Y:2003

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2003. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2003. They are ordered first by their pain relevance and then by number of times they were reported in 2003. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2003 Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 2 0.54 5.93 32.4
2 INT69872 Binding of MC1R and POMC 52 2 0.54 8.87 18.3
3 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 3 0.73 0.87 14.34
4 INT51205 Binding of OPRK1 and PDYN 7 1 0.00 2.01 7.8
5 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
6 INT155484 Binding of CD86 and CTLA4 15 1 0.52 8.85 6.09
7 INT15842 Crh Positive_regulation of Localization of Pomc 15 1 0.73 5 5.05
8 INT102122 Binding of Calca and RT1-M4 7 2 0.29 5.83 4.94
9 INT34444 Binding of Oprl1 and Ptprg 4 2 0.03 0.18 4.58
10 INT111758 Binding of Drd2 and Insrr 1 3 0.01 0.94 4.33
11 INT113223 POMC Regulation of MC1R 6 1 0.68 0.39 4.24
12 INT32911 Binding of Insrr and Rbm39 2 4 0.00 0 3.95
13 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 1 0.76 1 3.9
14 INT61359 TNF Positive_regulation of NFKB1 11 1 0.63 6.66 3.89
15 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 1 0.27 0.43 3.88
16 INT107331 Binding of PPBP and Adarb1 1 3 0.01 0 3.67
17 INT108473 Binding of ADCYAP1 and PNOC 1 3 0.32 0.64 3.41
18 INT73071 Binding of Cpe and Insrr 3 1 0.01 0.33 3.38
19 INT56458 Binding of GPM6A and IGHG3 4 3 0.02 0 3.31
20 INT108472 Binding of NOS1 and PNOC 1 3 0.32 0.64 3.27
21 INT108471 Binding of CALCA and PNOC 1 3 0.29 0.64 3.25
22 INT108810 Esr1 Positive_regulation of Binding of Oprm1 and 1 4 0.51 1.79 3.22
23 INT64719 IL1B Positive_regulation of IL6 7 2 0.41 6.84 3.14
24 INT113234 Binding of Pax3 and Tacr1 3 2 0.12 1.54 2.93
25 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 2 0.02 0.64 2.89
26 INT107723 POMC Positive_regulation of MC1R 7 2 0.68 0.71 2.82
27 INT175329 Binding of ICAM1 and ITGAL 14 2 0.18 10.06 2.81
28 INT83169 Binding of Cck and Lep 7 2 0.42 1.58 2.78
29 INT29446 Crh Positive_regulation of Localization of POMC 8 2 0.38 1.87 2.58
30 INT111787 Cck Regulation of Gene_expression of Npr1 1 3 0.22 1.68 2.57
31 INT111789 Cck Regulation of Gene_expression of Penk 1 3 0.49 1.68 2.57
32 INT111786 Penk Regulation of Gene_expression of Cck 1 3 0.49 1.66 2.55
33 INT107812 Nppa Positive_regulation of Localization of Sst 1 4 0.48 0.54 2.51
34 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 2 0.13 1.64 2.5
35 INT113714 Em Positive_regulation of tf 1 1 0.32 0 2.5
36 INT113715 Msh3 Positive_regulation of tf 1 1 0.11 0 2.47
37 INT115367 Binding of IL6 and IL6R 12 1 0.07 8.16 2.36
38 INT107578 Kitl Negative_regulation of Grin2b 1 4 0.12 2.05 2.36
39 INT107165 Binding of Gabrg1 and Trpv1 2 2 0.01 0.16 2.34
40 INT108987 Ngf Regulation of Gene_expression of Sit1 1 2 0.00 1.46 2.32
41 INT114432 Oprl1 Positive_regulation of Akt1 1 1 0.18 0.08 2.2
42 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 2 0.07 1.35 2.18
43 INT113452 Ngf Positive_regulation of Gene_expression of ASIC3 1 2 0.19 1.34 2.08
44 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 3 0.17 0.28 2.07
45 INT114923 Binding of Oprm1 and Creb1 1 3 0.16 0.28 2.06
46 INT115042 Gdnf Regulation of Calca 1 1 0.53 0.25 2.03
47 INT110525 Binding of MC1R and OCA2 1 3 0.41 1.08 1.97
48 INT83170 Lep Regulation of Cck 5 1 0.43 0.68 1.96
49 INT107738 Binding of Pld2 and Oprm1 1 5 0.23 0 1.93
50 INT113550 Binding of FN1 and VTN 6 5 0.30 5.24 1.91
51 INT112514 Binding of Prkaca and Trib3 1 3 0.03 1.18 1.9
52 INT113572 Binding of DMRT1 and OPRM1 1 4 0.01 0 1.9
53 INT205152 Binding of CD44 and MMP9 23 2 0.35 17.13 1.85
54 INT112517 Binding of Ephb1 and Prkaca 3 1 0.18 0.58 1.85
55 INT267133 Binding of ICAM1 and VCAM1 25 24 0.32 25.43 1.83
56 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 1 0.03 0.28 1.8
57 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 1 0.27 0.71 1.78
58 INT175986 Ros1 Positive_regulation of Gtf3a 2 1 0.01 4.75 1.71
59 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 2 0.21 0.39 1.71
60 INT108385 Binding of Crygs and Ntrk1 1 2 0.01 0 1.67
61 INT109525 Binding of DMRT1 and Oprm1 1 2 0.08 0 1.62
62 INT174503 Binding of HLA-B and KIR3DL1 6 1 0.37 3.48 1.61
63 INT86637 POMC Regulation of Gene_expression of KRT16 2 1 0.47 1.22 1.61
64 INT18592 Sst Regulation of Localization of Acot1 2 1 0.22 0 1.61
65 INT109739 Binding of ITPA and Pcyt1b 1 2 0.16 0.72 1.6
66 INT111076 Psen1 Regulation of Psenen 1 2 0.17 0.76 1.58
67 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 2 0.52 0.27 1.57
68 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 2 0.13 0.23 1.56
69 INT74937 IL1B Positive_regulation of CPOX 5 2 0.18 1.13 1.55
70 INT111892 Ptger2 Regulation of Ptger1 1 2 0.08 2.09 1.55
71 INT113337 EPO Positive_regulation of JAK2 1 2 0.76 2.8 1.55
72 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 2 0.17 3.36 1.53
73 INT174508 Binding of CD4 and HLA-B 1 4 0.14 4.68 1.53
74 INT111828 UPB1 Positive_regulation of Oprm1 1 1 0.00 0.85 1.53
75 INT174450 Positive_regulation of Binding of Cxcr3 and Smcp 1 2 0.18 2.83 1.49
76 INT112033 Gabrb3 Positive_regulation of Plcg1 1 1 0.05 0.18 1.49
77 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 1 0.08 0.18 1.48
78 INT59547 Avp Positive_regulation of Crh 2 2 0.14 1.13 1.47
79 INT107813 Sst Negative_regulation of Localization of Nppa 1 2 0.44 0.2 1.46
80 INT109958 Binding of CRH and HPSE 1 2 0.10 0.72 1.46
81 INT111760 Dio1 Positive_regulation of Binding of Cpe and 1 1 0.04 0.34 1.44
82 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 1 0.01 0.33 1.43
83 INT111756 Dio1 Positive_regulation of Cpe 1 1 0.04 0.34 1.42
84 INT111759 Binding of Cpe and Drd2 1 1 0.01 0.32 1.42
85 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 1 0.02 0.33 1.42
86 INT108583 Binding of Vip and Fos 1 2 0.36 0 1.39
87 INT108727 Binding of ATP1A2 and CACNA1A 2 1 0.34 1.97 1.37
88 INT117871 Sct Positive_regulation of Pes1 1 2 0.10 0 1.36
89 INT91305 Binding of Npff and Npffr2 2 3 0.31 0.64 1.32
90 INT107858 PRSS1 Positive_regulation of F2RL1 6 2 0.12 4.23 1.29
91 INT112097 Sstr1 Positive_regulation of Adarb1 1 1 0.02 0.15 1.29
92 INT108386 IL1B Positive_regulation of MMP1 3 2 0.27 1.56 1.28
93 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 1 0.39 0.83 1.28
94 INT115985 Cpe Positive_regulation of Binding of Gnas and 1 1 0.00 0.17 1.28
95 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 2 0.06 0.14 1.28
96 INT112961 NGF Positive_regulation of ICAM1 1 1 0.40 0.96 1.28
97 INT113844 CDKN1A Negative_regulation of CDK2 4 2 0.49 1.18 1.27
98 INT114925 Binding of Oprm1 and Crebbp 1 2 0.06 0.14 1.27
99 INT111211 Binding of Drd4 and Chdh 1 1 0.01 1.34 1.26
100 INT114635 Hmox2 Positive_regulation of Gene_expression of Fos 1 1 0.47 0.88 1.26
101 INT110542 SIGMAR1 Regulation of OPRM1 1 1 0.04 0.33 1.25
102 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 1 0.04 0.33 1.25
103 INT108389 IL1B Positive_regulation of ADAMTS4 1 2 0.51 1.19 1.24
104 INT63864 Oprd1 Regulation of Localization of Prl 2 1 0.16 0 1.23
105 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 1 0.38 0 1.21
106 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 1 0.40 0.89 1.2
107 INT108469 Tacr1 Regulation of Transcription of Drd2 1 1 0.07 0.14 1.2
108 INT113242 TNF Regulation of Transcription of OPRM1 2 1 0.45 1.53 1.19
109 INT109380 Binding of Adarb1 and Fos 1 1 0.02 0.38 1.19
110 INT107579 Kitl Negative_regulation of Grin2a 1 2 0.10 1.02 1.18
111 INT43509 Avp Positive_regulation of Localization of POMC 2 2 0.13 1.26 1.16
112 INT111221 MMEL1 Negative_regulation of HMOX1 1 1 0.01 1 1.16
113 INT107029 Cpox Regulation of Pag1 1 2 0.01 1.24 1.15
114 INT110671 Binding of Cnr1 and Alox5 1 2 0.07 0.2 1.13
115 INT110669 Binding of Alox5 and Trpv1 1 2 0.07 0.2 1.13
116 INT102570 Abat Regulation of Gene_expression of Penk 3 1 0.13 0 1.12
117 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 1 0.03 0.14 1.12
118 INT110522 Oprm1 Positive_regulation of Oprk1 1 1 0.11 0 1.12
119 INT112608 DNAJC15 Regulation of Gene_expression of Fos 1 1 0.02 0.14 1.12
120 INT108409 AGT Positive_regulation of AGTR2 2 1 0.31 1.49 1.11
121 INT109374 Ppp1cc Negative_regulation of Ppp2r1a 1 1 0.24 0 1.11
122 INT173059 Binding of KDR and VEGFA 43 6 0.43 29.63 1.1
123 INT113540 Binding of OPRM1 and Tac1 1 2 0.04 0.1 1.1
124 INT108546 BCL2L10 Regulation of MAPKAPK5 1 1 0.03 1.22 1.1
125 INT81788 Binding of AGRP and MC4R 4 7 0.51 0 1.09
126 INT76396 Il10 Negative_regulation of Il1b 2 2 0.65 1.89 1.08
127 INT108547 AKT1 Regulation of MAPKAPK5 1 1 0.04 1.2 1.08
128 INT71176 Binding of ICAM1 and ITGB2 4 2 0.21 4.93 1.07
129 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 1 0.42 1.09 1.07
130 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 1 0.05 1.85 1.06
131 INT108413 Binding of OPRK1 and Oprd1 1 1 0.00 0.08 1.04
132 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 2 0.26 1 1.04
133 INT65986 IL1B Positive_regulation of PTGS2 3 1 0.32 2.05 1.03
134 INT114555 Binding of Calca and St3gal3 1 1 0.01 0.44 1.03
135 INT114553 Binding of Trpv1 and Col4a4 1 1 0.01 0.44 1.03
136 INT114554 Binding of St3gal3 and Trpv1 1 1 0.01 0.44 1.03
137 INT175553 Binding of CASR and CP 1 1 0.11 1.65 1.03
138 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 1 0.11 1.13 1.02
139 INT174468 IL7 Positive_regulation of Gene_expression of IL4 1 4 0.40 1.88 1.02
140 INT114552 Binding of Calca and Col4a4 1 1 0.01 0.44 1.02
141 INT174910 Binding of LBP and IFIH1 1 1 0.04 1.01 1.01
142 INT113453 Ngf Positive_regulation of JUN 1 1 0.27 0.6 1.01
143 INT174451 Trav6-3 Regulation of Transcription of Cxcr3 1 1 0.06 1.86 1
144 INT112163 Calca Positive_regulation of Mpo 1 1 0.49 1.23 1
145 INT71319 Binding of Penk and Fos 3 1 0.40 0.15 0.99
146 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 2 0.12 1.07 0.99
147 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 2 0.05 0 0.99
148 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 1 0.05 0.9 0.98
149 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 2 0.07 1.73 0.97
150 INT81127 Binding of Gabrd and Abat 3 1 0.25 0 0.96
151 INT115049 Crem Regulation of Gene_expression of Pdyn 1 1 0.20 0.32 0.96
152 INT111504 Pnoc Positive_regulation of Binding of Ptprg and 1 2 0.01 0 0.96
153 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 1 0.03 0 0.96
154 INT108729 Binding of CACNA1A and Cacna1a 3 1 0.13 1.21 0.95
155 INT107951 Pax3 Positive_regulation of Tac1 1 2 0.11 1.21 0.95
156 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 1 0.02 0 0.93
157 INT114883 Akt1 Regulation of Pik3r1 2 1 0.16 0.65 0.92
158 INT112765 Binding of Nfkb1 and Bcl2 1 2 0.00 1.37 0.91
159 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 1 0.13 1.31 0.91
160 INT111924 Cpb2 Negative_regulation of Positive_regulation of Plg 1 2 0.02 1.29 0.9
161 INT113946 Binding of FLNA and OPRM1 1 3 0.10 0.37 0.9
162 INT108647 Binding of Grin2a and Camk1d 1 1 0.33 0.78 0.9
163 INT108438 Grin2b Regulation of Pdyn 1 1 0.16 0.25 0.9
164 INT112642 Positive_regulation of Kcnma1 Positive_regulation of Nav1 1 1 0.02 0 0.89
165 INT113383 Negative_regulation of Sert1 Positive_regulation of Prkcg 1 1 0.31 0 0.89
166 INT109103 MMP2 Positive_regulation of INS 1 2 0.33 1.07 0.89
167 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 2 0.50 1.28 0.88
168 INT108686 Nfkb1 Regulation of Nos2 1 2 0.69 1.27 0.88
169 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 1 0.22 0.13 0.86
170 INT111790 Penk Regulation of Gene_expression of Npr1 1 1 0.22 0.56 0.86
171 INT114546 Ins1 Positive_regulation of Positive_regulation of Trpv1 1 2 0.39 0.19 0.86
172 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 1 0.02 0.05 0.85
173 INT114323 Binding of ADCY6 and RAF1 1 1 0.02 0.05 0.85
174 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 2 0.13 0.26 0.84
175 INT113237 Il10 Negative_regulation of Gene_expression of Tacr1 1 1 0.35 0.81 0.84
176 INT174509 Binding of CD4 and CD28 1 2 0.26 1.68 0.84
177 INT110236 Hk1 Regulation of CSAD 1 2 0.01 1.57 0.84
178 INT113972 Regulation of Binding of Oprd1 and Smu1 1 1 0.00 0.45 0.84
179 INT113971 Binding of Oprd1 and Smu1 1 1 0.00 0.45 0.84
180 INT108128 GDNF Regulation of Localization of GRHL3 1 1 0.24 0.18 0.83
181 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 1 0.11 0 0.83
182 INT113250 Olr1259 Negative_regulation of Ache 1 4 0.01 0.38 0.83
183 INT102201 Tnf Regulation of Il1b 3 1 0.39 2.57 0.82
184 INT108072 Grip2 Positive_regulation of Gene_expression of Fos 1 1 0.08 0.21 0.82
185 INT113240 Il12a Regulation of Transcription of Tacr1 1 1 0.21 0.79 0.82
186 INT114844 Lgals1 Positive_regulation of TACR1 1 1 0.16 0.95 0.82
187 INT110118 A630055G03Rik Regulation of Car2 1 1 0.01 0.35 0.81
188 INT112842 Positive_regulation of Binding of Pdyn and Oprd1 1 2 0.00 0 0.81
189 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 1 0.28 0.82 0.81
190 INT110726 Binding of ALB and LTF 1 2 0.01 0 0.81
191 INT113239 Il10 Regulation of Transcription of Tacr1 1 1 0.45 0.79 0.81
192 INT112841 Binding of Pdyn and Oprd1 1 2 0.00 0 0.81
193 INT111744 Negative_regulation of Pcsk2 Positive_regulation of Sst 1 1 0.07 0 0.8
194 INT111745 Negative_regulation of Pcsk2 Positive_regulation of Npy 1 1 0.43 0 0.8
195 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 1 0.06 0 0.8
196 INT109142 Calca Positive_regulation of Transcription of Creb1 1 1 0.47 0.13 0.8
197 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 5 0.49 6.72 0.8
198 INT111746 Negative_regulation of Pcsk2 Positive_regulation of Gene_expression of Sst 1 1 0.07 0 0.8
199 INT114924 Creb1 Regulation of Positive_regulation of Oprm1 1 1 0.09 0.13 0.79
200 INT113238 Il12a Positive_regulation of Transcription of Tacr1 1 1 0.38 0.78 0.79

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2003. They are ordered first by their pain relevance and then by number of times they were reported in 2003. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2003 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 202 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 99 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 64 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 32 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 56 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 27 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 61 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 18 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 84 1163 0.70 319.28 684
10 INT292 Localization of Penk 9 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 77 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 31 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 49 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 18 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 20 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 12 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 17 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 21 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 82 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 55 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 34 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 43 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 50 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 26 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 8 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 49 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 29 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 19 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 44 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 64 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 9 790 0.70 104.54 374.78
32 INT287 Localization of Cck 7 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 15 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 31 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 15 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 1 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 22 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 22 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 18 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 27 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 7 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 19 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 49 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 47 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 25 530 0.78 264.29 310.56
46 INT46460 Gene_expression of NAV1 15 288 0.78 135.51 305.75
47 INT4941 Positive_regulation of Oprd1 18 345 0.70 74.26 304.41
48 INT9131 Positive_regulation of Prkcg 25 431 0.70 130.8 302.41
49 INT477 Localization of Avp 26 813 0.81 131.58 300.4
50 INT161 Regulation of Localization of Prl 9 615 0.62 65.37 298.66
51 INT63932 Positive_regulation of Ephb1 4 537 0.70 259.67 296.14
52 INT1352 Localization of Acot1 35 728 0.80 73.01 296.01
53 INT886 Gene_expression of Pomc 32 676 0.78 129.87 295.98
54 INT11624 Gene_expression of OPRM1 66 445 0.78 72.36 294.36
55 INT5379 Gene_expression of Fos 25 656 0.78 255.5 292.54
56 INT3579 Localization of Oxt 9 555 0.81 43.35 292.44
57 INT97367 Gene_expression of Nav1 4 243 0.78 132.97 286.66
58 INT9158 Gene_expression of Tnf 25 722 0.78 522.01 277.68
59 INT2365 Positive_regulation of Cck 18 354 0.70 87.8 277.41
60 INT9381 Positive_regulation of TRPV1 27 523 0.70 187.4 276.05
61 INT94450 Gene_expression of Nav1 34 359 0.78 131.85 275.46
62 INT49750 Negative_regulation of CPOX 39 735 0.58 360.06 274.19
63 INT6852 Localization of TNF 34 883 0.81 705.95 270.84
64 INT10832 Gene_expression of IL8 24 1050 0.78 698.72 270
65 INT1396 Binding of Penk 6 355 0.48 22.79 269.65
66 INT5591 Regulation of Gene_expression of Fos 36 425 0.62 129.06 265.78
67 INT9659 Gene_expression of Il6 18 991 0.78 715.11 265.57
68 INT5972 Gene_expression of IL1B 35 948 0.78 510.91 263.97
69 INT68684 Gene_expression of VEGFA 133 2371 0.78 1742.52 259.2
70 INT87687 Positive_regulation of Trpv1 17 409 0.70 210.24 257.59
71 INT1893 Localization of Gh 24 1041 0.79 340.23 256.58
72 INT16868 Gene_expression of Il6 25 807 0.78 499.48 256.57
73 INT2909 Positive_regulation of Abat 12 334 0.70 62.1 256.43
74 INT3948 Regulation of Cck 8 291 0.62 58.07 255.88
75 INT5501 Regulation of Oprd1 12 283 0.62 55.1 249.9
76 INT1005 Localization of Sst 20 385 0.81 26.31 244.56
77 INT738 Regulation of POMC 11 459 0.62 111.19 243.74
78 INT1902 Gene_expression of Cck 20 348 0.78 70.33 241.92
79 INT11377 Positive_regulation of Ngf 13 331 0.70 206.5 238
80 INT1562 Localization of Crh 26 499 0.81 126.74 236.68
81 INT5597 Gene_expression of Pdyn 17 433 0.78 62.97 235.47
82 INT1665 Positive_regulation of Pag1 10 270 0.68 186.63 229.87
83 INT4759 Negative_regulation of Localization of Calca 15 294 0.59 82.62 226.45
84 INT9987 Gene_expression of Abat 14 296 0.78 95.46 226.34
85 INT6406 Binding of Oprm1 13 280 0.48 40.54 226.26
86 INT1212 Binding of Oprl1 8 312 0.48 28.6 225.15
87 INT11009 Phosphorylation of Creb1 41 458 0.82 111.34 221.97
88 INT626 Localization of CALCA 8 289 0.81 125.39 221.15
89 INT95787 Positive_regulation of Mapk1 8 568 0.70 226.51 220.94
90 INT6665 Gene_expression of FOS 18 520 0.77 165.31 217.66
91 INT1308 Localization of Pomc 12 457 0.81 66.83 217.5
92 INT6293 Gene_expression of Oprm1 14 312 0.78 48.73 215.61
93 INT6481 Binding of TNF 9 624 0.48 510.2 214.82
94 INT767 Localization of Gnrhr 10 565 0.80 106.68 214.57
95 INT4893 Gene_expression of Tacr1 16 366 0.78 129.67 213.92
96 INT22548 Positive_regulation of Casp3 13 483 0.70 258.78 213.07
97 INT6482 Positive_regulation of Gene_expression of TNF 21 659 0.70 569.88 210
98 INT16259 Positive_regulation of Bdnf 11 336 0.70 183.48 209.82
99 INT48955 Gene_expression of Nos2 30 753 0.78 403.87 208.08
100 INT2651 Positive_regulation of Pomc 10 403 0.70 95.72 206.24
101 INT2391 Negative_regulation of PTGS1 18 501 0.59 207.62 205.6
102 INT9132 Negative_regulation of Prkcg 16 279 0.59 88.05 203.47
103 INT798 Positive_regulation of Gene_expression of Penk 31 394 0.70 78.53 203.07
104 INT11313 Positive_regulation of Il6 20 526 0.70 331.27 201.59
105 INT2211 Negative_regulation of Abat 15 267 0.59 66.51 200.98
106 INT50670 Gene_expression of CPOX 26 763 0.76 442.13 195.02
107 INT156 Negative_regulation of Prl 12 542 0.59 131.97 192.24
108 INT528 Gene_expression of Prl 6 693 0.78 217.18 192.2
109 INT6488 Gene_expression of Tnf 26 484 0.78 339.61 191.58
110 INT2085 Positive_regulation of LH 7 441 0.70 60.15 191.02
111 INT63934 Phosphorylation of Ephb1 11 377 0.82 150.52 188.66
112 INT6354 Localization of Gabrg1 2 321 0.74 41.41 186.74
113 INT94952 Positive_regulation of Mapk14 17 305 0.70 197.83 186.61
114 INT1652 Regulation of Pomc 15 387 0.62 61.01 186.51
115 INT24326 Gene_expression of Ngf 11 346 0.78 218.67 184.71
116 INT10194 Positive_regulation of IL6 29 702 0.70 600.62 183.38
117 INT4803 Transcription of Penk 20 435 0.72 59.09 182.4
118 INT3440 Negative_regulation of Localization of Abat 5 221 0.57 33.94 180.36
119 INT12602 Negative_regulation of Oprm1 13 190 0.59 36.11 177.85
120 INT49441 Negative_regulation of Cpox 39 494 0.59 303.22 177.46
121 INT7506 Negative_regulation of Ltp 3 267 0.46 91.01 176.8
122 INT1429 Gene_expression of PDYN 3 308 0.78 61.33 175.65
123 INT19472 Gene_expression of Il1 6 554 0.76 419.75 175.35
124 INT943 Negative_regulation of Cck 4 205 0.59 38.42 174.78
125 INT26472 Regulation of Oprm1 21 191 0.62 35.84 173.1
126 INT15516 Gene_expression of Crp 14 711 0.77 615.33 173.09
127 INT5930 Positive_regulation of Oprm1 13 221 0.70 31.19 172.93
128 INT159 Negative_regulation of Localization of Prl 3 416 0.59 55.34 171.8
129 INT4937 Negative_regulation of Oprd1 12 224 0.59 44.51 171.11
130 INT438 Gene_expression of Crh 27 376 0.78 159.11 169.17
131 INT867 Gene_expression of IFNA1 17 930 0.78 594.85 168.03
132 INT739 Negative_regulation of POMC 9 358 0.59 102.28 166.77
133 INT55879 Gene_expression of CCL2 22 421 0.78 240.74 166.02
134 INT1114 Localization of Ins1 28 748 0.80 192.95 165.48
135 INT4768 Positive_regulation of OPRM1 22 212 0.70 31.09 164.28
136 INT2366 Binding of Cck 7 192 0.48 30.64 163.46
137 INT5127 Localization of Lhb 2 488 0.80 50.48 162.66
138 INT3448 Positive_regulation of Gh 4 521 0.69 180.03 161.18
139 INT5513 Negative_regulation of Pomc 8 295 0.59 60.9 158.63
140 INT51921 Gene_expression of Cpox 37 501 0.73 229.81 157.81
141 INT21185 Binding of Ptprg 11 213 0.47 13.49 157.75
142 INT66280 Gene_expression of Nos2 13 534 0.78 330.78 157.07
143 INT768 Positive_regulation of Oprl1 2 179 0.70 40.05 156.93
144 INT1303 Negative_regulation of Npr1 4 278 0.55 35.1 156.78
145 INT2640 Gene_expression of Pomc 22 424 0.78 120.72 155.37
146 INT6042 Binding of Oprm1 14 248 0.48 31.77 154.34
147 INT4740 Gene_expression of Th 21 298 0.78 61.27 154.03
148 INT2910 Regulation of Abat 13 169 0.62 36.95 153.53
149 INT1044 Negative_regulation of Localization of LH 6 358 0.59 25.95 151.31
150 INT120811 Gene_expression of Gopc 16 1174 0.59 428.49 150.55
151 INT4829 Positive_regulation of Localization of Abat 3 199 0.55 20.91 150.48
152 INT15515 Positive_regulation of Crp 35 700 0.70 604.24 150.15
153 INT49134 Gene_expression of Grin1 14 270 0.78 84.78 148.61
154 INT5050 Regulation of Localization of Calca 18 149 0.62 41.25 148.57
155 INT6108 Gene_expression of Npy 10 292 0.78 110.65 148.21
156 INT13353 Positive_regulation of Tnf 10 332 0.70 248.75 148.1
157 INT7628 Gene_expression of Ltp 1 273 0.77 70.21 147.87
158 INT2451 Positive_regulation of Avp 20 355 0.70 102.66 147.69
159 INT1033 Positive_regulation of Ca2 5 507 0.68 131.76 147.64
160 INT9852 Positive_regulation of Gpt 15 563 0.70 364.64 146.82
161 INT5116 Gene_expression of IL2 32 670 0.78 291.13 146.69
162 INT812 Localization of INS 24 1026 0.81 515.6 145.31
163 INT2379 Positive_regulation of Localization of LH 7 349 0.70 27.86 144.53
164 INT3300 Positive_regulation of Gene_expression of Calca 22 179 0.70 77.76 144.2
165 INT2780 Regulation of Gene_expression of Penk 15 265 0.62 32.45 143.88
166 INT60694 Gene_expression of Il10 10 567 0.78 369.48 143.69
167 INT9660 Regulation of TNF 11 363 0.62 312.94 139.99
168 INT1414 Regulation of Oprl1 8 169 0.62 32.05 139.99
169 INT90910 Phosphorylation of Grin1 5 150 0.82 68.23 139.24
170 INT14843 Gene_expression of Gabrg1 2 301 0.77 62.63 139.16
171 INT1273 Gene_expression of Avp 19 356 0.78 90.56 138.7
172 INT48895 Gene_expression of Il10 15 333 0.78 221.2 138.52
173 INT2867 Gene_expression of CALCA 1 247 0.78 78.78 138.47
174 INT5061 Negative_regulation of Mme 4 306 0.59 51.97 136.9
175 INT4658 Binding of OPRM1 24 188 0.48 25.96 136.24
176 INT1047 Negative_regulation of LH 3 314 0.59 53.71 135.89
177 INT2541 Binding of Calca 5 200 0.48 67.14 134.62
178 INT60126 Regulation of Trpv1 8 186 0.62 85.53 133.4
179 INT11012 Positive_regulation of Creb1 14 258 0.70 84.4 132
180 INT48953 Positive_regulation of Nos2 41 486 0.70 239.85 131.87
181 INT5497 Positive_regulation of Crh 21 299 0.70 125.54 131.14
182 INT5380 Positive_regulation of Gene_expression of Fos 7 243 0.70 105.65 131.05
183 INT49439 Gene_expression of Cpox 40 508 0.73 326.97 130.17
184 INT5595 Positive_regulation of Pdyn 9 223 0.70 48.37 130.14
185 INT64161 Positive_regulation of Prkca 8 213 0.70 85.06 129.91
186 INT65600 Positive_regulation of Casp3 15 376 0.70 198.44 128.03
187 INT1614 Gene_expression of Oprl1 8 164 0.78 31.43 127.74
188 INT5842 Gene_expression of Gfap 1 372 0.78 153.71 127.71
189 INT1878 Binding of HLA-B 15 440 0.48 321.16 127.36
190 INT695 Binding of POMC 5 304 0.48 56.66 126.85
191 INT65054 Positive_regulation of Nfkb1 8 285 0.70 149.33 126.73
192 INT5931 Regulation of Oprm1 12 149 0.62 18.15 125.93
193 INT6822 Gene_expression of Pdyn 6 215 0.78 35.99 125.76
194 INT416 Regulation of LH 3 253 0.62 31.48 125.55
195 INT5008 Localization of Calca 4 204 0.81 80.35 125.16
196 INT6323 Positive_regulation of Gabrg1 4 213 0.70 45.08 124.34
197 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
198 INT4259 Positive_regulation of Npr1 2 262 0.70 49.37 123.11
199 INT2106 Regulation of Localization of LH 8 279 0.62 22.37 122.77
200 INT252 Localization of GH1 2 529 0.80 227.4 122.05
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