Y:2010

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This page displays the top molecular interactions and top single events that were mentioned in the literature in 2010. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported in 2010. They are ordered first by their pain relevance and then by number of times they were reported in 2010. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in 2010 Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 32 0.01 28.19 40.6
2 INT69872 Binding of MC1R and POMC 52 2 0.54 8.87 18.3
3 INT106676 Binding of Trpv1 and Phax 18 1 0.34 4.19 12.36
4 INT166591 Binding of CALCA and DCLK3 4 3 0.30 0.69 12.18
5 INT145775 Ngf Positive_regulation of Trpv1 11 2 0.72 7.71 11.25
6 INT77646 Binding of Ngf and Ntrk1 23 8 0.40 7.85 9.26
7 INT149117 Binding of CD80 and CTLA4 31 6 0.52 12.7 7.73
8 INT106559 Binding of Bdnf and Ntrk2 23 8 0.43 11.09 7.33
9 INT188692 Binding of Cd40 and Cd40lg 32 9 0.34 22.95 6.62
10 INT131249 Binding of Bdnf and Ntrk2 11 1 0.41 4 6.25
11 INT155484 Binding of CD86 and CTLA4 15 2 0.52 8.85 6.09
12 INT176477 Binding of CXCR3 and CXCL10 14 9 0.25 10.61 5.87
13 INT169218 Binding of EGFR and Coc 1 8 0.06 2.8 5.85
14 INT338167 Binding of CDKN2A and MC1R 1 8 0.42 6.14 5.76
15 INT179502 Binding of Cd14 and Tlr4 29 9 0.39 13.77 5.73
16 INT296275 Binding of Dlg4 and Kcnip3 1 13 0.39 3.58 5.6
17 INT126335 Binding of Pax3 and Tac1 6 6 0.07 6.22 5.27
18 INT88279 Ngf Positive_regulation of Ntrk1 5 5 0.76 3.06 5.23
19 INT166590 Binding of RAMP1 and DCLK3 2 1 0.37 0.39 4.8
20 INT211710 Binding of Mc1r and a 7 2 0.44 0.37 4.78
21 INT164362 Binding of NLRP1 and VTA1 1 7 0.15 2.37 4.67
22 INT182124 Binding of IRF6 and TLR4 14 8 0.10 16.11 4.65
23 INT351352 Binding of Trpv1 and Lpar1 1 6 0.21 5.86 4.62
24 INT296484 Binding of Gria2 and GRIP1 1 10 0.04 4.52 4.59
25 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 1 0.59 9.37 4.48
26 INT122567 Mog Positive_regulation of Eae1 8 2 0.31 10.18 4.26
27 INT143270 Binding of Cnr1 and Gprasp1 4 1 0.54 0.64 4.18
28 INT182194 Binding of IL8 and CXCR2 10 7 0.56 7.14 4.16
29 INT101942 Binding of CD40 and CD40LG 16 3 0.23 15.24 4.01
30 INT73539 Binding of Ngf and Ngfr 5 4 0.45 3.99 4
31 INT13966 Calca Positive_regulation of Localization of Sst 5 1 0.49 0.75 3.91
32 INT317511 Ppp1r9b Regulation of Oprm1 3 3 0.27 0.33 3.85
33 INT317517 Binding of Nos1 and Oprm1 1 4 0.17 0.22 3.85
34 INT132862 Ngf Positive_regulation of Bdnf 4 1 0.46 4.05 3.65
35 INT15984 Binding of Avp and Oxt 11 1 0.32 1.33 3.64
36 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 3 0.00 1.25 3.63
37 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 3 0.18 1.57 3.59
38 INT121651 Binding of CXCL12 and CXCR4 13 14 0.48 17.61 3.52
39 INT158770 Binding of Trpv1 and Trpa1 5 2 0.34 2.07 3.5
40 INT180984 IRF6 Positive_regulation of Localization of IL8 7 5 0.11 2.13 3.47
41 INT302118 Binding of Oprm1 and Ppp1r9b 2 3 0.24 0.26 3.45
42 INT340118 Binding of Sugt1 and Pain1 1 2 0.00 3.53 3.44
43 INT334928 Binding of pr and Aes 1 2 0.00 1.49 3.38
44 INT24388 CRH Positive_regulation of Localization of POMC 8 1 0.51 5.67 3.35
45 INT349584 Binding of Cyp2e1 and Aap 1 3 0.10 1.56 3.24
46 INT354207 Igfbp7 Positive_regulation of Accn3 1 11 0.52 6.55 3.24
47 INT194647 Binding of CD28 and CD80 15 3 0.40 4.9 3.22
48 INT166134 Binding of Cxcl12 and Cxcr4 3 1 0.49 5.69 3.17
49 INT64719 IL1B Positive_regulation of IL6 7 2 0.41 6.84 3.14
50 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 4 0.43 0.4 3.13
51 INT186126 Binding of CD28 and CTLA4 9 3 0.52 4.13 3.12
52 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 2 0.65 3.74 3.11
53 INT309150 Edc4 Positive_regulation of Creb1 1 8 0.03 3.46 3.09
54 INT208572 Binding of IL8 and CXCR1 6 4 0.33 5.2 3.08
55 INT317563 Binding of Hint1 and Oprm1 1 4 0.20 0.25 3.03
56 INT102284 Binding of Grin1 and Grin2a 5 2 0.27 1.79 3.01
57 INT182635 Binding of CCR5 and CCL5 2 6 0.09 4.19 3
58 INT324927 Syt17 Positive_regulation of Bdkrb1 1 2 0.04 4.29 2.96
59 INT312686 CP Positive_regulation of CP Positive_regulation of CCL20 1 4 0.03 10.97 2.94
60 INT166592 Binding of CALCA and RAMP1 2 1 0.35 0.33 2.91
61 INT318996 Binding of CCR3 and CCL5 1 6 0.07 3.39 2.9
62 INT319003 Binding of CCR1 and CCL5 1 6 0.08 3.38 2.89
63 INT130721 Binding of IL1B and IL1RN 6 1 0.05 5.29 2.85
64 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 2 0.00 1.86 2.85
65 INT206764 Binding of AQP4 and Nqo1 8 7 0.05 13.45 2.84
66 INT351349 Prkcg Positive_regulation of Binding of Lpar1 and 1 2 0.15 2 2.82
67 INT170367 Binding of Grin1 and Grin2a 5 1 0.23 1.72 2.79
68 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 4 0.02 0.44 2.79
69 INT169134 Binding of Calca and Trpa1 1 4 0.37 3.37 2.79
70 INT317551 Binding of Akt1 and Oprm1 1 3 0.19 0.21 2.74
71 INT349589 Aap Positive_regulation of Cyp2e1 1 4 0.21 1.84 2.71
72 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 2 0.17 0.55 2.7
73 INT326585 Binding of GYPA and SLC6A3 1 7 0.13 0.86 2.64
74 INT351444 Grin1 Positive_regulation of Gria2 1 2 0.22 1.5 2.64
75 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 3 0.38 0.86 2.63
76 INT128044 Bdnf Positive_regulation of Ephb1 2 1 0.31 1.89 2.57
77 INT340117 Binding of Bdnf and Pain1 1 2 0.01 2.48 2.55
78 INT356289 Binding of Egfr and Egf 1 4 0.13 3.02 2.52
79 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 5 0.09 5.43 2.51
80 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 1 0.13 1.64 2.5
81 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 4 0.44 5.57 2.5
82 INT299783 Binding of Cd28 and Cd80 7 2 0.14 6.49 2.49
83 INT317528 Ppp1r9b Regulation of Grin1 1 2 0.18 0.2 2.48
84 INT314141 Binding of Tacr3 and SFTPA1 1 3 0.00 3.02 2.48
85 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 1 0.59 2.72 2.42
86 INT122163 Binding of TNF and TNFRSF1B 6 2 0.44 6.06 2.41
87 INT318998 IFNA1 Positive_regulation of Localization of CXCL10 1 4 0.15 2.09 2.39
88 INT317526 Binding of Hint1 and Gipc1 1 3 0.00 0.25 2.38
89 INT284088 Binding of BDNF and NTRK2 5 1 0.41 3.4 2.37
90 INT115367 Binding of IL6 and IL6R 12 5 0.07 8.16 2.36
91 INT153728 RYBP Positive_regulation of Gpt 3 2 0.03 2.01 2.36
92 INT284860 Binding of Pdzd2 and Nav1 9 4 0.29 2.33 2.34
93 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 3 0.00 0.08 2.31
94 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 2 0.43 1.24 2.3
95 INT321474 Binding of Slc6a2 and Ubqln1 1 2 0.00 0.8 2.27
96 INT211748 Binding of Pag1 and Mors1 2 1 0.07 0.2 2.26
97 INT321477 Binding of Ubqln1 and Flvcr2 1 2 0.00 0.81 2.26
98 INT350148 Binding of IL12A and ERAL1 1 5 0.21 8.23 2.26
99 INT126717 Binding of Il6 and Il6st 3 3 0.21 3.35 2.22
100 INT197379 Tbs1 Positive_regulation of Ltp 6 2 0.07 1.87 2.21
101 INT317524 Binding of Camk2a and Grin1 1 2 0.17 0.06 2.21
102 INT312690 CP Positive_regulation of CCL20 1 3 0.11 8.23 2.2
103 INT334136 Binding of IFNA1 and Acsm3 1 2 0.01 4.52 2.19
104 INT86179 TNF Positive_regulation of Localization of IL6 5 1 0.35 1.66 2.17
105 INT49242 Binding of Mc1r and Pomc 10 1 0.38 3.79 2.15
106 INT239037 Binding of Cd28 and Cd86 9 1 0.16 3.69 2.14
107 INT319581 Binding of PIAS1 and TNFSF14 1 2 0.02 1.58 2.13
108 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 2 0.17 0.46 2.13
109 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 2 0.15 2.85 2.13
110 INT240131 Binding of Crp and Nppb 7 4 0.07 11.53 2.12
111 INT351380 Ngf Regulation of TPM1 1 2 0.44 2.17 2.11
112 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 1 0.04 2.02 2.08
113 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 2 0.04 0.64 2.07
114 INT296277 Binding of Car2 and Kcnip3 5 5 0.18 1.09 2.06
115 INT190524 Ros1 Positive_regulation of Nfkb1 3 4 0.02 4.24 2.06
116 INT281084 Prkaca Positive_regulation of Mapk1 2 3 0.25 0 2.06
117 INT167530 Phax Regulation of Gene_expression of Trpv1 1 2 0.16 0.86 2.05
118 INT70043 IL6 Regulation of IL10 3 1 0.18 3.59 2.01
119 INT349608 Binding of DIO2 and LMOD1 1 4 0.23 0.41 2.01
120 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 4 0.19 7.58 2
121 INT317540 Camk2a Negative_regulation of Oprm1 1 2 0.19 0 1.98
122 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 2 0.47 2.37 1.98
123 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 1 0.03 0.42 1.97
124 INT157767 Binding of TLR4 and LY96 8 3 0.54 4.05 1.95
125 INT217042 IRF6 Positive_regulation of TNF 4 1 0.27 3.03 1.95
126 INT349585 Aap Positive_regulation of Etf1 1 2 0.00 1.68 1.94
127 INT165284 Positive_regulation of Nts Positive_regulation of Crh 1 2 0.40 1.86 1.93
128 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 2 0.05 7.39 1.91
129 INT165200 Binding of CTLA4 and Crp 1 2 0.09 1.64 1.91
130 INT165285 Nts Positive_regulation of Crh 1 2 0.40 1.84 1.91
131 INT351281 AP1M2 Regulation of NCOR2 1 1 0.00 0.85 1.9
132 INT169498 Binding of Oprm1 and Mirlet7a-1 1 2 0.32 0 1.9
133 INT161079 Mcs18 Negative_regulation of Trpv1 1 2 0.40 0.82 1.9
134 INT169570 Binding of ROS1 and TRPV1 3 6 0.33 3.07 1.89
135 INT166945 Ngf Positive_regulation of Trpv1 1 1 0.01 0.47 1.88
136 INT338691 Binding of Trpv1 and Aff3 1 3 0.24 1.21 1.88
137 INT183781 Binding of IL6 and INS 6 3 0.22 8.97 1.87
138 INT169346 Nxn Negative_regulation of Dynll1 1 1 0.06 1.22 1.87
139 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 2 0.02 0.47 1.87
140 INT166947 Ngf Positive_regulation of KNG1 1 1 0.00 0.47 1.86
141 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 2 0.06 0.73 1.85
142 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 1 0.48 1.1 1.84
143 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 2 0.34 0.85 1.84
144 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 2 0.63 2.86 1.84
145 INT267133 Binding of ICAM1 and VCAM1 25 1 0.32 25.43 1.83
146 INT352464 Gse1 Positive_regulation of Gene_expression of Slc1a3 1 2 0.05 1.55 1.83
147 INT169468 Binding of Egfr and Spink3 1 4 0.37 3.73 1.83
148 INT334343 GRP Regulation of Binding of GRP and Helt 1 2 0.02 0 1.81
149 INT169502 Mirlet7a-1 Regulation of Oprm1 1 2 0.53 0 1.81
150 INT305741 Binding of Kcnk2 and Sort1 1 5 0.54 1.01 1.8
151 INT334345 Binding of GRP and Helt 1 2 0.02 0 1.79
152 INT66504 Binding of Agt and Agtr1a 8 1 0.39 3.78 1.78
153 INT145940 Binding of Gad1 and Abat 2 1 0.14 1.44 1.78
154 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 1 0.27 0.71 1.78
155 INT168925 Binding of Oprm1 and Imraq2 1 2 0.04 0.13 1.78
156 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 2 0.06 0.13 1.78
157 INT167319 Binding of OPRM1 and PCSK2 1 2 0.22 0.63 1.77
158 INT162992 Binding of Ephb1 and Ppm1e 1 3 0.03 0.25 1.77
159 INT167320 Binding of CPE and OPRM1 1 2 0.14 0.63 1.77
160 INT302646 ARSA Positive_regulation of TGFB1 1 4 0.10 0.52 1.76
161 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 6 0.08 1.87 1.76
162 INT167321 Binding of ENG and OPRM1 1 2 0.27 0.63 1.76
163 INT13979 Gast Positive_regulation of Localization of Sst 3 1 0.69 0.05 1.75
164 INT168715 Mapk8 Negative_regulation of Oprk1 1 1 0.18 0.26 1.75
165 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 1 0.04 0.73 1.75
166 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 1 0.19 0.26 1.75
167 INT168716 Mapk8 Negative_regulation of Insrr 1 1 0.01 0.25 1.75
168 INT167765 Prkca Positive_regulation of Sigmar1 1 2 0.41 0.63 1.74
169 INT86997 Binding of HIVEP1 and NGF 2 1 0.03 1.75 1.73
170 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 4 0.22 3.23 1.72
171 INT139156 Binding of Gria1 and Gria2 1 3 0.23 0.64 1.72
172 INT175986 Ros1 Positive_regulation of Gtf3a 2 3 0.01 4.75 1.71
173 INT296280 Binding of Car2 and Dlg4 1 3 0.19 0.45 1.71
174 INT169464 Akt1 Positive_regulation of Egfr 1 2 0.28 1.63 1.7
175 INT167427 Mapk8 Regulation of Regulation of Tnf 1 2 0.26 2.83 1.7
176 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 2 0.04 1.81 1.7
177 INT215100 Binding of Hmgb1 and Tlr4 5 2 0.29 3.21 1.68
178 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 1 0.52 6.58 1.68
179 INT102447 Binding of CALCA and CALCRL 2 2 0.26 0.33 1.67
180 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 1 0.01 0.95 1.67
181 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 2 0.03 1.11 1.67
182 INT101926 Binding of Dio1 and Drd2 4 1 0.28 0.39 1.66
183 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 4 0.75 3.05 1.66
184 INT347396 RYBP Positive_regulation of Binding of Sdcbp and 1 2 0.00 0.92 1.66
185 INT100274 IL1RN Negative_regulation of IL1B 5 1 0.53 1.79 1.65
186 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 3 0.01 0 1.65
187 INT297489 Ryr2 Regulation of Positive_regulation of Ltp 1 2 0.05 0.16 1.64
188 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 1 0.03 0.48 1.64
189 INT169441 TAC1 Positive_regulation of Tac1 1 2 0.01 1.7 1.64
190 INT354210 Binding of Igfbp7 and Accn3 1 6 0.27 3.91 1.64
191 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 1 0.03 0.48 1.64
192 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 1 0.47 1.01 1.63
193 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 1 0.23 0.45 1.62
194 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 1 0.03 1.94 1.62
195 INT215096 Binding of Hmgb1 and Tlr2 9 3 0.38 11.61 1.61
196 INT174503 Binding of HLA-B and KIR3DL1 6 1 0.37 3.48 1.61
197 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 6 0.08 4.21 1.61
198 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 1 0.23 0.45 1.61
199 INT335405 Binding of Arntl and Npas2 1 2 0.28 1.82 1.61
200 INT167200 Gtf3a Regulation of Gene_expression of Ngf 1 1 0.08 1.47 1.6

Single Events

The table below shows the top 100 pain related interactions that have been reported in 2010. They are ordered first by their pain relevance and then by number of times they were reported in 2010. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in 2010 Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 227 3083 0.78 894.43 1639.02
2 INT2542 Localization of Calca 96 2008 0.81 518.3 1408.65
3 INT796 Gene_expression of Penk 29 1902 0.78 275.47 1057.59
4 INT158 Localization of Prl 10 2431 0.81 378.96 952.2
5 INT6483 Gene_expression of TNF 729 3152 0.78 2515.62 929.82
6 INT7114 Positive_regulation of Ltp 258 1192 0.62 290.76 755.77
7 INT1912 Gene_expression of Calca 103 1152 0.78 453.25 739.84
8 INT3439 Localization of Abat 111 1017 0.78 112.39 727.06
9 INT5202 Positive_regulation of Gene_expression of Fos 70 1163 0.70 319.28 684
10 INT292 Localization of Penk 5 876 0.81 88.44 669.14
11 INT58061 Gene_expression of Trpv1 178 1117 0.78 451.54 637.59
12 INT728 Positive_regulation of Penk 6 1068 0.70 186.9 636.87
13 INT2543 Positive_regulation of Calca 51 787 0.70 331.13 592.08
14 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
15 INT5228 Positive_regulation of Fos 69 934 0.70 209.8 503.87
16 INT155 Positive_regulation of Prl 26 1233 0.70 317.93 457.82
17 INT1045 Localization of LH 33 1211 0.81 87.04 456.25
18 INT443 Localization of POMC 74 1020 0.81 284.52 443.17
19 INT50058 Negative_regulation of Cpox 50 907 0.58 426.28 428.29
20 INT9238 Gene_expression of IL6 400 1575 0.78 1135.66 424.22
21 INT4758 Positive_regulation of Localization of Calca 23 557 0.70 138.55 411.04
22 INT5895 Gene_expression of Oprm1 67 525 0.78 120.67 407.29
23 INT64202 Positive_regulation of Trpv1 106 643 0.70 249.66 397.42
24 INT467 Gene_expression of POMC 72 1048 0.78 332.8 394.16
25 INT1395 Negative_regulation of Penk 3 537 0.59 87.33 389.81
26 INT6056 Negative_regulation of Gene_expression of Fos 36 601 0.59 193.05 386.84
27 INT76660 Gene_expression of Trpv1 128 691 0.78 329.46 386.42
28 INT2540 Negative_regulation of Calca 20 538 0.59 172.11 384.38
29 INT18357 Gene_expression of TRPV1 80 825 0.78 307.11 382.81
30 INT6580 Negative_regulation of Ptgs1 43 929 0.59 381.53 376.26
31 INT157 Positive_regulation of Localization of Prl 4 790 0.70 104.54 374.78
32 INT287 Localization of Cck 7 518 0.81 86.84 364.04
33 INT439 Localization of Gnrh1 15 976 0.81 100.96 363.25
34 INT720 Positive_regulation of POMC 28 807 0.70 237.37 353.83
35 INT5660 Binding of Oprd1 23 477 0.48 71.86 342.06
36 INT16260 Gene_expression of Bdnf 97 671 0.78 283.44 339.1
37 INT5235 Negative_regulation of TNF 206 924 0.59 772.91 331.98
38 INT2649 Regulation of Calca 15 433 0.62 146.05 330.95
39 INT5059 Positive_regulation of TNF 234 1050 0.70 896.51 322.81
40 INT162 Regulation of Prl 7 794 0.62 165.01 322.24
41 INT5979 Gene_expression of Oprd1 33 428 0.78 75.64 320.32
42 INT34869 Negative_regulation of PTGS2 26 778 0.59 366.76 319.85
43 INT5540 Positive_regulation of Oprm1 30 344 0.70 76.77 319.71
44 INT5680 Gene_expression of Ngf 60 530 0.78 264.29 310.56
45 INT46460 Gene_expression of NAV1 111 288 0.78 135.51 305.75
46 INT4941 Positive_regulation of Oprd1 17 345 0.70 74.26 304.41
47 INT9131 Positive_regulation of Prkcg 51 431 0.70 130.8 302.41
48 INT477 Localization of Avp 47 813 0.81 131.58 300.4
49 INT161 Regulation of Localization of Prl 1 615 0.62 65.37 298.66
50 INT63932 Positive_regulation of Ephb1 108 537 0.70 259.67 296.14
51 INT1352 Localization of Acot1 21 728 0.80 73.01 296.01
52 INT886 Gene_expression of Pomc 12 676 0.78 129.87 295.98
53 INT11624 Gene_expression of OPRM1 60 445 0.78 72.36 294.36
54 INT5379 Gene_expression of Fos 154 656 0.78 255.5 292.54
55 INT3579 Localization of Oxt 17 555 0.81 43.35 292.44
56 INT97367 Gene_expression of Nav1 47 243 0.78 132.97 286.66
57 INT9158 Gene_expression of Tnf 128 722 0.78 522.01 277.68
58 INT2365 Positive_regulation of Cck 4 354 0.70 87.8 277.41
59 INT9381 Positive_regulation of TRPV1 72 523 0.70 187.4 276.05
60 INT94450 Gene_expression of Nav1 161 359 0.78 131.85 275.46
61 INT49750 Negative_regulation of CPOX 67 735 0.58 360.06 274.19
62 INT6852 Localization of TNF 278 883 0.81 705.95 270.84
63 INT10832 Gene_expression of IL8 327 1050 0.78 698.72 270
64 INT1396 Binding of Penk 1 355 0.48 22.79 269.65
65 INT5591 Regulation of Gene_expression of Fos 27 425 0.62 129.06 265.78
66 INT9659 Gene_expression of Il6 299 991 0.78 715.11 265.57
67 INT5972 Gene_expression of IL1B 159 948 0.78 510.91 263.97
68 INT68684 Gene_expression of VEGFA 847 2371 0.78 1742.52 259.2
69 INT87687 Positive_regulation of Trpv1 67 409 0.70 210.24 257.59
70 INT1893 Localization of Gh 62 1041 0.79 340.23 256.58
71 INT16868 Gene_expression of Il6 154 807 0.78 499.48 256.57
72 INT2909 Positive_regulation of Abat 17 334 0.70 62.1 256.43
73 INT3948 Regulation of Cck 1 291 0.62 58.07 255.88
74 INT5501 Regulation of Oprd1 20 283 0.62 55.1 249.9
75 INT1005 Localization of Sst 9 385 0.81 26.31 244.56
76 INT738 Regulation of POMC 12 459 0.62 111.19 243.74
77 INT1902 Gene_expression of Cck 9 348 0.78 70.33 241.92
78 INT11377 Positive_regulation of Ngf 36 331 0.70 206.5 238
79 INT1562 Localization of Crh 28 499 0.81 126.74 236.68
80 INT5597 Gene_expression of Pdyn 5 433 0.78 62.97 235.47
81 INT1665 Positive_regulation of Pag1 17 270 0.68 186.63 229.87
82 INT4759 Negative_regulation of Localization of Calca 13 294 0.59 82.62 226.45
83 INT9987 Gene_expression of Abat 52 296 0.78 95.46 226.34
84 INT6406 Binding of Oprm1 52 280 0.48 40.54 226.26
85 INT1212 Binding of Oprl1 6 312 0.48 28.6 225.15
86 INT11009 Phosphorylation of Creb1 35 458 0.82 111.34 221.97
87 INT626 Localization of CALCA 23 289 0.81 125.39 221.15
88 INT95787 Positive_regulation of Mapk1 147 568 0.70 226.51 220.94
89 INT6665 Gene_expression of FOS 65 520 0.77 165.31 217.66
90 INT1308 Localization of Pomc 12 457 0.81 66.83 217.5
91 INT6293 Gene_expression of Oprm1 4 312 0.78 48.73 215.61
92 INT6481 Binding of TNF 149 624 0.48 510.2 214.82
93 INT767 Localization of Gnrhr 10 565 0.80 106.68 214.57
94 INT4893 Gene_expression of Tacr1 23 366 0.78 129.67 213.92
95 INT22548 Positive_regulation of Casp3 76 483 0.70 258.78 213.07
96 INT6482 Positive_regulation of Gene_expression of TNF 144 659 0.70 569.88 210
97 INT16259 Positive_regulation of Bdnf 74 336 0.70 183.48 209.82
98 INT48955 Gene_expression of Nos2 145 753 0.78 403.87 208.08
99 INT2651 Positive_regulation of Pomc 5 403 0.70 95.72 206.24
100 INT2391 Negative_regulation of PTGS1 30 501 0.59 207.62 205.6
101 INT9132 Negative_regulation of Prkcg 40 279 0.59 88.05 203.47
102 INT798 Positive_regulation of Gene_expression of Penk 2 394 0.70 78.53 203.07
103 INT11313 Positive_regulation of Il6 62 526 0.70 331.27 201.59
104 INT2211 Negative_regulation of Abat 26 267 0.59 66.51 200.98
105 INT50670 Gene_expression of CPOX 88 763 0.76 442.13 195.02
106 INT156 Negative_regulation of Prl 12 542 0.59 131.97 192.24
107 INT528 Gene_expression of Prl 30 693 0.78 217.18 192.2
108 INT6488 Gene_expression of Tnf 75 484 0.78 339.61 191.58
109 INT2085 Positive_regulation of LH 18 441 0.70 60.15 191.02
110 INT63934 Phosphorylation of Ephb1 53 377 0.82 150.52 188.66
111 INT6354 Localization of Gabrg1 72 321 0.74 41.41 186.74
112 INT94952 Positive_regulation of Mapk14 56 305 0.70 197.83 186.61
113 INT1652 Regulation of Pomc 5 387 0.62 61.01 186.51
114 INT24326 Gene_expression of Ngf 73 346 0.78 218.67 184.71
115 INT10194 Positive_regulation of IL6 191 702 0.70 600.62 183.38
116 INT4803 Transcription of Penk 2 435 0.72 59.09 182.4
117 INT3440 Negative_regulation of Localization of Abat 35 221 0.57 33.94 180.36
118 INT12602 Negative_regulation of Oprm1 14 190 0.59 36.11 177.85
119 INT49441 Negative_regulation of Cpox 75 494 0.59 303.22 177.46
120 INT7506 Negative_regulation of Ltp 59 267 0.46 91.01 176.8
121 INT1429 Gene_expression of PDYN 8 308 0.78 61.33 175.65
122 INT19472 Gene_expression of Il1 134 554 0.76 419.75 175.35
123 INT943 Negative_regulation of Cck 7 205 0.59 38.42 174.78
124 INT26472 Regulation of Oprm1 30 191 0.62 35.84 173.1
125 INT15516 Gene_expression of Crp 189 711 0.77 615.33 173.09
126 INT5930 Positive_regulation of Oprm1 7 221 0.70 31.19 172.93
127 INT159 Negative_regulation of Localization of Prl 4 416 0.59 55.34 171.8
128 INT4937 Negative_regulation of Oprd1 12 224 0.59 44.51 171.11
129 INT438 Gene_expression of Crh 66 376 0.78 159.11 169.17
130 INT867 Gene_expression of IFNA1 322 930 0.78 594.85 168.03
131 INT739 Negative_regulation of POMC 13 358 0.59 102.28 166.77
132 INT55879 Gene_expression of CCL2 77 421 0.78 240.74 166.02
133 INT1114 Localization of Ins1 75 748 0.80 192.95 165.48
134 INT4768 Positive_regulation of OPRM1 37 212 0.70 31.09 164.28
135 INT5127 Localization of Lhb 20 488 0.80 50.48 162.66
136 INT3448 Positive_regulation of Gh 19 521 0.69 180.03 161.18
137 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
138 INT51921 Gene_expression of Cpox 31 501 0.73 229.81 157.81
139 INT21185 Binding of Ptprg 1 213 0.47 13.49 157.75
140 INT66280 Gene_expression of Nos2 185 534 0.78 330.78 157.07
141 INT768 Positive_regulation of Oprl1 4 179 0.70 40.05 156.93
142 INT1303 Negative_regulation of Npr1 2 278 0.55 35.1 156.78
143 INT2640 Gene_expression of Pomc 27 424 0.78 120.72 155.37
144 INT6042 Binding of Oprm1 8 248 0.48 31.77 154.34
145 INT4740 Gene_expression of Th 35 298 0.78 61.27 154.03
146 INT2910 Regulation of Abat 20 169 0.62 36.95 153.53
147 INT1044 Negative_regulation of Localization of LH 3 358 0.59 25.95 151.31
148 INT120811 Gene_expression of Gopc 421 1174 0.59 428.49 150.55
149 INT4829 Positive_regulation of Localization of Abat 23 199 0.55 20.91 150.48
150 INT15515 Positive_regulation of Crp 128 700 0.70 604.24 150.15
151 INT49134 Gene_expression of Grin1 24 270 0.78 84.78 148.61
152 INT5050 Regulation of Localization of Calca 6 149 0.62 41.25 148.57
153 INT6108 Gene_expression of Npy 26 292 0.78 110.65 148.21
154 INT13353 Positive_regulation of Tnf 42 332 0.70 248.75 148.1
155 INT7628 Gene_expression of Ltp 78 273 0.77 70.21 147.87
156 INT2451 Positive_regulation of Avp 22 355 0.70 102.66 147.69
157 INT1033 Positive_regulation of Ca2 110 507 0.68 131.76 147.64
158 INT9852 Positive_regulation of Gpt 138 563 0.70 364.64 146.82
159 INT5116 Gene_expression of IL2 132 670 0.78 291.13 146.69
160 INT812 Localization of INS 258 1026 0.81 515.6 145.31
161 INT425 Localization of PRL 35 455 0.81 189.64 144.8
162 INT2379 Positive_regulation of Localization of LH 17 349 0.70 27.86 144.53
163 INT3300 Positive_regulation of Gene_expression of Calca 19 179 0.70 77.76 144.2
164 INT60694 Gene_expression of Il10 158 567 0.78 369.48 143.69
165 INT9660 Regulation of TNF 75 363 0.62 312.94 139.99
166 INT90910 Phosphorylation of Grin1 45 150 0.82 68.23 139.24
167 INT14843 Gene_expression of Gabrg1 82 301 0.77 62.63 139.16
168 INT1273 Gene_expression of Avp 25 356 0.78 90.56 138.7
169 INT48895 Gene_expression of Il10 75 333 0.78 221.2 138.52
170 INT2867 Gene_expression of CALCA 18 247 0.78 78.78 138.47
171 INT5061 Negative_regulation of Mme 3 306 0.59 51.97 136.9
172 INT4658 Binding of OPRM1 21 188 0.48 25.96 136.24
173 INT1047 Negative_regulation of LH 6 314 0.59 53.71 135.89
174 INT2541 Binding of Calca 7 200 0.48 67.14 134.62
175 INT60126 Regulation of Trpv1 42 186 0.62 85.53 133.4
176 INT11012 Positive_regulation of Creb1 28 258 0.70 84.4 132
177 INT48953 Positive_regulation of Nos2 69 486 0.70 239.85 131.87
178 INT5497 Positive_regulation of Crh 15 299 0.70 125.54 131.14
179 INT5380 Positive_regulation of Gene_expression of Fos 55 243 0.70 105.65 131.05
180 INT49439 Gene_expression of Cpox 62 508 0.73 326.97 130.17
181 INT5595 Positive_regulation of Pdyn 3 223 0.70 48.37 130.14
182 INT64161 Positive_regulation of Prkca 52 213 0.70 85.06 129.91
183 INT115386 Gene_expression of Ppara 228 779 0.77 549.99 128.36
184 INT65600 Positive_regulation of Casp3 113 376 0.70 198.44 128.03
185 INT1614 Gene_expression of Oprl1 7 164 0.78 31.43 127.74
186 INT5842 Gene_expression of Gfap 152 372 0.78 153.71 127.71
187 INT1878 Binding of HLA-B 23 440 0.48 321.16 127.36
188 INT695 Binding of POMC 16 304 0.48 56.66 126.85
189 INT65054 Positive_regulation of Nfkb1 28 285 0.70 149.33 126.73
190 INT5931 Regulation of Oprm1 4 149 0.62 18.15 125.93
191 INT6822 Gene_expression of Pdyn 23 215 0.78 35.99 125.76
192 INT416 Regulation of LH 4 253 0.62 31.48 125.55
193 INT5008 Localization of Calca 23 204 0.81 80.35 125.16
194 INT6323 Positive_regulation of Gabrg1 48 213 0.70 45.08 124.34
195 INT4824 Positive_regulation of Tacr1 9 169 0.70 66.1 123.46
196 INT4259 Positive_regulation of Npr1 10 262 0.70 49.37 123.11
197 INT2106 Regulation of Localization of LH 6 279 0.62 22.37 122.77
198 INT252 Localization of GH1 114 529 0.80 227.4 122.05
199 INT6128 Positive_regulation of Localization of POMC 16 256 0.70 68.77 121.64
200 INT7533 Gene_expression of Tlr4 331 720 0.78 343.22 121.57
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