D:Bone Cysts

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Disease Term
Synonyms Bone Cyst, Cyst Bone, Cyst Solitary, Cyst Subchondral, CYSTS BONE, Cysts Solitary, Cysts Subchondral, Ganglia Intra Osseous, Ganglia Intraosseous, GANGLIAS INTRA OSSEOUS, GANGLIAS INTRAOSSEOUS
Documents 287
Hot Single Events 16
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bone Cysts. They are ordered first by their relevance to Bone Cysts and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT137834 Binding of CAMK2B and CTS 1 0.05 1.38 0.42 87.04
2 INT301289 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Atp6v0d2 1 0.02 1.01 0.28 24.40
3 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
4 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49 5.00
5 INT301277 Il6 Positive_regulation of Positive_regulation of Clec5a 1 0.16 0.37 0.29 5.00
6 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29 5.00
7 INT301292 Negative_regulation of Clec5a Negative_regulation of TNF 1 0.05 1.04 0.27 5.00
8 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26 5.00
9 INT301280 Il6 Positive_regulation of Gene_expression of Acp5 1 0.04 0.37 0.26 5.00
10 INT301291 Il6 Positive_regulation of Gene_expression of TNF 1 0.01 0.37 0.26 5.00
11 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21 5.00
12 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21 5.00
13 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2 5.00
14 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2 5.00
15 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
16 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 5.00
17 INT301278 Nfatc1 Regulation of Acp5 1 0.05 0.19 0.15 5.00
18 INT301283 Nfatc1 Regulation of Ctsk 1 0.06 0.19 0.13 5.00
19 INT253929 Binding of Vcam1 and Cd99l2 1 0.00 0.61 0.13 5.00
20 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11 5.00
21 INT301288 Clec5a Regulation of Nfatc1 1 0.21 0.25 0.1 5.00
22 INT253930 IFNA1 Positive_regulation of Cdc42ep3 1 0.00 0.65 0.08 5.00
23 INT239080 Binding of PPY and KAT2B 1 0.02 2.38 0 5.00
24 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bone Cysts. They are ordered first by their pain relevance and then by number of times they were reported in Bone Cysts. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28151 Positive_regulation of CTs 55 0.61 35.09 20.14 99.28
2 INT9784 Binding of B2M 9 0.47 6.18 1.44 98.42
3 INT27710 Binding of B2m 5 0.36 3.54 0.53 98.08
4 INT202606 Regulation of PTPN5 1 0.26 3.92 3.04 95.92
5 INT305914 Localization of Ods 1 0.30 0.56 0.1 95.76
6 INT673 Positive_regulation of B2m 24 0.68 24.24 4.82 94.72
7 INT21782 Negative_regulation of B2M 11 0.46 5.49 1.92 92.36
8 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 91.68
9 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 90.32
10 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 89.92
11 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 87.20
12 INT137835 Binding of CAMK2B 1 0.08 1.38 0.42 86.88
13 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 86.80
14 INT670 Gene_expression of B2m 31 0.66 27.32 8.49 85.24
15 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 84.84
16 INT19023 Localization of B2m 6 0.75 5.15 0.46 82.40
17 INT1168 Binding of PROC 62 0.38 44.15 9.04 75.00
18 INT75971 Regulation of B2m 7 0.45 3.96 0.37 69.28
19 INT209424 Binding of Tyrobp 5 0.43 2.03 0.33 55.60
20 INT301267 Binding of Clec5a 2 0.37 1.17 0.35 55.12
21 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 51.56
22 INT153794 Gene_expression of Ctsk 51 0.77 24.99 7.28 33.20
23 INT224620 Positive_regulation of Gene_expression of Ctsk 13 0.68 8.35 2.21 33.20
24 INT61465 Gene_expression of Acp5 22 0.75 7.06 2.55 31.92
25 INT146804 Positive_regulation of Gene_expression of Acp5 3 0.12 3.21 0.28 31.92
26 INT171998 Binding of DMD 58 0.47 38.13 3.35 27.88
27 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 24.40
28 INT111532 Gene_expression of Nfatc1 15 0.75 5.27 3.73 23.44
29 INT111528 Positive_regulation of Gene_expression of Nfatc1 5 0.67 3.24 2.52 23.44
30 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 22.72
31 INT17996 Binding of Crp 40 0.37 31.4 7.8 22.32
32 INT301269 Positive_regulation of Positive_regulation of Clec5a 1 0.50 1.28 0.45 21.44
33 INT301272 Positive_regulation of Clec5a 1 0.69 6.17 2.92 20.64
34 INT2578 Binding of Ins1 74 0.48 33.57 12.92 15.84
35 INT57643 Negative_regulation of Binding of Ins1 6 0.43 3.51 0.43 15.84
36 INT301263 Gene_expression of Clec5a 22 0.77 14.64 5.18 14.00
37 INT253918 Positive_regulation of Gene_expression of Rnf123 1 0.07 1.61 0.25 5.68
38 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
39 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
40 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
41 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
42 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
43 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
44 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
45 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
46 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
47 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
48 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
49 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
50 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
51 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
52 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
53 INT9664 Binding of LBP 127 0.48 94.9 63.42 5.00
54 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
55 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
56 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
57 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
58 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
59 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 5.00
60 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
61 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
62 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
63 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
64 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
65 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 5.00
66 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
67 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
68 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
69 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
70 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
71 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69 5.00
72 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
73 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 5.00
74 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
75 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 5.00
76 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
77 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
78 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
79 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
80 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
81 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
82 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
83 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
84 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
85 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 5.00
86 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
87 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
88 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
89 INT150851 Positive_regulation of Cxcl1 45 0.57 20.83 11.88 5.00
90 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
91 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
92 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 5.00
93 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53 5.00
94 INT101474 Positive_regulation of Gene_expression of Gfap 61 0.70 38.3 10.35 5.00
95 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3 5.00
96 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 5.00
97 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 5.00
98 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 5.00
99 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
100 INT186273 Negative_regulation of Il13 33 0.46 22.88 8.65 5.00
101 INT79693 Regulation of Il4 30 0.51 21.96 8.6 5.00
102 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
103 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87 5.00
104 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84 5.00
105 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45 5.00
106 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
107 INT66925 Positive_regulation of Gene_expression of Ik 22 0.15 10.47 6.4 5.00
108 INT57256 Gene_expression of HLA-DQA2 52 0.55 23.87 6.27 5.00
109 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2 5.00
110 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 5.00
111 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
112 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 5.00
113 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85 5.00
114 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 5.00
115 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
116 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35 5.00
117 INT4342 Localization of ALPP 27 0.69 15.19 5.32 5.00
118 INT178763 Binding of HHIP 37 0.08 6.3 5.29 5.00
119 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 5.00
120 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 5.00
121 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 5.00
122 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
123 INT181395 Gene_expression of Ccl8 11 0.67 13.88 4.56 5.00
124 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
125 INT186270 Regulation of Il13 13 0.43 11.58 4.19 5.00
126 INT95512 Transcription of Ghr 24 0.69 3.1 4.12 5.00
127 INT160915 Regulation of Mmp9 16 0.35 10.25 4.07 5.00
128 INT6507 Binding of C5 23 0.48 15.35 3.91 5.00
129 INT207426 Gene_expression of COL10A1 27 0.65 12.02 3.85 5.00
130 INT174277 Positive_regulation of Positive_regulation of Gopc 23 0.33 8.08 3.73 5.00
131 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
132 INT134914 Binding of Gfap 21 0.37 8.25 3.67 5.00
133 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
134 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 5.00
135 INT96150 Gene_expression of H2-D1 44 0.27 16.23 3.4 5.00
136 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 5.00
137 INT167647 Binding of PTPN5 2 0.32 3.21 3.38 5.00
138 INT61259 Negative_regulation of Itgam 16 0.47 11.11 3.27 5.00
139 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 5.00
140 INT234717 Regulation of Cxcl1 10 0.41 6.14 2.9 5.00
141 INT239083 Binding of PPY 9 0.32 7.59 2.9 5.00
142 INT170305 Regulation of Gene_expression of Mmp9 11 0.33 5.7 2.8 5.00
143 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73 5.00
144 INT91999 Transcription of Gfra1 10 0.67 4.67 2.45 5.00
145 INT137270 Positive_regulation of PDE4D 4 0.48 2.48 2.39 5.00
146 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39 5.00
147 INT35643 Positive_regulation of BPIFA4P 7 0.67 4.87 2.39 5.00
148 INT165841 Gene_expression of BPIFA4P 17 0.65 6.48 2.38 5.00
149 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29 5.00
150 INT163064 Positive_regulation of Gene_expression of C1qa 9 0.67 6.51 2.29 5.00
151 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
152 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18 5.00
153 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 5.00
154 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14 5.00
155 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 5.00
156 INT199084 Gene_expression of Cd36 31 0.53 16.94 1.94 5.00
157 INT184031 Gene_expression of Cish 14 0.49 9.82 1.86 5.00
158 INT202602 Positive_regulation of PTPN5 4 0.29 3.34 1.83 5.00
159 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
160 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 5.00
161 INT265567 Localization of PTPN5 1 0.49 1.39 1.47 5.00
162 INT34594 Negative_regulation of Gene_expression of ALPP 12 0.50 5.04 1.41 5.00
163 INT178898 Gene_expression of PTPN5 4 0.38 3.06 1.4 5.00
164 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34 5.00
165 INT207429 Positive_regulation of Gene_expression of COL10A1 8 0.42 4.16 1.34 5.00
166 INT117232 Localization of COL2A1 11 0.72 7.34 1.3 5.00
167 INT215380 Positive_regulation of Gene_expression of Cd36 12 0.47 8.51 1.3 5.00
168 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29 5.00
169 INT70067 Regulation of KNCN 2 0.07 1.71 1.17 5.00
170 INT61466 Positive_regulation of Acp5 15 0.66 10.17 1.16 5.00
171 INT169643 Binding of Ods 3 0.18 2.89 1.15 5.00
172 INT253925 Positive_regulation of Gene_expression of Pdcd1 5 0.06 5.03 1.08 5.00
173 INT13397 Localization of DMD 21 0.78 7.96 1.08 5.00
174 INT181973 Positive_regulation of MAS1 8 0.49 7.64 1.07 5.00
175 INT153769 Negative_regulation of Tnfrsf11a 4 0.39 2.13 1.05 5.00
176 INT301262 Negative_regulation of Gene_expression of Clec5a 1 0.43 3.01 1.02 5.00
177 INT131488 Binding of MAS1 9 0.36 8.49 1.01 5.00
178 INT130005 Protein_catabolism of MMP13 4 0.36 3.02 0.95 5.00
179 INT138683 Regulation of Ighg1 15 0.30 7.95 0.94 5.00
180 INT44972 Negative_regulation of Gfra1 16 0.58 10.17 0.93 5.00
181 INT265569 Negative_regulation of Binding of MRI1 1 0.16 0.79 0.87 5.00
182 INT265568 Binding of PDE4D 1 0.05 0.81 0.85 5.00
183 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 5.00
184 INT150108 Positive_regulation of Gene_expression of Slc37a4 5 0.35 2.09 0.83 5.00
185 INT190678 Binding of Nfatc1 6 0.26 1.04 0.83 5.00
186 INT190675 Phosphorylation of Nfatc1 6 0.56 0.68 0.76 5.00
187 INT203035 Gene_expression of Pdcd1lg2 4 0.58 1.97 0.74 5.00
188 INT142416 Binding of Ptch1 6 0.34 4.92 0.74 5.00
189 INT253922 Gene_expression of Otc 13 0.17 1.21 0.73 5.00
190 INT221108 Negative_regulation of Slc11a1 5 0.33 3.76 0.69 5.00
191 INT146109 Positive_regulation of Serping1 4 0.59 2.73 0.68 5.00
192 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 5.00
193 INT236356 Positive_regulation of Binding of Gfap 4 0.44 3.2 0.67 5.00
194 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67 5.00
195 INT301261 Negative_regulation of Clec5a 3 0.58 1.68 0.66 5.00
196 INT247954 Positive_regulation of Pdcd1 5 0.16 4.97 0.65 5.00
197 INT34593 Negative_regulation of Localization of ALPP 2 0.50 0.85 0.64 5.00
198 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61 5.00
199 INT224635 Positive_regulation of Lgals3bp 3 0.07 2.31 0.58 5.00
200 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 5.00
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