D:Conductive Hearing Loss

Disease Term Synonyms Eustachian Tube Block, Otosclerosis, Superior Canal Dehiscence Documents 134 Hot Single Events 8 Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Conductive Hearing Loss. They are ordered first by their relevance to Conductive Hearing Loss and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT254433	Binding of Lrp5 and Sost	2	0.39	1.51	0.03	48.76
2	INT335888	Lrp5 Negative_regulation of Gene_expression of Tph1	1	0.22	0.15	0.21	5.00
3	INT228216	Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2	1	0.09	1.11	0.15	5.00
4	INT335890	Binding of Dkk1 and Lrp4	1	0.37	0.64	0.07	5.00
5	INT335886	Binding of Sost and Lrp4	1	0.28	0.65	0.07	5.00
6	INT228212	Cpox Negative_regulation of Localization of Ptger2	1	0.00	0.88	0.04	5.00
7	INT228217	Nfkb1 Regulation of Gene_expression of Ptger2	1	0.01	1.22	0	5.00
8	INT335884	Akt1 Regulation of Positive_regulation of Wnt5a	1	0.03	0.15	0	5.00
9	INT228214	Nfkb1 Positive_regulation of Gene_expression of Ptger2	1	0.01	0.97	0	5.00
10	INT240685	Binding of DIRAS3 and KCNQ4	1	0.18	0.95	0	5.00
11	INT228215	Tlr2 Positive_regulation of Gene_expression of Tlr4	1	0.19	1.47	0	5.00
12	INT227399	Binding of D5Mit424 and Alms1	1	0.01	0.71	0	5.00
13	INT335887	Akt1 Regulation of Lrp6	1	0.06	0.15	0	5.00
14	INT335883	Binding of Lrp6 and Wnt5a	1	0.27	0.08	0	5.00
15	INT335891	Binding of Dkk1 and Lrp5	1	0.39	0.57	0	5.00
16	INT228213	Gopc Positive_regulation of Gene_expression of Ptger2	1	0.00	1.08	0	5.00
17	INT228218	Negative_regulation of Nfkb1 Negative_regulation of Gene_expression of Ptger2	1	0.01	1.13	0	5.00
18	INT335882	Dkk1 Negative_regulation of Wnt2	1	0.02	0.15	0	5.00
19	INT240684	Binding of NAT2 and DIRAS3	1	0.03	0.95	0	5.00
20	INT227398	Binding of H2afy and Alms1	1	0.01	1.42	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Conductive Hearing Loss. They are ordered first by their pain relevance and then by number of times they were reported in Conductive Hearing Loss. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT172328	Negative_regulation of Phl1	1	0.03	61.51	0.97	100.00
2	INT172323	Gene_expression of Phl1	1	0.03	14	0.16	100.00
3	INT172325	Positive_regulation of Gene_expression of Phl1	1	0.02	2.65	0.04	100.00
4	INT16772	Gene_expression of MPO	81	0.78	90.98	11.9	95.92
5	INT16068	Gene_expression of SERPINB1	27	0.60	20.51	6.56	95.92
6	INT335878	Localization of Sost	3	0.69	1.11	0.22	94.48
7	INT3361	Positive_regulation of Esr1	273	0.69	208.53	44.81	82.80
8	INT25208	Gene_expression of IGF2	43	0.74	30.64	2.31	82.12
9	INT45813	Negative_regulation of Negative_regulation of Gabrg1	10	0.46	0.66	4.51	73.24
10	INT200491	Gene_expression of Eng	1	0.13	0.79	0.16	72.20
11	INT9516	Negative_regulation of Gabrg1	149	0.53	27.83	91.02	71.76
12	INT335868	Negative_regulation of Gene_expression of Sost	2	0.58	1.12	0.04	71.00
13	INT335864	Gene_expression of Sost	4	0.77	2.36	0.2	70.28
14	INT335876	Negative_regulation of Sost	11	0.51	6.77	0.67	65.40
15	INT173223	Negative_regulation of BRCA2	7	0.54	6.79	0.25	64.60
16	INT119062	Negative_regulation of BRCA1	12	0.49	13.7	1.36	64.24
17	INT57343	Negative_regulation of ICK	1	0.15	0.16	0.08	63.68
18	INT1912	Gene_expression of Calca	1152	0.78	453.25	739.84	60.60
19	INT108519	Binding of Lrp6	8	0.44	1.47	1.19	59.12
20	INT254427	Binding of Lrp5	10	0.48	5.43	0.26	59.12
21	INT111156	Negative_regulation of Dkk1	21	0.58	20.08	4.27	58.56
22	INT200806	Binding of EEC1	6	0.39	4.24	0.29	58.12
23	INT39565	Gene_expression of Ptger2	424	0.75	229.28	72.68	56.48
24	INT49439	Gene_expression of Cpox	508	0.73	326.97	130.17	56.04
25	INT335869	Binding of Sost	6	0.32	1.79	0.18	48.76
26	INT180588	Gene_expression of HEYL	13	0.52	8.37	1.19	47.52
27	INT97885	Regulation of LOC500077	7	0.16	2.93	4.33	44.16
28	INT200492	Negative_regulation of Regulation of LOC500077	1	0.17	0.93	0.54	44.16
29	INT54701	Localization of Ptafr	19	0.49	18.68	3.82	38.32
30	INT57691	Regulation of Gene_expression of Ptger2	23	0.40	17.08	4.61	35.56
31	INT173117	Binding of Ltf	4	0.12	1.85	0.28	26.52
32	INT214056	Negative_regulation of NSD1	3	0.43	3.44	0.09	26.44
33	INT335861	Localization of Lrp6	1	0.69	0.54	0.17	26.00
34	INT6354	Localization of Gabrg1	321	0.74	41.41	186.74	21.44
35	INT173693	Localization of Gopc	249	0.65	70.49	38.81	21.44
36	INT49506	Regulation of Ptger2	29	0.44	17.38	6.75	19.12
37	INT72703	Gene_expression of Ide	79	0.70	45.04	4.47	16.80
38	INT4360	Gene_expression of Hypism	29	0.22	38.1	4.07	16.48
39	INT214055	Gene_expression of NSD1	8	0.67	4.46	0	15.04
40	INT9158	Gene_expression of Tnf	722	0.78	522.01	277.68	5.00
41	INT10832	Gene_expression of IL8	1050	0.78	698.72	270	5.00
42	INT49441	Negative_regulation of Cpox	494	0.59	303.22	177.46	5.00
43	INT14843	Gene_expression of Gabrg1	301	0.77	62.63	139.16	5.00
44	INT6323	Positive_regulation of Gabrg1	213	0.70	45.08	124.34	5.00
45	INT7533	Gene_expression of Tlr4	720	0.78	343.22	121.57	5.00
46	INT27096	Positive_regulation of Nfkb1	325	0.70	195.11	109.06	5.00
47	INT96917	Positive_regulation of Mapk14	261	0.70	173.29	88.79	5.00
48	INT73048	Gene_expression of MMP9	268	0.77	159.75	57.81	5.00
49	INT69876	Negative_regulation of Nfkb1	147	0.58	89.81	55.5	5.00
50	INT96914	Phosphorylation of Mapk14	168	0.82	108.46	53.32	5.00
51	INT110023	Negative_regulation of Mapk14	127	0.59	84.27	45.42	5.00
52	INT52531	Gene_expression of Nfkb1	153	0.75	82.84	42.9	5.00
53	INT157666	Positive_regulation of GOPC	335	0.60	120.19	42.75	5.00
54	INT81289	Positive_regulation of Gene_expression of Tlr4	192	0.69	104.5	33.89	5.00
55	INT110020	Gene_expression of Mapk14	142	0.77	72.33	30.08	5.00
56	INT6624	Gene_expression of Pth	135	0.76	110.27	27.54	5.00
57	INT703	Positive_regulation of Pth	177	0.70	127.09	27.26	5.00
58	INT47075	Positive_regulation of Ptger2	142	0.70	78.55	25.47	5.00
59	INT9886	Gene_expression of Ptgs1	92	0.77	40.66	25.31	5.00
60	INT172458	Regulation of Gopc	155	0.53	62.57	24.86	5.00
61	INT64185	Gene_expression of TNFRSF11A	131	0.76	75.15	24.73	5.00
62	INT151758	Gene_expression of PYCARD	91	0.63	14.54	24.27	5.00
63	INT66758	Binding of Nfkb1	97	0.48	50.65	23.65	5.00
64	INT71875	Localization of Nfkb1	92	0.78	48.13	22.94	5.00
65	INT11659	Gene_expression of COL2A1	164	0.78	78.49	22.58	5.00
66	INT142594	Gene_expression of Tlr2	165	0.78	139.73	22.26	5.00
67	INT52529	Regulation of Nfkb1	48	0.61	26.2	20.89	5.00
68	INT69877	Positive_regulation of Positive_regulation of Nfkb1	53	0.68	31.44	20.7	5.00
69	INT56749	Gene_expression of PCNA	219	0.77	111.25	18.42	5.00
70	INT78990	Regulation of Cpox	72	0.57	35.22	18.16	5.00
71	INT24225	Gene_expression of Alms1	93	0.62	52.75	16.93	5.00
72	INT108780	Positive_regulation of Gene_expression of Ptger2	94	0.49	59.71	16.22	5.00
73	INT124371	Negative_regulation of Gsk3b	170	0.55	87.92	15.51	5.00
74	INT22143	Gene_expression of Gad1	35	0.76	14.4	15.4	5.00
75	INT96911	Positive_regulation of Phosphorylation of Mapk14	46	0.70	43.03	15.15	5.00
76	INT25396	Localization of Ptger2	83	0.78	46.81	14.81	5.00
77	INT142593	Positive_regulation of Tlr2	85	0.70	75.9	13.62	5.00
78	INT39564	Negative_regulation of Gene_expression of Ptger2	50	0.42	30.9	12.97	5.00
79	INT129883	Gene_expression of Dkk1	56	0.77	45.42	12.52	5.00
80	INT75768	Transcription of Cpox	37	0.27	19.41	9.79	5.00
81	INT71878	Protein_catabolism of Nfkb1	24	0.65	10.85	9.46	5.00
82	INT180163	Positive_regulation of Nfasc	49	0.40	31.96	9.41	5.00
83	INT135372	Positive_regulation of Gsk3b	72	0.70	50.03	9.28	5.00
84	INT22083	Regulation of Pth	55	0.62	22.32	8.9	5.00
85	INT36798	Gene_expression of Mki67	178	0.77	132	8.24	5.00
86	INT79166	Regulation of TNC	12	0.44	9.42	8.13	5.00
87	INT123459	Gene_expression of Tnfrsf11b	35	0.58	24.16	7.26	5.00
88	INT88498	Protein_catabolism of Nfkbia	14	0.82	6.94	7.1	5.00
89	INT142596	Positive_regulation of Gene_expression of Tlr2	42	0.69	38.41	6.67	5.00
90	INT11258	Gene_expression of Gnas	58	0.58	21.6	6.33	5.00
91	INT61258	Transcription of Nfkb1	24	0.67	10.89	6.32	5.00
92	INT137052	Positive_regulation of PYCARD	30	0.43	4.72	6.17	5.00
93	INT9118	Gene_expression of Ceacam1	37	0.75	17.19	6.12	5.00
94	INT88873	Negative_regulation of Gene_expression of Nfkb1	24	0.56	9.93	5.97	5.00
95	INT16688	Positive_regulation of Cndp2	11	0.49	1.12	5.86	5.00
96	INT3731	Negative_regulation of Neu1	17	0.39	8.35	5.67	5.00
97	INT87211	Positive_regulation of Localization of Nfkb1	27	0.59	15.84	5.25	5.00
98	INT174688	Binding of Tlr2	45	0.42	36.65	5.25	5.00
99	INT87022	Gene_expression of Apc	68	0.67	46.98	5.22	5.00
100	INT19391	Gene_expression of Nt5e	44	0.72	13.99	5.14	5.00
101	INT26167	Positive_regulation of Hrasls	18	0.23	8.67	4.87	5.00
102	INT88496	Positive_regulation of Protein_catabolism of Nfkbia	8	0.53	3.05	4.78	5.00
103	INT129856	Positive_regulation of TNFRSF11A	26	0.68	16.21	4.75	5.00
104	INT14831	Negative_regulation of TNC	18	0.50	8.71	4.61	5.00
105	INT133231	Regulation of PYCARD	18	0.39	5.02	4.44	5.00
106	INT167284	Phosphorylation of Gsk3b	88	0.82	36.03	4.21	5.00
107	INT93016	Binding of TNFRSF11A	29	0.47	19.67	4.17	5.00
108	INT99608	Transcription of MMP9	18	0.65	9.67	4.11	5.00
109	INT71882	Phosphorylation of Nfkb1	20	0.81	11.46	4.1	5.00
110	INT126659	Gene_expression of Tph1	22	0.78	2.04	4.04	5.00
111	INT9500	Negative_regulation of Ceacam1	26	0.58	6.89	3.91	5.00
112	INT108761	Localization of Alms1	24	0.70	13.92	3.74	5.00
113	INT233945	Positive_regulation of Expi	5	0.04	2.53	3.46	5.00
114	INT25393	Positive_regulation of Localization of Ptger2	19	0.32	9.69	3.23	5.00
115	INT188047	Positive_regulation of Wnt2	51	0.58	31.41	2.94	5.00
116	INT90402	Positive_regulation of Gene_expression of Ptgs1	13	0.31	4.83	2.88	5.00
117	INT78581	Positive_regulation of Binding of Nfkb1	13	0.66	7.37	2.79	5.00
118	INT168188	Gene_expression of PLXNA2	13	0.58	9	2.73	5.00
119	INT143952	Regulation of Gene_expression of MMP9	14	0.53	10.16	2.73	5.00
120	INT69009	Regulation of Binding of Nfkb1	9	0.27	9.86	2.58	5.00
121	INT22082	Localization of Ceacam1	13	0.80	2.44	2.48	5.00
122	INT52441	Negative_regulation of Localization of Ptger2	10	0.21	5.23	2.41	5.00
123	INT71881	Positive_regulation of Phosphorylation of Nfkb1	5	0.45	1.38	2.24	5.00
124	INT121036	Positive_regulation of Transcription of Cpox	12	0.21	6.34	2.04	5.00
125	INT173512	Positive_regulation of Gene_expression of Alms1	12	0.44	8.66	1.95	5.00
126	INT198885	Gene_expression of Lrp1	33	0.57	10.2	1.91	5.00
127	INT169862	Regulation of NPC1	13	0.53	13.61	1.84	5.00
128	INT87214	Regulation of Positive_regulation of Nfkb1	7	0.43	5.85	1.79	5.00
129	INT228195	Negative_regulation of Gene_expression of Tlr2	14	0.40	12.17	1.74	5.00
130	INT127724	Localization of CSF1	12	0.73	9.35	1.56	5.00
131	INT65684	Gene_expression of MDM2	30	0.62	24.94	1.55	5.00
132	INT113659	Gene_expression of ABR	19	0.65	8.49	1.45	5.00
133	INT242153	Negative_regulation of Wnt2	19	0.49	11.87	1.37	5.00
134	INT180580	Binding of HEYL	7	0.17	4.49	1.15	5.00
135	INT147909	Gene_expression of Lpl	21	0.58	9.35	1.14	5.00
136	INT208536	Positive_regulation of Positive_regulation of Gsk3b	6	0.30	4.83	1.11	5.00
137	INT165338	Binding of Dkk1	4	0.37	3.64	1.04	5.00
138	INT124374	Binding of Wnt2	21	0.31	10.16	0.99	5.00
139	INT17554	Regulation of ABR	6	0.54	2.21	0.98	5.00
140	INT178391	Localization of Mapk14	9	0.68	5.27	0.97	5.00
141	INT22081	Regulation of Ceacam1	8	0.23	4.11	0.95	5.00
142	INT67320	Positive_regulation of CAPRIN2	11	0.48	2.73	0.94	5.00
143	INT117735	Positive_regulation of Regulation of Nfkb1	3	0.44	2.93	0.91	5.00
144	INT143714	Phosphorylation of Nfkbia	4	0.64	2.94	0.87	5.00
145	INT115757	Negative_regulation of ABR	3	0.57	0.53	0.8	5.00
146	INT228188	Regulation of Gene_expression of Tlr2	5	0.45	6.96	0.71	5.00
147	INT242137	Negative_regulation of Positive_regulation of Gsk3b	7	0.39	2.99	0.67	5.00
148	INT182010	Regulation of Tnfrsf11b	2	0.18	1.13	0.67	5.00
149	INT213739	Gene_expression of Expi	7	0.47	1.05	0.63	5.00
150	INT245721	Localization of FRZB	6	0.78	4.3	0.6	5.00
151	INT213503	Regulation of Wnt2	9	0.37	3.54	0.56	5.00
152	INT228180	Regulation of Localization of Ptger2	2	0.06	3.58	0.54	5.00
153	INT186882	Gene_expression of RTEL1	13	0.27	13.45	0.49	5.00
154	INT201524	Localization of Wnt2	14	0.62	9.24	0.46	5.00
155	INT248346	Binding of PLXNA2	4	0.29	1.38	0.46	5.00
156	INT206821	Positive_regulation of Muc2	6	0.47	2.85	0.44	5.00
157	INT43141	Negative_regulation of Hrasls	5	0.14	1.26	0.41	5.00
158	INT58566	Regulation of Gene_expression of Pth	5	0.58	2.3	0.38	5.00
159	INT39911	Negative_regulation of Positive_regulation of Pth	5	0.41	2.57	0.37	5.00
160	INT277463	Localization of Sfrp1	2	0.23	0.64	0.36	5.00
161	INT187022	Positive_regulation of Transcription of MMP9	3	0.45	3.27	0.34	5.00
162	INT335875	Regulation of Lrp6	1	0.57	0.43	0.27	5.00
163	INT297804	Regulation of Lrp5	6	0.60	2.31	0.27	5.00
164	INT209527	Regulation of Muc5ac	4	0.51	2.17	0.25	5.00
165	INT335874	Regulation of Lrp4	1	0.18	0	0.23	5.00
166	INT312604	Gene_expression of Lrp4	2	0.71	1.48	0.21	5.00
167	INT335879	Negative_regulation of Gene_expression of Tph1	1	0.19	0.15	0.21	5.00
168	INT254429	Negative_regulation of Lrp5	4	0.57	1.95	0.18	5.00
169	INT208539	Positive_regulation of Gene_expression of Gnas	4	0.08	2.76	0.18	5.00
170	INT251821	Negative_regulation of COL11A1	3	0.42	3.45	0.16	5.00
171	INT261721	Negative_regulation of Stl2	1	0.07	1.38	0.16	5.00
172	INT244657	Regulation of Lch	3	0.40	6.63	0.13	5.00
173	INT125391	Gene_expression of Rim5	2	0.01	1.94	0.11	5.00
174	INT254428	Binding of Lrp4	4	0.44	1.52	0.11	5.00
175	INT25530	Positive_regulation of ABR	3	0.33	0.34	0.1	5.00
176	INT328094	Positive_regulation of Gene_expression of ABR	1	0.33	0	0.09	5.00
177	INT151522	Binding of NSD1	2	0.37	4.28	0.09	5.00
178	INT264219	Regulation of HDC	1	0.14	0.07	0.09	5.00
179	INT264220	Gene_expression of HDC	1	0.17	0.14	0.08	5.00
180	INT162576	Positive_regulation of Wnt5a	3	0.48	0.71	0.08	5.00
181	INT264221	Regulation of Gene_expression of HDC	1	0.10	0.15	0.08	5.00
182	INT228198	Regulation of Regulation of Ptger2	1	0.02	0.79	0.08	5.00
183	INT354592	Positive_regulation of Gene_expression of PLXNA2	1	0.04	0.37	0.07	5.00
184	INT335871	Negative_regulation of Sfrp2	1	0.18	0.91	0.06	5.00
185	INT254426	Gene_expression of Lrp5	5	0.67	3.28	0.06	5.00
186	INT335860	Negative_regulation of Sfrp1	1	0.18	0.91	0.06	5.00
187	INT354590	Regulation of Gene_expression of Expi	1	0.02	0.34	0.05	5.00
188	INT335865	Positive_regulation of Phosphorylation of Lrp6	1	0.64	0.46	0.05	5.00
189	INT335862	Phosphorylation of Lrp6	1	0.76	0.37	0.05	5.00
190	INT201777	Phosphorylation of Wnt2	2	0.03	1.31	0.05	5.00
191	INT354591	Negative_regulation of Positive_regulation of PYCARD	1	0.05	0.34	0.05	5.00
192	INT349674	Regulation of Positive_regulation of PYCARD	2	0.11	0.34	0.05	5.00
193	INT183086	Regulation of HTL	3	0.24	1.46	0.05	5.00
194	INT228183	Regulation of Protein_catabolism of Nfkb1	1	0.12	0.24	0.05	5.00
195	INT354593	Regulation of Gene_expression of PLXNA2	1	0.04	0.34	0.05	5.00
196	INT172322	Negative_regulation of Gene_expression of Nt5e	1	0.41	1.03	0.04	5.00
197	INT228185	Regulation of Phosphorylation of Nfkb1	1	0.12	0.29	0.04	5.00
198	INT335867	Positive_regulation of Negative_regulation of Sfrp2	1	0.14	0.49	0.03	5.00
199	INT228192	Negative_regulation of Map2k2	2	0.35	0.96	0.03	5.00
200	INT335859	Regulation of Sfrp1	1	0.08	0.43	0.03	5.00