D:Agoraphobia

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Disease Term
Synonyms AGORAPHOBIAS, Fear Of Open Spaces
Documents 161
Hot Single Events 28
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Agoraphobia. They are ordered first by their relevance to Agoraphobia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT217075 Binding of Acsm3 and Slc26a4 1 0.04 2.11 0.04 48.16
2 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31 38.72
3 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
4 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
5 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
6 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
7 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
8 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
9 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
10 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35 5.00
11 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
12 INT310900 Binding of DEFB1 and Kdm5d 1 0.10 1.98 0.33 5.00
13 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
14 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
15 INT272618 Positive_regulation of Binding of GAD1 and CEBPZ 1 0.14 0.91 0.25 5.00
16 INT272619 Binding of GAD1 and CEBPZ 1 0.10 0.91 0.25 5.00
17 INT179689 Binding of CYP4F3 and DAK 1 0.00 1.23 0.2 5.00
18 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17 5.00
19 INT299889 Binding of MAT1A and MPP6 1 0.03 0.39 0 5.00
20 INT281402 Binding of AGRP and RAPGEFL1 1 0.05 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Agoraphobia. They are ordered first by their pain relevance and then by number of times they were reported in Agoraphobia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT129366 Positive_regulation of Bp2 2 0.23 1.75 0.7 99.62
2 INT181588 Regulation of OPN1SW 14 0.39 8.32 3.59 99.52
3 INT198565 Regulation of Ddit4l 1 0.06 2.36 0.45 98.72
4 INT53468 Binding of Acsm3 26 0.24 20.87 2.95 98.16
5 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 98.04
6 INT327 Negative_regulation of Positive_regulation of Gnrhr 17 0.53 4.22 10.21 97.56
7 INT181589 Binding of OPN1SW 13 0.32 9.47 4.07 97.00
8 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 96.56
9 INT179101 Gene_expression of CYP4F3 14 0.65 6.89 1.98 96.44
10 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 95.76
11 INT243845 Localization of MAOA 4 0.55 1.52 0.77 94.64
12 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 94.64
13 INT164220 Gene_expression of OPN1SW 21 0.65 13.7 4.14 93.52
14 INT246103 Negative_regulation of Gene_expression of OPN1SW 1 0.36 1.26 0.15 93.52
15 INT255416 Regulation of Bp2 1 0.15 3.75 0.07 93.48
16 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 93.24
17 INT232667 Binding of Pd 17 0.16 20.76 3.58 93.00
18 INT253 Regulation of PRL 184 0.62 47.27 65.79 91.28
19 INT2415 Binding of MAOA 26 0.47 13.26 11.86 90.96
20 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 90.76
21 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 90.60
22 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 90.16
23 INT425 Localization of PRL 455 0.81 189.64 144.8 88.72
24 INT42459 Positive_regulation of Gene_expression of Pag1 19 0.25 13.49 12.22 88.16
25 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 87.36
26 INT217072 Negative_regulation of Acsm3 5 0.29 6.15 1.59 85.76
27 INT138257 Gene_expression of Bp2 2 0.35 1.55 0.1 82.16
28 INT6926 Regulation of Pag1 72 0.39 55.79 65.09 80.88
29 INT63137 Regulation of Pd 10 0.12 4.01 0.81 79.28
30 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76 77.56
31 INT134346 Binding of PCS 51 0.37 22.27 5.67 76.36
32 INT179695 Negative_regulation of CYP4F3 4 0.45 4.94 1.38 73.84
33 INT189506 Gene_expression of Anxty 32 0.55 45.92 9.11 72.40
34 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 71.84
35 INT263967 Positive_regulation of Localization of PAG1 1 0.43 2.83 0.61 69.96
36 INT81419 Localization of PAG1 10 0.64 11.1 8.01 69.36
37 INT263969 Negative_regulation of Localization of PAG1 1 0.36 2.72 0.61 69.36
38 INT88868 Binding of MCS 45 0.40 37.43 7.98 66.64
39 INT255415 Binding of Bp2 1 0.12 1.58 0.04 65.64
40 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 63.88
41 INT263968 Positive_regulation of Negative_regulation of PAG1 1 0.43 1.29 0.33 63.88
42 INT70970 Binding of COPD 144 0.42 180.34 18.29 63.64
43 INT258773 Negative_regulation of Binding of Dpyd 1 0.11 0.6 0 63.32
44 INT92716 Negative_regulation of PAG1 6 0.51 5.82 6.32 63.08
45 INT97149 Binding of Dpyd 3 0.14 1.73 0.25 62.80
46 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 61.44
47 INT103477 Negative_regulation of Gene_expression of BDNF 23 0.52 10.63 6.26 61.44
48 INT756 Gene_expression of C3 138 0.75 100.6 19.2 56.12
49 INT40962 Localization of Avp 40 0.80 20.5 6.38 55.32
50 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 53.68
51 INT139863 Binding of amd 27 0.41 41.3 0.91 52.52
52 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 51.76
53 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 51.08
54 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 47.52
55 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 45.76
56 INT50309 Binding of Il1a 22 0.40 5.4 4.49 44.92
57 INT9973 Binding of MMVP1 14 0.48 22.66 1.79 41.20
58 INT143494 Binding of DCPS 24 0.29 24.41 3.67 40.20
59 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 39.36
60 INT19580 Binding of Pag1 24 0.30 15.13 20.88 38.08
61 INT215454 Regulation of amd 4 0.38 8.07 0.29 36.64
62 INT70782 Gene_expression of Dpyd 5 0.53 2.44 0 33.92
63 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 30.24
64 INT101193 Regulation of Gene_expression of Pag1 13 0.22 8.62 6.77 27.92
65 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 24.80
66 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 23.44
67 INT11300 Positive_regulation of Gene_expression of Avp 24 0.50 10.18 2.69 22.56
68 INT232452 Positive_regulation of Binding of PRL 1 0.50 0.18 0.27 22.12
69 INT6021 Binding of PRL 18 0.48 12.55 4.3 21.20
70 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 20.84
71 INT179857 Gene_expression of ATF7IP 14 0.65 4.12 0.89 19.68
72 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 19.00
73 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 18.96
74 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 16.32
75 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 16.32
76 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 13.52
77 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 12.88
78 INT101022 Regulation of Il1rn 5 0.44 2.15 1.21 10.68
79 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 7.76
80 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.48
81 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
82 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
83 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
84 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
85 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
86 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
87 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
88 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 5.00
89 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 5.00
90 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
91 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
92 INT477 Localization of Avp 813 0.81 131.58 300.4 5.00
93 INT1352 Localization of Acot1 728 0.80 73.01 296.01 5.00
94 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
95 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
96 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
97 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 5.00
98 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 5.00
99 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
100 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
101 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 5.00
102 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
103 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 5.00
104 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
105 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 5.00
106 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
107 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 5.00
108 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
109 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
110 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03 5.00
111 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 5.00
112 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37 5.00
113 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 5.00
114 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 5.00
115 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
116 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
117 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
118 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65 5.00
119 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
120 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
121 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
122 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
123 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
124 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02 5.00
125 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 5.00
126 INT50308 Binding of Cnr1 61 0.48 14.41 33.52 5.00
127 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
128 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
129 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
130 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 5.00
131 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 5.00
132 INT5966 Localization of Il1a 50 0.78 22.91 26.54 5.00
133 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
134 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
135 INT7584 Gene_expression of Crh 112 0.78 39.15 25.33 5.00
136 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54 5.00
137 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
138 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 5.00
139 INT5586 Binding of Fos 47 0.48 12.7 21.33 5.00
140 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
141 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
142 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
143 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 5.00
144 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24 5.00
145 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
146 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 5.00
147 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
148 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
149 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
150 INT131871 Negative_regulation of Mgll 23 0.58 5.1 16.03 5.00
151 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 5.00
152 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82 5.00
153 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
154 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
155 INT7587 Localization of GAL 27 0.78 4.79 14.29 5.00
156 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
157 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66 5.00
158 INT6749 Binding of Dio1 25 0.38 4.41 13.07 5.00
159 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
160 INT88365 Regulation of Faah 18 0.45 6.63 12.54 5.00
161 INT69763 Positive_regulation of Positive_regulation of Cnr1 12 0.50 9.05 12.46 5.00
162 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23 5.00
163 INT79556 Gene_expression of GRIN3B 16 0.77 7.71 10.75 5.00
164 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
165 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
166 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93 5.00
167 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
168 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
169 INT85144 Binding of Cnr2 14 0.47 6.41 9.49 5.00
170 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45 5.00
171 INT179696 Negative_regulation of DAK 5 0.02 16.79 9.42 5.00
172 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
173 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
174 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
175 INT23178 Gene_expression of H1 38 0.68 13.37 9.09 5.00
176 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
177 INT15308 Localization of Chat 29 0.81 2.35 8.47 5.00
178 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
179 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
180 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
181 INT36678 Binding of TIMP1 33 0.36 14.99 7.87 5.00
182 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
183 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
184 INT168915 Gene_expression of Oxtr 49 0.75 20.53 7.22 5.00
185 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 5.00
186 INT19806 Regulation of Avp 29 0.53 14.17 6.94 5.00
187 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71 5.00
188 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36 5.00
189 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
190 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95 5.00
191 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
192 INT19805 Negative_regulation of Avp 18 0.59 4.57 5.87 5.00
193 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84 5.00
194 INT18648 Binding of Ptgdr 15 0.42 2.26 5.61 5.00
195 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 5.00
196 INT81796 Binding of AGRP 62 0.36 37.19 5.3 5.00
197 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 5.00
198 INT36778 Positive_regulation of Anxty 14 0.48 12.85 5.08 5.00
199 INT71418 Binding of CES1 42 0.40 29.78 5.01 5.00
200 INT90962 Regulation of Positive_regulation of Cnr1 6 0.61 1.25 4.99 5.00
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