Y:2009

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2009. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2009. They are ordered first by their pain relevance and then by number of times they were reported in 2009. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2009 Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 21 0.03 0.25 25.89
2 INT69872 Binding of MC1R and POMC 52 6 0.54 8.87 18.3
3 INT106676 Binding of Trpv1 and Phax 18 3 0.34 4.19 12.36
4 INT77646 Binding of Ngf and Ntrk1 23 4 0.40 7.85 9.26
5 INT149117 Binding of CD80 and CTLA4 31 2 0.52 12.7 7.73
6 INT106559 Binding of Bdnf and Ntrk2 23 10 0.43 11.09 7.33
7 INT259228 Binding of Oprm1 and Glul 1 5 0.00 0.08 7.22
8 INT131249 Binding of Bdnf and Ntrk2 11 2 0.41 4 6.25
9 INT84921 Binding of NGF and NTRK1 13 7 0.50 6.39 6.1
10 INT155484 Binding of CD86 and CTLA4 15 3 0.52 8.85 6.09
11 INT176477 Binding of CXCR3 and CXCL10 14 1 0.25 10.61 5.87
12 INT179502 Binding of Cd14 and Tlr4 29 3 0.39 13.77 5.73
13 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 4 0.78 3.57 5.71
14 INT211710 Binding of Mc1r and a 7 2 0.44 0.37 4.78
15 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 1 0.59 9.37 4.48
16 INT122567 Mog Positive_regulation of Eae1 8 2 0.31 10.18 4.26
17 INT259209 Binding of Glul and Flna 1 3 0.03 0 4.2
18 INT161109 Avp Positive_regulation of Chkb 1 2 0.12 0.18 4.19
19 INT143270 Binding of Cnr1 and Gprasp1 4 1 0.54 0.64 4.18
20 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 3 0.02 0 4.15
21 INT29240 Binding of POMC and YY1 5 1 0.40 0.17 4.06
22 INT127128 Binding of CNR1 and CNR2 8 2 0.39 3.98 3.97
23 INT136514 Binding of Grm1 and Grm5 4 1 0.12 1.8 3.9
24 INT140011 Avp Positive_regulation of Dbi 2 1 0.07 0.93 3.61
25 INT85743 Pdyn Positive_regulation of Oprk1 3 1 0.32 2.12 3.52
26 INT158770 Binding of Trpv1 and Trpa1 5 1 0.34 2.07 3.5
27 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 3 0.27 0.17 3.48
28 INT180984 IRF6 Positive_regulation of Localization of IL8 7 1 0.11 2.13 3.47
29 INT24388 CRH Positive_regulation of Localization of POMC 8 2 0.51 5.67 3.35
30 INT276678 Nkx1-1 Regulation of Nav1 1 2 0.15 0.88 3.31
31 INT276676 Prkcg Regulation of Nav1 1 2 0.30 0.82 3.29
32 INT189488 Binding of Ccr1 and Ccl5 8 1 0.40 9.26 3.27
33 INT194647 Binding of CD28 and CD80 15 2 0.40 4.9 3.22
34 INT270949 Binding of Slc6a3 and Cpe 1 26 0.28 0.25 3.19
35 INT275850 Binding of NDUFAB1 and SNCA 1 2 0.00 3.78 3.16
36 INT186126 Binding of CD28 and CTLA4 9 1 0.52 4.13 3.12
37 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 2 0.41 0.62 3.11
38 INT158752 Binding of TRPV1 and Rvm 1 2 0.05 1.6 3.1
39 INT158751 Binding of TRPV1 and Pag1 1 2 0.03 1.59 3.08
40 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 2 0.07 0.94 3.08
41 INT102284 Binding of Grin1 and Grin2a 5 1 0.27 1.79 3.01
42 INT134212 CRH Regulation of Localization of POMC 1 1 0.47 2.89 2.9
43 INT156381 Binding of Grin1 and Dlg4 1 5 0.39 0.86 2.9
44 INT264929 Binding of Cnr1 and Gnaz 1 3 0.18 1.71 2.89
45 INT130721 Binding of IL1B and IL1RN 6 1 0.05 5.29 2.85
46 INT175329 Binding of ICAM1 and ITGAL 14 7 0.18 10.06 2.81
47 INT170367 Binding of Grin1 and Grin2a 5 2 0.23 1.72 2.79
48 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 4 0.09 4.04 2.69
49 INT259231 Binding of Oprm1 and Ppp1r9b 1 2 0.01 0 2.67
50 INT150455 Binding of Prss12 and Nts 3 3 0.24 1.42 2.66
51 INT150457 Binding of Sort1 and Prss12 3 3 0.21 1.36 2.64
52 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 2 0.00 0 2.64
53 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 2 0.01 0 2.64
54 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 1 0.46 0.75 2.61
55 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 1 0.49 2.75 2.61
56 INT152501 Binding of Tnf and Tnfrsf1a 4 3 0.31 3 2.58
57 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 8 0.07 1.72 2.46
58 INT156799 Gria1 Regulation of Grm8 1 2 0.11 1.29 2.45
59 INT74840 Binding of Cacna1a and Cacna1a 5 1 0.00 4.24 2.36
60 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 1 0.26 1.99 2.36
61 INT284860 Binding of Pdzd2 and Nav1 9 9 0.29 2.33 2.34
62 INT158809 Pag1 Regulation of Rvm 1 1 0.02 1.28 2.33
63 INT156622 Umod Regulation of Phosphorylation of Creb1 1 2 0.05 0.33 2.27
64 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 2 0.05 0.33 2.27
65 INT194646 Binding of CD28 and CD86 7 1 0.40 2.69 2.21
66 INT197379 Tbs1 Positive_regulation of Ltp 6 1 0.07 1.87 2.21
67 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 2 0.24 0.92 2.2
68 INT140659 Phax Positive_regulation of Trpv1 3 2 0.49 0.68 2.18
69 INT86179 TNF Positive_regulation of Localization of IL6 5 1 0.35 1.66 2.17
70 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
71 INT142527 Binding of Slc1a2 and Slc1a3 2 1 0.31 0.12 2.13
72 INT273120 NOVA2 Regulation of Gene_expression of MET 1 1 0.23 1.17 2.11
73 INT83425 Binding of CD40LG and IGHG3 11 1 0.21 4.56 2.09
74 INT158964 FosB Negative_regulation of Creb1 1 2 0.21 0 2.07
75 INT281084 Prkaca Positive_regulation of Mapk1 2 1 0.25 0 2.06
76 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 3 0.04 3.05 2.06
77 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 3 0.43 3.05 2.06
78 INT281381 FSCN1 Positive_regulation of Gene_expression of Gfap 1 2 0.06 1.13 1.98
79 INT163266 Crh Negative_regulation of Tyr 1 2 0.01 0.45 1.98
80 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 4 0.32 3.42 1.97
81 INT264953 Binding of POMC and TLR4 1 1 0.03 0.89 1.96
82 INT157767 Binding of TLR4 and LY96 8 4 0.54 4.05 1.95
83 INT217042 IRF6 Positive_regulation of TNF 4 1 0.27 3.03 1.95
84 INT264947 Binding of POMC and TLR2 1 1 0.03 0.89 1.95
85 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 2 0.28 1.93 1.93
86 INT283050 Binding of Gad2 and Trpm8 1 2 0.23 2.02 1.93
87 INT153533 NMS Regulation of Gene_expression of Ephb1 1 3 0.48 3.96 1.93
88 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 1 0.51 0.48 1.92
89 INT264928 Binding of Cnr1 and Hrh1 1 2 0.01 1.61 1.92
90 INT161224 Ccl2 Positive_regulation of Ccr2 1 2 0.52 2.09 1.88
91 INT161225 Ccl2 Positive_regulation of Ccl2 Positive_regulation of Ccr2 1 2 0.57 2.09 1.88
92 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 4 0.09 4.89 1.88
93 INT201940 Binding of IL8 and CXCL10 2 4 0.28 2.46 1.86
94 INT112517 Binding of Ephb1 and Prkaca 3 1 0.18 0.58 1.85
95 INT276668 Ngf Regulation of Nav1 1 1 0.09 0.98 1.85
96 INT275851 PES1 Negative_regulation of CP 1 1 0.01 1.96 1.83
97 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 2 0.30 2.21 1.82
98 INT168010 Asap1 Positive_regulation of HBG2 1 3 0.01 3.03 1.82
99 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 2 0.42 2.39 1.82
100 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 1 0.21 0.68 1.82
101 INT276674 Negative_regulation of Nkx1-1 Regulation of Nav1 1 1 0.11 0.68 1.81
102 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 2 0.30 1.36 1.8
103 INT150456 Binding of Sort1 and Nts 3 3 0.45 0.64 1.79
104 INT102160 Binding of Mmp2 and Mmp9 3 2 0.28 2.87 1.75
105 INT276863 Gpr65 Regulation of Trpv1 1 2 0.25 1.78 1.75
106 INT157524 Binding of GRM5 and OPRM1 1 2 0.36 0 1.74
107 INT165183 Ifnb1 Positive_regulation of P2rx4 1 2 0.04 1.73 1.73
108 INT282398 Binding of Mefv and Nlrp3 1 6 0.40 6.8 1.72
109 INT264922 Binding of Cnr1 and Mors1 1 1 0.14 0.1 1.71
110 INT158302 Il23a Regulation of Gene_expression of Il17a 1 3 0.06 1.45 1.7
111 INT157459 Binding of CX3CR1 and CX3CL1 1 1 0.32 2.12 1.7
112 INT266391 Binding of Ager and S100a1 1 8 0.01 5.63 1.69
113 INT160304 Npy Regulation of Gene_expression of Fos 3 3 0.67 1.43 1.68
114 INT45306 Pomc Positive_regulation of ENG 2 2 0.07 1.11 1.68
115 INT276672 Binding of Prkcg and Nav1 1 1 0.16 0.18 1.67
116 INT142437 Urb1 Negative_regulation of Faah 3 1 0.41 2.12 1.66
117 INT276680 Binding of Prkcg and Nkx1-1 1 1 0.05 0.18 1.66
118 INT24157 Binding of CALCA and SFTPA1 2 1 0.07 0.96 1.64
119 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 2 0.42 2.45 1.63
120 INT215096 Binding of Hmgb1 and Tlr2 9 6 0.38 11.61 1.61
121 INT160578 Binding of CALCA and TAC1 1 3 0.07 0.91 1.61
122 INT288731 Binding of Got1 and Gpt 1 5 0.23 1.25 1.61
123 INT276670 Binding of Trpv1 and Nkx1-1 1 1 0.07 0.68 1.6
124 INT158774 Mapk14 Regulation of Il6 1 1 0.11 0.08 1.57
125 INT266406 Binding of APP and Ager 1 3 0.00 2.34 1.57
126 INT208980 Binding of Ca2 and Trpv1 4 2 0.32 0.67 1.55
127 INT276671 Prkcg Positive_regulation of Nav1 1 1 0.23 0.21 1.55
128 INT264950 Binding of FPR1 and BOC 1 2 0.11 0.67 1.55
129 INT254205 Binding of Myd88 and Tlr4 12 1 0.19 3.17 1.54
130 INT158877 PRS Positive_regulation of Gene_expression of Fos 1 3 0.09 5.14 1.54
131 INT284785 Gch1 Regulation of Bh4p 1 1 0.00 1.48 1.54
132 INT274943 Positive_regulation of Ltp Positive_regulation of Positive_regulation of Tac2 1 1 0.04 0.49 1.53
133 INT158778 Ptges3l1 Regulation of Ephb1 1 1 0.06 0.09 1.53
134 INT158775 Regulation of Tnf Regulation of Ephb1 1 1 0.18 0.09 1.52
135 INT158777 Tnf Regulation of Ephb1 1 1 0.18 0.09 1.51
136 INT159657 Binding of INSRR and NGF 3 2 0.00 1.65 1.48
137 INT222185 Binding of Ccr1 and Ccl3 4 1 0.23 2.7 1.47
138 INT276687 Pax3 Positive_regulation of Nkx1-1 1 1 0.00 0.59 1.47
139 INT158776 Il1b Regulation of Ephb1 1 1 0.15 0.09 1.46
140 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 1 0.02 0 1.46
141 INT276688 Positive_regulation of Prkcg Positive_regulation of Nkx1-1 Regulation of Trpv1 1 1 0.05 0.16 1.46
142 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 2 0.03 2.83 1.46
143 INT276675 Binding of Nkx1-1 and Nav1 1 1 0.09 0.21 1.46
144 INT276681 Calca Regulation of Nav1 1 1 0.07 0.74 1.45
145 INT276686 Calca Regulation of Nav1 1 1 0.26 0.74 1.45
146 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 1 0.10 0.1 1.44
147 INT150392 Binding of MEFV and PSTPIP1 2 39 0.51 10.49 1.44
148 INT155371 VIP Positive_regulation of Localization of IL6 1 3 0.64 3.37 1.44
149 INT158282 Binding of Penk and Csf2 1 1 0.33 0.87 1.44
150 INT158283 Binding of Penk and Accn4 1 1 0.07 0.87 1.43
151 INT150069 Cnr1 Regulation of Cnr2 2 1 0.50 0.83 1.42
152 INT131156 Binding of RUNX1 and TNF 2 1 0.03 3.44 1.42
153 INT157540 Binding of SP1 and YY1 1 4 0.41 2.55 1.42
154 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 1 0.14 0.73 1.41
155 INT161188 NMS Regulation of Gene_expression of Rvm 1 2 0.03 2 1.39
156 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 1 0.24 0.4 1.39
157 INT161189 CRX Regulation of Gene_expression of Rvm 1 2 0.00 2 1.39
158 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 1 0.03 0 1.39
159 INT262568 Prkaca Regulation of Trpv1 2 1 0.10 0.65 1.38
160 INT161191 CRX Regulation of Gene_expression of Trib3 1 2 0.00 2 1.38
161 INT162105 Nr4a3 Regulation of ACPT-I 1 1 0.10 0.26 1.38
162 INT161185 NMS Regulation of Gene_expression of Trib3 1 2 0.03 2 1.38
163 INT276673 Nkx1-1 Regulation of Trpv1 1 1 0.05 0.16 1.37
164 INT158762 Binding of Vwf and Mthfr 1 3 0.05 1.85 1.37
165 INT279165 Calca Regulation of Gene_expression of Fdft1 1 1 0.02 0.41 1.37
166 INT157460 CX3CL1 Regulation of Gene_expression of COL1A1 1 1 0.11 1.57 1.37
167 INT290542 Crh Positive_regulation of Insr 1 2 0.02 0.36 1.36
168 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 1 0.41 0.27 1.36
169 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 2 0.16 0.54 1.35
170 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 1 0.33 0.27 1.35
171 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 and 1 1 0.08 0.65 1.35
172 INT158079 Binding of Esr1 and Gper 1 2 0.31 0.97 1.35
173 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 2 0.14 0.54 1.35
174 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 2 0.20 0.54 1.35
175 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 2 0.18 0.54 1.35
176 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 2 0.09 0.54 1.35
177 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 2 0.13 0.54 1.35
178 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 1 0.42 1.86 1.34
179 INT259211 Binding of Ppp1r9b and Flna 1 1 0.06 0 1.33
180 INT281382 FSCN1 Positive_regulation of Sds 1 1 0.02 0.84 1.33
181 INT94630 Positive_regulation of Adarb1 Positive_regulation of Gene_expression of Fos 2 1 0.03 0.1 1.32
182 INT265213 Binding of Ctla4 and Cd86 2 1 0.13 1.93 1.31
183 INT281479 Drd2 Positive_regulation of Penk 1 3 0.23 0.4 1.3
184 INT186393 Binding of TNF and Tnfrsf1a 9 1 0.37 8.55 1.29
185 INT121096 Binding of Calca and Trpv1 3 1 0.37 1.23 1.29
186 INT158144 Binding of Gpx1 and Glyat 2 1 0.31 0 1.29
187 INT276282 Binding of Atrn and Mc1r 1 2 0.32 0.41 1.29
188 INT154518 Binding of Ephb6 and Grin2b 1 1 0.21 0.24 1.28
189 INT161995 Binding of Ctu2 and Fbxo23 1 2 0.06 0.33 1.28
190 INT280480 Binding of Bdnf and Ngfr 5 4 0.25 3.14 1.27
191 INT162482 Binding of Agt and Vta1 1 2 0.23 0 1.27
192 INT159655 Binding of BDNF and INSRR 2 1 0.00 1.25 1.26
193 INT287104 Binding of Ntrk2 and T 1 5 0.20 3.29 1.26
194 INT162165 WDTC1 Positive_regulation of PLD2 1 2 0.50 0 1.25
195 INT271602 Binding of Pdgfa and Pdgfrl 1 2 0.02 0.86 1.25
196 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 1 0.24 0.19 1.25
197 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 1 0.12 3 1.24
198 INT251142 Binding of Dlg4 and Grin2a 3 1 0.30 0.5 1.24
199 INT161508 Tlr4 Positive_regulation of Mapk14 2 1 0.19 0.46 1.24
200 INT162163 CDKN2A Positive_regulation of PLD2 1 2 0.24 0 1.24

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2009. They are ordered first by their pain relevance and then by number of times they were reported in 2009. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2009 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 176 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 120 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 33 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 55 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 239 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 186 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 112 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 28 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 46 1163 0.70 319.28 684
10 INT292 Localization of Penk 5 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 150 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 7 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 41 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 4 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 37 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 28 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 3 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 44 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 34 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 179 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 45 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 25 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 60 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 41 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 34 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 113 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 24 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 87 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 38 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 17 790 0.70 104.54 374.78
32 INT287 Localization of Cck 3 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 26 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 17 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 6 477 0.48 71.86 342.06
36 INT876 Localization of Gh1 8 843 0.80 67.75 340.82
37 INT16260 Gene_expression of Bdnf 92 671 0.78 283.44 339.1
38 INT5235 Negative_regulation of TNF 77 924 0.59 772.91 331.98
39 INT2649 Regulation of Calca 17 433 0.62 146.05 330.95
40 INT5059 Positive_regulation of TNF 73 1050 0.70 896.51 322.81
41 INT162 Regulation of Prl 8 794 0.62 165.01 322.24
42 INT5979 Gene_expression of Oprd1 14 428 0.78 75.64 320.32
43 INT34869 Negative_regulation of PTGS2 38 778 0.59 366.76 319.85
44 INT5540 Positive_regulation of Oprm1 8 344 0.70 76.77 319.71
45 INT5680 Gene_expression of Ngf 76 530 0.78 264.29 310.56
46 INT46460 Gene_expression of NAV1 49 288 0.78 135.51 305.75
47 INT4941 Positive_regulation of Oprd1 14 345 0.70 74.26 304.41
48 INT9131 Positive_regulation of Prkcg 27 431 0.70 130.8 302.41
49 INT477 Localization of Avp 16 813 0.81 131.58 300.4
50 INT161 Regulation of Localization of Prl 13 615 0.62 65.37 298.66
51 INT63932 Positive_regulation of Ephb1 31 537 0.70 259.67 296.14
52 INT1352 Localization of Acot1 8 728 0.80 73.01 296.01
53 INT886 Gene_expression of Pomc 31 676 0.78 129.87 295.98
54 INT11624 Gene_expression of OPRM1 33 445 0.78 72.36 294.36
55 INT5379 Gene_expression of Fos 91 656 0.78 255.5 292.54
56 INT3579 Localization of Oxt 5 555 0.81 43.35 292.44
57 INT97367 Gene_expression of Nav1 54 243 0.78 132.97 286.66
58 INT9158 Gene_expression of Tnf 84 722 0.78 522.01 277.68
59 INT2365 Positive_regulation of Cck 10 354 0.70 87.8 277.41
60 INT9381 Positive_regulation of TRPV1 37 523 0.70 187.4 276.05
61 INT94450 Gene_expression of Nav1 34 359 0.78 131.85 275.46
62 INT49750 Negative_regulation of CPOX 29 735 0.58 360.06 274.19
63 INT6852 Localization of TNF 60 883 0.81 705.95 270.84
64 INT10832 Gene_expression of IL8 108 1050 0.78 698.72 270
65 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
66 INT5591 Regulation of Gene_expression of Fos 32 425 0.62 129.06 265.78
67 INT9659 Gene_expression of Il6 125 991 0.78 715.11 265.57
68 INT5972 Gene_expression of IL1B 67 948 0.78 510.91 263.97
69 INT68684 Gene_expression of VEGFA 306 2371 0.78 1742.52 259.2
70 INT87687 Positive_regulation of Trpv1 96 409 0.70 210.24 257.59
71 INT1893 Localization of Gh 19 1041 0.79 340.23 256.58
72 INT16868 Gene_expression of Il6 115 807 0.78 499.48 256.57
73 INT2909 Positive_regulation of Abat 11 334 0.70 62.1 256.43
74 INT3948 Regulation of Cck 2 291 0.62 58.07 255.88
75 INT5501 Regulation of Oprd1 7 283 0.62 55.1 249.9
76 INT1005 Localization of Sst 7 385 0.81 26.31 244.56
77 INT738 Regulation of POMC 16 459 0.62 111.19 243.74
78 INT1902 Gene_expression of Cck 11 348 0.78 70.33 241.92
79 INT11377 Positive_regulation of Ngf 19 331 0.70 206.5 238
80 INT1562 Localization of Crh 8 499 0.81 126.74 236.68
81 INT5597 Gene_expression of Pdyn 5 433 0.78 62.97 235.47
82 INT1665 Positive_regulation of Pag1 36 270 0.68 186.63 229.87
83 INT4759 Negative_regulation of Localization of Calca 13 294 0.59 82.62 226.45
84 INT9987 Gene_expression of Abat 30 296 0.78 95.46 226.34
85 INT6406 Binding of Oprm1 21 280 0.48 40.54 226.26
86 INT11009 Phosphorylation of Creb1 68 458 0.82 111.34 221.97
87 INT626 Localization of CALCA 12 289 0.81 125.39 221.15
88 INT95787 Positive_regulation of Mapk1 81 568 0.70 226.51 220.94
89 INT6665 Gene_expression of FOS 24 520 0.77 165.31 217.66
90 INT1308 Localization of Pomc 2 457 0.81 66.83 217.5
91 INT6293 Gene_expression of Oprm1 17 312 0.78 48.73 215.61
92 INT6481 Binding of TNF 50 624 0.48 510.2 214.82
93 INT767 Localization of Gnrhr 6 565 0.80 106.68 214.57
94 INT4893 Gene_expression of Tacr1 51 366 0.78 129.67 213.92
95 INT22548 Positive_regulation of Casp3 55 483 0.70 258.78 213.07
96 INT6482 Positive_regulation of Gene_expression of TNF 47 659 0.70 569.88 210
97 INT16259 Positive_regulation of Bdnf 24 336 0.70 183.48 209.82
98 INT48955 Gene_expression of Nos2 70 753 0.78 403.87 208.08
99 INT2651 Positive_regulation of Pomc 12 403 0.70 95.72 206.24
100 INT2391 Negative_regulation of PTGS1 27 501 0.59 207.62 205.6
101 INT9132 Negative_regulation of Prkcg 16 279 0.59 88.05 203.47
102 INT798 Positive_regulation of Gene_expression of Penk 4 394 0.70 78.53 203.07
103 INT11313 Positive_regulation of Il6 64 526 0.70 331.27 201.59
104 INT2211 Negative_regulation of Abat 8 267 0.59 66.51 200.98
105 INT50670 Gene_expression of CPOX 22 763 0.76 442.13 195.02
106 INT156 Negative_regulation of Prl 3 542 0.59 131.97 192.24
107 INT528 Gene_expression of Prl 20 693 0.78 217.18 192.2
108 INT6488 Gene_expression of Tnf 43 484 0.78 339.61 191.58
109 INT2085 Positive_regulation of LH 10 441 0.70 60.15 191.02
110 INT63934 Phosphorylation of Ephb1 23 377 0.82 150.52 188.66
111 INT6354 Localization of Gabrg1 13 321 0.74 41.41 186.74
112 INT94952 Positive_regulation of Mapk14 42 305 0.70 197.83 186.61
113 INT1652 Regulation of Pomc 3 387 0.62 61.01 186.51
114 INT24326 Gene_expression of Ngf 32 346 0.78 218.67 184.71
115 INT10194 Positive_regulation of IL6 77 702 0.70 600.62 183.38
116 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
117 INT3440 Negative_regulation of Localization of Abat 5 221 0.57 33.94 180.36
118 INT12602 Negative_regulation of Oprm1 6 190 0.59 36.11 177.85
119 INT49441 Negative_regulation of Cpox 17 494 0.59 303.22 177.46
120 INT7506 Negative_regulation of Ltp 37 267 0.46 91.01 176.8
121 INT1429 Gene_expression of PDYN 9 308 0.78 61.33 175.65
122 INT19472 Gene_expression of Il1 53 554 0.76 419.75 175.35
123 INT943 Negative_regulation of Cck 2 205 0.59 38.42 174.78
124 INT26472 Regulation of Oprm1 7 191 0.62 35.84 173.1
125 INT15516 Gene_expression of Crp 95 711 0.77 615.33 173.09
126 INT5930 Positive_regulation of Oprm1 11 221 0.70 31.19 172.93
127 INT159 Negative_regulation of Localization of Prl 3 416 0.59 55.34 171.8
128 INT4937 Negative_regulation of Oprd1 9 224 0.59 44.51 171.11
129 INT438 Gene_expression of Crh 14 376 0.78 159.11 169.17
130 INT867 Gene_expression of IFNA1 128 930 0.78 594.85 168.03
131 INT739 Negative_regulation of POMC 10 358 0.59 102.28 166.77
132 INT55879 Gene_expression of CCL2 48 421 0.78 240.74 166.02
133 INT1114 Localization of Ins1 13 748 0.80 192.95 165.48
134 INT4768 Positive_regulation of OPRM1 5 212 0.70 31.09 164.28
135 INT2366 Binding of Cck 1 192 0.48 30.64 163.46
136 INT5127 Localization of Lhb 13 488 0.80 50.48 162.66
137 INT3448 Positive_regulation of Gh 8 521 0.69 180.03 161.18
138 INT5513 Negative_regulation of Pomc 6 295 0.59 60.9 158.63
139 INT51921 Gene_expression of Cpox 38 501 0.73 229.81 157.81
140 INT66280 Gene_expression of Nos2 32 534 0.78 330.78 157.07
141 INT768 Positive_regulation of Oprl1 3 179 0.70 40.05 156.93
142 INT1303 Negative_regulation of Npr1 8 278 0.55 35.1 156.78
143 INT2640 Gene_expression of Pomc 36 424 0.78 120.72 155.37
144 INT6042 Binding of Oprm1 9 248 0.48 31.77 154.34
145 INT4740 Gene_expression of Th 26 298 0.78 61.27 154.03
146 INT2910 Regulation of Abat 4 169 0.62 36.95 153.53
147 INT1044 Negative_regulation of Localization of LH 2 358 0.59 25.95 151.31
148 INT120811 Gene_expression of Gopc 220 1174 0.59 428.49 150.55
149 INT4829 Positive_regulation of Localization of Abat 6 199 0.55 20.91 150.48
150 INT15515 Positive_regulation of Crp 71 700 0.70 604.24 150.15
151 INT49134 Gene_expression of Grin1 55 270 0.78 84.78 148.61
152 INT5050 Regulation of Localization of Calca 6 149 0.62 41.25 148.57
153 INT6108 Gene_expression of Npy 21 292 0.78 110.65 148.21
154 INT13353 Positive_regulation of Tnf 29 332 0.70 248.75 148.1
155 INT7628 Gene_expression of Ltp 53 273 0.77 70.21 147.87
156 INT2451 Positive_regulation of Avp 16 355 0.70 102.66 147.69
157 INT1033 Positive_regulation of Ca2 41 507 0.68 131.76 147.64
158 INT9852 Positive_regulation of Gpt 48 563 0.70 364.64 146.82
159 INT5116 Gene_expression of IL2 38 670 0.78 291.13 146.69
160 INT812 Localization of INS 42 1026 0.81 515.6 145.31
161 INT425 Localization of PRL 10 455 0.81 189.64 144.8
162 INT2379 Positive_regulation of Localization of LH 3 349 0.70 27.86 144.53
163 INT3300 Positive_regulation of Gene_expression of Calca 26 179 0.70 77.76 144.2
164 INT2780 Regulation of Gene_expression of Penk 4 265 0.62 32.45 143.88
165 INT60694 Gene_expression of Il10 110 567 0.78 369.48 143.69
166 INT9660 Regulation of TNF 30 363 0.62 312.94 139.99
167 INT1414 Regulation of Oprl1 3 169 0.62 32.05 139.99
168 INT90910 Phosphorylation of Grin1 16 150 0.82 68.23 139.24
169 INT14843 Gene_expression of Gabrg1 23 301 0.77 62.63 139.16
170 INT1273 Gene_expression of Avp 19 356 0.78 90.56 138.7
171 INT48895 Gene_expression of Il10 34 333 0.78 221.2 138.52
172 INT2867 Gene_expression of CALCA 19 247 0.78 78.78 138.47
173 INT5061 Negative_regulation of Mme 4 306 0.59 51.97 136.9
174 INT4658 Binding of OPRM1 6 188 0.48 25.96 136.24
175 INT1047 Negative_regulation of LH 7 314 0.59 53.71 135.89
176 INT2541 Binding of Calca 7 200 0.48 67.14 134.62
177 INT60126 Regulation of Trpv1 27 186 0.62 85.53 133.4
178 INT11012 Positive_regulation of Creb1 67 258 0.70 84.4 132
179 INT48953 Positive_regulation of Nos2 38 486 0.70 239.85 131.87
180 INT5497 Positive_regulation of Crh 1 299 0.70 125.54 131.14
181 INT5380 Positive_regulation of Gene_expression of Fos 43 243 0.70 105.65 131.05
182 INT49439 Gene_expression of Cpox 11 508 0.73 326.97 130.17
183 INT5595 Positive_regulation of Pdyn 2 223 0.70 48.37 130.14
184 INT64161 Positive_regulation of Prkca 10 213 0.70 85.06 129.91
185 INT115386 Gene_expression of Ppara 47 779 0.77 549.99 128.36
186 INT65600 Positive_regulation of Casp3 74 376 0.70 198.44 128.03
187 INT1614 Gene_expression of Oprl1 6 164 0.78 31.43 127.74
188 INT5842 Gene_expression of Gfap 37 372 0.78 153.71 127.71
189 INT1878 Binding of HLA-B 29 440 0.48 321.16 127.36
190 INT695 Binding of POMC 2 304 0.48 56.66 126.85
191 INT65054 Positive_regulation of Nfkb1 30 285 0.70 149.33 126.73
192 INT5931 Regulation of Oprm1 10 149 0.62 18.15 125.93
193 INT6822 Gene_expression of Pdyn 10 215 0.78 35.99 125.76
194 INT5008 Localization of Calca 41 204 0.81 80.35 125.16
195 INT6323 Positive_regulation of Gabrg1 14 213 0.70 45.08 124.34
196 INT4824 Positive_regulation of Tacr1 2 169 0.70 66.1 123.46
197 INT4259 Positive_regulation of Npr1 3 262 0.70 49.37 123.11
198 INT252 Localization of GH1 4 529 0.80 227.4 122.05
199 INT6128 Positive_regulation of Localization of POMC 7 256 0.70 68.77 121.64
200 INT7533 Gene_expression of Tlr4 74 720 0.78 343.22 121.57
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