Y:2000

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2000. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2000. They are ordered first by their pain relevance and then by number of times they were reported in 2000. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2000 Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 9 0.54 5.93 32.4
2 INT69872 Binding of MC1R and POMC 52 2 0.54 8.87 18.3
3 INT65724 Binding of Pnoc and Oprl1 8 2 0.33 2.94 8.82
4 INT21276 Binding of Oprd1 and Penk 9 2 0.54 1.14 8.28
5 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 5 0.78 0.08 7.29
6 INT91538 Pomc Positive_regulation of P9Ehs1 6 4 0.11 1.47 6.23
7 INT92466 Pomc Positive_regulation of Binding of Crygs and 8 7 0.06 0 5.56
8 INT88279 Ngf Positive_regulation of Ntrk1 5 1 0.76 3.06 5.23
9 INT10844 Ghrh Regulation of Gh 13 2 0.13 4.77 4.71
10 INT29206 Crh Regulation of Localization of POMC 4 2 0.64 0.96 4.68
11 INT34444 Binding of Oprl1 and Ptprg 4 2 0.03 0.18 4.58
12 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 1 0.59 9.37 4.48
13 INT7022 Drd1a Positive_regulation of Npr1 6 1 0.05 0.26 4.32
14 INT82023 Binding of Ntrk1 and Ngf 5 1 0.53 3.48 3.92
15 INT69938 Cck Positive_regulation of Localization of Abat 2 3 0.29 0 3.78
16 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 5 0.72 0.92 3.52
17 INT17317 Binding of Jun and Fos 7 2 0.42 1.03 3.5
18 INT56458 Binding of GPM6A and IGHG3 4 1 0.02 0 3.31
19 INT13729 GHRH Positive_regulation of Localization of GH1 13 1 0.62 0.59 3.2
20 INT91271 Mtr Regulation of Gene_expression of Il6 1 4 0.20 0 3.17
21 INT91539 Pomc Positive_regulation of Pomc Positive_regulation of P9Ehs1 1 4 0.03 0.84 3.13
22 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 1 0.35 13.11 3.11
23 INT69937 Cck Positive_regulation of Abat 2 2 0.31 0 2.88
24 INT91649 Binding of Lbp and SPECC1 1 2 0.12 2.88 2.78
25 INT87267 Binding of BMP8B and KRIT1 1 2 0.06 0.16 2.69
26 INT92738 Binding of Ephb1 and Tcas1 1 2 0.00 0.43 2.67
27 INT91350 Binding of Pla2g4a and RYBP 1 2 0.00 1.15 2.65
28 INT70757 Binding of Oprl1 and Pnoc 5 3 0.03 0.23 2.55
29 INT69665 Binding of Oprd1 and Pnoc 5 2 0.35 0.4 2.5
30 INT92182 Mir702 Negative_regulation of Adk 1 3 0.07 1.29 2.47
31 INT170038 Gtf3a Regulation of Gene_expression of DRGX 1 2 0.00 1.36 2.46
32 INT170037 Ngf Regulation of Gene_expression of DRGX 1 2 0.01 1.37 2.46
33 INT88730 Binding of OPRM1 and Mop3 1 2 0.00 0 2.34
34 INT76776 Binding of Pnoc and Ptprg 2 1 0.02 0 2.29
35 INT91860 Npy Regulation of Npy1r 2 1 0.28 1.13 2.24
36 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 4 0.27 3.81 2.19
37 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 4 0.25 3.81 2.19
38 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 4 0.30 3.8 2.19
39 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 4 0.27 3.81 2.19
40 INT89733 Binding of Calca and Nrm 1 2 0.31 0.71 2.09
41 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 2 0.39 0.87 2.05
42 INT88883 IRF6 Positive_regulation of Nfkb1 1 2 0.11 0.53 2.01
43 INT45423 Avp Positive_regulation of Localization of Prl 4 1 0.67 1.37 1.98
44 INT87891 Agt Regulation of Cck 1 2 0.28 0 1.97
45 INT91607 Binding of EDN1 and POMC 1 2 0.12 0 1.9
46 INT86997 Binding of HIVEP1 and NGF 2 1 0.03 1.75 1.73
47 INT92369 Binding of CYP2D6 and RYBP 1 2 0.25 0.15 1.73
48 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 1 0.50 4.37 1.69
49 INT90658 Abat Regulation of Localization of Cck 2 2 0.24 0 1.64
50 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 1 0.16 0.92 1.63
51 INT86637 POMC Regulation of Gene_expression of KRT16 2 1 0.47 1.22 1.61
52 INT90929 Binding of Ap1m1 and Insrr 1 1 0.01 0.19 1.6
53 INT89011 Lep Positive_regulation of Insr 1 6 0.19 2.41 1.57
54 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 2 0.17 3.36 1.53
55 INT92057 Ifng Positive_regulation of Gene_expression of Ik 1 2 0.03 0.45 1.49
56 INT92430 LOC681261 Positive_regulation of Ean2 1 2 0.01 1.52 1.41
57 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 1 0.05 0.07 1.37
58 INT87812 Penk Regulation of Prl 1 2 0.16 0 1.34
59 INT19633 GNRH1 Regulation of Localization of CGA 4 1 0.44 0.82 1.33
60 INT91305 Binding of Npff and Npffr2 2 1 0.31 0.64 1.32
61 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 2 0.35 0 1.29
62 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 2 0.23 0 1.29
63 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 1 0.39 0.83 1.28
64 INT89943 Binding of Oprm1 and Il2 1 1 0.03 0.53 1.28
65 INT89876 Pdyn Positive_regulation of Gata4 1 2 0.23 0 1.28
66 INT86518 Ass1 Positive_regulation of Hmox2 1 1 0.03 0.08 1.27
67 INT88449 Uncx Positive_regulation of Penk 1 7 0.12 0 1.27
68 INT87375 Binding of Gabrg1 and Oprm1 1 1 0.00 0.83 1.25
69 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 1 0.00 0 1.25
70 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 1 0.05 0 1.24
71 INT92800 Arrb2 Negative_regulation of Oprm1 1 1 0.37 0.33 1.24
72 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 1 0.14 0.89 1.23
73 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 1 0.00 0.05 1.21
74 INT87585 RPL7AP5 Negative_regulation of Calca 1 1 0.00 0.05 1.21
75 INT90644 Slc6a3 Positive_regulation of Th 1 4 0.51 0 1.2
76 INT75126 Pnoc Regulation of Localization of Avp 2 1 0.26 0.24 1.18
77 INT92995 SFTPA1 Regulation of Gene_expression of CALM1 1 2 0.06 0.93 1.17
78 INT13205 Oprd1 Negative_regulation of Npr1 2 1 0.01 0 1.16
79 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 2 0.33 1.97 1.15
80 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 2 0.28 1.97 1.15
81 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 2 0.36 1.96 1.15
82 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 1 0.25 0.15 1.15
83 INT88778 Binding of Oprm1 and Pomc 3 2 0.21 0.56 1.14
84 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 2 0.42 1.96 1.14
85 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 2 0.24 1.94 1.13
86 INT86263 Binding of Tacr3 and Tac2 1 1 0.16 0.52 1.13
87 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 1 0.25 1.3 1.12
88 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 2 0.29 1.94 1.12
89 INT88446 Uncx Positive_regulation of Th 1 6 0.13 0 1.1
90 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 2 0.30 1.9 1.09
91 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 2 0.25 1.9 1.09
92 INT90145 Binding of OPRL1 and OPRM1 2 1 0.27 0.31 1.08
93 INT88614 Penk Negative_regulation of Il2 1 1 0.23 0 1.08
94 INT87805 Pnoc Negative_regulation of Gene_expression of Fosl1 1 1 0.33 0 1.08
95 INT91395 MMP2 Positive_regulation of CALCA 1 1 0.36 0.17 1.07
96 INT87222 Nrg1 Regulation of Oprd1 1 1 0.00 0 1.07
97 INT87320 Ngf Regulation of Gene_expression of Bdnf 2 1 0.38 0.97 1.06
98 INT90050 Binding of GRP and Penk 1 1 0.06 0 1.06
99 INT93614 Ngf Positive_regulation of Ntrk1 2 1 0.52 0.85 1.05
100 INT87855 Flvcr2 Positive_regulation of Localization of Abat 1 1 0.02 0 1.05
101 INT65986 IL1B Positive_regulation of PTGS2 3 1 0.32 2.05 1.03
102 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 1 0.02 0.27 1.03
103 INT88971 Binding of Sult4a1 and Atrn 1 1 0.02 0.54 1.03
104 INT86073 Med15 Regulation of Calca 1 1 0.49 0.2 1.03
105 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 1 0.09 0.27 1.03
106 INT74027 Creb1 Regulation of Jun 4 1 0.27 1.04 1.02
107 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 1 0.21 0.27 1.02
108 INT88874 Ifng Regulation of Nos2 1 1 0.01 0.26 1.01
109 INT88879 Ifng Positive_regulation of Nfkb1 1 1 0.01 0.26 1.01
110 INT88884 IRF6 Regulation of Nos2 1 1 0.12 0.26 1
111 INT88886 IRF6 Positive_regulation of Nos2 1 1 0.22 0.26 1
112 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 1 0.20 0.26 1
113 INT91813 Binding of FAS and FASLG 4 1 0.23 9.89 0.99
114 INT32327 POMC Positive_regulation of Localization of PRL 4 1 0.45 0 0.99
115 INT86662 Ngf Regulation of SCN10A 1 1 0.27 1.24 0.99
116 INT90385 EXTL3 Regulation of Ctsl 1 1 0.00 1.1 0.98
117 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 1 0.05 1.73 0.97
118 INT86960 ADRA1D Negative_regulation of Prl 1 1 0.00 0 0.97
119 INT89828 Atp4b Positive_regulation of Localization of Grip2 1 2 0.10 0.54 0.97
120 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 1 0.08 0 0.96
121 INT88583 Hal Positive_regulation of Prl 1 4 0.15 0.44 0.95
122 INT89514 Pnoc Regulation of Gene_expression of Fos 1 1 0.47 0.98 0.93
123 INT89515 Pnoc Regulation of Gene_expression of Fosl1 1 1 0.09 0.98 0.93
124 INT86350 Negative_regulation of Adarb1 Negative_regulation of Positive_regulation of Fos 1 1 0.04 0.8 0.92
125 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 1 0.03 1.63 0.92
126 INT86349 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Fos 1 1 0.42 0.8 0.92
127 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 1 0.20 0.89 0.92
128 INT90561 Slc6a1 Negative_regulation of Abat 1 2 0.02 0.25 0.91
129 INT85485 Phax Regulation of Gene_expression of Cck 1 1 0.07 0.61 0.91
130 INT89314 Binding of CRYGS and OPRM1 1 1 0.07 0.08 0.91
131 INT86589 Oprd1 Regulation of Localization of Pomc 1 1 0.18 0 0.9
132 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 1 0.00 0 0.89
133 INT92404 PSRC1 Regulation of CDKN1A 1 3 0.33 0.66 0.89
134 INT91273 Mtr Positive_regulation of Localization of Il6 1 1 0.17 0 0.88
135 INT91272 Ifng Positive_regulation of Localization of Il6 1 1 0.29 0 0.88
136 INT90387 ROS1 Positive_regulation of NFKB1 4 1 0.32 2.35 0.87
137 INT87416 SNORD50A Regulation of Positive_regulation of Fos 1 1 0.13 0 0.87
138 INT90559 Gm5114 Regulation of Abat 1 1 0.02 0.31 0.87
139 INT97795 IRF6 Positive_regulation of Localization of TNF 3 1 0.09 1.57 0.86
140 INT92423 EC3 Negative_regulation of Mme 1 2 0.02 0.28 0.86
141 INT90560 Gm5114 Positive_regulation of Abat 1 1 0.03 0.25 0.86
142 INT91992 IGKV1-22 Negative_regulation of Sell 1 1 0.40 0.31 0.86
143 INT91005 Binding of Oprl1 and CCRN4L 1 1 0.14 0.37 0.85
144 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 2 0.15 3.61 0.83
145 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 1 0.30 0.14 0.81
146 INT90382 Binding of CRH and GH1 1 1 0.34 0.05 0.81
147 INT89529 OPRM1 Regulation of CALM1 1 1 0.27 0 0.81
148 INT87494 CALCA Positive_regulation of IL8 1 1 0.48 0.15 0.81
149 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 1 0.21 0.1 0.81
150 INT87487 CALCA Regulation of CALCA Positive_regulation of IL8 1 1 0.32 0.15 0.81
151 INT90381 Binding of GH1 and LAMC2 1 1 0.34 0.05 0.81
152 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 1 0.06 0.1 0.81
153 INT87488 CALCA Positive_regulation of CALCA Regulation of IL8 1 1 0.54 0.15 0.81
154 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 1 0.43 0.14 0.81
155 INT92372 CYP2B6 Positive_regulation of Binding of RYBP and 1 1 0.17 0.09 0.81
156 INT87492 CALCA Regulation of IL8 1 1 0.28 0.15 0.81
157 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 1 0.31 0.07 0.8
158 INT62176 Binding of PTGS2 and Ptgs1 2 1 0.00 0.69 0.79
159 INT92293 Tacr1 Regulation of Tac2 1 1 0.17 0.07 0.79
160 INT92793 Gh Positive_regulation of CTS 1 2 0.04 1.39 0.78
161 INT87513 Binding of Tac2 and Abat 1 1 0.09 0.26 0.78
162 INT90750 Oprd1 Regulation of Positive_regulation of Gpd1 1 1 0.10 0.25 0.78
163 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 1 0.38 0.39 0.76
164 INT87493 Binding of CALCA and Positive_regulation of Gene_expression of IL8 1 1 0.52 0.18 0.76
165 INT90118 Jun Regulation of Gene_expression of Nfkb1 1 1 0.18 0.39 0.76
166 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 1 0.43 0 0.76
167 INT90117 Jun Regulation of Gene_expression of Nos1 1 1 0.21 0.39 0.76
168 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 1 0.17 0.39 0.76
169 INT90123 Jun Positive_regulation of Gene_expression of Fos 1 1 0.47 0.39 0.76
170 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 1 0.32 0.39 0.76
171 INT12396 Binding of Avp and IGKV1-5 3 2 0.04 1.38 0.75
172 INT90959 PPIG Regulation of CYP2C9 1 1 0.43 0 0.75
173 INT91655 SLC8A1 Negative_regulation of CASP1 1 2 0.02 0.43 0.75
174 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 1 0.00 0.8 0.75
175 INT90122 Nfkb1 Positive_regulation of Gene_expression of Fos 1 1 0.39 0.39 0.75
176 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 1 0.00 0.8 0.75
177 INT86657 TNF Regulation of H2-Ab1 1 1 0.02 0.84 0.74
178 INT93709 Positive_regulation of Oprd1 Regulation of Calm3 1 1 0.01 0 0.74
179 INT93708 Oprd1 Regulation of Calm3 1 1 0.01 0 0.73
180 INT92370 Binding of CYP2B6 and CYP2D6 1 1 0.21 0 0.73
181 INT93710 Oprm1 Positive_regulation of Gene_expression of Calm3 1 1 0.25 0 0.73
182 INT88500 RYBP Negative_regulation of Positive_regulation of Gtf3a 1 1 0.00 0.19 0.73
183 INT172134 Binding of IL6 and IL15 2 1 0.01 1.18 0.72
184 INT172147 Binding of IL15 and TNF 2 1 0.05 1.19 0.72
185 INT87646 Dbi Regulation of Olfr1507 1 1 0.00 0.69 0.72
186 INT87274 CALM1 Regulation of Oprd1 1 1 0.01 0.08 0.72
187 INT87275 KRIT1 Regulation of Oprd1 1 1 0.01 0.08 0.72
188 INT172097 Binding of HLA-E and Trav6-3 10 1 0.02 3.71 0.71
189 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 1 0.23 2.62 0.71
190 INT92721 Positive_regulation of Penk Regulation of OTSC1 1 1 0.02 0.14 0.71
191 INT89936 Tlr4 Positive_regulation of Il6 3 1 0.49 0.95 0.7
192 INT91700 Il6 Negative_regulation of Oprd1 1 1 0.23 0 0.7
193 INT92720 Penk Regulation of OTSC1 1 1 0.01 0.14 0.7
194 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 1 0.11 1.7 0.69
195 INT89009 Lep Positive_regulation of Cck 2 1 0.67 0.43 0.69
196 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 1 0.15 1.69 0.69
197 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 1 0.03 1.69 0.68
198 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 1 0.02 1.69 0.68
199 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 1 0.34 0.33 0.68
200 INT92025 Egr1 Positive_regulation of Jun 1 1 0.15 0.61 0.67

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2000. They are ordered first by their pain relevance and then by number of times they were reported in 2000. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2000 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 209 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 67 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 61 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 39 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 66 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 12 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 37 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 46 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 91 1163 0.70 319.28 684
10 INT292 Localization of Penk 8 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 22 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 61 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 30 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 30 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 76 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 36 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 11 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 27 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 39 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 49 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 15 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 11 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 6 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 25 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 14 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 44 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 9 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 19 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 7 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 35 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 11 790 0.70 104.54 374.78
32 INT287 Localization of Cck 40 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 25 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 15 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 21 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 2 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 21 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 14 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 11 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 27 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 8 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 20 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 37 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 13 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 24 530 0.78 264.29 310.56
46 INT4941 Positive_regulation of Oprd1 14 345 0.70 74.26 304.41
47 INT9131 Positive_regulation of Prkcg 20 431 0.70 130.8 302.41
48 INT477 Localization of Avp 24 813 0.81 131.58 300.4
49 INT161 Regulation of Localization of Prl 5 615 0.62 65.37 298.66
50 INT1352 Localization of Acot1 28 728 0.80 73.01 296.01
51 INT886 Gene_expression of Pomc 22 676 0.78 129.87 295.98
52 INT11624 Gene_expression of OPRM1 22 445 0.78 72.36 294.36
53 INT5379 Gene_expression of Fos 15 656 0.78 255.5 292.54
54 INT3579 Localization of Oxt 8 555 0.81 43.35 292.44
55 INT9158 Gene_expression of Tnf 42 722 0.78 522.01 277.68
56 INT2365 Positive_regulation of Cck 17 354 0.70 87.8 277.41
57 INT9381 Positive_regulation of TRPV1 8 523 0.70 187.4 276.05
58 INT49750 Negative_regulation of CPOX 32 735 0.58 360.06 274.19
59 INT6852 Localization of TNF 12 883 0.81 705.95 270.84
60 INT10832 Gene_expression of IL8 24 1050 0.78 698.72 270
61 INT1396 Binding of Penk 3 355 0.48 22.79 269.65
62 INT5591 Regulation of Gene_expression of Fos 33 425 0.62 129.06 265.78
63 INT9659 Gene_expression of Il6 26 991 0.78 715.11 265.57
64 INT5972 Gene_expression of IL1B 42 948 0.78 510.91 263.97
65 INT68684 Gene_expression of VEGFA 12 2371 0.78 1742.52 259.2
66 INT87687 Positive_regulation of Trpv1 1 409 0.70 210.24 257.59
67 INT1893 Localization of Gh 51 1041 0.79 340.23 256.58
68 INT16868 Gene_expression of Il6 33 807 0.78 499.48 256.57
69 INT2909 Positive_regulation of Abat 12 334 0.70 62.1 256.43
70 INT3948 Regulation of Cck 15 291 0.62 58.07 255.88
71 INT5501 Regulation of Oprd1 14 283 0.62 55.1 249.9
72 INT1005 Localization of Sst 6 385 0.81 26.31 244.56
73 INT738 Regulation of POMC 9 459 0.62 111.19 243.74
74 INT1902 Gene_expression of Cck 9 348 0.78 70.33 241.92
75 INT11377 Positive_regulation of Ngf 26 331 0.70 206.5 238
76 INT1562 Localization of Crh 13 499 0.81 126.74 236.68
77 INT5597 Gene_expression of Pdyn 12 433 0.78 62.97 235.47
78 INT1665 Positive_regulation of Pag1 13 270 0.68 186.63 229.87
79 INT4759 Negative_regulation of Localization of Calca 10 294 0.59 82.62 226.45
80 INT9987 Gene_expression of Abat 6 296 0.78 95.46 226.34
81 INT6406 Binding of Oprm1 17 280 0.48 40.54 226.26
82 INT1212 Binding of Oprl1 9 312 0.48 28.6 225.15
83 INT11009 Phosphorylation of Creb1 15 458 0.82 111.34 221.97
84 INT626 Localization of CALCA 6 289 0.81 125.39 221.15
85 INT6665 Gene_expression of FOS 14 520 0.77 165.31 217.66
86 INT1308 Localization of Pomc 15 457 0.81 66.83 217.5
87 INT6293 Gene_expression of Oprm1 16 312 0.78 48.73 215.61
88 INT6481 Binding of TNF 14 624 0.48 510.2 214.82
89 INT767 Localization of Gnrhr 2 565 0.80 106.68 214.57
90 INT4893 Gene_expression of Tacr1 17 366 0.78 129.67 213.92
91 INT22548 Positive_regulation of Casp3 20 483 0.70 258.78 213.07
92 INT6482 Positive_regulation of Gene_expression of TNF 17 659 0.70 569.88 210
93 INT16259 Positive_regulation of Bdnf 2 336 0.70 183.48 209.82
94 INT48955 Gene_expression of Nos2 34 753 0.78 403.87 208.08
95 INT2651 Positive_regulation of Pomc 11 403 0.70 95.72 206.24
96 INT2391 Negative_regulation of PTGS1 27 501 0.59 207.62 205.6
97 INT9132 Negative_regulation of Prkcg 11 279 0.59 88.05 203.47
98 INT798 Positive_regulation of Gene_expression of Penk 19 394 0.70 78.53 203.07
99 INT11313 Positive_regulation of Il6 34 526 0.70 331.27 201.59
100 INT2211 Negative_regulation of Abat 8 267 0.59 66.51 200.98
101 INT50670 Gene_expression of CPOX 36 763 0.76 442.13 195.02
102 INT156 Negative_regulation of Prl 10 542 0.59 131.97 192.24
103 INT528 Gene_expression of Prl 21 693 0.78 217.18 192.2
104 INT6488 Gene_expression of Tnf 27 484 0.78 339.61 191.58
105 INT2085 Positive_regulation of LH 2 441 0.70 60.15 191.02
106 INT6354 Localization of Gabrg1 2 321 0.74 41.41 186.74
107 INT1652 Regulation of Pomc 14 387 0.62 61.01 186.51
108 INT24326 Gene_expression of Ngf 15 346 0.78 218.67 184.71
109 INT10194 Positive_regulation of IL6 17 702 0.70 600.62 183.38
110 INT4803 Transcription of Penk 21 435 0.72 59.09 182.4
111 INT3440 Negative_regulation of Localization of Abat 7 221 0.57 33.94 180.36
112 INT12602 Negative_regulation of Oprm1 10 190 0.59 36.11 177.85
113 INT49441 Negative_regulation of Cpox 17 494 0.59 303.22 177.46
114 INT7506 Negative_regulation of Ltp 2 267 0.46 91.01 176.8
115 INT1429 Gene_expression of PDYN 15 308 0.78 61.33 175.65
116 INT19472 Gene_expression of Il1 2 554 0.76 419.75 175.35
117 INT943 Negative_regulation of Cck 6 205 0.59 38.42 174.78
118 INT26472 Regulation of Oprm1 9 191 0.62 35.84 173.1
119 INT15516 Gene_expression of Crp 9 711 0.77 615.33 173.09
120 INT5930 Positive_regulation of Oprm1 10 221 0.70 31.19 172.93
121 INT159 Negative_regulation of Localization of Prl 10 416 0.59 55.34 171.8
122 INT4937 Negative_regulation of Oprd1 16 224 0.59 44.51 171.11
123 INT438 Gene_expression of Crh 8 376 0.78 159.11 169.17
124 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
125 INT739 Negative_regulation of POMC 13 358 0.59 102.28 166.77
126 INT55879 Gene_expression of CCL2 12 421 0.78 240.74 166.02
127 INT1114 Localization of Ins1 8 748 0.80 192.95 165.48
128 INT4768 Positive_regulation of OPRM1 12 212 0.70 31.09 164.28
129 INT2366 Binding of Cck 9 192 0.48 30.64 163.46
130 INT5127 Localization of Lhb 16 488 0.80 50.48 162.66
131 INT3448 Positive_regulation of Gh 25 521 0.69 180.03 161.18
132 INT5513 Negative_regulation of Pomc 5 295 0.59 60.9 158.63
133 INT51921 Gene_expression of Cpox 20 501 0.73 229.81 157.81
134 INT21185 Binding of Ptprg 27 213 0.47 13.49 157.75
135 INT66280 Gene_expression of Nos2 1 534 0.78 330.78 157.07
136 INT768 Positive_regulation of Oprl1 7 179 0.70 40.05 156.93
137 INT1303 Negative_regulation of Npr1 11 278 0.55 35.1 156.78
138 INT2640 Gene_expression of Pomc 16 424 0.78 120.72 155.37
139 INT6042 Binding of Oprm1 16 248 0.48 31.77 154.34
140 INT4740 Gene_expression of Th 22 298 0.78 61.27 154.03
141 INT2910 Regulation of Abat 3 169 0.62 36.95 153.53
142 INT1044 Negative_regulation of Localization of LH 3 358 0.59 25.95 151.31
143 INT4829 Positive_regulation of Localization of Abat 9 199 0.55 20.91 150.48
144 INT15515 Positive_regulation of Crp 14 700 0.70 604.24 150.15
145 INT49134 Gene_expression of Grin1 14 270 0.78 84.78 148.61
146 INT5050 Regulation of Localization of Calca 6 149 0.62 41.25 148.57
147 INT6108 Gene_expression of Npy 10 292 0.78 110.65 148.21
148 INT13353 Positive_regulation of Tnf 24 332 0.70 248.75 148.1
149 INT2451 Positive_regulation of Avp 16 355 0.70 102.66 147.69
150 INT1033 Positive_regulation of Ca2 8 507 0.68 131.76 147.64
151 INT9852 Positive_regulation of Gpt 22 563 0.70 364.64 146.82
152 INT5116 Gene_expression of IL2 10 670 0.78 291.13 146.69
153 INT812 Localization of INS 5 1026 0.81 515.6 145.31
154 INT425 Localization of PRL 2 455 0.81 189.64 144.8
155 INT3300 Positive_regulation of Gene_expression of Calca 1 179 0.70 77.76 144.2
156 INT2780 Regulation of Gene_expression of Penk 9 265 0.62 32.45 143.88
157 INT60694 Gene_expression of Il10 14 567 0.78 369.48 143.69
158 INT9660 Regulation of TNF 7 363 0.62 312.94 139.99
159 INT1414 Regulation of Oprl1 13 169 0.62 32.05 139.99
160 INT90910 Phosphorylation of Grin1 5 150 0.82 68.23 139.24
161 INT14843 Gene_expression of Gabrg1 2 301 0.77 62.63 139.16
162 INT1273 Gene_expression of Avp 7 356 0.78 90.56 138.7
163 INT48895 Gene_expression of Il10 14 333 0.78 221.2 138.52
164 INT2867 Gene_expression of CALCA 4 247 0.78 78.78 138.47
165 INT5061 Negative_regulation of Mme 10 306 0.59 51.97 136.9
166 INT4658 Binding of OPRM1 11 188 0.48 25.96 136.24
167 INT1047 Negative_regulation of LH 2 314 0.59 53.71 135.89
168 INT2541 Binding of Calca 6 200 0.48 67.14 134.62
169 INT60126 Regulation of Trpv1 3 186 0.62 85.53 133.4
170 INT11012 Positive_regulation of Creb1 6 258 0.70 84.4 132
171 INT48953 Positive_regulation of Nos2 17 486 0.70 239.85 131.87
172 INT5497 Positive_regulation of Crh 4 299 0.70 125.54 131.14
173 INT5380 Positive_regulation of Gene_expression of Fos 6 243 0.70 105.65 131.05
174 INT49439 Gene_expression of Cpox 13 508 0.73 326.97 130.17
175 INT5595 Positive_regulation of Pdyn 13 223 0.70 48.37 130.14
176 INT65600 Positive_regulation of Casp3 2 376 0.70 198.44 128.03
177 INT1614 Gene_expression of Oprl1 6 164 0.78 31.43 127.74
178 INT5842 Gene_expression of Gfap 3 372 0.78 153.71 127.71
179 INT1878 Binding of HLA-B 13 440 0.48 321.16 127.36
180 INT695 Binding of POMC 7 304 0.48 56.66 126.85
181 INT65054 Positive_regulation of Nfkb1 8 285 0.70 149.33 126.73
182 INT5931 Regulation of Oprm1 8 149 0.62 18.15 125.93
183 INT6822 Gene_expression of Pdyn 20 215 0.78 35.99 125.76
184 INT416 Regulation of LH 2 253 0.62 31.48 125.55
185 INT5008 Localization of Calca 1 204 0.81 80.35 125.16
186 INT6323 Positive_regulation of Gabrg1 5 213 0.70 45.08 124.34
187 INT4824 Positive_regulation of Tacr1 10 169 0.70 66.1 123.46
188 INT4259 Positive_regulation of Npr1 8 262 0.70 49.37 123.11
189 INT2106 Regulation of Localization of LH 5 279 0.62 22.37 122.77
190 INT252 Localization of GH1 4 529 0.80 227.4 122.05
191 INT6128 Positive_regulation of Localization of POMC 4 256 0.70 68.77 121.64
192 INT7533 Gene_expression of Tlr4 2 720 0.78 343.22 121.57
193 INT14151 Gene_expression of Casp3 3 311 0.78 140.26 120.68
194 INT218 Positive_regulation of Th 9 245 0.70 40.5 120.1
195 INT2555 Positive_regulation of Localization of Penk 1 116 0.70 24.35 119.73
196 INT8243 Positive_regulation of Il6 12 451 0.70 358.24 119.28
197 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 2 1138 0.72 311.58 119.18
198 INT1026 Binding of Lbp 6 207 0.48 150.96 119.16
199 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
200 INT12501 Positive_regulation of Adarb1 7 166 0.58 36.94 118.92
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