D:Achalasia

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pChart

Disease Term
Synonyms Achalasia Esophageal, Achalasias Esophageal, CARDIOSPASM, Cardiospasms, Dysphagea, Esophageal Achalasia, Esophageal Achalasias, Esophageal Aperistalsis, MEGAESOPHAGUS, Oesophageal Aperistalsis
Documents 68
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Achalasia. They are ordered first by their relevance to Achalasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
2 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 5.00
3 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 5.00
4 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 5.00
5 INT274233 Negative_regulation of Binding of Cd4 and Fasl 1 0.13 0.91 0.08 5.00
6 INT274232 Binding of Cd4 and Fasl 1 0.11 0.9 0.08 5.00
7 INT274231 Fasl Positive_regulation of Gene_expression of Cd8a 1 0.03 1.01 0.07 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Achalasia. They are ordered first by their pain relevance and then by number of times they were reported in Achalasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83891 Gene_expression of FUT3 20 0.61 10.49 1.41 99.84
2 INT214692 Negative_regulation of Gene_expression of FUT3 3 0.24 2.2 0.17 99.84
3 INT1153 Negative_regulation of FUT3 17 0.38 8.61 2.21 99.48
4 INT5045 Regulation of VIP 26 0.62 7.15 11.61 99.40
5 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 99.24
6 INT94189 Positive_regulation of FUT3 11 0.31 6.61 1.5 98.88
7 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 98.68
8 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 98.48
9 INT7383 Localization of VIP 53 0.81 17.7 22.65 98.16
10 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 87.52
11 INT354726 Binding of Tymp 1 0.30 1.08 0.23 86.96
12 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 86.68
13 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33 78.16
14 INT16012 Binding of Rac1 17 0.37 6.9 0.53 77.64
15 INT251830 Binding of TYMP 2 0.13 4.36 0.37 77.60
16 INT28576 Binding of MLN 18 0.48 5.45 2.26 48.92
17 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 38.44
18 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 38.44
19 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 37.92
20 INT104395 Gene_expression of Cxcl9 83 0.76 73.1 19.79 35.88
21 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 35.40
22 INT79693 Regulation of Il4 30 0.51 21.96 8.6 32.96
23 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39 32.96
24 INT98225 Regulation of Il5 8 0.45 5.07 2.06 32.96
25 INT142147 Regulation of Gene_expression of Il5 4 0.22 1.58 1.07 32.96
26 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 32.36
27 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 32.00
28 INT120722 Gene_expression of TYMP 35 0.75 19.26 1.31 27.20
29 INT211375 Regulation of Gene_expression of TYMP 2 0.43 2.44 0.22 13.92
30 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
31 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
32 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
33 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
34 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
35 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
36 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
37 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
38 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
39 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
40 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
41 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
42 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
43 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
44 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
45 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
46 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 5.00
47 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 5.00
48 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
49 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
50 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
51 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
52 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
53 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
54 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
55 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
56 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
57 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
58 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
59 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
60 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
61 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
62 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
63 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
64 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
65 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
66 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
67 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
68 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 5.00
69 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18 5.00
70 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
71 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
72 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
73 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 5.00
74 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11 5.00
75 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
76 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
77 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
78 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
79 INT177759 Negative_regulation of IFN1@ 51 0.57 31.81 7.76 5.00
80 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22 5.00
81 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 5.00
82 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
83 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
84 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 5.00
85 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 5.00
86 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
87 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 5.00
88 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
89 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 5.00
90 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
91 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
92 INT10053 Localization of Paf 15 0.80 9.14 3.64 5.00
93 INT188406 Binding of Fasl 19 0.44 24.67 3.17 5.00
94 INT22389 Regulation of MLN 9 0.61 4.39 3.08 5.00
95 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04 5.00
96 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 5.00
97 INT98554 Positive_regulation of Casp8 20 0.67 21.32 2.9 5.00
98 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
99 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84 5.00
100 INT92835 Gene_expression of Col4a1 22 0.49 13.5 2.27 5.00
101 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
102 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12 5.00
103 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
104 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
105 INT167035 Regulation of Cd8a 25 0.41 16.78 1.9 5.00
106 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 5.00
107 INT109973 Positive_regulation of Tnfrsf21 4 0.19 4.06 1.78 5.00
108 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 5.00
109 INT117014 Binding of TCN2 11 0.13 1.6 1.38 5.00
110 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 5.00
111 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 5.00
112 INT39919 Negative_regulation of MLN 9 0.36 2.91 1.06 5.00
113 INT155156 Gene_expression of TCN1 13 0.58 3.25 0.99 5.00
114 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89 5.00
115 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
116 INT178175 Positive_regulation of Gene_expression of Cd8a 17 0.43 13.05 0.78 5.00
117 INT132281 Binding of TCN1 2 0.33 0.95 0.74 5.00
118 INT138555 Negative_regulation of Tymp 3 0.39 3.31 0.74 5.00
119 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67 5.00
120 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 5.00
121 INT170314 Positive_regulation of Gene_expression of Col4a1 7 0.18 3.52 0.49 5.00
122 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 5.00
123 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42 5.00
124 INT324886 Transcription of Ece1 2 0.37 1.95 0.4 5.00
125 INT151274 Negative_regulation of Gene_expression of Cd40lg 3 0.32 2.16 0.3 5.00
126 INT138556 Positive_regulation of TYMP 23 0.58 12.9 0.28 5.00
127 INT167206 Positive_regulation of Positive_regulation of Casp8 4 0.49 2.11 0.26 5.00
128 INT181133 Negative_regulation of Gene_expression of Cd8a 7 0.37 2.65 0.25 5.00
129 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24 5.00
130 INT274228 Positive_regulation of Positive_regulation of Cxcl12 4 0.44 2.82 0.23 5.00
131 INT165643 Regulation of TCN1 4 0.39 0.56 0.22 5.00
132 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1 5.00
133 INT293570 Gene_expression of CHST14 1 0.22 0.65 0.08 5.00
134 INT274227 Negative_regulation of Binding of Fasl 2 0.37 1.96 0.08 5.00
135 INT329321 Positive_regulation of Positive_regulation of Tbxa2r 1 0.26 1.76 0.07 5.00
136 INT274229 Negative_regulation of Tnnc2 1 0.11 0.8 0.04 5.00
137 INT293569 Positive_regulation of Gene_expression of TPO 1 0.05 0.37 0 5.00
138 INT274230 Localization of Tnnc2 1 0.14 0.56 0 5.00
139 INT175738 Regulation of ARNTL 4 0.28 0.29 0 5.00
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