Y:2001

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2001. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2001. They are ordered first by their pain relevance and then by number of times they were reported in 2001. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2001 Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 7 0.54 5.93 32.4
2 INT10268 Binding of PDYN and POMC 11 1 0.39 0.08 10.36
3 INT26468 Ghrh Positive_regulation of Localization of Gh 21 1 0.37 3.26 9.21
4 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 6 0.10 2.91 6.54
5 INT91538 Pomc Positive_regulation of P9Ehs1 6 1 0.11 1.47 6.23
6 INT95068 Tlr4 Positive_regulation of IL1B 1 6 0.03 4.54 5.6
7 INT170447 Binding of Pax3 and Spr 1 9 0.01 0.1 5.37
8 INT14095 Binding of Vsig2 and Coq10a 2 2 0.33 1.98 4.55
9 INT30423 Penk Regulation of Localization of Ins1 4 3 0.26 0.77 4.42
10 INT95730 Binding of CP and SPINK1 2 1 0.19 5.65 4.02
11 INT18026 Binding of Oprd1 and Oprm1 4 1 0.40 0.83 3.53
12 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 3 0.02 2.15 3.12
13 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 2 0.35 13.11 3.11
14 INT170367 Binding of Grin1 and Grin2a 5 1 0.23 1.72 2.79
15 INT83169 Binding of Cck and Lep 7 2 0.42 1.58 2.78
16 INT29446 Crh Positive_regulation of Localization of POMC 8 1 0.38 1.87 2.58
17 INT69665 Binding of Oprd1 and Pnoc 5 1 0.35 0.4 2.5
18 INT96462 Pnoc Positive_regulation of Pag1 1 2 0.01 0.74 2.45
19 INT96465 Pnoc Positive_regulation of GEM 1 2 0.01 0.74 2.39
20 INT81657 Binding of CPOX and PTGS1 5 2 0.15 1.9 2.37
21 INT96461 Pnoc Positive_regulation of Oprm1 1 2 0.09 0.73 2.34
22 INT14781 Cck Regulation of Gast 3 1 0.38 0.28 2.3
23 INT96652 F2rl1 Positive_regulation of Tac1 1 4 0.47 2.62 2.25
24 INT213973 Binding of Pax3 and Mthfd1 1 3 0.00 0.16 1.99
25 INT213968 Binding of Calca and Mthfd1 1 3 0.05 0.16 1.99
26 INT83170 Lep Regulation of Cck 5 1 0.43 0.68 1.96
27 INT69556 Slc7a11 Regulation of Cpe 2 1 0.06 0.46 1.95
28 INT97208 Binding of Gabrg1 and Gabbr1 2 1 0.07 0.31 1.94
29 INT93293 Ngf Regulation of Trpv1 2 1 0.28 0.71 1.9
30 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 1 0.08 1.33 1.89
31 INT99138 Coq10a Regulation of Insrr 1 1 0.01 0.73 1.81
32 INT79365 Pnoc Negative_regulation of Oprl1 2 1 0.41 0.16 1.72
33 INT94203 SP5 Positive_regulation of FOS 1 2 0.25 1.41 1.72
34 INT94617 KNG1 Positive_regulation of Localization of Calca 1 1 0.00 0.75 1.7
35 INT94618 KNG1 Positive_regulation of Calca 1 1 0.00 0.75 1.66
36 INT100274 IL1RN Negative_regulation of IL1B 5 2 0.53 1.79 1.65
37 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 2 0.09 0.31 1.65
38 INT96296 Oprm1 Negative_regulation of Npr1 2 1 0.05 0.32 1.65
39 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 1 0.16 0.92 1.63
40 INT94033 Binding of Adarb1 and SLAMF6 1 3 0.01 0 1.61
41 INT94270 Pomc Regulation of Transcription of Crh 1 2 0.17 0.67 1.6
42 INT94271 Pomc Regulation of Avp 1 2 0.20 0.67 1.57
43 INT74843 Binding of Cacna1a and Ea2 3 1 0.13 3.29 1.55
44 INT170654 Binding of Ntf3 and Ngf 1 4 0.38 1.66 1.54
45 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 1 0.02 0.07 1.49
46 INT93782 Racgap1 Positive_regulation of Rgs9 1 1 0.55 0.07 1.49
47 INT93783 Racgap1 Positive_regulation of Gnptab 1 1 0.02 0.07 1.49
48 INT96784 Binding of CALCA and Calca 3 2 0.23 0.27 1.47
49 INT95325 HTR1B Negative_regulation of Calca 1 1 0.47 0.69 1.43
50 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 1 0.20 0.89 1.41
51 INT93388 Rbm39 Positive_regulation of Positive_regulation of Pdyn 1 1 0.03 0.32 1.4
52 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 1 0.03 0 1.39
53 INT51160 Binding of TAC1 and Tacr1 2 1 0.28 0.55 1.38
54 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 1 0.03 0.1 1.32
55 INT95093 ITIH4 Positive_regulation of IL1B 1 1 0.43 1.04 1.32
56 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 1 0.36 1.04 1.32
57 INT96707 Ntf3 Positive_regulation of Localization of SST 1 2 0.01 0 1.3
58 INT96708 Bdnf Positive_regulation of Localization of SST 1 2 0.01 0 1.3
59 INT95275 Binding of Edn1 and Ece1 1 3 0.32 2.09 1.3
60 INT95274 Regulation of Binding of Edn1 and Ece1 1 3 0.39 2.09 1.3
61 INT95457 Nka1 Positive_regulation of Tacr1 1 2 0.63 0.29 1.3
62 INT94367 Binding of ARRB1 and TP53INP2 1 2 0.25 0 1.3
63 INT95406 Trib3 Positive_regulation of Ephb1 2 1 0.08 0.96 1.29
64 INT98833 Th Regulation of Gene_expression of Drd2 1 2 0.19 0.64 1.27
65 INT99695 Binding of Tspo and Insrr 1 1 0.02 0.52 1.25
66 INT42554 Oprl1 Regulation of Npr1 2 1 0.06 0 1.22
67 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 1 0.02 0 1.21
68 INT98832 Th Regulation of Dbh 1 2 0.32 0.53 1.2
69 INT93294 Ngf Regulation of Transcription of Trpv1 1 1 0.01 0.36 1.19
70 INT94091 Binding of Pnoc and Tbce 1 2 0.03 0.19 1.19
71 INT170655 Binding of Csf2 and Ngf 1 3 0.36 1.25 1.18
72 INT93435 Binding of Casp3 and Cckbr 1 1 0.06 0.15 1.18
73 INT98908 Binding of NTRK1 and PKLR 1 2 0.41 1.95 1.18
74 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 2 0.56 1.95 1.18
75 INT93290 Ngf Regulation of Transcription of Trpv1 1 1 0.02 0.34 1.16
76 INT93289 Ngf Regulation of Trpv1 1 1 0.05 0.34 1.16
77 INT95045 Binding of Commd3 and Oprl1 1 1 0.34 0 1.16
78 INT99577 Binding of KITLG and Kit 3 1 0.34 2.33 1.11
79 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 1 0.01 0.72 1.11
80 INT57982 Il1b Positive_regulation of Crh 2 1 0.38 0.98 1.09
81 INT96906 Plxna3 Regulation of Regulation of Prkaca 1 1 0.17 0.71 1.08
82 INT96905 Plxna3 Regulation of Regulation of Prkce 1 1 0.18 0.71 1.07
83 INT69340 Binding of Igh-6 and Ngf 2 1 0.06 1.04 1.06
84 INT94205 TACR1 Regulation of Gene_expression of SP5 1 1 0.04 0.72 1.06
85 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 1 0.40 0 1.05
86 INT170653 Ngf Regulation of Csf2 1 2 0.34 1.11 1.05
87 INT97011 Binding of CALM3 and OPRM1 1 1 0.35 0 1.05
88 INT101443 Penk Positive_regulation of Localization of Gcg 1 4 0.50 1.21 1.04
89 INT95378 Binding of Jun and Jund 5 1 0.20 2.06 1.02
90 INT98555 Oprm1 Positive_regulation of Casp8 1 1 0.51 0.36 1.02
91 INT98556 Oprm1 Positive_regulation of Casp3 1 1 0.38 0.36 1.01
92 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 1 0.10 0 1
93 INT170449 Pax3 Positive_regulation of Spr 1 2 0.01 0.26 0.99
94 INT95791 Binding of SSTR1 and GRHL3 1 1 0.38 0.57 0.99
95 INT93114 Positive_regulation of Lta Positive_regulation of Gene_expression of Ltp 1 1 0.06 0.08 0.99
96 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 1 0.24 0 0.98
97 INT97721 Akr1d1 Regulation of Gene_expression of Penk 1 1 0.00 0 0.98
98 INT94206 SP5 Regulation of Gene_expression of FOS 1 1 0.22 0.7 0.98
99 INT93306 Binding of TRPV1 and CAP1 2 1 0.18 0.07 0.97
100 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 1 0.00 1.08 0.97
101 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 1 0.41 0.1 0.96
102 INT93307 CAP1 Positive_regulation of TRPV1 1 1 0.15 0.07 0.96
103 INT60868 Abat Regulation of Localization of LH 2 1 0.17 0 0.92
104 INT96260 Pik3cd Regulation of Plcg2 1 1 0.02 0 0.92
105 INT97184 Oprm1 Regulation of Gene_expression of Pomc 1 1 0.31 0 0.89
106 INT96008 Binding of KNG1 and EBP 1 1 0.01 0.15 0.88
107 INT96010 KNG1 Positive_regulation of Binding of MTG1 and 1 1 0.32 0.15 0.88
108 INT96009 KNG1 Positive_regulation of MTG1 1 1 0.32 0.15 0.88
109 INT96811 Nfkb1 Regulation of Gene_expression of IK 1 1 0.00 1.06 0.87
110 INT97738 Mdk Positive_regulation of Mapk3 1 1 0.08 0.66 0.87
111 INT97735 Trib3 Positive_regulation of Mapk3 1 1 0.05 0.66 0.87
112 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 1 0.00 0.25 0.86
113 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 1 0.03 0.25 0.86
114 INT113542 Binding of Calca and Adarb1 2 1 0.00 0.44 0.85
115 INT97913 NCOR2 Regulation of ABAT 1 1 0.00 0 0.85
116 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 4 0.54 0.5 0.85
117 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 1 0.36 0.51 0.83
118 INT94665 Nisch Negative_regulation of Maoa 1 1 0.07 0 0.83
119 INT97058 Cpz Regulation of Gene_expression of Trp53 1 1 0.27 0.57 0.83
120 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 1 0.22 0.57 0.83
121 INT94331 IFNG Positive_regulation of CXCL10 4 2 0.11 1.31 0.82
122 INT97012 Binding of CALM1 and OPRM1 1 1 0.18 0 0.82
123 INT98479 Lif Regulation of Gene_expression of Grin1 1 2 0.04 0.35 0.82
124 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 1 0.40 0 0.81
125 INT99578 Binding of CEL and Kit 1 1 0.04 1.07 0.81
126 INT98863 Penk Positive_regulation of Mpv17l 1 1 0.01 0 0.8
127 INT213972 Calca Regulation of Mthfd1 1 1 0.05 0.19 0.8
128 INT96501 Il11 Regulation of Gene_expression of NOS2 1 2 0.00 1.04 0.8
129 INT213978 Binding of TAC1 and Tac1 1 1 0.02 0.36 0.78
130 INT95458 Nka1 Positive_regulation of Positive_regulation of Tacr1 1 1 0.52 0.16 0.77
131 INT96783 Positive_regulation of Binding of CALCA and Calca 1 1 0.29 0.17 0.77
132 INT97863 Binding of NOS1 and GRHPR 1 1 0.05 0.23 0.77
133 INT99335 Binding of Agrp and Mc1r 1 1 0.30 0 0.77
134 INT96307 Binding of Pnoc and Adarb1 1 1 0.12 0.37 0.77
135 INT94816 Prkcg Positive_regulation of TACR1 1 1 0.06 0.1 0.76
136 INT170369 Binding of Car2 and Nono 1 1 0.01 0 0.76
137 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 1 0.49 0.17 0.76
138 INT98572 Binding of ABAT and CRYGS 1 1 0.01 0 0.75
139 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 1 0.05 0 0.74
140 INT170658 Binding of Ntf3 and Csf2 1 2 0.33 0.8 0.74
141 INT98179 Aap Positive_regulation of Mapk8 1 1 0.01 0.75 0.74
142 INT98771 Binding of Dll1 and Oprm1 1 1 0.29 0 0.74
143 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 1 0.14 0 0.74
144 INT101442 Penk Positive_regulation of Localization of Ins1 1 3 0.29 0.9 0.73
145 INT17623 Gnrh1 Positive_regulation of Localization of Lhb 4 2 0.72 1.46 0.71
146 INT101444 Penk Regulation of Localization of Gcg 1 3 0.45 0.77 0.71
147 INT82759 Binding of IGHG3 and OPRM1 2 1 0.06 0 0.7
148 INT171901 Binding of TNF and Il1 2 1 0.18 1.07 0.7
149 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 1 0.00 0 0.7
150 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 1 0.00 0 0.7
151 INT98957 Binding of NR5A2 and SP3 1 1 0.00 0 0.7
152 INT95148 CEL Regulation of IL1B 1 1 0.24 0.88 0.7
153 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 1 0.04 0.82 0.7
154 INT98958 Binding of NR5A2 and SP1 1 1 0.00 0 0.7
155 INT99172 Pomc Positive_regulation of Tyr 1 2 0.35 0.17 0.69
156 INT98525 Binding of Accn2 and Accn3 1 1 0.01 0.38 0.68
157 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 1 0.00 0.14 0.68
158 INT170832 Cftr Regulation of Scnn1a 2 1 0.16 1.2 0.67
159 INT94241 Binding of Cp and Slc2a2 1 1 0.13 0.81 0.67
160 INT94366 Binding of ARRB1 and OPRD1 1 1 0.11 0 0.67
161 INT61798 Binding of NDP and POMC 2 1 0.22 0 0.66
162 INT95560 Binding of Msr1 and Zfp940 1 1 0.00 0.24 0.66
163 INT92872 SON Positive_regulation of IL1RN 1 2 0.06 0.64 0.65
164 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 1 0.31 0.89 0.65
165 INT94020 Binding of EDN2 and INSRR 1 4 0.03 0 0.65
166 INT95546 KNG1 Positive_regulation of Ptgir 1 1 0.02 0.93 0.64
167 INT96496 Binding of Oprk1 and Cq1 1 1 0.01 0.27 0.64
168 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 2 0.01 1.37 0.64
169 INT96472 KNG1 Positive_regulation of Gene_expression of TRPV1 1 1 0.01 0.22 0.64
170 INT99170 Binding of Mc1r and Tyr 1 2 0.11 0.2 0.64
171 INT102316 Ugt1a6a Positive_regulation of Cyb5 1 1 0.16 0.08 0.64
172 INT99728 Binding of F13A1 and PLG 4 3 0.02 2.51 0.63
173 INT96475 Ngf Positive_regulation of Gene_expression of TRPV1 1 1 0.03 0.22 0.63
174 INT170558 Binding of Myoc and Narf 1 2 0.04 3.03 0.63
175 INT95545 Ptgir Regulation of Gene_expression of Il10 1 1 0.04 0.97 0.63
176 INT97202 Binding of APLNR and Pnoc 1 1 0.02 0.27 0.63
177 INT99602 ZNF398 Negative_regulation of MMP2 1 2 0.14 0.85 0.63
178 INT98386 GAD1 Positive_regulation of Gene_expression of Abat 1 2 0.30 1.67 0.62
179 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 2 0.28 0.26 0.62
180 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 1 0.00 0 0.62
181 INT96945 Hrh1 Negative_regulation of Spdya 1 1 0.00 0.32 0.62
182 INT96765 LBR Positive_regulation of Gene_expression of TP53INP2 1 1 0.11 0.5 0.62
183 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 1 0.00 0 0.62
184 INT95431 Il1a Regulation of Mmp2 1 1 0.48 0.25 0.61
185 INT98954 Binding of SP1 and CFHR4 1 1 0.00 0 0.61
186 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 2 0.52 0.42 0.61
187 INT93690 Bdnf Regulation of Localization of Tacr1 1 1 0.10 0.28 0.61
188 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 2 0.52 0.42 0.61
189 INT98952 Binding of SP3 and CFHR4 1 1 0.00 0 0.61
190 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 1 0.59 0.25 0.61
191 INT95436 Il1a Positive_regulation of Mmp3 1 1 0.59 0.25 0.61
192 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 1 0.42 0.23 0.61
193 INT95433 Mmp3 Regulation of Mmp2 1 1 0.17 0.24 0.6
194 INT97916 Tinag Negative_regulation of Gene_expression of Fos 1 1 0.01 0.35 0.6
195 INT96228 COX5A Regulation of Ak1 1 1 0.01 0.6 0.6
196 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 1 0.37 0.25 0.6
197 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 1 0.00 0.09 0.6
198 INT95430 Mmp9 Positive_regulation of Mmp3 1 1 0.38 0.24 0.6
199 INT96241 Il13 Negative_regulation of Tnf 1 1 0.08 0.6 0.59
200 INT95559 Msr1 Negative_regulation of Binding of Zfp940 and 1 1 0.00 0.23 0.59

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2001. They are ordered first by their pain relevance and then by number of times they were reported in 2001. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2001 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 167 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 135 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 72 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 45 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 66 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 16 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 36 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 42 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 79 1163 0.70 319.28 684
10 INT292 Localization of Penk 18 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 65 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 41 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 48 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 22 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 63 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 17 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 14 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 9 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 58 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 14 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 65 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 40 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 23 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 20 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 8 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 37 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 6 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 29 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 55 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 36 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 23 790 0.70 104.54 374.78
32 INT287 Localization of Cck 21 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 24 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 15 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 24 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 6 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 14 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 11 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 23 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 28 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 11 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 26 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 59 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 35 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 22 530 0.78 264.29 310.56
46 INT4941 Positive_regulation of Oprd1 18 345 0.70 74.26 304.41
47 INT9131 Positive_regulation of Prkcg 19 431 0.70 130.8 302.41
48 INT477 Localization of Avp 8 813 0.81 131.58 300.4
49 INT161 Regulation of Localization of Prl 14 615 0.62 65.37 298.66
50 INT63932 Positive_regulation of Ephb1 13 537 0.70 259.67 296.14
51 INT1352 Localization of Acot1 39 728 0.80 73.01 296.01
52 INT886 Gene_expression of Pomc 15 676 0.78 129.87 295.98
53 INT11624 Gene_expression of OPRM1 25 445 0.78 72.36 294.36
54 INT5379 Gene_expression of Fos 24 656 0.78 255.5 292.54
55 INT3579 Localization of Oxt 11 555 0.81 43.35 292.44
56 INT97367 Gene_expression of Nav1 6 243 0.78 132.97 286.66
57 INT9158 Gene_expression of Tnf 51 722 0.78 522.01 277.68
58 INT2365 Positive_regulation of Cck 8 354 0.70 87.8 277.41
59 INT9381 Positive_regulation of TRPV1 22 523 0.70 187.4 276.05
60 INT94450 Gene_expression of Nav1 1 359 0.78 131.85 275.46
61 INT49750 Negative_regulation of CPOX 18 735 0.58 360.06 274.19
62 INT6852 Localization of TNF 13 883 0.81 705.95 270.84
63 INT10832 Gene_expression of IL8 40 1050 0.78 698.72 270
64 INT1396 Binding of Penk 4 355 0.48 22.79 269.65
65 INT5591 Regulation of Gene_expression of Fos 18 425 0.62 129.06 265.78
66 INT9659 Gene_expression of Il6 12 991 0.78 715.11 265.57
67 INT5972 Gene_expression of IL1B 13 948 0.78 510.91 263.97
68 INT68684 Gene_expression of VEGFA 34 2371 0.78 1742.52 259.2
69 INT87687 Positive_regulation of Trpv1 5 409 0.70 210.24 257.59
70 INT1893 Localization of Gh 23 1041 0.79 340.23 256.58
71 INT16868 Gene_expression of Il6 27 807 0.78 499.48 256.57
72 INT2909 Positive_regulation of Abat 10 334 0.70 62.1 256.43
73 INT3948 Regulation of Cck 10 291 0.62 58.07 255.88
74 INT5501 Regulation of Oprd1 13 283 0.62 55.1 249.9
75 INT1005 Localization of Sst 4 385 0.81 26.31 244.56
76 INT738 Regulation of POMC 8 459 0.62 111.19 243.74
77 INT1902 Gene_expression of Cck 11 348 0.78 70.33 241.92
78 INT11377 Positive_regulation of Ngf 24 331 0.70 206.5 238
79 INT1562 Localization of Crh 7 499 0.81 126.74 236.68
80 INT5597 Gene_expression of Pdyn 23 433 0.78 62.97 235.47
81 INT1665 Positive_regulation of Pag1 17 270 0.68 186.63 229.87
82 INT4759 Negative_regulation of Localization of Calca 34 294 0.59 82.62 226.45
83 INT9987 Gene_expression of Abat 5 296 0.78 95.46 226.34
84 INT6406 Binding of Oprm1 20 280 0.48 40.54 226.26
85 INT1212 Binding of Oprl1 7 312 0.48 28.6 225.15
86 INT11009 Phosphorylation of Creb1 27 458 0.82 111.34 221.97
87 INT626 Localization of CALCA 8 289 0.81 125.39 221.15
88 INT95787 Positive_regulation of Mapk1 5 568 0.70 226.51 220.94
89 INT6665 Gene_expression of FOS 14 520 0.77 165.31 217.66
90 INT1308 Localization of Pomc 10 457 0.81 66.83 217.5
91 INT6293 Gene_expression of Oprm1 18 312 0.78 48.73 215.61
92 INT6481 Binding of TNF 10 624 0.48 510.2 214.82
93 INT767 Localization of Gnrhr 11 565 0.80 106.68 214.57
94 INT4893 Gene_expression of Tacr1 6 366 0.78 129.67 213.92
95 INT22548 Positive_regulation of Casp3 20 483 0.70 258.78 213.07
96 INT6482 Positive_regulation of Gene_expression of TNF 9 659 0.70 569.88 210
97 INT16259 Positive_regulation of Bdnf 10 336 0.70 183.48 209.82
98 INT48955 Gene_expression of Nos2 47 753 0.78 403.87 208.08
99 INT2651 Positive_regulation of Pomc 9 403 0.70 95.72 206.24
100 INT2391 Negative_regulation of PTGS1 38 501 0.59 207.62 205.6
101 INT9132 Negative_regulation of Prkcg 11 279 0.59 88.05 203.47
102 INT798 Positive_regulation of Gene_expression of Penk 30 394 0.70 78.53 203.07
103 INT11313 Positive_regulation of Il6 25 526 0.70 331.27 201.59
104 INT2211 Negative_regulation of Abat 12 267 0.59 66.51 200.98
105 INT50670 Gene_expression of CPOX 38 763 0.76 442.13 195.02
106 INT156 Negative_regulation of Prl 13 542 0.59 131.97 192.24
107 INT528 Gene_expression of Prl 9 693 0.78 217.18 192.2
108 INT6488 Gene_expression of Tnf 5 484 0.78 339.61 191.58
109 INT2085 Positive_regulation of LH 2 441 0.70 60.15 191.02
110 INT63934 Phosphorylation of Ephb1 4 377 0.82 150.52 188.66
111 INT6354 Localization of Gabrg1 9 321 0.74 41.41 186.74
112 INT94952 Positive_regulation of Mapk14 8 305 0.70 197.83 186.61
113 INT1652 Regulation of Pomc 8 387 0.62 61.01 186.51
114 INT24326 Gene_expression of Ngf 14 346 0.78 218.67 184.71
115 INT10194 Positive_regulation of IL6 12 702 0.70 600.62 183.38
116 INT4803 Transcription of Penk 18 435 0.72 59.09 182.4
117 INT3440 Negative_regulation of Localization of Abat 8 221 0.57 33.94 180.36
118 INT12602 Negative_regulation of Oprm1 19 190 0.59 36.11 177.85
119 INT49441 Negative_regulation of Cpox 26 494 0.59 303.22 177.46
120 INT7506 Negative_regulation of Ltp 8 267 0.46 91.01 176.8
121 INT1429 Gene_expression of PDYN 6 308 0.78 61.33 175.65
122 INT19472 Gene_expression of Il1 24 554 0.76 419.75 175.35
123 INT943 Negative_regulation of Cck 4 205 0.59 38.42 174.78
124 INT26472 Regulation of Oprm1 10 191 0.62 35.84 173.1
125 INT15516 Gene_expression of Crp 17 711 0.77 615.33 173.09
126 INT5930 Positive_regulation of Oprm1 15 221 0.70 31.19 172.93
127 INT159 Negative_regulation of Localization of Prl 8 416 0.59 55.34 171.8
128 INT4937 Negative_regulation of Oprd1 6 224 0.59 44.51 171.11
129 INT438 Gene_expression of Crh 5 376 0.78 159.11 169.17
130 INT867 Gene_expression of IFNA1 11 930 0.78 594.85 168.03
131 INT739 Negative_regulation of POMC 5 358 0.59 102.28 166.77
132 INT55879 Gene_expression of CCL2 8 421 0.78 240.74 166.02
133 INT1114 Localization of Ins1 25 748 0.80 192.95 165.48
134 INT4768 Positive_regulation of OPRM1 6 212 0.70 31.09 164.28
135 INT2366 Binding of Cck 8 192 0.48 30.64 163.46
136 INT5127 Localization of Lhb 14 488 0.80 50.48 162.66
137 INT3448 Positive_regulation of Gh 13 521 0.69 180.03 161.18
138 INT5513 Negative_regulation of Pomc 6 295 0.59 60.9 158.63
139 INT51921 Gene_expression of Cpox 25 501 0.73 229.81 157.81
140 INT21185 Binding of Ptprg 7 213 0.47 13.49 157.75
141 INT66280 Gene_expression of Nos2 7 534 0.78 330.78 157.07
142 INT768 Positive_regulation of Oprl1 7 179 0.70 40.05 156.93
143 INT1303 Negative_regulation of Npr1 13 278 0.55 35.1 156.78
144 INT2640 Gene_expression of Pomc 12 424 0.78 120.72 155.37
145 INT6042 Binding of Oprm1 17 248 0.48 31.77 154.34
146 INT4740 Gene_expression of Th 9 298 0.78 61.27 154.03
147 INT2910 Regulation of Abat 15 169 0.62 36.95 153.53
148 INT1044 Negative_regulation of Localization of LH 2 358 0.59 25.95 151.31
149 INT120811 Gene_expression of Gopc 24 1174 0.59 428.49 150.55
150 INT4829 Positive_regulation of Localization of Abat 5 199 0.55 20.91 150.48
151 INT880 Positive_regulation of Localization of Gh1 3 304 0.70 14.79 150.23
152 INT15515 Positive_regulation of Crp 32 700 0.70 604.24 150.15
153 INT49134 Gene_expression of Grin1 11 270 0.78 84.78 148.61
154 INT5050 Regulation of Localization of Calca 10 149 0.62 41.25 148.57
155 INT6108 Gene_expression of Npy 10 292 0.78 110.65 148.21
156 INT13353 Positive_regulation of Tnf 19 332 0.70 248.75 148.1
157 INT7628 Gene_expression of Ltp 3 273 0.77 70.21 147.87
158 INT2451 Positive_regulation of Avp 11 355 0.70 102.66 147.69
159 INT1033 Positive_regulation of Ca2 5 507 0.68 131.76 147.64
160 INT9852 Positive_regulation of Gpt 8 563 0.70 364.64 146.82
161 INT5116 Gene_expression of IL2 13 670 0.78 291.13 146.69
162 INT812 Localization of INS 6 1026 0.81 515.6 145.31
163 INT425 Localization of PRL 1 455 0.81 189.64 144.8
164 INT2379 Positive_regulation of Localization of LH 5 349 0.70 27.86 144.53
165 INT3300 Positive_regulation of Gene_expression of Calca 2 179 0.70 77.76 144.2
166 INT2780 Regulation of Gene_expression of Penk 12 265 0.62 32.45 143.88
167 INT60694 Gene_expression of Il10 4 567 0.78 369.48 143.69
168 INT9660 Regulation of TNF 9 363 0.62 312.94 139.99
169 INT1414 Regulation of Oprl1 5 169 0.62 32.05 139.99
170 INT14843 Gene_expression of Gabrg1 18 301 0.77 62.63 139.16
171 INT1273 Gene_expression of Avp 10 356 0.78 90.56 138.7
172 INT48895 Gene_expression of Il10 18 333 0.78 221.2 138.52
173 INT2867 Gene_expression of CALCA 4 247 0.78 78.78 138.47
174 INT5061 Negative_regulation of Mme 13 306 0.59 51.97 136.9
175 INT4658 Binding of OPRM1 5 188 0.48 25.96 136.24
176 INT1047 Negative_regulation of LH 1 314 0.59 53.71 135.89
177 INT2541 Binding of Calca 3 200 0.48 67.14 134.62
178 INT60126 Regulation of Trpv1 9 186 0.62 85.53 133.4
179 INT11012 Positive_regulation of Creb1 10 258 0.70 84.4 132
180 INT48953 Positive_regulation of Nos2 40 486 0.70 239.85 131.87
181 INT5497 Positive_regulation of Crh 16 299 0.70 125.54 131.14
182 INT5380 Positive_regulation of Gene_expression of Fos 11 243 0.70 105.65 131.05
183 INT49439 Gene_expression of Cpox 28 508 0.73 326.97 130.17
184 INT5595 Positive_regulation of Pdyn 7 223 0.70 48.37 130.14
185 INT64161 Positive_regulation of Prkca 4 213 0.70 85.06 129.91
186 INT65600 Positive_regulation of Casp3 10 376 0.70 198.44 128.03
187 INT1614 Gene_expression of Oprl1 7 164 0.78 31.43 127.74
188 INT5842 Gene_expression of Gfap 4 372 0.78 153.71 127.71
189 INT1878 Binding of HLA-B 11 440 0.48 321.16 127.36
190 INT695 Binding of POMC 8 304 0.48 56.66 126.85
191 INT65054 Positive_regulation of Nfkb1 16 285 0.70 149.33 126.73
192 INT5931 Regulation of Oprm1 11 149 0.62 18.15 125.93
193 INT6822 Gene_expression of Pdyn 5 215 0.78 35.99 125.76
194 INT416 Regulation of LH 3 253 0.62 31.48 125.55
195 INT5008 Localization of Calca 11 204 0.81 80.35 125.16
196 INT6323 Positive_regulation of Gabrg1 8 213 0.70 45.08 124.34
197 INT4824 Positive_regulation of Tacr1 14 169 0.70 66.1 123.46
198 INT4259 Positive_regulation of Npr1 6 262 0.70 49.37 123.11
199 INT2106 Regulation of Localization of LH 3 279 0.62 22.37 122.77
200 INT252 Localization of GH1 12 529 0.80 227.4 122.05
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