D:Chronic Progressive Multiple Sclerosis

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pChart

Disease Term
Synonyms Multiple Sclerosis Primary Progressive, Multiple Sclerosis Progressive Relapsing, Multiple Sclerosis Remittent Progressive, Multiple Sclerosis Secondary Progressive, Primary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis, Remittent Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Documents 29
Hot Single Events 8
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic Progressive Multiple Sclerosis. They are ordered first by their relevance to Chronic Progressive Multiple Sclerosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT329086 Binding of Gc and Scly 1 0.03 0.75 0.38 35.92
2 INT248172 Epo Regulation of Cysltr1 1 0.01 0.74 0.63 5.00
3 INT248170 Epo Regulation of Ltp 1 0.11 0.74 0.62 5.00
4 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42 5.00
5 INT310255 Tlr4 Positive_regulation of Gene_expression of Cd86 2 0.18 0.06 0.27 5.00
6 INT248173 Car2 Positive_regulation of GRIN1 1 0.08 0 0.22 5.00
7 INT248171 Epo Regulation of Sult1a1 1 0.08 0.11 0.21 5.00
8 INT310256 Tlr4 Positive_regulation of Gene_expression of H2 1 0.05 0.06 0.15 5.00
9 INT310257 Tlr4 Positive_regulation of Gene_expression of Cd40 1 0.13 0.06 0.15 5.00
10 INT310258 Tlr4 Positive_regulation of Gene_expression of Cd80 1 0.18 0.06 0.15 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic Progressive Multiple Sclerosis. They are ordered first by their pain relevance and then by number of times they were reported in Chronic Progressive Multiple Sclerosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT178026 Positive_regulation of Epo 12 0.70 8.14 0.95 99.28
2 INT94777 Positive_regulation of EDSS2 2 0.03 2.58 0.27 99.14
3 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28 91.12
4 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22 89.24
5 INT234321 Regulation of EDSS2 1 0.01 1.58 0.03 88.08
6 INT234320 Negative_regulation of Regulation of EDSS2 1 0.01 0.8 0.03 86.68
7 INT234322 Negative_regulation of EDSS2 1 0.01 0.79 0.03 86.68
8 INT75932 Binding of Csf2 45 0.37 33.2 8.01 80.56
9 INT3838 Regulation of FCGR3B 16 0.60 6.67 5.53 75.00
10 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 75.00
11 INT303362 Regulation of Jag1 2 0.22 2.91 1.22 72.76
12 INT320988 Regulation of Gc 3 0.13 2.52 0.62 72.76
13 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 65.40
14 INT25238 Localization of REG1A 5 0.78 2.93 0.81 63.12
15 INT25237 Binding of NRSN1 4 0.29 2.58 0.53 46.32
16 INT25236 Binding of REG1A 6 0.47 3.69 0.91 45.76
17 INT67135 Binding of Gc 5 0.10 3.2 0.94 35.92
18 INT149380 Localization of Cish 3 0.64 3.44 1.06 25.00
19 INT144993 Gene_expression of Epor 4 0.75 5.7 1.61 18.08
20 INT178029 Gene_expression of Epo 25 0.76 14.98 1.46 18.08
21 INT40128 Binding of Noc2l 7 0.27 0.67 3.03 7.40
22 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
23 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
24 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
25 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
26 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
27 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
28 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
29 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
30 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52 5.00
31 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
32 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
33 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
34 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
35 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
36 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45 5.00
37 INT21937 Positive_regulation of Scly 16 0.39 22.34 13.76 5.00
38 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5 5.00
39 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94 5.00
40 INT96157 Gene_expression of Cd80 74 0.77 31.19 9.78 5.00
41 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
42 INT18524 Regulation of Gene_expression of IFNA1 37 0.44 18.79 7.62 5.00
43 INT139493 Gene_expression of Scly 11 0.57 16.96 7.61 5.00
44 INT8793 Gene_expression of H2 58 0.75 26.36 7.07 5.00
45 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 5.00
46 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 5.00
47 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31 5.00
48 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 5.00
49 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 5.00
50 INT142606 Regulation of Gene_expression of Cd40 13 0.56 6.15 3.27 5.00
51 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 5.00
52 INT33661 Regulation of Tbpl1 7 0.44 5.36 3.26 5.00
53 INT245671 Positive_regulation of Gene_expression of Car1 15 0.28 4.31 2.67 5.00
54 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
55 INT329080 Positive_regulation of Gene_expression of Scly 4 0.43 6.3 2.43 5.00
56 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41 5.00
57 INT303352 Gene_expression of Jag1 19 0.73 7.68 1.89 5.00
58 INT26850 Negative_regulation of H2 13 0.32 9.4 1.82 5.00
59 INT228401 Positive_regulation of Cd86 24 0.53 6.46 1.8 5.00
60 INT329078 Positive_regulation of Positive_regulation of Scly 1 0.13 3.73 1.73 5.00
61 INT135991 Positive_regulation of Gene_expression of Cd80 19 0.54 6.9 1.71 5.00
62 INT24605 Negative_regulation of Scly 6 0.34 3.98 1.71 5.00
63 INT148237 Positive_regulation of Tbpl1 4 0.49 2.05 1.59 5.00
64 INT210455 Gene_expression of Noc2l 3 0.33 1.01 1.58 5.00
65 INT237377 Regulation of Gene_expression of Cd86 10 0.47 3.64 1.52 5.00
66 INT168565 Positive_regulation of Gc 4 0.13 3.74 1.45 5.00
67 INT233551 Gene_expression of Apod 8 0.74 12.25 1.4 5.00
68 INT90865 Regulation of Scly 5 0.23 3.26 1.34 5.00
69 INT178023 Regulation of Epo 11 0.45 3.87 1.22 5.00
70 INT189836 Regulation of Cd40 10 0.40 3.02 1.1 5.00
71 INT233568 Positive_regulation of Apod 4 0.66 4.91 0.87 5.00
72 INT303347 Positive_regulation of Gene_expression of Jag1 6 0.65 4.06 0.77 5.00
73 INT329081 Positive_regulation of Stard4 1 0.12 1.68 0.76 5.00
74 INT37113 Positive_regulation of Sult1a1 3 0.44 0.81 0.75 5.00
75 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 5.00
76 INT302544 Regulation of Cd86 10 0.34 1.89 0.62 5.00
77 INT248166 Protein_catabolism of Epo 1 0.89 0.71 0.59 5.00
78 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 5.00
79 INT288058 Regulation of Gene_expression of Cd80 6 0.35 2.13 0.55 5.00
80 INT142605 Regulation of Gene_expression of H2 2 0.15 0.99 0.54 5.00
81 INT329079 Negative_regulation of Positive_regulation of Apod 1 0.03 1.54 0.54 5.00
82 INT183164 Regulation of Cd80 6 0.33 2.69 0.52 5.00
83 INT231296 Gene_expression of Syn1 8 0.23 0.65 0.49 5.00
84 INT197369 Regulation of Gene_expression of Car1 4 0.24 0.25 0.47 5.00
85 INT329084 Negative_regulation of Gene_expression of Gc 2 0.12 1.63 0.45 5.00
86 INT252308 Positive_regulation of Cd80 9 0.51 1.24 0.45 5.00
87 INT166218 Positive_regulation of Negative_regulation of H2 2 0.29 1.39 0.43 5.00
88 INT329082 Positive_regulation of Gene_expression of Gc 1 0.20 1.09 0.41 5.00
89 INT257931 Regulation of H2 7 0.26 5.12 0.3 5.00
90 INT233563 Binding of Apod 2 0.34 2.29 0.29 5.00
91 INT273867 Binding of Jag1 18 0.45 3.14 0.25 5.00
92 INT303374 Negative_regulation of Jag1 2 0.48 0.9 0.23 5.00
93 INT248168 Positive_regulation of Transcription of Epor 1 0.36 0 0.19 5.00
94 INT248169 Positive_regulation of Transcription of Epo 1 0.50 0 0.19 5.00
95 INT248165 Transcription of Epo 1 0.69 0 0.19 5.00
96 INT248167 Transcription of Epor 1 0.49 0 0.19 5.00
97 INT200796 Negative_regulation of Epo 7 0.43 3.22 0.18 5.00
98 INT310253 Positive_regulation of Positive_regulation of Cd80 1 0.34 0.08 0.11 5.00
99 INT310254 Negative_regulation of Si-r 1 0.01 0 0 5.00
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