Y:2008

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2008. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2008. They are ordered first by their pain relevance and then by number of times they were reported in 2008. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2008 Documents TM Confidence Disease Relevance Pain Relevance
1 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 1 0.73 0.87 14.34
2 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 3 0.64 2.12 14.2
3 INT221180 Binding of OPRM1 and Flna 1 10 0.09 0.22 12.65
4 INT106676 Binding of Trpv1 and Phax 18 4 0.34 4.19 12.36
5 INT206768 TP53 Positive_regulation of Ltp 2 8 0.01 5.83 10.21
6 INT77646 Binding of Ngf and Ntrk1 23 6 0.40 7.85 9.26
7 INT2714 Pomc Positive_regulation of Localization of Prl 17 1 0.79 0.5 8.18
8 INT51205 Binding of OPRK1 and PDYN 7 1 0.00 2.01 7.8
9 INT149117 Binding of CD80 and CTLA4 31 13 0.52 12.7 7.73
10 INT106559 Binding of Bdnf and Ntrk2 23 1 0.43 11.09 7.33
11 INT254001 Binding of Cxcr4 and Mif 1 27 0.52 14.17 7.18
12 INT188692 Binding of Cd40 and Cd40lg 32 13 0.34 22.95 6.62
13 INT251170 Clu Positive_regulation of Trpv1 1 11 0.28 2.61 6.49
14 INT84921 Binding of NGF and NTRK1 13 1 0.50 6.39 6.1
15 INT155484 Binding of CD86 and CTLA4 15 7 0.52 8.85 6.09
16 INT269444 Binding of RAB5A and HHIP 1 28 0.04 0 5.79
17 INT179502 Binding of Cd14 and Tlr4 29 8 0.39 13.77 5.73
18 INT227157 Binding of PEBP1 and Gpm6a 1 5 0.00 1.28 5.52
19 INT20133 Trh Positive_regulation of Localization of Prl 23 2 0.78 2.04 5.44
20 INT9546 Binding of Adarb1 and Penk 5 2 0.03 0 5.1
21 INT15842 Crh Positive_regulation of Localization of Pomc 15 1 0.73 5 5.05
22 INT182124 Binding of IRF6 and TLR4 14 4 0.10 16.11 4.65
23 INT1392 Trh Regulation of Prl 15 1 0.29 2.47 4.29
24 INT122567 Mog Positive_regulation of Eae1 8 4 0.31 10.18 4.26
25 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 2 0.55 2.97 4.23
26 INT182194 Binding of IL8 and CXCR2 10 2 0.56 7.14 4.16
27 INT95730 Binding of CP and SPINK1 2 6 0.19 5.65 4.02
28 INT101942 Binding of CD40 and CD40LG 16 8 0.23 15.24 4.01
29 INT73539 Binding of Ngf and Ngfr 5 2 0.45 3.99 4
30 INT127128 Binding of CNR1 and CNR2 8 4 0.39 3.98 3.97
31 INT82023 Binding of Ntrk1 and Ngf 5 1 0.53 3.48 3.92
32 INT130625 Prkcg Regulation of Prkaca 1 1 0.23 1.32 3.87
33 INT69032 IL18 Positive_regulation of IFNA1 12 1 0.23 7.87 3.83
34 INT220623 Binding of Stat1 and Bace1 11 7 0.25 10.33 3.81
35 INT249566 Binding of Oprd1 and Psmd1 1 3 0.01 0.82 3.8
36 INT181455 Binding of Ccr5 and Ccl5 11 1 0.39 12.13 3.66
37 INT132862 Ngf Positive_regulation of Bdnf 4 1 0.46 4.05 3.65
38 INT57985 Il1b Positive_regulation of Il6 5 1 0.59 1.66 3.53
39 INT121651 Binding of CXCL12 and CXCR4 13 8 0.48 17.61 3.52
40 INT158770 Binding of Trpv1 and Trpa1 5 3 0.34 2.07 3.5
41 INT152035 Binding of HLA-A and MRAP 2 1 0.31 6.95 3.4
42 INT194647 Binding of CD28 and CD80 15 3 0.40 4.9 3.22
43 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 2 0.66 5.22 3.22
44 INT166134 Binding of Cxcl12 and Cxcr4 3 7 0.49 5.69 3.17
45 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 4 0.15 0.68 3.17
46 INT251146 Binding of Grin1 and Dlg2 1 3 0.36 1.95 3.16
47 INT289979 Binding of Helt and Negative_regulation of Maoa 1 4 0.00 0.17 3.14
48 INT186126 Binding of CD28 and CTLA4 9 3 0.52 4.13 3.12
49 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 1 0.35 13.11 3.11
50 INT208572 Binding of IL8 and CXCR1 6 1 0.33 5.2 3.08
51 INT102284 Binding of Grin1 and Grin2a 5 1 0.27 1.79 3.01
52 INT152699 Bdnf Positive_regulation of Ltp 5 2 0.05 1.22 2.95
53 INT150889 Il1a Regulation of Il10 1 4 0.22 3.49 2.95
54 INT150886 Il1a Regulation of Il1b 1 4 0.02 3.46 2.93
55 INT150888 Il1a Regulation of Il6 1 4 0.10 3.47 2.93
56 INT150632 Ea1 Negative_regulation of Mpo 1 2 0.17 1.55 2.9
57 INT130721 Binding of IL1B and IL1RN 6 2 0.05 5.29 2.85
58 INT106560 Binding of Ntf3 and Ntrk2 3 2 0.14 2.47 2.84
59 INT175329 Binding of ICAM1 and ITGAL 14 4 0.18 10.06 2.81
60 INT229497 Binding of Vim and Ndel1 1 18 0.33 3.5 2.81
61 INT170367 Binding of Grin1 and Grin2a 5 1 0.23 1.72 2.79
62 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 7 0.06 1.79 2.79
63 INT186128 Binding of CD2 and CD58 8 1 0.10 7.59 2.76
64 INT226118 Ghrl Regulation of Prkag1 1 9 0.08 0.72 2.72
65 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 2 0.08 3.07 2.71
66 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 2 0.76 3.07 2.71
67 INT151381 St8sia1 Positive_regulation of Cck 1 2 0.19 0.45 2.7
68 INT150455 Binding of Prss12 and Nts 3 2 0.24 1.42 2.66
69 INT150457 Binding of Sort1 and Prss12 3 2 0.21 1.36 2.64
70 INT152113 Binding of NTSR1 and Ngf 3 4 0.33 2.09 2.62
71 INT251150 Binding of Nos1 and Dlg2 1 2 0.30 1.98 2.62
72 INT121742 Prkcg Positive_regulation of Ephb1 3 2 0.49 0.99 2.6
73 INT150596 Binding of Oprd1 and Oprk1 1 2 0.08 0.14 2.59
74 INT29446 Crh Positive_regulation of Localization of POMC 8 1 0.38 1.87 2.58
75 INT152501 Binding of Tnf and Tnfrsf1a 4 1 0.31 3 2.58
76 INT253988 Binding of Cd74 and Mif 1 6 0.36 6.57 2.52
77 INT151826 Tnf Positive_regulation of TNF 1 2 0.04 3.38 2.51
78 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 2 0.01 0.66 2.5
79 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 3 0.19 0.52 2.46
80 INT231968 Binding of Cpn1 and Rvm 1 3 0.11 1.57 2.45
81 INT231970 Binding of Cpn1 and Pag1 1 3 0.07 1.56 2.44
82 INT251147 Binding of Grin2b and Dlg2 1 6 0.33 2.75 2.43
83 INT255317 Binding of Dpep1 and Nav1 1 3 0.01 0 2.42
84 INT122163 Binding of TNF and TNFRSF1B 6 2 0.44 6.06 2.41
85 INT284088 Binding of BDNF and NTRK2 5 4 0.41 3.4 2.37
86 INT115367 Binding of IL6 and IL6R 12 7 0.07 8.16 2.36
87 INT74840 Binding of Cacna1a and Cacna1a 5 2 0.00 4.24 2.36
88 INT153728 RYBP Positive_regulation of Gpt 3 1 0.03 2.01 2.36
89 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 1 0.23 0 2.35
90 INT121746 Prkaca Positive_regulation of Ephb1 2 1 0.23 0.92 2.35
91 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 2 0.19 3.22 2.35
92 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 1 0.28 0.07 2.32
93 INT249013 Gabrg1 Negative_regulation of Per2 1 4 0.34 0.07 2.31
94 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 4 0.69 0.73 2.29
95 INT152901 TRPV1 Regulation of Localization of CALCA 1 4 0.44 0.73 2.29
96 INT247601 Binding of PEPD and SCN9A 1 2 0.15 2.26 2.27
97 INT231971 Binding of Cpn1 and Shbdp1 1 3 0.04 1.39 2.26
98 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 2 0.39 2.97 2.26
99 INT231967 Binding of Psmd1 and Cpn1 1 3 0.06 1.39 2.25
100 INT231969 Binding of Cfp and Cpn1 1 3 0.05 1.38 2.25
101 INT251164 Binding of Clu and Trpv1 1 4 0.19 0.44 2.23
102 INT194646 Binding of CD28 and CD86 7 1 0.40 2.69 2.21
103 INT279361 Binding of TNF and KLF1 4 4 0.00 3.72 2.19
104 INT255318 Binding of Dpep1 and Nrcam 1 3 0.00 0 2.16
105 INT239037 Binding of Cd28 and Cd86 9 3 0.16 3.69 2.14
106 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 11 0.06 4.35 2.14
107 INT240131 Binding of Crp and Nppb 7 8 0.07 11.53 2.12
108 INT251145 Binding of Grin2a and Dlg2 1 5 0.31 2.3 2.11
109 INT83425 Binding of CD40LG and IGHG3 11 1 0.21 4.56 2.09
110 INT148704 Binding of TNF and TNFRSF1A 5 2 0.44 3.3 2.09
111 INT221181 Binding of GOPC and Flna 1 2 0.03 0.06 2.08
112 INT245348 Binding of Abat and Vta1 1 2 0.03 0.53 2.01
113 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 1 0.43 2.23 2
114 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 1 0.48 2.23 2
115 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 1 0.49 2.23 2
116 INT60626 Crh Positive_regulation of Localization of Pomc 7 4 0.54 2.3 1.99
117 INT274372 Phc1 Negative_regulation of Slc6a3 1 4 0.06 0.47 1.99
118 INT240658 Ngf Positive_regulation of Ngf Positive_regulation of Bdnf 1 1 0.33 1.67 1.99
119 INT217042 IRF6 Positive_regulation of TNF 4 1 0.27 3.03 1.95
120 INT129212 RYBP Positive_regulation of Tnf 2 1 0.03 1.9 1.95
121 INT97208 Binding of Gabrg1 and Gabbr1 2 1 0.07 0.31 1.94
122 INT60867 Binding of G2e3 and Gpm6a 2 2 0.01 0.1 1.93
123 INT227493 Binding of TCEA1 and SIRT2 1 3 0.01 1.55 1.93
124 INT104855 Prkaca Regulation of TRPV1 3 2 0.06 1.52 1.92
125 INT6931 Binding of Oprk1 and Pdyn 2 1 0.24 0.92 1.92
126 INT262558 Phax Positive_regulation of Trpv1 1 2 0.01 1.26 1.92
127 INT149470 Oxt Regulation of Gene_expression of Avp 1 2 0.46 1.2 1.92
128 INT227543 Mtx1 Positive_regulation of Prep 1 2 0.22 1.19 1.92
129 INT227542 Mtx1 Positive_regulation of Binding of Prep and 1 2 0.23 1.2 1.92
130 INT113550 Binding of FN1 and VTN 6 1 0.30 5.24 1.91
131 INT279359 Binding of ADA and TNF 1 4 0.20 2.61 1.91
132 INT149469 Oxt Regulation of Gene_expression of Crh 1 2 0.45 1.2 1.91
133 INT93293 Ngf Regulation of Trpv1 2 1 0.28 0.71 1.9
134 INT151965 SORBS1 Positive_regulation of TRPV1 1 3 0.18 0 1.89
135 INT183781 Binding of IL6 and INS 6 1 0.22 8.97 1.87
136 INT153582 Binding of Oprm1 and Hint1 1 3 0.01 0 1.87
137 INT243043 Binding of Mmp9 and Timp1 1 2 0.05 0.25 1.86
138 INT112517 Binding of Ephb1 and Prkaca 3 1 0.18 0.58 1.85
139 INT9786 Gnrh1 Regulation of LH 7 1 0.40 0.58 1.82
140 INT150456 Binding of Sort1 and Nts 3 2 0.45 0.64 1.79
141 INT136273 NGF Regulation of Gene_expression of BDNF 2 1 0.41 1.14 1.78
142 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 2 0.40 0.37 1.76
143 INT102160 Binding of Mmp2 and Mmp9 3 1 0.28 2.87 1.75
144 INT253895 Binding of Htr1b and Htr1d 1 1 0.40 0.52 1.74
145 INT137207 Tnf Positive_regulation of Nfkb1 3 1 0.23 2.69 1.71
146 INT148090 Binding of CALCA and NCOR2 1 1 0.00 0.65 1.71
147 INT249005 Gabrg1 Positive_regulation of Per2 1 3 0.39 0 1.7
148 INT62065 Binding of YY1 and Penk 3 1 0.14 0 1.69
149 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 1 0.52 6.58 1.68
150 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 2 0.01 1.74 1.67
151 INT101926 Binding of Dio1 and Drd2 4 1 0.28 0.39 1.66
152 INT142437 Urb1 Negative_regulation of Faah 3 1 0.41 2.12 1.66
153 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 3 0.75 3.05 1.66
154 INT108066 Binding of NTRK1 and Ngf 3 2 0.33 2.56 1.66
155 INT249483 Binding of Ephb1 and Efnb2 1 2 0.02 2.35 1.66
156 INT149680 Binding of Parp1 and Oprm1 1 3 0.53 0 1.66
157 INT151889 Binding of Adarb1 and DLL1 1 2 0.00 0 1.66
158 INT96296 Oprm1 Negative_regulation of Npr1 2 1 0.05 0.32 1.65
159 INT236491 GCH1 Regulation of Pain1 1 1 0.01 0.89 1.65
160 INT194863 Binding of IL1R1 and IL1RN 5 2 0.09 2.23 1.64
161 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 1 0.47 1.01 1.63
162 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 1 0.46 2.13 1.63
163 INT45816 Binding of Car2 and Gabrg1 2 1 0.28 0.15 1.63
164 INT247281 GLC1N Negative_regulation of HRAS 1 2 0.02 1.98 1.62
165 INT151020 Binding of Pdyn and Crh 1 1 0.14 0.42 1.59
166 INT149632 Binding of HK1 and NCOR2 1 1 0.01 0.13 1.58
167 INT254243 Binding of HOMER1 and MRI1 1 2 0.03 1.99 1.57
168 INT237286 Dlat Regulation of Prep 1 3 0.01 0 1.57
169 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 1 0.07 0 1.57
170 INT148935 Ramp1 Regulation of Calca 1 2 0.27 0.69 1.56
171 INT208991 Binding of CALM1 and Ca2 10 2 0.06 1.34 1.55
172 INT148821 Binding of Oprm1 and Grin1 1 1 0.05 0.24 1.55
173 INT148820 Binding of Oprm1 and Naa15 1 1 0.02 0.24 1.55
174 INT254205 Binding of Myd88 and Tlr4 12 1 0.19 3.17 1.54
175 INT252633 Binding of TNF and Tnfrsf1b 4 2 0.05 3.66 1.54
176 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 3 0.14 3.26 1.54
177 INT106751 Pes1 Negative_regulation of Casp3 2 1 0.23 0 1.54
178 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 2 0.22 1.11 1.54
179 INT241750 Binding of CD4 and ITIH4 14 12 0.18 5.72 1.53
180 INT245347 Binding of Penk and Vta1 1 1 0.05 0.14 1.53
181 INT256360 Car2 Positive_regulation of Localization of Rela 1 2 0.14 0 1.51
182 INT260897 CRH Positive_regulation of Localization of IL8 1 3 0.24 0.09 1.51
183 INT253863 Binding of LBP and PNP 1 1 0.13 1.5 1.5
184 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 1 0.10 1.54 1.5
185 INT240057 Binding of RHOB and NME8 1 5 0.41 4.11 1.5
186 INT229094 Binding of IL1RN and Il1r1 1 3 0.01 1.9 1.5
187 INT64628 Binding of Oxt and Gal 2 1 0.29 0.29 1.49
188 INT159657 Binding of INSRR and NGF 3 2 0.00 1.65 1.48
189 INT155497 Oprk1 Negative_regulation of Tenc1 1 2 0.08 0.34 1.48
190 INT222185 Binding of Ccr1 and Ccl3 4 3 0.23 2.7 1.47
191 INT156008 Bcl2 Regulation of Localization of Aifm1 1 2 0.17 1.92 1.47
192 INT161870 OPRM1 Positive_regulation of Prkcg 1 1 0.01 0.12 1.47
193 INT150885 Il6 Regulation of Il10 1 2 0.22 1.74 1.47
194 INT161865 Mors1 Positive_regulation of Prkcg 1 1 0.00 0.12 1.47
195 INT150887 Il1b Regulation of Il10 1 2 0.04 1.74 1.47
196 INT131564 Binding of Npw and Npbwr1 3 2 0.41 0.35 1.46
197 INT161871 Mors1 Positive_regulation of GRIN1 1 1 0.01 0.12 1.46
198 INT161858 OPRM1 Positive_regulation of GRIN1 1 1 0.50 0.12 1.45
199 INT161860 OPRM1 Positive_regulation of OPRM1 Positive_regulation of GRIN1 1 1 0.56 0.12 1.45
200 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 1 0.62 0.7 1.44

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2008. They are ordered first by their pain relevance and then by number of times they were reported in 2008. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2008 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 231 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 141 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 60 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 140 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 594 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 210 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 70 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 55 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 87 1163 0.70 319.28 684
10 INT292 Localization of Penk 11 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 140 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 15 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 41 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 4 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 62 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 61 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 57 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 35 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 63 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 266 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 37 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 54 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 112 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 30 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 8 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 33 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 185 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 25 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 163 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 33 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 36 790 0.70 104.54 374.78
32 INT287 Localization of Cck 2 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 26 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 23 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 14 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 106 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 164 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 227 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 17 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 196 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 18 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 20 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 52 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 36 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 57 530 0.78 264.29 310.56
46 INT46460 Gene_expression of NAV1 87 288 0.78 135.51 305.75
47 INT4941 Positive_regulation of Oprd1 23 345 0.70 74.26 304.41
48 INT9131 Positive_regulation of Prkcg 33 431 0.70 130.8 302.41
49 INT477 Localization of Avp 26 813 0.81 131.58 300.4
50 INT161 Regulation of Localization of Prl 18 615 0.62 65.37 298.66
51 INT63932 Positive_regulation of Ephb1 114 537 0.70 259.67 296.14
52 INT1352 Localization of Acot1 19 728 0.80 73.01 296.01
53 INT886 Gene_expression of Pomc 22 676 0.78 129.87 295.98
54 INT11624 Gene_expression of OPRM1 39 445 0.78 72.36 294.36
55 INT5379 Gene_expression of Fos 96 656 0.78 255.5 292.54
56 INT3579 Localization of Oxt 20 555 0.81 43.35 292.44
57 INT97367 Gene_expression of Nav1 34 243 0.78 132.97 286.66
58 INT9158 Gene_expression of Tnf 88 722 0.78 522.01 277.68
59 INT2365 Positive_regulation of Cck 7 354 0.70 87.8 277.41
60 INT9381 Positive_regulation of TRPV1 88 523 0.70 187.4 276.05
61 INT94450 Gene_expression of Nav1 65 359 0.78 131.85 275.46
62 INT49750 Negative_regulation of CPOX 169 735 0.58 360.06 274.19
63 INT6852 Localization of TNF 129 883 0.81 705.95 270.84
64 INT10832 Gene_expression of IL8 155 1050 0.78 698.72 270
65 INT1396 Binding of Penk 6 355 0.48 22.79 269.65
66 INT5591 Regulation of Gene_expression of Fos 29 425 0.62 129.06 265.78
67 INT9659 Gene_expression of Il6 166 991 0.78 715.11 265.57
68 INT5972 Gene_expression of IL1B 117 948 0.78 510.91 263.97
69 INT68684 Gene_expression of VEGFA 396 2371 0.78 1742.52 259.2
70 INT87687 Positive_regulation of Trpv1 89 409 0.70 210.24 257.59
71 INT1893 Localization of Gh 106 1041 0.79 340.23 256.58
72 INT16868 Gene_expression of Il6 125 807 0.78 499.48 256.57
73 INT2909 Positive_regulation of Abat 21 334 0.70 62.1 256.43
74 INT3948 Regulation of Cck 3 291 0.62 58.07 255.88
75 INT5501 Regulation of Oprd1 17 283 0.62 55.1 249.9
76 INT1005 Localization of Sst 6 385 0.81 26.31 244.56
77 INT738 Regulation of POMC 7 459 0.62 111.19 243.74
78 INT1902 Gene_expression of Cck 5 348 0.78 70.33 241.92
79 INT11377 Positive_regulation of Ngf 20 331 0.70 206.5 238
80 INT1562 Localization of Crh 25 499 0.81 126.74 236.68
81 INT5597 Gene_expression of Pdyn 7 433 0.78 62.97 235.47
82 INT1665 Positive_regulation of Pag1 7 270 0.68 186.63 229.87
83 INT4759 Negative_regulation of Localization of Calca 25 294 0.59 82.62 226.45
84 INT9987 Gene_expression of Abat 48 296 0.78 95.46 226.34
85 INT6406 Binding of Oprm1 20 280 0.48 40.54 226.26
86 INT1212 Binding of Oprl1 2 312 0.48 28.6 225.15
87 INT11009 Phosphorylation of Creb1 35 458 0.82 111.34 221.97
88 INT626 Localization of CALCA 29 289 0.81 125.39 221.15
89 INT95787 Positive_regulation of Mapk1 101 568 0.70 226.51 220.94
90 INT6665 Gene_expression of FOS 140 520 0.77 165.31 217.66
91 INT1308 Localization of Pomc 10 457 0.81 66.83 217.5
92 INT6293 Gene_expression of Oprm1 17 312 0.78 48.73 215.61
93 INT6481 Binding of TNF 153 624 0.48 510.2 214.82
94 INT767 Localization of Gnrhr 8 565 0.80 106.68 214.57
95 INT4893 Gene_expression of Tacr1 34 366 0.78 129.67 213.92
96 INT22548 Positive_regulation of Casp3 85 483 0.70 258.78 213.07
97 INT6482 Positive_regulation of Gene_expression of TNF 120 659 0.70 569.88 210
98 INT16259 Positive_regulation of Bdnf 110 336 0.70 183.48 209.82
99 INT48955 Gene_expression of Nos2 56 753 0.78 403.87 208.08
100 INT2651 Positive_regulation of Pomc 20 403 0.70 95.72 206.24
101 INT2391 Negative_regulation of PTGS1 30 501 0.59 207.62 205.6
102 INT9132 Negative_regulation of Prkcg 25 279 0.59 88.05 203.47
103 INT798 Positive_regulation of Gene_expression of Penk 18 394 0.70 78.53 203.07
104 INT11313 Positive_regulation of Il6 56 526 0.70 331.27 201.59
105 INT2211 Negative_regulation of Abat 22 267 0.59 66.51 200.98
106 INT50670 Gene_expression of CPOX 127 763 0.76 442.13 195.02
107 INT156 Negative_regulation of Prl 20 542 0.59 131.97 192.24
108 INT528 Gene_expression of Prl 73 693 0.78 217.18 192.2
109 INT6488 Gene_expression of Tnf 52 484 0.78 339.61 191.58
110 INT2085 Positive_regulation of LH 1 441 0.70 60.15 191.02
111 INT63934 Phosphorylation of Ephb1 70 377 0.82 150.52 188.66
112 INT6354 Localization of Gabrg1 36 321 0.74 41.41 186.74
113 INT94952 Positive_regulation of Mapk14 52 305 0.70 197.83 186.61
114 INT1652 Regulation of Pomc 10 387 0.62 61.01 186.51
115 INT24326 Gene_expression of Ngf 26 346 0.78 218.67 184.71
116 INT10194 Positive_regulation of IL6 117 702 0.70 600.62 183.38
117 INT4803 Transcription of Penk 9 435 0.72 59.09 182.4
118 INT3440 Negative_regulation of Localization of Abat 10 221 0.57 33.94 180.36
119 INT12602 Negative_regulation of Oprm1 15 190 0.59 36.11 177.85
120 INT49441 Negative_regulation of Cpox 61 494 0.59 303.22 177.46
121 INT7506 Negative_regulation of Ltp 35 267 0.46 91.01 176.8
122 INT1429 Gene_expression of PDYN 20 308 0.78 61.33 175.65
123 INT19472 Gene_expression of Il1 123 554 0.76 419.75 175.35
124 INT943 Negative_regulation of Cck 3 205 0.59 38.42 174.78
125 INT26472 Regulation of Oprm1 13 191 0.62 35.84 173.1
126 INT15516 Gene_expression of Crp 106 711 0.77 615.33 173.09
127 INT5930 Positive_regulation of Oprm1 9 221 0.70 31.19 172.93
128 INT159 Negative_regulation of Localization of Prl 32 416 0.59 55.34 171.8
129 INT4937 Negative_regulation of Oprd1 13 224 0.59 44.51 171.11
130 INT438 Gene_expression of Crh 28 376 0.78 159.11 169.17
131 INT867 Gene_expression of IFNA1 144 930 0.78 594.85 168.03
132 INT739 Negative_regulation of POMC 5 358 0.59 102.28 166.77
133 INT55879 Gene_expression of CCL2 72 421 0.78 240.74 166.02
134 INT1114 Localization of Ins1 81 748 0.80 192.95 165.48
135 INT4768 Positive_regulation of OPRM1 31 212 0.70 31.09 164.28
136 INT5127 Localization of Lhb 7 488 0.80 50.48 162.66
137 INT3448 Positive_regulation of Gh 34 521 0.69 180.03 161.18
138 INT5513 Negative_regulation of Pomc 7 295 0.59 60.9 158.63
139 INT51921 Gene_expression of Cpox 32 501 0.73 229.81 157.81
140 INT21185 Binding of Ptprg 2 213 0.47 13.49 157.75
141 INT66280 Gene_expression of Nos2 131 534 0.78 330.78 157.07
142 INT768 Positive_regulation of Oprl1 1 179 0.70 40.05 156.93
143 INT1303 Negative_regulation of Npr1 15 278 0.55 35.1 156.78
144 INT2640 Gene_expression of Pomc 27 424 0.78 120.72 155.37
145 INT6042 Binding of Oprm1 3 248 0.48 31.77 154.34
146 INT4740 Gene_expression of Th 18 298 0.78 61.27 154.03
147 INT2910 Regulation of Abat 13 169 0.62 36.95 153.53
148 INT1044 Negative_regulation of Localization of LH 5 358 0.59 25.95 151.31
149 INT120811 Gene_expression of Gopc 297 1174 0.59 428.49 150.55
150 INT4829 Positive_regulation of Localization of Abat 7 199 0.55 20.91 150.48
151 INT880 Positive_regulation of Localization of Gh1 23 304 0.70 14.79 150.23
152 INT15515 Positive_regulation of Crp 74 700 0.70 604.24 150.15
153 INT49134 Gene_expression of Grin1 37 270 0.78 84.78 148.61
154 INT5050 Regulation of Localization of Calca 18 149 0.62 41.25 148.57
155 INT6108 Gene_expression of Npy 15 292 0.78 110.65 148.21
156 INT13353 Positive_regulation of Tnf 23 332 0.70 248.75 148.1
157 INT7628 Gene_expression of Ltp 46 273 0.77 70.21 147.87
158 INT2451 Positive_regulation of Avp 16 355 0.70 102.66 147.69
159 INT1033 Positive_regulation of Ca2 98 507 0.68 131.76 147.64
160 INT9852 Positive_regulation of Gpt 89 563 0.70 364.64 146.82
161 INT5116 Gene_expression of IL2 123 670 0.78 291.13 146.69
162 INT812 Localization of INS 183 1026 0.81 515.6 145.31
163 INT425 Localization of PRL 40 455 0.81 189.64 144.8
164 INT2379 Positive_regulation of Localization of LH 17 349 0.70 27.86 144.53
165 INT3300 Positive_regulation of Gene_expression of Calca 16 179 0.70 77.76 144.2
166 INT2780 Regulation of Gene_expression of Penk 5 265 0.62 32.45 143.88
167 INT60694 Gene_expression of Il10 92 567 0.78 369.48 143.69
168 INT9660 Regulation of TNF 66 363 0.62 312.94 139.99
169 INT1414 Regulation of Oprl1 3 169 0.62 32.05 139.99
170 INT90910 Phosphorylation of Grin1 18 150 0.82 68.23 139.24
171 INT14843 Gene_expression of Gabrg1 54 301 0.77 62.63 139.16
172 INT1273 Gene_expression of Avp 26 356 0.78 90.56 138.7
173 INT48895 Gene_expression of Il10 23 333 0.78 221.2 138.52
174 INT2867 Gene_expression of CALCA 21 247 0.78 78.78 138.47
175 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
176 INT4658 Binding of OPRM1 26 188 0.48 25.96 136.24
177 INT1047 Negative_regulation of LH 5 314 0.59 53.71 135.89
178 INT2541 Binding of Calca 15 200 0.48 67.14 134.62
179 INT60126 Regulation of Trpv1 29 186 0.62 85.53 133.4
180 INT11012 Positive_regulation of Creb1 20 258 0.70 84.4 132
181 INT48953 Positive_regulation of Nos2 61 486 0.70 239.85 131.87
182 INT5497 Positive_regulation of Crh 15 299 0.70 125.54 131.14
183 INT5380 Positive_regulation of Gene_expression of Fos 12 243 0.70 105.65 131.05
184 INT49439 Gene_expression of Cpox 137 508 0.73 326.97 130.17
185 INT5595 Positive_regulation of Pdyn 3 223 0.70 48.37 130.14
186 INT64161 Positive_regulation of Prkca 43 213 0.70 85.06 129.91
187 INT115386 Gene_expression of Ppara 332 779 0.77 549.99 128.36
188 INT65600 Positive_regulation of Casp3 53 376 0.70 198.44 128.03
189 INT1614 Gene_expression of Oprl1 5 164 0.78 31.43 127.74
190 INT5842 Gene_expression of Gfap 61 372 0.78 153.71 127.71
191 INT1878 Binding of HLA-B 50 440 0.48 321.16 127.36
192 INT695 Binding of POMC 13 304 0.48 56.66 126.85
193 INT65054 Positive_regulation of Nfkb1 33 285 0.70 149.33 126.73
194 INT5931 Regulation of Oprm1 6 149 0.62 18.15 125.93
195 INT6822 Gene_expression of Pdyn 9 215 0.78 35.99 125.76
196 INT416 Regulation of LH 2 253 0.62 31.48 125.55
197 INT5008 Localization of Calca 38 204 0.81 80.35 125.16
198 INT6323 Positive_regulation of Gabrg1 54 213 0.70 45.08 124.34
199 INT4824 Positive_regulation of Tacr1 6 169 0.70 66.1 123.46
200 INT4259 Positive_regulation of Npr1 10 262 0.70 49.37 123.11
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