0.80 106.68 214.57
27 INT156 Negative_regulation of Prl 6 542 0.59 131.97 192.24
28 INT528 Gene_expression of Prl 9 693 0.78 217.18 192.2
29 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
30 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
31 INT1429 Gene_expression of PDYN 3 308 0.78 61.33 175.65
32 INT159 Negative_regulation of Localization of Prl 3 416 0.59 55.34 171.8
33 INT1114 Localization of Ins1 3 748 0.80 192.95 165.48
34 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
35 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
36 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
37 INT2640 Gene_expression of Pomc 1 424 0.78 120.72 155.37
38 INT880 Positive_regulation of Localization of Gh1 4 304 0.70 14.79 150.23
39 INT812 Localization of INS 3 1026 0.81 515.6 145.31
40 INT425 Localization of PRL 6 455 0.81 189.64 144.8
41 INT1414 Regulation of Oprl1 1 169 0.62 32.05 139.99
42 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
43 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
44 INT1878 Binding of HLA-B 4 440 0.48 321.16 127.36
45 INT416 Regulation of LH 5 253 0.62 31.48 125.55
46 INT2106 Regulation of Localization of LH 1 279 0.62 22.37 122.77
47 INT252 Localization of GH1 3 529 0.80 227.4 122.05
48 INT218 Positive_regulation of Th 1 245 0.70 40.5 120.1
49 INT1438 Localization of Pomc 1 360 0.81 101.26 116.47
50 INT1793 Localization of CGA 1 379 0.81 67.38 114.69
51 INT90 Localization of Gast 3 400 0.81 137.67 113
52 INT3038 Gene_expression of INS 3 1583 0.78 1174.16 107.01
53 INT114 Binding of Oprl1 1 139 0.48 23 103.35
54 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
55 INT2159 Regulation of Localization of Gnrh1 1 200 0.62 13.28 99.07
56 INT1351 Gene_expression of Pag1 1 131 0.57 89.48 98.76
57 INT874 Positive_regulation of Gh1 1 244 0.70 27.17 97.98
58 INT2862 Positive_regulation of Localization of Cck 1 108 0.70 20.75 94.25
59 INT203 Positive_regulation of Pomc 3 257 0.70 90.56 92.84
60 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
61 INT214 Localization of AVP 3 370 0.81 208.51 91.09
62 INT1160 Positive_regulation of Rbm39 1 122 0.57 28.19 90.28
63 INT3766 Positive_regulation of Localization of Acot1 3 192 0.69 21.8 85.35
64 INT875 Regulation of Localization of Gh1 2 166 0.62 12.87 84.97
65 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
66 INT1309 Positive_regulation of Localization of Gnrhr 5 152 0.69 24.25 81.56
67 INT403 Localization of Trh 3 241 0.81 28.55 81.45
68 INT148 Positive_regulation of Gnrhr 2 182 0.70 47.44 79.64
69 INT749 Gene_expression of HLA-B 7 341 0.75 224.12 77.37
70 INT881 Negative_regulation of Localization of Gh1 1 164 0.58 15.1 75.28
71 INT1353 Negative_regulation of Localization of Acot1 2 153 0.53 15.05 75.17
72 INT3034 Localization of Ngf 2 126 0.81 50.81 72.84
73 INT2055 Regulation of Gnrh1 2 185 0.62 23.65 71.26
74 INT1376 Binding of Trh 1 121 0.48 20 69.86
75 INT1377 Positive_regulation of Trh 2 172 0.70 40.55 69.83
76 INT1046 Gene_expression of LH 1 180 0.77 29.75 66.87
77 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
78 INT1425 Gene_expression of Rbm39 1 143 0.58 51.32 65.44
79 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
80 INT217 Negative_regulation of Th 4 134 0.59 26.83 62.63
81 INT46 Localization of Ren 5 233 0.81 46.15 62.44
82 INT3950 Gene_expression of Ptger2 1 293 0.77 122.28 62.42
83 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
84 INT1437 Negative_regulation of Pomc 1 132 0.59 35.22 60.97
85 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
86 INT1794 Regulation of Localization of CGA 1 136 0.57 13.39 59.07
87 INT3920 Localization of Ldha 1 241 0.81 83.08 58.72
88 INT1307 Positive_regulation of Localization of Pomc 1 120 0.70 24.58 58.48
89 INT770 Regulation of Localization of Gnrhr 3 127 0.61 17.91 58.23
90 INT647 Gene_expression of SGCG 1 211 0.75 78.46 55.82
91 INT1782 Regulation of Gh1 1 125 0.62 22 55.74
92 INT19 Regulation of Gnrhr 2 131 0.62 36.4 55.66
93 INT251 Regulation of INS 3 398 0.62 232.47 55.04
94 INT771 Regulation of Nts 1 93 0.61 13.13 53.57
95 INT929 Positive_regulation of Oprl1 1 64 0.70 14.67 52.84
96 INT249 Localization of GHRH 1 215 0.80 78.02 51.87
97 INT1781 Negative_regulation of Gh1 1 127 0.59 16.94 51.77
98 INT1199 Positive_regulation of INS 3 579 0.70 399.64 50.43
99 INT2323 Gene_expression of Trh 4 146 0.78 29.92 49.5
100 INT937 Positive_regulation of Oxt 1 195 0.70 37.82 49.3
101 INT654 Localization of REN 7 250 0.81 75.12 47.86
102 INT2463 Localization of CCK 1 101 0.81 37.54 47.59
103 INT375 Positive_regulation of REN 6 293 0.70 152.46 47.55
104 INT873 Gene_expression of Gh1 2 130 0.76 26.15 46.75
105 INT847 Regulation of Lhb 1 131 0.61 22.08 46.54
106 INT1322 Positive_regulation of Localization of INS 2 293 0.70 120.86 45.98
107 INT1474 Regulation of Localization of Ins1 1 132 0.61 25.96 43.07
108 INT1319 Gene_expression of Oprl1 1 65 0.78 9.34 42.41
109 INT89 Positive_regulation of Gast 3 187 0.70 80.49 42.07
110 INT3933 Positive_regulation of PLOD1 1 128 0.70 30.76 42.03
111 INT2364 Localization of Sct 1 134 0.80 26.21 41.47
112 INT3252 Negative_regulation of INS 2 428 0.59 271.65 39.52
113 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
114 INT3253 Negative_regulation of Localization of INS 1 205 0.59 130.39 36.61
115 INT1354 Negative_regulation of Acot1 1 87 0.43 15.01 36.44
116 INT1976 Regulation of Gene_expression of Prl 2 80 0.62 20.19 36
117 INT49 Negative_regulation of Ren 2 129 0.59 37.48 35.62
118 INT1361 Negative_regulation of Gnrhr 2 118 0.58 57.77 35.54
119 INT2296 Positive_regulation of Gene_expression of Prl 2 137 0.70 36.96 35.39
120 INT255 Regulation of Localization of GH1 2 89 0.62 18.71 35.3
121 INT3679 Gene_expression of AVP 1 171 0.78 72.9 35.23
122 INT326 Gene_expression of Gnrhr 1 105 0.76 35.87 34.93
123 INT1457 Negative_regulation of Binding of Penk 1 40 0.57 0.25 34.24
124 INT3913 Positive_regulation of ABAT 1 47 0.69 22.73 33.4
125 INT234 Binding of Alb 2 151 0.48 52.34 32.97
126 INT248 Positive_regulation of Localization of GH1 1 137 0.69 49.25 32.92
127 INT2330 Regulation of CB 1 78 0.10 20.46 32.6
128 INT1495 Positive_regulation of Rtcd1 1 91 0.54 22.93 32.43
129 INT2884 Positive_regulation of CCK 2 66 0.69 25.25 30.6
130 INT1473 Localization of Gcg 2 95 0.80 17.35 30.31
131 INT50 Negative_regulation of Localization of Ren 3 87 0.59 14.94 30.22
132 INT28 Regulation of Gast 1 106 0.62 26.37 29.85
133 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
134 INT91 Positive_regulation of Localization of Gast 1 96 0.70 23.22 29.36
135 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
136 INT3841 Gene_expression of FCGR3B 6 117 0.75 58.99 28.87
137 INT1166 Negative_regulation of Dbh 2 56 0.59 12.54 28.26
138 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
139 INT3760 Positive_regulation of ALB 2 142 0.70 87.46 26.7
140 INT605 Regulation of Acot1 1 61 0.62 10.7 26.34
141 INT3777 Positive_regulation of NARFL 1 256 0.56 302.43 25.74
142 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
143 INT2614 Gene_expression of CGA 2 187 0.78 105.89 24.77
144 INT288 Positive_regulation of Sct 6 88 0.70 32.83 24.5
145 INT3028 Negative_regulation of Oxt 1 76 0.58 18.52 24.4
146 INT250 Regulation of GHRH 1 65 0.61 17.46 23.19
147 INT956 Negative_regulation of PRL 1 94 0.59 42.72 23.01
148 INT1221 Regulation of SGCG 1 65 0.60 24.21 22.94
149 INT1327 Regulation of Localization of Trh 2 45 0.62 6.05 22.09
150 INT3299 Positive_regulation of AGT 2 126 0.68 79.45 21.91
151 INT2978 Gene_expression of Tbxa2r 2 76 0.77 28.4 21.27
152 INT1876 Positive_regulation of HLA-B 2 82 0.69 52.16 21.08
153 INT160 Regulation of Positive_regulation of Prl 1 37 0.62 7.56 20.09
154 INT3030 Gene_expression of Adra2a 1 37 0.68 5.58 19.76
155 INT712 Positive_regulation of LDHA 2 160 0.70 175.25 19.11
156 INT636 Binding of MRAP 5 54 0.48 40.36 18.77
157 INT3060 Negative_regulation of Bche 3 94 0.59 46.75 18.51
158 INT48 Positive_regulation of Localization of Ren 1 69 0.70 12.47 18.03
159 INT871 Negative_regulation of Gene_expression of Prl 1 53 0.58 18.89 17.79
160 INT219 Negative_regulation of Th 1 55 0.59 20.88 17.09
161 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
162 INT213 Negative_regulation of Localization of AVP 1 46 0.59 19.78 16.79
163 INT653 Negative_regulation of Localization of REN 4 67 0.59 20.33 16.7
164 INT209 Positive_regulation of Pde5a 3 30 0.21 2.54 16.31
165 INT899 Gene_expression of F13A1 2 122 0.70 78.02 16.26
166 INT2066 Localization of Agt 1 56 0.80 9.95 16.25
167 INT3926 Regulation of Bdkrb1 1 22 0.61 16.72 16.1
168 INT2480 Negative_regulation of Got1 1 43 0.51 14.47 16.09
169 INT3793 Regulation of CEBPZ 1 59 0.61 20.91 15.83
170 INT3466 Gene_expression of Ptger1 2 39 0.75 18.34 15.75
171 INT1416 Transcription of POMC 1 40 0.72 10.71 15.38
172 INT2064 Positive_regulation of BTG3 1 29 0.49 25.58 15.37
173 INT1888 Protein_catabolism of F13A1 2 97 0.99 63.48 14.82
174 INT170 Negative_regulation of Adrb1 1 52 0.55 13.46 14.78
175 INT663 Negative_regulation of Adrb3 2 55 0.59 15.95 14.68
176 INT95 Positive_regulation of Adrb1 1 34 0.62 11.95 14.41
177 INT1982 Regulation of NARFL 1 119 0.49 116.2 14.35
178 INT1873 Gene_expression of MRAP 4 51 0.76 31.75 13.92
179 INT3796 Gene_expression of Ighm 1 130 0.77 69.61 13.78
180 INT2336 Negative_regulation of Lct 1 51 0.58 33.79 13.73
181 INT655 Positive_regulation of Localization of REN 2 86 0.70 32.41 13.56
182 INT1491 Regulation of Rtcd1 2 33 0.53 5.17 13.4
183 INT2038 Localization of Esr1 1 104 0.79 40.12 13.27
184 INT711 Positive_regulation of PIK3C2A 2 83 0.70 76.87 13.18
185 INT2490 Regulation of Sct 5 44 0.62 9.45 13.11
186 INT3877 Negative_regulation of MUC7 1 30 0.57 1.62 12.89
187 INT3770 Negative_regulation of Nrm 1 13 0.43 3.55 12.83
188 INT635 Negative_regulation of MAOB 2 51 0.59 24.5 12.66
189 INT3040 Gene_expression of MIA3 2 81 0.24 53.61 12.62
190 INT3699 Gene_expression of H2-Ab1 1 24 0.74 12.06 11.82
191 INT2586 Positive_regulation of Gcg 1 35 0.70 9.25 11.75
192 INT3057 Gene_expression of Ptgfr 1 60 0.58 14.54 11.73
193 INT481 Regulation of Localization of Ren 1 37 0.62 5.95 11.61
194 INT1636 Gene_expression of Sct 2 58 0.77 16.14 11.57
195 INT254 Regulation of Localization of GHRH 1 30 0.60 5.17 11.46
196 INT661 Gene_expression of REN 3 100 0.78 48.21 11.36
197 INT686 Negative_regulation of Sct 1 35 0.59 9.59 11.32
198 INT152 Negative_regulation of MBD2 1 31 0.38 3.95 11.31
199 INT1436 Negative_regulation of Localization of Pomc 1 41 0.58 10.85 11.26
200 INT3845 Gene_expression of GSR 1 79 0.76 44.69 11.19
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