D:Central Core Disease

Disease Term Synonyms Central Core Diseases, Central Core Myopathies, CENTRAL CORE MYOPATHY, Myopathies Central Core, Myopathy Central Core, SHY MAGEE SYNDROME, Shy S Disease, Syndrome Shy Magee Documents 30 Hot Single Events 14 Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Central Core Disease. They are ordered first by their relevance to Central Core Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT266703	Binding of RYR1 and DIXDC1	1	0.26	0.1	0	100.00
2	INT207785	Binding of RYR1 and Ap3d1	1	0.06	3.24	0.13	97.20
3	INT207783	Binding of MRC1 and Ap3d1	1	0.00	2.54	0.22	29.84
4	INT207776	Binding of FKBP1A and RYR1	1	0.05	0.59	0.12	12.44
5	INT271071	Binding of ACTA1 and Hypism	1	0.00	1.54	0.15	6.72
6	INT204943	Il6 Regulation of Slc39a14	1	0.00	0.54	0.36	5.00
7	INT331966	Binding of DES and SACM1L	1	0.01	1.86	0.36	5.00
8	INT207784	Ap3d1 Regulation of CACNA1S	1	0.05	0.97	0.16	5.00
9	INT266704	Binding of RYR1 and TRDN	1	0.34	0	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Central Core Disease. They are ordered first by their pain relevance and then by number of times they were reported in Central Core Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT207777	Binding of Ap3d1	1	0.07	14.51	1.91	99.80
2	INT207779	Localization of Ap3d1	1	0.11	3.16	0.14	99.80
3	INT59555	Binding of RYR1	39	0.42	8.65	4.92	99.48
4	INT11713	Localization of RYR1	22	0.76	10.42	1.64	99.36
5	INT211758	Binding of Mmd	1	0.13	3.09	0.1	98.54
6	INT28320	Negative_regulation of Abo	16	0.58	5.69	4.7	97.36
7	INT211756	Phosphorylation of Mmd	1	0.17	1.44	0.03	96.44
8	INT107987	Gene_expression of MRC1	27	0.75	36.94	1.99	94.08
9	INT21855	Gene_expression of Ap3d1	4	0.32	12.21	4.66	92.88
10	INT245157	Negative_regulation of Gene_expression of DMD	8	0.57	4.79	0.09	90.20
11	INT13396	Gene_expression of DMD	125	0.75	57.81	5.45	89.88
12	INT68500	Regulation of Ar	6	0.27	4.16	1.32	85.84
13	INT55305	Regulation of RYR1	14	0.45	5.27	1.33	82.08
14	INT24712	Positive_regulation of Ap3d1	18	0.54	8.58	2.71	81.92
15	INT36040	Localization of Itpr3	21	0.70	4.87	7.77	79.52
16	INT17561	Localization of Car2	303	0.79	60.95	44.52	76.48
17	INT207778	Positive_regulation of Binding of Ap3d1	1	0.06	1.26	0.52	75.12
18	INT211757	Negative_regulation of Mmd	1	0.11	1.02	0.08	74.60
19	INT60209	Transcription of RYR1	3	0.69	3.06	0.16	73.80
20	INT3537	Positive_regulation of Car2	413	0.56	103.51	94.35	71.44
21	INT16167	Negative_regulation of DMD	186	0.57	108.71	15.25	60.64
22	INT42425	Gene_expression of Mmd	2	0.75	1.68	0.91	60.48
23	INT8243	Positive_regulation of Il6	451	0.70	358.24	119.28	43.44
24	INT9657	Positive_regulation of Gene_expression of Il6	237	0.70	180.45	63.6	43.44
25	INT9659	Gene_expression of Il6	991	0.78	715.11	265.57	43.04
26	INT207782	Binding of CACNA1S	1	0.30	0.53	0.03	42.00
27	INT49908	Regulation of Gene_expression of RYR1	3	0.45	0.32	0.19	39.00
28	INT211753	Negative_regulation of ACADS	1	0.03	1.49	0.08	38.96
29	INT6508	Gene_expression of RYR1	34	0.77	11.11	2.04	38.56
30	INT17962	Regulation of Car2	124	0.41	33.98	22.71	35.28
31	INT11937	Localization of Il6	228	0.81	139.83	64.39	31.44
32	INT121774	Binding of ACTA1	4	0.47	2.31	0.85	20.96
33	INT82913	Regulation of Ppara	15	0.61	10.66	3.03	17.68
34	INT98607	Regulation of Regulation of TNF	8	0.44	6.95	2.56	17.68
35	INT9660	Regulation of TNF	363	0.62	312.94	139.99	15.76
36	INT65057	Regulation of Nfkb1	28	0.47	16.48	11.62	14.60
37	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	5.00
38	INT6665	Gene_expression of FOS	520	0.77	165.31	217.66	5.00
39	INT3038	Gene_expression of INS	1583	0.78	1174.16	107.01	5.00
40	INT8357	Gene_expression of KNG1	153	0.75	77.26	68.66	5.00
41	INT11491	Positive_regulation of KNG1	128	0.67	60.41	58.74	5.00
42	INT17458	Negative_regulation of Gene_expression of FOS	98	0.57	36.77	55.69	5.00
43	INT157666	Positive_regulation of GOPC	335	0.60	120.19	42.75	5.00
44	INT9094	Gene_expression of COL7A1	277	0.77	143.42	38.73	5.00
45	INT53475	Gene_expression of MRI1	116	0.59	77.68	33.98	5.00
46	INT9655	Regulation of Il6	98	0.62	70.92	31.95	5.00
47	INT58192	Positive_regulation of MRI1	86	0.61	53.81	24.68	5.00
48	INT11938	Positive_regulation of Localization of Il6	61	0.70	35.72	18.25	5.00
49	INT20631	Positive_regulation of CHKB	166	0.69	109.86	17.92	5.00
50	INT171666	Regulation of GOPC	117	0.39	40.41	15.47	5.00
51	INT180497	Binding of MRI1	45	0.42	28.35	14.77	5.00
52	INT70265	Regulation of MRI1	42	0.39	30.95	14.18	5.00
53	INT8210	Positive_regulation of Gene_expression of INS	188	0.68	146.57	12.83	5.00
54	INT25963	Gene_expression of DES	122	0.75	98.81	11.25	5.00
55	INT26551	Positive_regulation of Gene_expression of KNG1	19	0.67	11.05	7.98	5.00
56	INT14207	Gene_expression of DNM2	20	0.67	5.76	7.64	5.00
57	INT62336	Positive_regulation of Hdc	38	0.70	14.45	5.51	5.00
58	INT49375	Regulation of Localization of Il6	16	0.62	4.54	5.08	5.00
59	INT10138	Negative_regulation of Gene_expression of KNG1	13	0.57	9.57	4.9	5.00
60	INT57274	Positive_regulation of Gene_expression of COL7A1	50	0.69	24.19	4.72	5.00
61	INT15648	Positive_regulation of RYR1	30	0.67	12.03	3.26	5.00
62	INT26273	Negative_regulation of RYR1	18	0.43	7.64	3.11	5.00
63	INT21853	Regulation of Ap3d1	3	0.10	1.4	2.95	5.00
64	INT105824	Regulation of Casq1	4	0.07	2.66	2.1	5.00
65	INT21852	Regulation of Gene_expression of Ap3d1	2	0.18	1.34	1.54	5.00
66	INT71918	Gene_expression of ACTA1	16	0.75	7.73	1.45	5.00
67	INT11367	Localization of MB	9	0.78	9.34	1.24	5.00
68	INT207780	Positive_regulation of NMS	2	0.28	3.2	0.61	5.00
69	INT94347	Gene_expression of DYSF	4	0.75	3.25	0.41	5.00
70	INT2090	Negative_regulation of Gaa	5	0.21	3.43	0.4	5.00
71	INT331973	Gene_expression of MYOT	4	0.64	3.83	0.4	5.00
72	INT211586	Regulation of DMPK	6	0.31	2.11	0.33	5.00
73	INT204941	Protein_catabolism of Timp2	1	0.03	0.35	0.32	5.00
74	INT123637	Gene_expression of LGMD2I	2	0.08	1.7	0.29	5.00
75	INT260581	Binding of DMPK	7	0.43	5.09	0.28	5.00
76	INT264998	Regulation of Binding of MRI1	1	0.31	1.34	0.27	5.00
77	INT331969	Regulation of Gene_expression of MYOT	1	0.43	2.22	0.27	5.00
78	INT175417	Binding of SACM1L	8	0.29	6.06	0.22	5.00
79	INT331970	Regulation of Regulation of LDB3	1	0.37	1.12	0.14	5.00
80	INT179320	Regulation of LDB3	3	0.37	1.55	0.14	5.00
81	INT331968	Positive_regulation of Gene_expression of SEPN1	1	0.31	1	0.13	5.00
82	INT289892	Gene_expression of SEPN1	3	0.42	1.17	0.13	5.00
83	INT158175	Positive_regulation of Gene_expression of RYR1	2	0.48	1.35	0.13	5.00
84	INT88416	Positive_regulation of Gene_expression of ACTA1	2	0.67	1.05	0.13	5.00
85	INT331971	Positive_regulation of Gene_expression of DNM2	1	0.31	1	0.13	5.00
86	INT331967	Negative_regulation of LGMD2A	1	0.06	0.48	0.11	5.00
87	INT331972	Positive_regulation of Gene_expression of DYSF	1	0.28	0.48	0.11	5.00
88	INT166811	Regulation of Casq1	3	0.04	1.18	0.1	5.00
89	INT272205	Positive_regulation of LGMD2I	2	0.12	2.08	0.08	5.00
90	INT207781	Gene_expression of CACNA1S	3	0.63	0.9	0.03	5.00
91	INT266731	Binding of TRDN	1	0.47	0	0.03	5.00
92	INT204938	Positive_regulation of Casq1	1	0.08	0.17	0.03	5.00