Y:1978

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 1978. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 1978. They are ordered first by their pain relevance and then by number of times they were reported in 1978. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 1978 Documents TM Confidence Disease Relevance Pain Relevance
1 INT1390 Trh Positive_regulation of Prl 14 1 0.67 4.42 4.39
2 INT3434 Vip Positive_regulation of Localization of Prl 6 2 0.76 0.16 3.21
3 INT3302 Penk Positive_regulation of Slc43a3 1 1 0.01 0.09 1.19
4 INT3432 Vip Positive_regulation of Prl 2 1 0.45 0 0.82
5 INT802 Aap Regulation of Grhpr 1 1 0.01 0 0.6
6 INT803 Aap Regulation of Cyb5 1 1 0.05 0 0.6
7 INT804 Aap Negative_regulation of MBD2 1 1 0.01 0 0.57
8 INT3433 Vip Positive_regulation of Positive_regulation of Oprl1 1 1 0.26 0 0.53
9 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 1 0.10 0 0.52
10 INT3435 Positive_regulation of Vip Positive_regulation of Prl 1 1 0.45 0 0.49
11 INT3178 TSHR Positive_regulation of Prl 1 1 0.00 0.58 0.31
12 INT2927 Positive_regulation of Mpo Positive_regulation of Localization of LH 1 1 0.26 0.28 0.14
13 INT3326 PRSS1 Positive_regulation of ATP6AP2 1 1 0.01 0 0.11
14 INT2993 Binding of HLA-B and SUGT1 1 1 0.00 0.6 0.1
15 INT2928 Binding of sch and LH 1 1 0.03 0.2 0
16 INT2929 Binding of sch and Prl 1 1 0.04 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in 1978. They are ordered first by their pain relevance and then by number of times they were reported in 1978. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 1978 Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 6 1902 0.78 275.47 1057.59
2 INT158 Localization of Prl 57 2431 0.81 378.96 952.2
3 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
4 INT3439 Localization of Abat 3 1017 0.78 112.39 727.06
5 INT292 Localization of Penk 2 876 0.81 88.44 669.14
6 INT728 Positive_regulation of Penk 3 1068 0.70 186.9 636.87
7 INT797 Regulation of Penk 3 812 0.62 111.13 542.24
8 INT155 Positive_regulation of Prl 36 1233 0.70 317.93 457.82
9 INT1045 Localization of LH 20 1211 0.81 87.04 456.25
10 INT443 Localization of POMC 5 1020 0.81 284.52 443.17
11 INT467 Gene_expression of POMC 10 1048 0.78 332.8 394.16
12 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
13 INT157 Positive_regulation of Localization of Prl 8 790 0.70 104.54 374.78
14 INT287 Localization of Cck 2 518 0.81 86.84 364.04
15 INT439 Localization of Gnrh1 3 976 0.81 100.96 363.25
16 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
17 INT876 Localization of Gh1 22 843 0.80 67.75 340.82
18 INT162 Regulation of Prl 21 794 0.62 165.01 322.24
19 INT161 Regulation of Localization of Prl 11 615 0.62 65.37 298.66
20 INT1352 Localization of Acot1 3 728 0.80 73.01 296.01
21 INT886 Gene_expression of Pomc 4 676 0.78 129.87 295.98
22 INT1396 Binding of Penk 5 355 0.48 22.79 269.65
23 INT1893 Localization of Gh 4 1041 0.79 340.23 256.58
24 INT2909 Positive_regulation of Abat 7 334 0.70 62.1 256.43
25 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
26 INT1902 Gene_expression of Cck 2 348 0.78 70.33 241.92
27 INT1562 Localization of Crh 1 499 0.81 126.74 236.68
28 INT1212 Binding of Oprl1 3 312 0.48 28.6 225.15
29 INT767 Localization of Gnrhr 10 565 0.80 106.68 214.57
30 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
31 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
32 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
33 INT156 Negative_regulation of Prl 13 542 0.59 131.97 192.24
34 INT528 Gene_expression of Prl 22 693 0.78 217.18 192.2
35 INT2085 Positive_regulation of LH 10 441 0.70 60.15 191.02
36 INT3440 Negative_regulation of Localization of Abat 2 221 0.57 33.94 180.36
37 INT159 Negative_regulation of Localization of Prl 8 416 0.59 55.34 171.8
38 INT438 Gene_expression of Crh 1 376 0.78 159.11 169.17
39 INT739 Negative_regulation of POMC 5 358 0.59 102.28 166.77
40 INT1114 Localization of Ins1 3 748 0.80 192.95 165.48
41 INT3448 Positive_regulation of Gh 1 521 0.69 180.03 161.18
42 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
43 INT2640 Gene_expression of Pomc 3 424 0.78 120.72 155.37
44 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
45 INT1044 Negative_regulation of Localization of LH 4 358 0.59 25.95 151.31
46 INT880 Positive_regulation of Localization of Gh1 10 304 0.70 14.79 150.23
47 INT812 Localization of INS 8 1026 0.81 515.6 145.31
48 INT425 Localization of PRL 2 455 0.81 189.64 144.8
49 INT2379 Positive_regulation of Localization of LH 3 349 0.70 27.86 144.53
50 INT3300 Positive_regulation of Gene_expression of Calca 1 179 0.70 77.76 144.2
51 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
52 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
53 INT1878 Binding of HLA-B 6 440 0.48 321.16 127.36
54 INT695 Binding of POMC 4 304 0.48 56.66 126.85
55 INT416 Regulation of LH 10 253 0.62 31.48 125.55
56 INT2106 Regulation of Localization of LH 5 279 0.62 22.37 122.77
57 INT218 Positive_regulation of Th 3 245 0.70 40.5 120.1
58 INT2555 Positive_regulation of Localization of Penk 1 116 0.70 24.35 119.73
59 INT90 Localization of Gast 4 400 0.81 137.67 113
60 INT1530 Regulation of Gh 2 382 0.61 115.96 112.47
61 INT915 Positive_regulation of PRL 3 342 0.70 141.96 104.31
62 INT114 Binding of Oprl1 3 139 0.48 23 103.35
63 INT397 Localization of SST 1 232 0.81 58.05 101.19
64 INT293 Protein_catabolism of Penk 2 161 1.00 11.71 98.45
65 INT874 Positive_regulation of Gh1 3 244 0.70 27.17 97.98
66 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
67 INT203 Positive_regulation of Pomc 2 257 0.70 90.56 92.84
68 INT2122 Negative_regulation of Localization of Gnrh1 1 226 0.59 26.92 92.04
69 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
70 INT3441 Regulation of Localization of Abat 1 117 0.38 8.67 87.59
71 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
72 INT2149 Positive_regulation of Oxt 1 181 0.70 24.8 85.43
73 INT875 Regulation of Localization of Gh1 8 166 0.62 12.87 84.97
74 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
75 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
76 INT403 Localization of Trh 1 241 0.81 28.55 81.45
77 INT1498 Gene_expression of Gh 1 521 0.75 220.84 81.16
78 INT148 Positive_regulation of Gnrhr 1 182 0.70 47.44 79.64
79 INT2289 Gene_expression of PENK 1 203 0.78 55.62 79.49
80 INT2893 Localization of Oxt 1 219 0.80 28.96 79.43
81 INT3214 Localization of Ins1 2 527 0.80 196.9 79.26
82 INT2431 Positive_regulation of Mpo 1 275 0.70 211.99 78.47
83 INT749 Gene_expression of HLA-B 4 341 0.75 224.12 77.37
84 INT881 Negative_regulation of Localization of Gh1 7 164 0.58 15.1 75.28
85 INT1497 Negative_regulation of Gh 3 415 0.59 192.95 74.71
86 INT442 Localization of PDYN 3 99 0.81 11.87 72.75
87 INT1080 Negative_regulation of Ache 4 343 0.59 108.51 72.4
88 INT2055 Regulation of Gnrh1 2 185 0.62 23.65 71.26
89 INT2123 Positive_regulation of Gnrh1 1 209 0.70 24.2 68.97
90 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
91 INT1046 Gene_expression of LH 10 180 0.77 29.75 66.87
92 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
93 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
94 INT3375 Gene_expression of IGHE 2 535 0.77 387.47 65.46
95 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
96 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
97 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
98 INT217 Negative_regulation of Th 1 134 0.59 26.83 62.63
99 INT46 Localization of Ren 18 233 0.81 46.15 62.44
100 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
101 INT1169 Negative_regulation of Bche 2 322 0.59 149.22 61.27
102 INT546 Binding of ALB 2 311 0.48 85.98 60.14
103 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
104 INT3161 Regulation of Localization of Gh 1 163 0.61 35.43 59.45
105 INT770 Regulation of Localization of Gnrhr 5 127 0.61 17.91 58.23
106 INT2148 Negative_regulation of Oxt 1 105 0.59 11.42 57
107 INT1510 Binding of PDYN 1 94 0.48 4.68 56.44
108 INT1463 Binding of Pomc 1 129 0.48 15.89 56.27
109 INT1782 Regulation of Gh1 5 125 0.62 22 55.74
110 INT19 Regulation of Gnrhr 4 131 0.62 36.4 55.66
111 INT314 Positive_regulation of Ren 12 212 0.70 66.68 55.56
112 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
113 INT251 Regulation of INS 1 398 0.62 232.47 55.04
114 INT1027 Gene_expression of Lbp 1 132 0.77 106.7 54.16
115 INT1486 Negative_regulation of Cpe 1 85 0.59 28.78 54.08
116 INT771 Regulation of Nts 2 93 0.61 13.13 53.57
117 INT3213 Gene_expression of Ins1 1 511 0.76 357.59 53.32
118 INT1487 Regulation of Cpe 2 68 0.62 10.24 52.91
119 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
120 INT929 Positive_regulation of Oprl1 3 64 0.70 14.67 52.84
121 INT1781 Negative_regulation of Gh1 3 127 0.59 16.94 51.77
122 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
123 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
124 INT1977 Negative_regulation of Positive_regulation of Prl 5 98 0.59 17.06 47.88
125 INT654 Localization of REN 3 250 0.81 75.12 47.86
126 INT671 Positive_regulation of Cea 4 221 0.69 164.5 47.79
127 INT375 Positive_regulation of REN 3 293 0.70 152.46 47.55
128 INT374 Positive_regulation of Ldha 2 212 0.70 107.08 47.43
129 INT789 Positive_regulation of YY1 1 69 0.67 14.07 47.06
130 INT873 Gene_expression of Gh1 1 130 0.76 26.15 46.75
131 INT847 Regulation of Lhb 1 131 0.61 22.08 46.54
132 INT683 Positive_regulation of AVP 3 173 0.70 74.55 46.41
133 INT1322 Positive_regulation of Localization of INS 3 293 0.70 120.86 45.98
134 INT619 Positive_regulation of Positive_regulation of Prl 4 116 0.70 22.69 45.06
135 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
136 INT1564 Localization of OPRM1 1 41 0.80 8.03 44.67
137 INT1894 Negative_regulation of Localization of Gh 3 168 0.58 64.12 43.56
138 INT1474 Regulation of Localization of Ins1 2 132 0.61 25.96 43.07
139 INT1295 Binding of Pomc 1 85 0.48 12.92 42.8
140 INT1319 Gene_expression of Oprl1 1 65 0.78 9.34 42.41
141 INT89 Positive_regulation of Gast 2 187 0.70 80.49 42.07
142 INT2364 Localization of Sct 11 134 0.80 26.21 41.47
143 INT957 Positive_regulation of GHRH 1 136 0.70 36.84 40.52
144 INT685 Regulation of AVP 5 124 0.62 34.9 39.91
145 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
146 INT115 Negative_regulation of Maoa 1 65 0.59 16.27 38.66
147 INT3188 Regulation of Localization of Acot1 2 84 0.59 8.94 38.56
148 INT3253 Negative_regulation of Localization of INS 3 205 0.59 130.39 36.61
149 INT1976 Regulation of Gene_expression of Prl 3 80 0.62 20.19 36
150 INT927 Gene_expression of Oxt 1 184 0.78 44.71 35.79
151 INT3216 Positive_regulation of Localization of Ins1 1 170 0.69 56.78 35.63
152 INT49 Negative_regulation of Ren 8 129 0.59 37.48 35.62
153 INT1361 Negative_regulation of Gnrhr 3 118 0.58 57.77 35.54
154 INT316 Regulation of Cebpz 1 105 0.00 27.21 35.41
155 INT2296 Positive_regulation of Gene_expression of Prl 2 137 0.70 36.96 35.39
156 INT326 Gene_expression of Gnrhr 1 105 0.76 35.87 34.93
157 INT1705 Gene_expression of pCA 1 126 0.65 88.65 34.81
158 INT2274 Regulation of Localization of INS 2 101 0.62 41.55 34.79
159 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
160 INT1457 Negative_regulation of Binding of Penk 2 40 0.57 0.25 34.24
161 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
162 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
163 INT1116 Regulation of Ren 8 103 0.62 27.66 33.26
164 INT691 Binding of SST 1 67 0.48 24.66 32.67
165 INT1495 Positive_regulation of Rtcd1 3 91 0.54 22.93 32.43
166 INT985 Negative_regulation of GH1 1 213 0.57 89.53 32.39
167 INT3117 Regulation of Oxt 1 103 0.61 17.93 32.28
168 INT1159 Negative_regulation of Agt 1 133 0.59 40.14 31.67
169 INT1473 Localization of Gcg 1 95 0.80 17.35 30.31
170 INT1079 Positive_regulation of Ache 2 104 0.70 23.52 30.28
171 INT719 Negative_regulation of SGCG 1 96 0.57 47.91 30.22
172 INT50 Negative_regulation of Localization of Ren 7 87 0.59 14.94 30.22
173 INT28 Regulation of Gast 1 106 0.62 26.37 29.85
174 INT724 Negative_regulation of Alb 2 151 0.59 93.57 29.65
175 INT660 Negative_regulation of REN 3 194 0.59 82.06 29.46
176 INT91 Positive_regulation of Localization of Gast 2 96 0.70 23.22 29.36
177 INT2671 Positive_regulation of Odc1 3 82 0.70 11.03 29
178 INT3286 Positive_regulation of Gpt 2 90 0.69 45.08 28.34
179 INT1166 Negative_regulation of Dbh 2 56 0.59 12.54 28.26
180 INT3076 Regulation of KNG1 1 52 0.60 20.39 27.89
181 INT2912 Positive_regulation of Positive_regulation of Abat 2 29 0.66 6.48 27.54
182 INT3217 Regulation of Ins1 1 154 0.62 87.11 27.29
183 INT703 Positive_regulation of Pth 1 177 0.70 127.09 27.26
184 INT97 Negative_regulation of Adrb1 1 102 0.59 32.44 26.9
185 INT3167 Binding of KNG1 3 48 0.48 23.26 26.77
186 INT276 Regulation of Ache 3 83 0.62 16.75 25.99
187 INT1030 Localization of Lbp 1 52 0.74 38.92 24.91
188 INT288 Positive_regulation of Sct 4 88 0.70 32.83 24.5
189 INT2140 Regulation of REN 6 104 0.62 28.24 24.49
190 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
191 INT2103 Localization of Rhd 1 35 0.77 3.16 23.5
192 INT1704 Positive_regulation of PCa 1 68 0.59 34.92 23.36
193 INT2290 Protein_catabolism of POMC 5 41 0.99 4.86 23.36
194 INT956 Negative_regulation of PRL 2 94 0.59 42.72 23.01
195 INT825 Negative_regulation of ADRA1D 1 54 0.58 20.25 22.78
196 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
197 INT823 Negative_regulation of ESR1 1 144 0.58 63.72 22.52
198 INT2911 Positive_regulation of Glul 3 36 0.70 11.09 22.07
199 INT3299 Positive_regulation of AGT 1 126 0.68 79.45 21.91
200 INT693 Negative_regulation of Localization of SST 1 46 0.59 8.57 21.75
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