D:Chondrodysplasia

From wiki-pain
Revision as of 00:43, 13 October 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search

pChart

Disease Term
Synonyms Cartilage Hair Hypoplasia, Chondrodysplasia Punctata, CHONDRODYSTROPHIA CALCIFICANS CONGENITA, Conradi Hunermann Syndrome, Dysplasia Epiphysialis Punctata, EPIPHYSES STIPPLED, Hunermann Conradi Syndrome, Jansen Metaphyseal Dysostosis, Mckusick Type Metaphyseal Chondrodysplasia, MURK JANSEN TYPE METAPHYSEAL CHONDRODYSPLASIA, Stippled Epiphyses
Documents 29
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chondrodysplasia. They are ordered first by their relevance to Chondrodysplasia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT233779 PTH1R Regulation of Positive_regulation of PTH 1 0.08 0.34 0 63.40
2 INT245732 Binding of COL9A2 and DISC1 1 0.07 1.34 0.08 54.56
3 INT245728 Binding of TRNAP2 and DISC1 1 0.03 0.54 0 38.24
4 INT223962 Tnf Negative_regulation of Gene_expression of Bglap 1 0.21 1.21 0.32 5.00
5 INT223964 Tnf Negative_regulation of Bglap 1 0.21 1.2 0.32 5.00
6 INT223965 Binding of AMY2A and Bglap 1 0.05 1.5 0.28 5.00
7 INT233785 Binding of SCT and VIPR1 1 0.08 0 0.27 5.00
8 INT233784 Binding of GCG and SCT 1 0.06 0 0.27 5.00
9 INT233781 Binding of PTH1R and SCT 1 0.18 0 0.27 5.00
10 INT233786 Binding of CALCR and SCT 1 0.05 0 0.27 5.00
11 INT233780 Binding of ADCYAP1 and SCT 1 0.16 0 0.27 5.00
12 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27 5.00
13 INT233783 Binding of SCT and VIPR2 1 0.13 0 0.27 5.00
14 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22 5.00
15 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13 5.00
16 INT302979 Binding of Gnb2l1 and Smpd2 1 0.07 0.71 0.09 5.00
17 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09 5.00
18 INT302980 Mmp2 Positive_regulation of Smpd3 1 0.29 0.78 0.05 5.00
19 INT302983 Fadd Positive_regulation of Casp3 1 0.15 1.13 0.04 5.00
20 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04 5.00
21 INT302982 Smpd1 Positive_regulation of Gene_expression of Smpd3 1 0.30 0.64 0.04 5.00
22 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04 5.00
23 INT302974 Nqo1 Positive_regulation of Jag2 1 0.00 0.45 0.04 5.00
24 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0 5.00
25 INT172580 Binding of CD97 and CD55 1 0.14 0 0 5.00
26 INT245731 Binding of COL5A2 and DISC1 1 0.01 0.42 0 5.00
27 INT245727 Binding of SUGT1 and DISC1 1 0.00 1.57 0 5.00
28 INT245733 Binding of VDR and DISC1 1 0.03 0.75 0 5.00
29 INT245730 RENBP Regulation of DISC1 1 0.01 0.58 0 5.00
30 INT245734 Binding of COL9A1 and COL9A2 1 0.26 0.52 0 5.00
31 INT245729 Binding of COL9A1 and COL9A3 1 0.29 0.52 0 5.00
32 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chondrodysplasia. They are ordered first by their pain relevance and then by number of times they were reported in Chondrodysplasia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5793 Binding of CTS 110 0.48 63.91 40.62 99.50
2 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 98.88
3 INT223948 Negative_regulation of Gene_expression of Bglap 1 0.56 6.49 0.44 98.88
4 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5 98.88
5 INT97908 Binding of Col9a2 3 0.18 2.51 0.29 97.84
6 INT159378 Localization of Hspg2 6 0.80 0.9 1.35 97.56
7 INT97909 Binding of COMP 13 0.37 5.98 1.22 97.04
8 INT223959 Localization of Bglap 10 0.77 11.25 1.74 96.96
9 INT106127 Negative_regulation of CASR 7 0.43 7.12 0.67 93.80
10 INT233816 Negative_regulation of PTH1R 2 0.58 4.08 1.07 93.56
11 INT106638 Negative_regulation of AVPR2 2 0.39 2.05 0.2 93.16
12 INT184301 Negative_regulation of Bglap 16 0.56 11.22 1.22 86.08
13 INT175555 Gene_expression of CASR 17 0.78 14.83 3.73 82.24
14 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 80.56
15 INT302953 Positive_regulation of Smpd2 1 0.52 9.07 0.83 79.96
16 INT232639 Positive_regulation of Jag2 4 0.14 10.63 1.03 79.68
17 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 79.20
18 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73 79.20
19 INT210430 Gene_expression of Arl3 1 0.55 1.85 0.12 77.60
20 INT172595 Negative_regulation of Gene_expression of ADCYAP1R1 1 0.01 0.4 0 69.72
21 INT172594 Gene_expression of ADCYAP1R1 1 0.02 0.4 0 69.72
22 INT80822 Positive_regulation of MRGPRX1 30 0.67 3.66 7.73 69.36
23 INT97906 Binding of Col9a3 1 0.07 0.89 0.09 69.16
24 INT97907 Binding of Col9a1 1 0.10 0.89 0.09 69.16
25 INT171995 Binding of PTH1R 8 0.35 1.16 0.31 67.12
26 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15 63.40
27 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 59.68
28 INT233815 Positive_regulation of Regulation of PTH 1 0.11 0.32 0 59.68
29 INT245750 Regulation of COL9A3 1 0.20 0.7 0.06 59.36
30 INT3343 Regulation of PTH 24 0.62 11.18 1.62 59.28
31 INT245744 Protein_catabolism of DISC1 1 0.18 4.92 0.21 58.32
32 INT245737 Positive_regulation of Protein_catabolism of DISC1 1 0.09 1.04 0.06 58.32
33 INT302945 Positive_regulation of Smpd3 1 0.70 9.99 0.93 57.28
34 INT245747 Positive_regulation of Binding of COL9A3 1 0.42 1.05 0.06 57.16
35 INT245740 Binding of COL9A3 2 0.31 1.85 0.08 56.60
36 INT245754 Regulation of Positive_regulation of COL9A2 1 0.34 0.74 0.06 56.24
37 INT245736 Gene_expression of DISC1 13 0.61 7.65 1.33 55.20
38 INT245738 Positive_regulation of COL9A2 1 0.38 0.72 0.06 51.68
39 INT223949 Transcription of Bglap 1 0.68 19.96 3.98 45.08
40 INT173592 Binding of COL5A2 32 0.33 9.14 2.48 39.44
41 INT245748 Binding of DISC1 1 0.07 5.21 1.08 38.24
42 INT223958 Positive_regulation of Transcription of Bglap 1 0.66 6.57 1.19 37.72
43 INT158025 Regulation of Bglap 6 0.60 7.03 1.11 37.72
44 INT223960 Positive_regulation of Transcription of AMY2A 1 0.08 4.88 1.07 36.80
45 INT223955 Positive_regulation of Transcription of Amy2a1 1 0.49 1.77 0.41 36.80
46 INT223950 Transcription of Amy2a1 2 0.69 1.98 0.41 36.24
47 INT223961 Transcription of AMY2A 1 0.11 4.83 1.06 35.76
48 INT223954 Negative_regulation of Transcription of Bglap 1 0.41 2.7 0.49 33.96
49 INT302956 Localization of Smpd3 1 0.75 2.92 0.24 31.20
50 INT48253 Positive_regulation of AMY2A 8 0.59 3.86 1.79 29.96
51 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25 29.96
52 INT181922 Binding of RENBP 16 0.36 13.92 3.71 29.76
53 INT101177 Regulation of COL5A2 12 0.45 4.03 0.62 24.88
54 INT245762 Transcription of COL5A2 4 0.09 2.82 0 24.88
55 INT245761 Positive_regulation of Regulation of COL5A2 1 0.06 0.76 0 24.88
56 INT73297 Positive_regulation of Transcription of Col1a1 2 0.32 3.12 0.14 23.68
57 INT245745 Regulation of TRNAP2 1 0.16 0.45 0 23.68
58 INT223956 Regulation of Transcription of Bglap 1 0.43 1.4 0.44 23.44
59 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12 22.96
60 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48 22.96
61 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34 21.64
62 INT245725 Positive_regulation of Negative_regulation of Col1a1 1 0.21 0.7 0 21.64
63 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 21.28
64 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 21.28
65 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24 21.28
66 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 20.72
67 INT245749 Gene_expression of TRNAP2 1 0.27 1.16 0 20.72
68 INT15506 Localization of Cp 11 0.80 4.26 1.9 19.88
69 INT302938 Gene_expression of Smpd3 1 0.78 16.18 1.17 19.32
70 INT245753 Regulation of Transcription of COL5A2 1 0.08 0.64 0 12.60
71 INT2250 Binding of REG3A 3 0.47 3.58 1.33 12.40
72 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 10.72
73 INT19900 Binding of GHRH 22 0.37 5.75 5 10.72
74 INT245759 Localization of DISC1 1 0.14 2.85 0.04 8.16
75 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 7.72
76 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
77 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
78 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
79 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
80 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
81 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 5.00
82 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
83 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
84 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
85 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
86 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
87 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
88 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
89 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
90 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
91 INT27933 Gene_expression of NCOR2 65 0.72 31.35 24.23 5.00
92 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
93 INT127435 Gene_expression of Per1 89 0.77 13.94 22.31 5.00
94 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 5.00
95 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
96 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
97 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 5.00
98 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19 5.00
99 INT82854 Gene_expression of MRGPRX1 61 0.75 10.14 10.65 5.00
100 INT39188 Gene_expression of IGKV5-2 22 0.38 10.95 9.91 5.00
101 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
102 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 5.00
103 INT211363 Positive_regulation of RENBP 13 0.22 13.26 6.48 5.00
104 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 5.00
105 INT49027 Gene_expression of TYRP1 35 0.75 9.81 6.06 5.00
106 INT190298 Binding of MRGPRX1 61 0.46 2.66 5.75 5.00
107 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38 5.00
108 INT68591 Regulation of TYRP1 14 0.44 3.93 5.05 5.00
109 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 5.00
110 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
111 INT159122 Positive_regulation of Gnb2l1 8 0.69 2.2 4.61 5.00
112 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23 5.00
113 INT51898 Binding of PECAM1 26 0.36 18.87 4.22 5.00
114 INT3598 Regulation of Pla2g1b 12 0.44 3.45 3.9 5.00
115 INT2886 Gene_expression of SCT 13 0.78 4.55 3.57 5.00
116 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 5.00
117 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
118 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
119 INT102638 Regulation of VDR 21 0.44 9.92 2.54 5.00
120 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 5.00
121 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
122 INT34864 Binding of Cp 23 0.47 5.17 1.78 5.00
123 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74 5.00
124 INT178841 Localization of SNRNP70 27 0.78 10.35 1.71 5.00
125 INT102178 Gene_expression of CD97 10 0.73 6.68 1.7 5.00
126 INT141967 Gene_expression of RAMP3 4 0.69 3.35 1.69 5.00
127 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61 5.00
128 INT102989 Regulation of Gene_expression of MMP3 10 0.53 3.29 1.47 5.00
129 INT179644 Gene_expression of RENBP 26 0.35 13.74 1.38 5.00
130 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2 5.00
131 INT15419 Gene_expression of IL31RA 6 0.65 5.02 1.19 5.00
132 INT184314 Regulation of Gene_expression of Bglap 6 0.59 7.11 1.16 5.00
133 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
134 INT11658 Regulation of Gene_expression of COL2A1 9 0.62 3.09 1.11 5.00
135 INT135806 Regulation of Bcl2l1 10 0.44 7.21 1.05 5.00
136 INT86800 Positive_regulation of Binding of CALCRL 3 0.37 0 1.01 5.00
137 INT139176 Gene_expression of Fadd 5 0.51 5.26 0.92 5.00
138 INT153327 Gene_expression of Aspscr1 5 0.57 3.28 0.91 5.00
139 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 5.00
140 INT209948 Gene_expression of CLEC3B 3 0.78 11.51 0.6 5.00
141 INT78999 Binding of AKR1C1 3 0.36 1.75 0.58 5.00
142 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58 5.00
143 INT69761 Gene_expression of Jag2 5 0.67 6.17 0.53 5.00
144 INT281657 Positive_regulation of CLEC4F 2 0.10 2.02 0.49 5.00
145 INT140270 Localization of CLEC4F 2 0.03 2.24 0.47 5.00
146 INT223952 Regulation of Gene_expression of Cp 2 0.08 1.36 0.45 5.00
147 INT165342 Gene_expression of TGFBI 13 0.59 5.81 0.39 5.00
148 INT245764 Regulation of DISC1 1 0.08 1.23 0.38 5.00
149 INT144617 Gene_expression of RHO 13 0.75 1.74 0.38 5.00
150 INT211361 Regulation of RENBP 5 0.08 2.8 0.38 5.00
151 INT159856 Positive_regulation of RHO 5 0.67 0.94 0.37 5.00
152 INT245741 Negative_regulation of Gene_expression of DISC1 2 0.17 1.29 0.34 5.00
153 INT223947 Localization of Panc1 2 0.15 1.73 0.33 5.00
154 INT302947 Negative_regulation of Gene_expression of Smpd3 1 0.43 3.76 0.31 5.00
155 INT336270 Localization of AKR1C1 1 0.06 1.56 0.29 5.00
156 INT134342 Binding of CD55 7 0.35 1.83 0.28 5.00
157 INT302967 Localization of Smpd2 1 0.56 1.29 0.24 5.00
158 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22 5.00
159 INT302952 Negative_regulation of Smpd3 1 0.43 2.57 0.22 5.00
160 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 5.00
161 INT245763 Regulation of SOX9 4 0.43 1.68 0.21 5.00
162 INT172597 Positive_regulation of ADCYAP1R1 1 0.01 0.14 0.2 5.00
163 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19 5.00
164 INT223946 Positive_regulation of Localization of Bglap 1 0.48 1.25 0.17 5.00
165 INT138436 Positive_regulation of Gene_expression of Smpd1 3 0.41 0.6 0.17 5.00
166 INT233805 Gene_expression of lgr 1 0.65 0 0.17 5.00
167 INT245756 Regulation of Binding of DISC1 1 0.08 0.63 0.16 5.00
168 INT172598 Gene_expression of EMR1 3 0.65 1.36 0.15 5.00
169 INT223953 Localization of Aspscr1 1 0.10 1.05 0.13 5.00
170 INT302942 Regulation of Smpd2 1 0.46 0.55 0.11 5.00
171 INT302948 Negative_regulation of Binding of Smpd3 1 0.43 1.54 0.1 5.00
172 INT233806 Gene_expression of Slc52a2 1 0.65 0.15 0.1 5.00
173 INT302940 Binding of Smpd3 1 0.37 1.53 0.1 5.00
174 INT302950 Negative_regulation of Gene_expression of Jag2 1 0.08 1.42 0.09 5.00
175 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09 5.00
176 INT302949 Negative_regulation of Positive_regulation of Smpd2 1 0.32 0.75 0.09 5.00
177 INT223957 Negative_regulation of Regulation of Bglap 1 0.41 1.47 0.08 5.00
178 INT302963 Protein_catabolism of Smpd1 1 0.39 0.86 0.08 5.00
179 INT233814 Positive_regulation of Gene_expression of RHO 1 0.29 0 0.08 5.00
180 INT233804 Binding of Slc52a2 1 0.36 0 0.07 5.00
181 INT245743 Positive_regulation of Gene_expression of DISC1 1 0.09 0.72 0.07 5.00
182 INT245760 Regulation of Gene_expression of DISC1 1 0.08 0.72 0.07 5.00
183 INT233807 Positive_regulation of Gene_expression of Slc52a2 1 0.49 0 0.07 5.00
184 INT302960 Positive_regulation of Protein_catabolism of Jag2 1 0.08 0.87 0.07 5.00
185 INT302941 Protein_catabolism of Jag2 1 0.11 0.86 0.07 5.00
186 INT302964 Protein_catabolism of Tbx15 1 0.02 0.86 0.07 5.00
187 INT302969 Positive_regulation of Positive_regulation of Smpd3 1 0.50 1.27 0.06 5.00
188 INT302958 Negative_regulation of Positive_regulation of Jag2 1 0.08 0.51 0.06 5.00
189 INT233817 Gene_expression of MAS1L 2 0.13 15.97 0.05 5.00
190 INT245751 Gene_expression of COL9A2 4 0.65 1.83 0.04 5.00
191 INT172596 Gene_expression of EMR2 1 0.28 0.05 0.04 5.00
192 INT233810 Regulation of Gene_expression of LPHN2 1 0.19 0.12 0.04 5.00
193 INT302959 Positive_regulation of Positive_regulation of Jag2 1 0.10 0.24 0.04 5.00
194 INT245746 Positive_regulation of Localization of DISC1 1 0.09 0.35 0.04 5.00
195 INT233820 Binding of LPHN2 1 0.20 0.11 0.04 5.00
196 INT233809 Regulation of LPHN1 1 0.04 0.12 0.04 5.00
197 INT302955 Regulation of Positive_regulation of Smpd2 1 0.34 0.24 0.04 5.00
198 INT302966 Positive_regulation of Gene_expression of Jag2 1 0.08 0.4 0.04 5.00
199 INT233818 Gene_expression of LPHN3 1 0.37 0.12 0.04 5.00
200 INT172593 Gene_expression of EMR3 1 0.36 0.05 0.04 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox