Y:2004

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2004. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2004. They are ordered first by their pain relevance and then by number of times they were reported in 2004. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2004 Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 3 0.54 5.93 32.4
2 INT69872 Binding of MC1R and POMC 52 2 0.54 8.87 18.3
3 INT69886 Ngf Positive_regulation of Calca 8 2 0.76 2.98 12.77
4 INT106676 Binding of Trpv1 and Phax 18 8 0.34 4.19 12.36
5 INT2714 Pomc Positive_regulation of Localization of Prl 17 1 0.79 0.5 8.18
6 INT51205 Binding of OPRK1 and PDYN 7 1 0.00 2.01 7.8
7 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 4 0.76 8.19 6.66
8 INT84921 Binding of NGF and NTRK1 13 2 0.50 6.39 6.1
9 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 1 0.74 4.31 6.1
10 INT176477 Binding of CXCR3 and CXCL10 14 1 0.25 10.61 5.87
11 INT179502 Binding of Cd14 and Tlr4 29 1 0.39 13.77 5.73
12 INT92466 Pomc Positive_regulation of Binding of Crygs and 8 1 0.06 0 5.56
13 INT88279 Ngf Positive_regulation of Ntrk1 5 1 0.76 3.06 5.23
14 INT69888 Ngf Positive_regulation of Localization of Calca 4 1 0.52 0.51 4.95
15 INT102122 Binding of Calca and RT1-M4 7 1 0.29 5.83 4.94
16 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 2 0.59 9.37 4.48
17 INT122567 Mog Positive_regulation of Eae1 8 1 0.31 10.18 4.26
18 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 2 0.30 0.91 4.18
19 INT107801 Ugt1a5 Positive_regulation of Localization of Prl 3 1 0.76 1 3.9
20 INT69032 IL18 Positive_regulation of IFNA1 12 7 0.23 7.87 3.83
21 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 1 0.47 0.72 3.63
22 INT29837 Gnrh1 Positive_regulation of LH 6 3 0.67 0 3.53
23 INT121651 Binding of CXCL12 and CXCR4 13 2 0.48 17.61 3.52
24 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 2 0.65 3.74 3.11
25 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 1 0.67 2.13 3.06
26 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 1 0.34 0 3.01
27 INT182635 Binding of CCR5 and CCL5 2 1 0.09 4.19 3
28 INT123451 Binding of YY1 and Adra2a 1 4 0.37 0 2.98
29 INT118158 Binding of Prkca and Prkcz 1 2 0.07 1.14 2.98
30 INT114126 Binding of APLNR and OPRL1 1 2 0.01 0.47 2.85
31 INT31513 Crh Regulation of POMC 3 4 0.29 5.06 2.78
32 INT69030 IL18 Positive_regulation of IL12A 3 5 0.31 5.57 2.72
33 INT114134 Penk Positive_regulation of Oprm1 2 1 0.24 1.48 2.68
34 INT121742 Prkcg Positive_regulation of Ephb1 3 1 0.49 0.99 2.6
35 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 3 0.06 0.5 2.6
36 INT20411 Ghrh Positive_regulation of Gh1 6 1 0.56 0.62 2.47
37 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 3 0.54 0.85 2.44
38 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 2 0.59 2.72 2.42
39 INT122163 Binding of TNF and TNFRSF1B 6 1 0.44 6.06 2.41
40 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 1 0.26 1.99 2.36
41 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 1 0.23 0 2.35
42 INT121746 Prkaca Positive_regulation of Ephb1 2 1 0.23 0.92 2.35
43 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 2 0.37 1.4 2.34
44 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 2 0.12 0 2.19
45 INT120319 Ghrh Regulation of Ngf 1 2 0.25 1.89 2.11
46 INT122660 Binding of CACNA1A and DNAH8 2 1 0.28 2.68 2.08
47 INT117821 Binding of Tacr1 and Cd4 1 2 0.34 0.86 2.02
48 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 1 0.02 0.32 2.02
49 INT179443 Vta1 Positive_regulation of Gpr156 1 2 0.20 0 1.99
50 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 3 2 0.17 0.15 1.98
51 INT179445 Vta1 Positive_regulation of Gabrd 1 2 0.09 0 1.98
52 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 2 0.36 1.11 1.96
53 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 1 0.51 0.48 1.92
54 INT116815 Binding of Pias1 and Ppbp 1 1 0.36 0.86 1.92
55 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 2 0.01 0 1.82
56 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 1 0.48 1.04 1.81
57 INT117269 Binding of Avp and Prl 1 2 0.25 0.47 1.8
58 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 1 0.17 0.23 1.8
59 INT179444 Hmmr Negative_regulation of Gpr156 1 2 0.03 0 1.79
60 INT122966 FSCN1 Positive_regulation of FSCN1 Positive_regulation of Bdnf 1 1 0.02 1.14 1.79
61 INT122964 FSCN1 Positive_regulation of Bdnf 1 1 0.01 1.14 1.79
62 INT116092 TFF2 Positive_regulation of NFKB1 1 1 0.17 0.06 1.77
63 INT115443 Regulation of Binding of Cpox and Defb40 1 2 0.00 1.28 1.76
64 INT115435 Binding of Cpox and Defb40 Positive_regulation of Localization of Defb42 1 2 0.00 1.28 1.76
65 INT115442 Binding of Cpox and Defb40 1 2 0.00 1.28 1.76
66 INT27788 Gnrh1 Positive_regulation of Positive_regulation of LH 3 1 0.55 0.17 1.72
67 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 2 0.10 2.48 1.7
68 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 1 0.50 4.37 1.69
69 INT62065 Binding of YY1 and Penk 3 1 0.14 0 1.69
70 INT105917 Binding of SLC22A6 and SLC22A8 2 1 0.31 0.34 1.67
71 INT122428 Binding of Ighm and Prkci 1 3 0.00 0 1.66
72 INT119918 Zfp821 Positive_regulation of Binding of ACAA1 and 1 2 0.00 0 1.64
73 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 1 0.12 0.54 1.63
74 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 1 0.03 0 1.63
75 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 1 0.27 0.56 1.58
76 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 1 0.36 0.08 1.56
77 INT182097 Binding of Il6 and Il1 4 1 0.07 4.67 1.55
78 INT118157 Binding of Prkca and Prkcz Positive_regulation of Binding of Prkca Prkcz 1 1 0.02 0.58 1.55
79 INT118159 Binding of Prkca and Prkcz Positive_regulation of Prkcz 1 1 0.02 0.58 1.54
80 INT118160 Binding of Prkca and Prkcz Positive_regulation of Prkca 1 1 0.11 0.58 1.54
81 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 2 0.17 3.36 1.53
82 INT66713 Binding of BDKRB1 and KNG1 2 1 0.22 0.39 1.53
83 INT69031 IL12A Positive_regulation of IFNA1 9 4 0.13 4.23 1.52
84 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 1 0.16 0.2 1.5
85 INT117008 Sfpi1 Regulation of Oprm1 1 3 0.56 0.56 1.49
86 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 1 0.10 0.2 1.49
87 INT116094 Binding of TACR1 and TFF2 1 1 0.06 0 1.47
88 INT118812 Cck Positive_regulation of Rvm 1 1 0.21 0.65 1.46
89 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 1 0.10 0.1 1.44
90 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 1 0.62 0.7 1.44
91 INT118980 NTRK1 Positive_regulation of NGF 1 2 0.56 1.45 1.39
92 INT116827 Binding of UCHL1 and TRPV1 1 1 0.41 0.88 1.39
93 INT55837 Binding of HLA-B and PHB2 3 2 0.20 3.52 1.37
94 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 1 0.49 0.73 1.36
95 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 2 0.00 0 1.36
96 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 1 0.16 4.47 1.35
97 INT115272 Neu1 Positive_regulation of Coq10a 1 1 0.43 0.41 1.35
98 INT115271 Neu1 Positive_regulation of Coq10a 1 1 0.01 0.41 1.35
99 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 3 0.16 2.53 1.35
100 INT122659 Binding of CACNA1A and SAR1B 1 1 0.06 1.38 1.35
101 INT178986 Binding of MMP9 and TIMP1 4 1 0.47 2.58 1.33
102 INT121457 KNG1 Positive_regulation of Trpv1 1 2 0.16 0.91 1.33
103 INT116102 Cck Positive_regulation of Negative_regulation of Pnoc 1 1 0.51 0.41 1.33
104 INT76508 Pnoc Regulation of Oprl1 1 1 0.47 0.25 1.32
105 INT182096 Positive_regulation of Binding of Il6 and Il1 2 1 0.09 4.26 1.31
106 INT120929 Prkcg Regulation of Gene_expression of Fos 2 1 0.50 0.34 1.31
107 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 1 0.49 1.2 1.3
108 INT121096 Binding of Calca and Trpv1 3 2 0.37 1.23 1.29
109 INT121802 DEAF1 Negative_regulation of HTR1A 1 2 0.46 0.88 1.29
110 INT177232 ICAM1 Regulation of Gene_expression of Vcam1 1 6 0.03 5.52 1.28
111 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 1 0.49 1.14 1.27
112 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 1 0.39 0.71 1.26
113 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 1 0.34 0 1.26
114 INT116628 St13 Regulation of Positive_regulation of P9Ehs1 1 1 0.00 0 1.25
115 INT121000 Binding of PAG1 and Nrm 1 1 0.13 0.67 1.25
116 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 1 0.07 0.07 1.25
117 INT116892 Binding of TRPV1 and Phax 4 3 0.00 0.1 1.24
118 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 2 0.03 0.54 1.24
119 INT121465 Binding of Dnm2 and Oprm1 1 1 0.23 0 1.24
120 INT123453 Binding of POMC and Penk 1 1 0.01 0.31 1.23
121 INT121189 KCNMA1 Positive_regulation of IL6 1 2 0.04 0.54 1.23
122 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 1 0.24 0.69 1.22
123 INT121724 Ngf Positive_regulation of Ephb1 1 1 0.40 0.68 1.21
124 INT116730 Rac1 Regulation of Localization of Calca 1 1 0.13 1.32 1.19
125 INT122370 Positive_regulation of Tacr1 Positive_regulation of Ngf 1 1 0.30 0.17 1.18
126 INT120205 Binding of App and Ern1 1 2 0.05 2.55 1.18
127 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 2 0.06 0.61 1.18
128 INT117082 TNS3 Regulation of Ssr1 1 1 0.05 0 1.16
129 INT121725 Binding of Trpv1 and Pik3cb 1 1 0.35 0.62 1.15
130 INT122267 Prkcg Positive_regulation of Grin2b 1 1 0.26 0.61 1.14
131 INT122369 Tacr1 Positive_regulation of Ngf 1 1 0.30 0.16 1.14
132 INT123387 Binding of Camk2a and Gria2 1 1 0.13 0.32 1.14
133 INT117504 OPA1 Positive_regulation of CPP 1 1 0.09 1.09 1.13
134 INT121362 Trpv1 Regulation of Localization of Ins1 1 2 0.51 0.17 1.12
135 INT123454 CNR1 Regulation of Fos 1 1 0.00 0.06 1.12
136 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 1 0.00 0.06 1.12
137 INT83616 Binding of IL6 and IL8 5 1 0.09 5.8 1.11
138 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 1 0.45 0.69 1.11
139 INT120323 Slc5a7 Negative_regulation of Flvcr2 1 1 0.02 0.43 1.1
140 INT122268 Binding of Grin2b and Grm5 1 1 0.40 0.52 1.1
141 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 1 0.02 0.97 1.1
142 INT120324 Hc3 Negative_regulation of Flvcr2 1 1 0.06 0.42 1.09
143 INT121730 Pik3cb Regulation of Trpv1 1 1 0.58 0.54 1.09
144 INT114007 Binding of Crygs and Oprm1 1 2 0.03 0 1.09
145 INT119744 Binding of BHLHE22 and NAV1 1 2 0.29 0.49 1.09
146 INT121089 Binding of Oprd1 and Adarb1 2 1 0.06 0 1.07
147 INT119108 Binding of LTBR and TNF 2 1 0.15 1.47 1.07
148 INT120313 Gnrhr Negative_regulation of Mmp2 1 1 0.03 0.85 1.07
149 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 1 0.11 0.85 1.07
150 INT120318 Gnrhr Negative_regulation of Ngf 1 1 0.11 0.85 1.07
151 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 1 0.25 0.95 1.06
152 INT121727 Pik3cb Positive_regulation of Ephb1 1 1 0.49 0.6 1.06
153 INT116777 Psma5 Positive_regulation of Binding of Fn1 and 1 1 0.01 1.24 1.06
154 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 1 0.01 0 1.06
155 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 1 0.25 0.95 1.06
156 INT176474 Binding of CXCR3 and CXCL9 3 1 0.22 1.9 1.05
157 INT120312 Ghrh Regulation of Tnf 1 1 0.26 0.95 1.05
158 INT119887 Binding of Atf4 and Usf1 1 2 0.21 0.15 1.05
159 INT119888 Binding of Creb1 and Usf1 1 2 0.18 0.15 1.05
160 INT120316 Ghrh Regulation of Il6 1 1 0.11 0.95 1.05
161 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 1 0.43 0.95 1.05
162 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 1 0.18 0.95 1.05
163 INT117908 Em Regulation of Localization of Pax3 1 1 0.00 0.07 1.03
164 INT118859 GNA14 Positive_regulation of STAT3 1 4 0.01 0.38 1.03
165 INT122429 Prkci Regulation of Gene_expression of Ighm 1 1 0.00 0 1.02
166 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 1 0.00 0 1.02
167 INT122433 Prkci Negative_regulation of Ighm 1 1 0.00 0 1.02
168 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 1 0.27 0 1.02
169 INT178663 Binding of CXCR3 and TH1L 2 1 0.04 2.24 1.01
170 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 1 0.28 0.38 1.01
171 INT119914 Olr1714 Negative_regulation of Nos1 1 2 0.02 0.47 1.01
172 INT117311 HP Positive_regulation of Lep 1 2 0.00 1.78 1.01
173 INT195668 Binding of F2 and THBD 7 1 0.08 5.67 0.98
174 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 2 0.78 1.23 0.98
175 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 1 0.08 1 0.98
176 INT122380 Pnoc Positive_regulation of Oprl1 1 1 0.36 0.55 0.98
177 INT54972 Binding of EDNRA and EDNRB 7 1 0.52 3.31 0.97
178 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 1 0.09 1.18 0.97
179 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 1 0.09 1.18 0.97
180 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 1 0.48 1.26 0.96
181 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 1 0.35 0 0.96
182 INT122144 Binding of Trpv1 and Prkd1 1 4 0.02 0.39 0.96
183 INT116185 Npy Negative_regulation of Positive_regulation of Npy1r 1 2 0.41 0.32 0.96
184 INT108729 Binding of CACNA1A and Cacna1a 3 1 0.13 1.21 0.95
185 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 1 0.67 1.91 0.94
186 INT123052 Gpbar1 Regulation of Phosphorylation of Grk4 1 1 0.37 0 0.94
187 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 1 0.43 0 0.94
188 INT123049 Grk4 Regulation of Phosphorylation of Gpbar1 1 1 0.37 0 0.94
189 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 1 0.33 0 0.94
190 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 1 0.33 0 0.94
191 INT117005 Sfpi1 Positive_regulation of Oprm1 1 2 0.52 0.56 0.94
192 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 1 0.43 0 0.94
193 INT116930 OPRK1 Positive_regulation of Binding of PTK2 and 1 2 0.28 0.35 0.93
194 INT123023 Ednra Regulation of Adarb1 1 1 0.00 0 0.93
195 INT118204 ST14 Regulation of YY1 1 1 0.04 0 0.93
196 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 1 0.27 0.44 0.92
197 INT123024 Csf2 Regulation of Ednra 1 1 0.06 0 0.92
198 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 1 0.42 5.23 0.91
199 INT122266 Src Negative_regulation of Grin2b 1 1 0.27 0.43 0.91
200 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 1 0.54 3.85 0.9

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2004. They are ordered first by their pain relevance and then by number of times they were reported in 2004. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2004 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 204 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 98 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 11 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 57 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 158 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 29 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 78 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 41 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 89 1163 0.70 319.28 684
10 INT292 Localization of Penk 14 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 98 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 13 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 48 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 11 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 57 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 23 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 3 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 17 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 108 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 77 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 33 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 28 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 41 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 53 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 9 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 39 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 20 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 22 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 76 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 68 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 10 790 0.70 104.54 374.78
32 INT287 Localization of Cck 10 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 17 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 38 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 18 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 16 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 27 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 31 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 27 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 43 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 14 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 17 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 85 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 28 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 38 530 0.78 264.29 310.56
46 INT4941 Positive_regulation of Oprd1 20 345 0.70 74.26 304.41
47 INT9131 Positive_regulation of Prkcg 17 431 0.70 130.8 302.41
48 INT477 Localization of Avp 13 813 0.81 131.58 300.4
49 INT161 Regulation of Localization of Prl 25 615 0.62 65.37 298.66
50 INT63932 Positive_regulation of Ephb1 51 537 0.70 259.67 296.14
51 INT1352 Localization of Acot1 21 728 0.80 73.01 296.01
52 INT886 Gene_expression of Pomc 40 676 0.78 129.87 295.98
53 INT11624 Gene_expression of OPRM1 25 445 0.78 72.36 294.36
54 INT5379 Gene_expression of Fos 47 656 0.78 255.5 292.54
55 INT3579 Localization of Oxt 7 555 0.81 43.35 292.44
56 INT97367 Gene_expression of Nav1 16 243 0.78 132.97 286.66
57 INT9158 Gene_expression of Tnf 42 722 0.78 522.01 277.68
58 INT2365 Positive_regulation of Cck 17 354 0.70 87.8 277.41
59 INT9381 Positive_regulation of TRPV1 46 523 0.70 187.4 276.05
60 INT94450 Gene_expression of Nav1 9 359 0.78 131.85 275.46
61 INT49750 Negative_regulation of CPOX 38 735 0.58 360.06 274.19
62 INT6852 Localization of TNF 28 883 0.81 705.95 270.84
63 INT10832 Gene_expression of IL8 62 1050 0.78 698.72 270
64 INT1396 Binding of Penk 5 355 0.48 22.79 269.65
65 INT5591 Regulation of Gene_expression of Fos 32 425 0.62 129.06 265.78
66 INT9659 Gene_expression of Il6 32 991 0.78 715.11 265.57
67 INT5972 Gene_expression of IL1B 52 948 0.78 510.91 263.97
68 INT68684 Gene_expression of VEGFA 59 2371 0.78 1742.52 259.2
69 INT87687 Positive_regulation of Trpv1 20 409 0.70 210.24 257.59
70 INT1893 Localization of Gh 15 1041 0.79 340.23 256.58
71 INT16868 Gene_expression of Il6 33 807 0.78 499.48 256.57
72 INT2909 Positive_regulation of Abat 7 334 0.70 62.1 256.43
73 INT3948 Regulation of Cck 7 291 0.62 58.07 255.88
74 INT5501 Regulation of Oprd1 14 283 0.62 55.1 249.9
75 INT1005 Localization of Sst 4 385 0.81 26.31 244.56
76 INT738 Regulation of POMC 15 459 0.62 111.19 243.74
77 INT1902 Gene_expression of Cck 8 348 0.78 70.33 241.92
78 INT11377 Positive_regulation of Ngf 33 331 0.70 206.5 238
79 INT1562 Localization of Crh 19 499 0.81 126.74 236.68
80 INT5597 Gene_expression of Pdyn 21 433 0.78 62.97 235.47
81 INT1665 Positive_regulation of Pag1 6 270 0.68 186.63 229.87
82 INT4759 Negative_regulation of Localization of Calca 24 294 0.59 82.62 226.45
83 INT9987 Gene_expression of Abat 17 296 0.78 95.46 226.34
84 INT6406 Binding of Oprm1 11 280 0.48 40.54 226.26
85 INT1212 Binding of Oprl1 4 312 0.48 28.6 225.15
86 INT11009 Phosphorylation of Creb1 43 458 0.82 111.34 221.97
87 INT626 Localization of CALCA 8 289 0.81 125.39 221.15
88 INT95787 Positive_regulation of Mapk1 53 568 0.70 226.51 220.94
89 INT6665 Gene_expression of FOS 21 520 0.77 165.31 217.66
90 INT1308 Localization of Pomc 15 457 0.81 66.83 217.5
91 INT6293 Gene_expression of Oprm1 13 312 0.78 48.73 215.61
92 INT6481 Binding of TNF 22 624 0.48 510.2 214.82
93 INT767 Localization of Gnrhr 14 565 0.80 106.68 214.57
94 INT4893 Gene_expression of Tacr1 18 366 0.78 129.67 213.92
95 INT22548 Positive_regulation of Casp3 20 483 0.70 258.78 213.07
96 INT6482 Positive_regulation of Gene_expression of TNF 36 659 0.70 569.88 210
97 INT16259 Positive_regulation of Bdnf 16 336 0.70 183.48 209.82
98 INT48955 Gene_expression of Nos2 29 753 0.78 403.87 208.08
99 INT2651 Positive_regulation of Pomc 14 403 0.70 95.72 206.24
100 INT2391 Negative_regulation of PTGS1 21 501 0.59 207.62 205.6
101 INT9132 Negative_regulation of Prkcg 20 279 0.59 88.05 203.47
102 INT798 Positive_regulation of Gene_expression of Penk 6 394 0.70 78.53 203.07
103 INT11313 Positive_regulation of Il6 26 526 0.70 331.27 201.59
104 INT2211 Negative_regulation of Abat 13 267 0.59 66.51 200.98
105 INT50670 Gene_expression of CPOX 28 763 0.76 442.13 195.02
106 INT156 Negative_regulation of Prl 8 542 0.59 131.97 192.24
107 INT528 Gene_expression of Prl 11 693 0.78 217.18 192.2
108 INT6488 Gene_expression of Tnf 31 484 0.78 339.61 191.58
109 INT2085 Positive_regulation of LH 5 441 0.70 60.15 191.02
110 INT63934 Phosphorylation of Ephb1 31 377 0.82 150.52 188.66
111 INT6354 Localization of Gabrg1 10 321 0.74 41.41 186.74
112 INT94952 Positive_regulation of Mapk14 8 305 0.70 197.83 186.61
113 INT1652 Regulation of Pomc 8 387 0.62 61.01 186.51
114 INT24326 Gene_expression of Ngf 4 346 0.78 218.67 184.71
115 INT10194 Positive_regulation of IL6 29 702 0.70 600.62 183.38
116 INT4803 Transcription of Penk 9 435 0.72 59.09 182.4
117 INT3440 Negative_regulation of Localization of Abat 16 221 0.57 33.94 180.36
118 INT12602 Negative_regulation of Oprm1 8 190 0.59 36.11 177.85
119 INT49441 Negative_regulation of Cpox 14 494 0.59 303.22 177.46
120 INT7506 Negative_regulation of Ltp 2 267 0.46 91.01 176.8
121 INT1429 Gene_expression of PDYN 10 308 0.78 61.33 175.65
122 INT19472 Gene_expression of Il1 12 554 0.76 419.75 175.35
123 INT943 Negative_regulation of Cck 4 205 0.59 38.42 174.78
124 INT26472 Regulation of Oprm1 13 191 0.62 35.84 173.1
125 INT15516 Gene_expression of Crp 48 711 0.77 615.33 173.09
126 INT5930 Positive_regulation of Oprm1 11 221 0.70 31.19 172.93
127 INT159 Negative_regulation of Localization of Prl 11 416 0.59 55.34 171.8
128 INT4937 Negative_regulation of Oprd1 13 224 0.59 44.51 171.11
129 INT438 Gene_expression of Crh 26 376 0.78 159.11 169.17
130 INT867 Gene_expression of IFNA1 40 930 0.78 594.85 168.03
131 INT739 Negative_regulation of POMC 6 358 0.59 102.28 166.77
132 INT55879 Gene_expression of CCL2 18 421 0.78 240.74 166.02
133 INT1114 Localization of Ins1 34 748 0.80 192.95 165.48
134 INT4768 Positive_regulation of OPRM1 9 212 0.70 31.09 164.28
135 INT2366 Binding of Cck 2 192 0.48 30.64 163.46
136 INT5127 Localization of Lhb 8 488 0.80 50.48 162.66
137 INT3448 Positive_regulation of Gh 9 521 0.69 180.03 161.18
138 INT5513 Negative_regulation of Pomc 8 295 0.59 60.9 158.63
139 INT51921 Gene_expression of Cpox 39 501 0.73 229.81 157.81
140 INT21185 Binding of Ptprg 12 213 0.47 13.49 157.75
141 INT66280 Gene_expression of Nos2 9 534 0.78 330.78 157.07
142 INT768 Positive_regulation of Oprl1 4 179 0.70 40.05 156.93
143 INT1303 Negative_regulation of Npr1 9 278 0.55 35.1 156.78
144 INT2640 Gene_expression of Pomc 9 424 0.78 120.72 155.37
145 INT6042 Binding of Oprm1 10 248 0.48 31.77 154.34
146 INT4740 Gene_expression of Th 6 298 0.78 61.27 154.03
147 INT2910 Regulation of Abat 6 169 0.62 36.95 153.53
148 INT1044 Negative_regulation of Localization of LH 2 358 0.59 25.95 151.31
149 INT120811 Gene_expression of Gopc 12 1174 0.59 428.49 150.55
150 INT4829 Positive_regulation of Localization of Abat 11 199 0.55 20.91 150.48
151 INT880 Positive_regulation of Localization of Gh1 4 304 0.70 14.79 150.23
152 INT15515 Positive_regulation of Crp 65 700 0.70 604.24 150.15
153 INT49134 Gene_expression of Grin1 17 270 0.78 84.78 148.61
154 INT5050 Regulation of Localization of Calca 7 149 0.62 41.25 148.57
155 INT6108 Gene_expression of Npy 19 292 0.78 110.65 148.21
156 INT13353 Positive_regulation of Tnf 24 332 0.70 248.75 148.1
157 INT7628 Gene_expression of Ltp 3 273 0.77 70.21 147.87
158 INT2451 Positive_regulation of Avp 6 355 0.70 102.66 147.69
159 INT1033 Positive_regulation of Ca2 30 507 0.68 131.76 147.64
160 INT9852 Positive_regulation of Gpt 18 563 0.70 364.64 146.82
161 INT5116 Gene_expression of IL2 15 670 0.78 291.13 146.69
162 INT812 Localization of INS 2 1026 0.81 515.6 145.31
163 INT425 Localization of PRL 2 455 0.81 189.64 144.8
164 INT2379 Positive_regulation of Localization of LH 2 349 0.70 27.86 144.53
165 INT3300 Positive_regulation of Gene_expression of Calca 9 179 0.70 77.76 144.2
166 INT2780 Regulation of Gene_expression of Penk 1 265 0.62 32.45 143.88
167 INT60694 Gene_expression of Il10 16 567 0.78 369.48 143.69
168 INT9660 Regulation of TNF 22 363 0.62 312.94 139.99
169 INT1414 Regulation of Oprl1 6 169 0.62 32.05 139.99
170 INT90910 Phosphorylation of Grin1 20 150 0.82 68.23 139.24
171 INT14843 Gene_expression of Gabrg1 31 301 0.77 62.63 139.16
172 INT1273 Gene_expression of Avp 11 356 0.78 90.56 138.7
173 INT48895 Gene_expression of Il10 10 333 0.78 221.2 138.52
174 INT2867 Gene_expression of CALCA 15 247 0.78 78.78 138.47
175 INT5061 Negative_regulation of Mme 5 306 0.59 51.97 136.9
176 INT4658 Binding of OPRM1 6 188 0.48 25.96 136.24
177 INT1047 Negative_regulation of LH 2 314 0.59 53.71 135.89
178 INT2541 Binding of Calca 5 200 0.48 67.14 134.62
179 INT60126 Regulation of Trpv1 18 186 0.62 85.53 133.4
180 INT11012 Positive_regulation of Creb1 29 258 0.70 84.4 132
181 INT48953 Positive_regulation of Nos2 32 486 0.70 239.85 131.87
182 INT5497 Positive_regulation of Crh 20 299 0.70 125.54 131.14
183 INT5380 Positive_regulation of Gene_expression of Fos 26 243 0.70 105.65 131.05
184 INT49439 Gene_expression of Cpox 28 508 0.73 326.97 130.17
185 INT5595 Positive_regulation of Pdyn 7 223 0.70 48.37 130.14
186 INT64161 Positive_regulation of Prkca 16 213 0.70 85.06 129.91
187 INT115386 Gene_expression of Ppara 2 779 0.77 549.99 128.36
188 INT65600 Positive_regulation of Casp3 26 376 0.70 198.44 128.03
189 INT1614 Gene_expression of Oprl1 3 164 0.78 31.43 127.74
190 INT5842 Gene_expression of Gfap 5 372 0.78 153.71 127.71
191 INT1878 Binding of HLA-B 29 440 0.48 321.16 127.36
192 INT695 Binding of POMC 17 304 0.48 56.66 126.85
193 INT65054 Positive_regulation of Nfkb1 25 285 0.70 149.33 126.73
194 INT5931 Regulation of Oprm1 7 149 0.62 18.15 125.93
195 INT6822 Gene_expression of Pdyn 5 215 0.78 35.99 125.76
196 INT416 Regulation of LH 1 253 0.62 31.48 125.55
197 INT5008 Localization of Calca 15 204 0.81 80.35 125.16
198 INT6323 Positive_regulation of Gabrg1 4 213 0.70 45.08 124.34
199 INT4824 Positive_regulation of Tacr1 5 169 0.70 66.1 123.46
200 INT4259 Positive_regulation of Npr1 6 262 0.70 49.37 123.11
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