Y:2006

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2006. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2006. They are ordered first by their pain relevance and then by number of times they were reported in 2006. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2006 Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 4 0.54 5.93 32.4
2 INT69872 Binding of MC1R and POMC 52 8 0.54 8.87 18.3
3 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 1 0.73 0.87 14.34
4 INT106676 Binding of Trpv1 and Phax 18 1 0.34 4.19 12.36
5 INT166591 Binding of CALCA and DCLK3 4 19 0.30 0.69 12.18
6 INT68514 Pnoc Positive_regulation of Oprl1 10 3 0.59 3.56 9.57
7 INT77646 Binding of Ngf and Ntrk1 23 1 0.40 7.85 9.26
8 INT51205 Binding of OPRK1 and PDYN 7 2 0.00 2.01 7.8
9 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
10 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 8 0.10 3.92 7.2
11 INT140015 Avp Positive_regulation of Localization of Penk 3 2 0.63 3.48 6.63
12 INT131249 Binding of Bdnf and Ntrk2 11 2 0.41 4 6.25
13 INT155484 Binding of CD86 and CTLA4 15 1 0.52 8.85 6.09
14 INT179502 Binding of Cd14 and Tlr4 29 1 0.39 13.77 5.73
15 INT88279 Ngf Positive_regulation of Ntrk1 5 1 0.76 3.06 5.23
16 INT69888 Ngf Positive_regulation of Localization of Calca 4 1 0.52 0.51 4.95
17 INT102122 Binding of Calca and RT1-M4 7 4 0.29 5.83 4.94
18 INT166590 Binding of RAMP1 and DCLK3 2 7 0.37 0.39 4.8
19 INT113223 POMC Regulation of MC1R 6 1 0.68 0.39 4.24
20 INT101942 Binding of CD40 and CD40LG 16 3 0.23 15.24 4.01
21 INT73539 Binding of Ngf and Ngfr 5 1 0.45 3.99 4
22 INT138961 Dbi Positive_regulation of Chkb 1 2 0.00 3.05 3.99
23 INT138959 Dbi Positive_regulation of Penk 1 2 0.01 3.05 3.99
24 INT200322 Binding of Rest and Sp3 1 20 0.39 2.93 3.98
25 INT136514 Binding of Grm1 and Grm5 4 3 0.12 1.8 3.9
26 INT61359 TNF Positive_regulation of NFKB1 11 5 0.63 6.66 3.89
27 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 2 0.27 0.43 3.88
28 INT136525 Binding of Prokr1 and Trpv1 1 3 0.39 2.9 3.76
29 INT134284 Binding of OPRM1 and PLD2 1 8 0.52 0 3.72
30 INT132862 Ngf Positive_regulation of Bdnf 4 1 0.46 4.05 3.65
31 INT140011 Avp Positive_regulation of Dbi 2 1 0.07 0.93 3.61
32 INT132228 Negative_regulation of Binding of Pik3cg and Sh2d6 1 4 0.07 1.96 3.6
33 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 4 0.34 1.96 3.6
34 INT18026 Binding of Oprd1 and Oprm1 4 1 0.40 0.83 3.53
35 INT195931 Binding of OPRM1 and Trpv1 1 3 0.07 0.87 3.43
36 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 5 0.41 0 3.31
37 INT194647 Binding of CD28 and CD80 15 1 0.40 4.9 3.22
38 INT64719 IL1B Positive_regulation of IL6 7 1 0.41 6.84 3.14
39 INT202959 Binding of BAG3 and MCRS1 1 6 0.11 7.46 3.14
40 INT202965 Binding of STC2 and BAG3 1 6 0.02 7.86 2.96
41 INT166592 Binding of CALCA and RAMP1 2 4 0.35 0.33 2.91
42 INT140014 Avp Negative_regulation of Chkb 1 2 0.04 1.58 2.86
43 INT130721 Binding of IL1B and IL1RN 6 1 0.05 5.29 2.85
44 INT194409 Binding of CALCA and IGKV1D-8 1 5 0.15 0 2.84
45 INT137230 Trh Regulation of Gene_expression of Oprd1 1 2 0.01 1.62 2.75
46 INT202974 Binding of BAG3 and CPP 1 5 0.25 6.22 2.73
47 INT134294 Binding of Pdyn and Penk 1 2 0.23 0 2.69
48 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 1 0.49 2.75 2.61
49 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 2 0.01 0 2.44
50 INT136129 Calca Positive_regulation of ATP8A2 1 2 0.38 0.89 2.4
51 INT81657 Binding of CPOX and PTGS1 5 1 0.15 1.9 2.37
52 INT134872 Binding of Calm3 and IQCJ 1 2 0.00 0.82 2.26
53 INT198958 Cnr1 Positive_regulation of Kcnj9 1 2 0.00 0.15 2.24
54 INT194646 Binding of CD28 and CD86 7 1 0.40 2.69 2.21
55 INT197379 Tbs1 Positive_regulation of Ltp 6 1 0.07 1.87 2.21
56 INT86179 TNF Positive_regulation of Localization of IL6 5 1 0.35 1.66 2.17
57 INT134583 Arrb2 Regulation of Oprm1 1 2 0.41 1.23 2.15
58 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
59 INT39108 Binding of PDYN and YY1 2 1 0.50 0.44 2.14
60 INT135035 Binding of Hk1 and Tac1 1 2 0.35 0.18 2.14
61 INT140019 Avp Positive_regulation of Localization of Kitl 1 2 0.00 1 2.13
62 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 and 1 2 0.00 0 2.11
63 INT133946 Binding of DNM2 and OPRK1 1 3 0.11 0 2.1
64 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 1 0.04 2.02 2.08
65 INT190524 Ros1 Positive_regulation of Nfkb1 3 1 0.02 4.24 2.06
66 INT202963 Binding of STC2 and CPP 1 4 0.02 5.16 2.04
67 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 1 0.43 2.23 2
68 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 1 0.48 2.23 2
69 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 1 0.49 2.23 2
70 INT138962 Dbi Positive_regulation of Pomc 1 1 0.00 1.53 2
71 INT138960 Dbi Positive_regulation of Avp 1 1 0.02 1.53 2
72 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 1 0.02 1.53 2
73 INT137917 Oprm1 Positive_regulation of Kdr 1 3 0.43 0 1.98
74 INT189999 Binding of Vta1 and Cfp 2 1 0.08 1.25 1.97
75 INT129212 RYBP Positive_regulation of Tnf 2 1 0.03 1.9 1.95
76 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 1 0.51 0.48 1.92
77 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 1 0.05 7.39 1.91
78 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 1 0.08 1.33 1.89
79 INT134686 FSCN1 Positive_regulation of Gfap 1 1 0.00 0.71 1.89
80 INT51051 IL1B Positive_regulation of Localization of IL6 7 1 0.57 3.79 1.87
81 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 2 0.06 1.02 1.87
82 INT203044 Binding of PDCD1 and DTHD1 1 3 0.02 3.19 1.87
83 INT201940 Binding of IL8 and CXCL10 2 2 0.28 2.46 1.86
84 INT192161 Mmp14 Positive_regulation of Mmp2 2 1 0.19 1.23 1.81
85 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 1 0.02 1.86 1.8
86 INT132229 Binding of Akt1 and Sh2d6 1 2 0.09 0.98 1.8
87 INT136273 NGF Regulation of Gene_expression of BDNF 2 1 0.41 1.14 1.78
88 INT203149 Binding of Mif and Osm 1 2 0.02 2.93 1.78
89 INT190981 Binding of Npy and Scn2a1 1 2 0.10 0 1.75
90 INT129953 Oprd1 Regulation of Cspg5 1 1 0.17 0.15 1.74
91 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 2 0.39 0.39 1.72
92 INT139190 Binding of Fadd and Fas 4 2 0.38 2.65 1.71
93 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 1 0.38 4.29 1.71
94 INT137207 Tnf Positive_regulation of Nfkb1 3 1 0.23 2.69 1.71
95 INT200335 Binding of Oprm1 and Rest 1 6 0.40 0.07 1.7
96 INT134363 Prkcg Regulation of ADCY2 1 2 0.00 0.14 1.7
97 INT139433 Binding of Prkaca and Prkca 1 1 0.37 0.13 1.67
98 INT278223 Binding of NOS3 and ACSM3 1 5 0.41 6.32 1.65
99 INT191618 Binding of App and Nf1 1 9 0.35 3.77 1.65
100 INT194863 Binding of IL1R1 and IL1RN 5 3 0.09 2.23 1.64
101 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 1 0.40 0.77 1.64
102 INT134742 Binding of OPRM1 and SV2A 1 2 0.33 0.18 1.64
103 INT138777 Binding of Galr2 and Galr1 1 2 0.08 1.18 1.64
104 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 1 0.12 0 1.62
105 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 1 0.00 0.76 1.62
106 INT174503 Binding of HLA-B and KIR3DL1 6 4 0.37 3.48 1.61
107 INT107965 Binding of HLA-B and Mefv 2 2 0.34 3.91 1.61
108 INT195930 OPRM1 Regulation of Prkaca 1 1 0.01 0 1.59
109 INT136034 Edn1 Regulation of Trpv1 2 1 0.66 0.39 1.58
110 INT127253 Binding of Npb and Npbwr1 2 1 0.29 0.61 1.55
111 INT198653 TNF Positive_regulation of MIF 1 3 0.15 3.81 1.55
112 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 1 0.07 0.85 1.52
113 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 1 0.21 0.85 1.52
114 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 1 0.38 0.85 1.52
115 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 2 0.02 0.52 1.52
116 INT137657 Gorasp2 Regulation of Binding of Casp3 and 1 2 0.09 0 1.52
117 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 2 0.10 0.23 1.51
118 INT140008 Avp Positive_regulation of Pomc 1 1 0.38 0.84 1.51
119 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 1 0.43 1.69 1.5
120 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 1 0.48 1.69 1.5
121 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 1 0.03 1.28 1.49
122 INT96784 Binding of CALCA and Calca 3 1 0.23 0.27 1.47
123 INT136844 Binding of Prkca and Nrgn 1 1 0.33 0 1.47
124 INT201950 IFNA1 Positive_regulation of Binding of DPP4 and 1 2 0.12 2.17 1.47
125 INT136843 Binding of Camk2a and Nrgn 1 1 0.47 0 1.47
126 INT131564 Binding of Npw and Npbwr1 3 1 0.41 0.35 1.46
127 INT201946 IFNA1 Positive_regulation of DPP4 1 2 0.17 2.16 1.46
128 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 1 0.06 1.26 1.45
129 INT131039 Binding of Oprm1 and Prf1 1 1 0.17 0 1.45
130 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 1 0.21 0 1.45
131 INT131040 Binding of Oprm1 and S100a9 1 1 0.24 0 1.45
132 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 1 0.06 1.26 1.45
133 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 1 0.62 0.7 1.44
134 INT202958 Binding of STC2 and MCRS1 1 3 0.01 3.48 1.44
135 INT136346 Binding of Aap and Ads1 1 2 0.09 2.95 1.44
136 INT140012 Avp Negative_regulation of Dbi 1 1 0.06 0.8 1.44
137 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 1 0.21 0 1.43
138 INT139768 Binding of TRPV1 and ICK 1 2 0.41 1.59 1.42
139 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 2 0.05 1.65 1.42
140 INT139767 ICK Regulation of TRPV1 1 2 0.30 1.59 1.42
141 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 2 0.08 1.64 1.42
142 INT134760 Ghrl Regulation of Transcription of Calca 1 3 0.24 2.71 1.42
143 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 1 0.20 0.89 1.41
144 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 3 0.02 2.66 1.4
145 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 1 0.39 2.42 1.4
146 INT197111 Binding of IL1B and MCF2 1 2 0.02 2.12 1.4
147 INT133937 Binding of OPRK1 and ARFGEF1 1 2 0.01 0 1.39
148 INT134681 FSCN1 Positive_regulation of FSCN1 Positive_regulation of MAPK8 1 1 0.00 0.56 1.39
149 INT134679 FSCN1 Positive_regulation of MAPK8 1 1 0.01 0.56 1.39
150 INT133933 Binding of DNM2 and TP53INP2 1 2 0.00 0 1.38
151 INT140021 Avp Positive_regulation of Pag1 1 1 0.03 0.85 1.38
152 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 1 0.04 0.85 1.38
153 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 1 0.04 1.21 1.38
154 INT140020 Avp Positive_regulation of Localization of Pag1 1 1 0.03 0.85 1.38
155 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 1 0.16 4.47 1.35
156 INT140532 Gtf3a Positive_regulation of DYT10 1 1 0.12 1.83 1.34
157 INT140531 Ngf Positive_regulation of DYT10 1 1 0.72 1.83 1.34
158 INT178986 Binding of MMP9 and TIMP1 4 2 0.47 2.58 1.33
159 INT136603 Calca Positive_regulation of Localization of Il6 1 1 0.67 0.78 1.32
160 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 2 0.44 3.31 1.31
161 INT120929 Prkcg Regulation of Gene_expression of Fos 2 1 0.50 0.34 1.31
162 INT194513 Timp1 Negative_regulation of Cpox 1 2 0.00 0.9 1.31
163 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 1 0.01 0.81 1.31
164 INT198957 Binding of Cnr1 and Mastl 1 1 0.00 0 1.31
165 INT192080 Foxm1 Positive_regulation of Cnr1 2 1 0.14 0.72 1.3
166 INT201942 DPP4 Negative_regulation of CXCL10 1 2 0.33 0.9 1.3
167 INT138211 Mzb1 Regulation of Sst 1 1 0.05 0.41 1.29
168 INT138212 Mzb1 Regulation of Localization of Sst 1 1 0.12 0.41 1.29
169 INT138213 Mzb1 Regulation of Localization of Tac1 1 1 0.01 0.41 1.29
170 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 2 0.63 2.47 1.29
171 INT194408 Regulation of Binding of CALCA and DCLK3 1 2 0.15 0 1.29
172 INT135830 Gch1 Regulation of Nos2 1 2 0.65 0 1.29
173 INT138210 Mzb1 Regulation of Calca 1 1 0.25 0.41 1.29
174 INT136200 Binding of Penk and NUP37 1 2 0.04 0 1.28
175 INT138214 Mzb1 Regulation of Tac1 1 1 0.01 0.41 1.28
176 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 1 0.15 1.14 1.27
177 INT195929 Binding of OPRM1 and Prkaca 1 1 0.02 0.33 1.27
178 INT132943 Insrr Positive_regulation of Rbm39 1 1 0.00 0 1.27
179 INT195541 Lct Positive_regulation of Gene_expression of Grm2 1 4 0.02 0.4 1.27
180 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 1 0.00 0 1.27
181 INT202042 CAMK2N2 Negative_regulation of MMP9 1 1 0.01 0.73 1.25
182 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 1 0.00 0.74 1.25
183 INT66205 TNF Positive_regulation of TNF Positive_regulation of NFKB1 4 2 0.41 2.74 1.24
184 INT132465 Ltf Positive_regulation of Nos1 1 1 0.35 0.05 1.24
185 INT202039 CAMK2N2 Negative_regulation of MMP1 1 1 0.00 0.73 1.24
186 INT136257 Tff3 Regulation of SGCG 1 1 0.00 0.18 1.24
187 INT202036 CAMK2N2 Negative_regulation of MMP3 1 1 0.00 0.73 1.24
188 INT136255 Tff3 Regulation of GRIA1 1 1 0.00 0.18 1.24
189 INT136250 Phosphorylation of Tff3 Regulation of Creb1 1 1 0.02 0.18 1.24
190 INT202040 CAMK2N2 Negative_regulation of MMP7 1 1 0.00 0.73 1.24
191 INT195926 Prkaca Positive_regulation of Trpv1 1 1 0.10 0.44 1.24
192 INT199593 Binding of TRPV1 and Myoz1 1 2 0.10 1.7 1.23
193 INT136256 Creb1 Regulation of SGCG 1 1 0.26 0.18 1.23
194 INT136258 Creb1 Regulation of GRIA1 1 1 0.26 0.18 1.23
195 INT190130 Binding of CPOX and MRXS5 1 2 0.00 1.4 1.23
196 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 1 0.01 0.18 1.23
197 INT197092 TNF Regulation of VEGFA 4 1 0.21 2.78 1.22
198 INT197231 Grik1 Regulation of Gabrg1 1 1 0.19 0.13 1.22
199 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 2 0.32 2.09 1.22
200 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 1 0.19 0.07 1.21

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2006. They are ordered first by their pain relevance and then by number of times they were reported in 2006. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2006 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 120 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 112 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 57 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 28 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 218 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 60 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 53 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 52 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 53 1163 0.70 319.28 684
10 INT292 Localization of Penk 13 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 123 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 12 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 53 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 18 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 28 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 32 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 9 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 25 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 75 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 65 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 36 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 64 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 87 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 33 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 14 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 30 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 116 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 19 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 61 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 53 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 8 790 0.70 104.54 374.78
32 INT287 Localization of Cck 8 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 10 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 18 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 15 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 1 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 50 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 84 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 18 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 66 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 11 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 22 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 72 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 24 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 40 530 0.78 264.29 310.56
46 INT46460 Gene_expression of NAV1 8 288 0.78 135.51 305.75
47 INT4941 Positive_regulation of Oprd1 18 345 0.70 74.26 304.41
48 INT9131 Positive_regulation of Prkcg 37 431 0.70 130.8 302.41
49 INT477 Localization of Avp 8 813 0.81 131.58 300.4
50 INT161 Regulation of Localization of Prl 5 615 0.62 65.37 298.66
51 INT63932 Positive_regulation of Ephb1 79 537 0.70 259.67 296.14
52 INT1352 Localization of Acot1 13 728 0.80 73.01 296.01
53 INT886 Gene_expression of Pomc 25 676 0.78 129.87 295.98
54 INT11624 Gene_expression of OPRM1 66 445 0.78 72.36 294.36
55 INT5379 Gene_expression of Fos 50 656 0.78 255.5 292.54
56 INT3579 Localization of Oxt 8 555 0.81 43.35 292.44
57 INT97367 Gene_expression of Nav1 50 243 0.78 132.97 286.66
58 INT9158 Gene_expression of Tnf 42 722 0.78 522.01 277.68
59 INT2365 Positive_regulation of Cck 11 354 0.70 87.8 277.41
60 INT9381 Positive_regulation of TRPV1 42 523 0.70 187.4 276.05
61 INT94450 Gene_expression of Nav1 32 359 0.78 131.85 275.46
62 INT49750 Negative_regulation of CPOX 64 735 0.58 360.06 274.19
63 INT6852 Localization of TNF 56 883 0.81 705.95 270.84
64 INT10832 Gene_expression of IL8 58 1050 0.78 698.72 270
65 INT1396 Binding of Penk 6 355 0.48 22.79 269.65
66 INT5591 Regulation of Gene_expression of Fos 20 425 0.62 129.06 265.78
67 INT9659 Gene_expression of Il6 49 991 0.78 715.11 265.57
68 INT5972 Gene_expression of IL1B 43 948 0.78 510.91 263.97
69 INT68684 Gene_expression of VEGFA 139 2371 0.78 1742.52 259.2
70 INT87687 Positive_regulation of Trpv1 44 409 0.70 210.24 257.59
71 INT1893 Localization of Gh 42 1041 0.79 340.23 256.58
72 INT16868 Gene_expression of Il6 37 807 0.78 499.48 256.57
73 INT2909 Positive_regulation of Abat 23 334 0.70 62.1 256.43
74 INT3948 Regulation of Cck 11 291 0.62 58.07 255.88
75 INT5501 Regulation of Oprd1 9 283 0.62 55.1 249.9
76 INT1005 Localization of Sst 5 385 0.81 26.31 244.56
77 INT738 Regulation of POMC 10 459 0.62 111.19 243.74
78 INT1902 Gene_expression of Cck 16 348 0.78 70.33 241.92
79 INT11377 Positive_regulation of Ngf 28 331 0.70 206.5 238
80 INT1562 Localization of Crh 9 499 0.81 126.74 236.68
81 INT5597 Gene_expression of Pdyn 31 433 0.78 62.97 235.47
82 INT1665 Positive_regulation of Pag1 7 270 0.68 186.63 229.87
83 INT4759 Negative_regulation of Localization of Calca 20 294 0.59 82.62 226.45
84 INT9987 Gene_expression of Abat 23 296 0.78 95.46 226.34
85 INT6406 Binding of Oprm1 13 280 0.48 40.54 226.26
86 INT1212 Binding of Oprl1 4 312 0.48 28.6 225.15
87 INT11009 Phosphorylation of Creb1 22 458 0.82 111.34 221.97
88 INT626 Localization of CALCA 26 289 0.81 125.39 221.15
89 INT95787 Positive_regulation of Mapk1 91 568 0.70 226.51 220.94
90 INT6665 Gene_expression of FOS 20 520 0.77 165.31 217.66
91 INT1308 Localization of Pomc 5 457 0.81 66.83 217.5
92 INT6293 Gene_expression of Oprm1 22 312 0.78 48.73 215.61
93 INT6481 Binding of TNF 34 624 0.48 510.2 214.82
94 INT767 Localization of Gnrhr 9 565 0.80 106.68 214.57
95 INT4893 Gene_expression of Tacr1 18 366 0.78 129.67 213.92
96 INT22548 Positive_regulation of Casp3 52 483 0.70 258.78 213.07
97 INT6482 Positive_regulation of Gene_expression of TNF 43 659 0.70 569.88 210
98 INT16259 Positive_regulation of Bdnf 20 336 0.70 183.48 209.82
99 INT48955 Gene_expression of Nos2 58 753 0.78 403.87 208.08
100 INT2651 Positive_regulation of Pomc 22 403 0.70 95.72 206.24
101 INT2391 Negative_regulation of PTGS1 23 501 0.59 207.62 205.6
102 INT9132 Negative_regulation of Prkcg 28 279 0.59 88.05 203.47
103 INT798 Positive_regulation of Gene_expression of Penk 15 394 0.70 78.53 203.07
104 INT11313 Positive_regulation of Il6 25 526 0.70 331.27 201.59
105 INT2211 Negative_regulation of Abat 11 267 0.59 66.51 200.98
106 INT50670 Gene_expression of CPOX 87 763 0.76 442.13 195.02
107 INT156 Negative_regulation of Prl 2 542 0.59 131.97 192.24
108 INT528 Gene_expression of Prl 17 693 0.78 217.18 192.2
109 INT6488 Gene_expression of Tnf 41 484 0.78 339.61 191.58
110 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
111 INT63934 Phosphorylation of Ephb1 45 377 0.82 150.52 188.66
112 INT6354 Localization of Gabrg1 15 321 0.74 41.41 186.74
113 INT94952 Positive_regulation of Mapk14 53 305 0.70 197.83 186.61
114 INT1652 Regulation of Pomc 7 387 0.62 61.01 186.51
115 INT24326 Gene_expression of Ngf 35 346 0.78 218.67 184.71
116 INT10194 Positive_regulation of IL6 37 702 0.70 600.62 183.38
117 INT4803 Transcription of Penk 10 435 0.72 59.09 182.4
118 INT3440 Negative_regulation of Localization of Abat 6 221 0.57 33.94 180.36
119 INT12602 Negative_regulation of Oprm1 10 190 0.59 36.11 177.85
120 INT49441 Negative_regulation of Cpox 67 494 0.59 303.22 177.46
121 INT7506 Negative_regulation of Ltp 22 267 0.46 91.01 176.8
122 INT1429 Gene_expression of PDYN 10 308 0.78 61.33 175.65
123 INT19472 Gene_expression of Il1 34 554 0.76 419.75 175.35
124 INT943 Negative_regulation of Cck 10 205 0.59 38.42 174.78
125 INT26472 Regulation of Oprm1 16 191 0.62 35.84 173.1
126 INT15516 Gene_expression of Crp 57 711 0.77 615.33 173.09
127 INT5930 Positive_regulation of Oprm1 14 221 0.70 31.19 172.93
128 INT159 Negative_regulation of Localization of Prl 5 416 0.59 55.34 171.8
129 INT4937 Negative_regulation of Oprd1 4 224 0.59 44.51 171.11
130 INT438 Gene_expression of Crh 7 376 0.78 159.11 169.17
131 INT867 Gene_expression of IFNA1 56 930 0.78 594.85 168.03
132 INT739 Negative_regulation of POMC 4 358 0.59 102.28 166.77
133 INT55879 Gene_expression of CCL2 76 421 0.78 240.74 166.02
134 INT1114 Localization of Ins1 10 748 0.80 192.95 165.48
135 INT4768 Positive_regulation of OPRM1 21 212 0.70 31.09 164.28
136 INT2366 Binding of Cck 6 192 0.48 30.64 163.46
137 INT5127 Localization of Lhb 7 488 0.80 50.48 162.66
138 INT3448 Positive_regulation of Gh 14 521 0.69 180.03 161.18
139 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
140 INT51921 Gene_expression of Cpox 48 501 0.73 229.81 157.81
141 INT21185 Binding of Ptprg 3 213 0.47 13.49 157.75
142 INT66280 Gene_expression of Nos2 31 534 0.78 330.78 157.07
143 INT768 Positive_regulation of Oprl1 11 179 0.70 40.05 156.93
144 INT1303 Negative_regulation of Npr1 4 278 0.55 35.1 156.78
145 INT2640 Gene_expression of Pomc 4 424 0.78 120.72 155.37
146 INT6042 Binding of Oprm1 12 248 0.48 31.77 154.34
147 INT4740 Gene_expression of Th 13 298 0.78 61.27 154.03
148 INT2910 Regulation of Abat 6 169 0.62 36.95 153.53
149 INT1044 Negative_regulation of Localization of LH 5 358 0.59 25.95 151.31
150 INT120811 Gene_expression of Gopc 42 1174 0.59 428.49 150.55
151 INT4829 Positive_regulation of Localization of Abat 13 199 0.55 20.91 150.48
152 INT15515 Positive_regulation of Crp 35 700 0.70 604.24 150.15
153 INT49134 Gene_expression of Grin1 33 270 0.78 84.78 148.61
154 INT5050 Regulation of Localization of Calca 10 149 0.62 41.25 148.57
155 INT6108 Gene_expression of Npy 15 292 0.78 110.65 148.21
156 INT13353 Positive_regulation of Tnf 34 332 0.70 248.75 148.1
157 INT7628 Gene_expression of Ltp 18 273 0.77 70.21 147.87
158 INT2451 Positive_regulation of Avp 11 355 0.70 102.66 147.69
159 INT1033 Positive_regulation of Ca2 46 507 0.68 131.76 147.64
160 INT9852 Positive_regulation of Gpt 41 563 0.70 364.64 146.82
161 INT5116 Gene_expression of IL2 33 670 0.78 291.13 146.69
162 INT812 Localization of INS 26 1026 0.81 515.6 145.31
163 INT425 Localization of PRL 22 455 0.81 189.64 144.8
164 INT3300 Positive_regulation of Gene_expression of Calca 8 179 0.70 77.76 144.2
165 INT2780 Regulation of Gene_expression of Penk 17 265 0.62 32.45 143.88
166 INT60694 Gene_expression of Il10 22 567 0.78 369.48 143.69
167 INT9660 Regulation of TNF 36 363 0.62 312.94 139.99
168 INT1414 Regulation of Oprl1 3 169 0.62 32.05 139.99
169 INT90910 Phosphorylation of Grin1 11 150 0.82 68.23 139.24
170 INT14843 Gene_expression of Gabrg1 26 301 0.77 62.63 139.16
171 INT1273 Gene_expression of Avp 27 356 0.78 90.56 138.7
172 INT48895 Gene_expression of Il10 37 333 0.78 221.2 138.52
173 INT2867 Gene_expression of CALCA 29 247 0.78 78.78 138.47
174 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
175 INT4658 Binding of OPRM1 27 188 0.48 25.96 136.24
176 INT1047 Negative_regulation of LH 6 314 0.59 53.71 135.89
177 INT2541 Binding of Calca 10 200 0.48 67.14 134.62
178 INT60126 Regulation of Trpv1 27 186 0.62 85.53 133.4
179 INT11012 Positive_regulation of Creb1 22 258 0.70 84.4 132
180 INT48953 Positive_regulation of Nos2 46 486 0.70 239.85 131.87
181 INT5497 Positive_regulation of Crh 6 299 0.70 125.54 131.14
182 INT5380 Positive_regulation of Gene_expression of Fos 35 243 0.70 105.65 131.05
183 INT49439 Gene_expression of Cpox 54 508 0.73 326.97 130.17
184 INT5595 Positive_regulation of Pdyn 9 223 0.70 48.37 130.14
185 INT64161 Positive_regulation of Prkca 22 213 0.70 85.06 129.91
186 INT115386 Gene_expression of Ppara 56 779 0.77 549.99 128.36
187 INT65600 Positive_regulation of Casp3 21 376 0.70 198.44 128.03
188 INT1614 Gene_expression of Oprl1 10 164 0.78 31.43 127.74
189 INT5842 Gene_expression of Gfap 23 372 0.78 153.71 127.71
190 INT1878 Binding of HLA-B 36 440 0.48 321.16 127.36
191 INT695 Binding of POMC 15 304 0.48 56.66 126.85
192 INT65054 Positive_regulation of Nfkb1 26 285 0.70 149.33 126.73
193 INT5931 Regulation of Oprm1 10 149 0.62 18.15 125.93
194 INT6822 Gene_expression of Pdyn 16 215 0.78 35.99 125.76
195 INT416 Regulation of LH 2 253 0.62 31.48 125.55
196 INT5008 Localization of Calca 27 204 0.81 80.35 125.16
197 INT6323 Positive_regulation of Gabrg1 4 213 0.70 45.08 124.34
198 INT4824 Positive_regulation of Tacr1 5 169 0.70 66.1 123.46
199 INT4259 Positive_regulation of Npr1 6 262 0.70 49.37 123.11
200 INT2106 Regulation of Localization of LH 4 279 0.62 22.37 122.77
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