D:Dermatological Disease

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Disease Term
Synonyms Dermatological Diseases
Documents 59
Hot Single Events 18
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Dermatological Disease. They are ordered first by their relevance to Dermatological Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22 92.84
2 INT226901 Slc11a1 Regulation of Hist1h3f 1 0.02 0.41 0.15 85.60
3 INT306452 Binding of MBL2 and TLR4 1 0.38 0.37 0.1 50.00
4 INT306453 MBL2 Regulation of Binding of TLR4 1 0.48 0.37 0.1 50.00
5 INT329797 Positive_regulation of TLR2 Positive_regulation of Gene_expression of IL6 1 0.02 1.67 0.11 46.00
6 INT329802 Positive_regulation of TLR2 Regulation of Gene_expression of IL6 1 0.01 1.67 0.11 46.00
7 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48 5.00
8 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
9 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
10 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23 5.00
11 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
12 INT314136 Binding of TAC1 and SFTPA1 2 0.03 0.78 1.06 5.00
13 INT314142 Binding of TAC1 and Tacr3 1 0.06 0.73 0.94 5.00
14 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78 5.00
15 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44 5.00
16 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41 5.00
17 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41 5.00
18 INT329801 Binding of CAMP and IFNA1 1 0.03 1.48 0.4 5.00
19 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39 5.00
20 INT226911 Slc11a1 Positive_regulation of Gene_expression of Il6 1 0.09 1.12 0.24 5.00
21 INT226903 Txnl1 Regulation of Ins1 1 0.01 0.59 0.19 5.00
22 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17 5.00
23 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17 5.00
24 INT267138 Binding of CDH5 and PECAM1 2 0.16 2.69 0.16 5.00
25 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15 5.00
26 INT226907 Binding of E2f1 and Nfkb1 1 0.14 0.6 0.12 5.00
27 INT226904 Nfkb1 Regulation of Gene_expression of Vcam1 1 0.14 0.27 0.12 5.00
28 INT226899 Slc11a1 Positive_regulation of Localization of Gtf3a 1 0.00 0.54 0.11 5.00
29 INT226910 Slc11a1 Positive_regulation of Localization of Nfkb1 1 0.11 0.62 0.11 5.00
30 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1 5.00
31 INT279400 GANAB Regulation of ITGAL 1 0.01 0.75 0.09 5.00
32 INT226912 Slc11a1 Positive_regulation of Localization of IL8 1 0.05 0.58 0.08 5.00
33 INT226906 Binding of Ido1 and Il6 1 0.07 0.67 0.08 5.00
34 INT226913 Slc11a1 Positive_regulation of Gene_expression of IL8 1 0.05 0.63 0.07 5.00
35 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07 5.00
36 INT226897 Binding of Slc11a1 and Tg(CAG-EGFP)D4Nagy 1 0.01 0.17 0.04 5.00
37 INT226905 Slc11a1 Regulation of Nfkb1 1 0.04 0.41 0.03 5.00
38 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0 5.00
39 INT226900 Binding of Mdk and Map3k8 1 0.05 0.14 0 5.00
40 INT226896 Slc11a1 Positive_regulation of Binding of Nfkb1 1 0.11 0.08 0 5.00
41 INT267136 Binding of CD44 and FN1 2 0.04 0.56 0 5.00
42 INT226909 Positive_regulation of Binding of Nfkb1 and Slc11a1 1 0.07 0.18 0 5.00
43 INT226898 Binding of Nfkb1 and Slc11a1 1 0.06 0.2 0 5.00
44 INT226908 Binding of Nfkb1 and Map3k8 1 0.14 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Dermatological Disease. They are ordered first by their pain relevance and then by number of times they were reported in Dermatological Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171773 Regulation of SELE 7 0.23 10.3 0.4 99.40
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 97.40
3 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73 94.48
4 INT103638 Negative_regulation of MEFV 7 0.39 5.88 0.54 91.60
5 INT150395 Binding of MEFV 55 0.44 31.18 3.42 90.44
6 INT289616 Regulation of Gene_expression of SMYD1 2 0.60 0.42 0 90.44
7 INT289617 Gene_expression of SMYD1 2 0.75 0.84 0 90.44
8 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 90.12
9 INT289614 Positive_regulation of CITED2 1 0.37 0.41 0.03 90.00
10 INT306468 Positive_regulation of Gene_expression of MBL2 7 0.47 4.3 0.17 89.52
11 INT306472 Positive_regulation of Negative_regulation of MASP2 1 0.40 1.31 0.08 89.52
12 INT279572 Gene_expression of MBL2 27 0.64 20.88 1.51 88.84
13 INT306469 Negative_regulation of Gene_expression of MBL2 1 0.40 1.72 0.29 88.84
14 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 88.20
15 INT306465 Negative_regulation of MASP2 1 0.34 1.3 0.08 87.00
16 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 86.64
17 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 84.88
18 INT115213 Regulation of SFTPA1 13 0.32 6.91 7.11 81.16
19 INT213788 Gene_expression of Tfeb 18 0.66 7.9 2.07 77.44
20 INT213758 Regulation of Tfeb 3 0.23 0.97 0.28 77.44
21 INT133317 Positive_regulation of Binding of CD44 6 0.55 6.28 0 76.28
22 INT78816 Positive_regulation of Positive_regulation of ICAM1 9 0.68 8.36 1.55 76.28
23 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 75.88
24 INT279576 Positive_regulation of MBL2 4 0.38 4.1 0 75.80
25 INT43907 Binding of CD79A 28 0.48 28.11 3.04 75.36
26 INT195869 Positive_regulation of MASP1 3 0.08 1.58 0.03 75.16
27 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 74.96
28 INT91429 Binding of CD44 34 0.41 17.67 2.51 74.28
29 INT118791 Binding of AKT1 32 0.48 15.51 2.25 73.40
30 INT170856 Binding of IFI27 4 0.35 1.14 0 73.20
31 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 67.24
32 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 67.24
33 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 67.24
34 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 65.44
35 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 65.44
36 INT169952 Gene_expression of E2f1 12 0.64 4.35 0.43 65.44
37 INT102695 Localization of ITGAL 2 0.73 1.26 0.61 64.60
38 INT196920 Transcription of E2f1 4 0.68 2.65 0.21 64.32
39 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47 63.84
40 INT205639 Transcription of TAS2R20 1 0.19 0.77 0.14 62.44
41 INT150540 Binding of TLR2 50 0.45 35.86 10.43 61.48
42 INT49801 Positive_regulation of SELP 21 0.48 21.34 5.25 61.36
43 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 60.72
44 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 58.96
45 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08 55.12
46 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 54.16
47 INT247102 Binding of MBL2 16 0.38 14.18 1.54 52.92
48 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 52.08
49 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 52.04
50 INT15202 Regulation of Tacr1 26 0.60 9.65 16.48 52.04
51 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 50.00
52 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 50.00
53 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 50.00
54 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 50.00
55 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 50.00
56 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 50.00
57 INT134651 Binding of TLR4 89 0.48 66.96 23.19 50.00
58 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 50.00
59 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07 50.00
60 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 50.00
61 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 50.00
62 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 50.00
63 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 50.00
64 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 50.00
65 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75 50.00
66 INT109405 Binding of MASP1 2 0.07 0.49 0.21 50.00
67 INT279580 Positive_regulation of Binding of MBL2 4 0.48 2.15 0.08 50.00
68 INT306470 Positive_regulation of Binding of MASP1 1 0.09 0.49 0.06 50.00
69 INT306467 Transcription of MBL2 1 0.44 0.7 0.05 50.00
70 INT281032 Gene_expression of MASP2 2 0.48 0.67 0.03 50.00
71 INT306473 Negative_regulation of Binding of MBL2 1 0.36 0.07 0.03 50.00
72 INT306466 Negative_regulation of MAGEA3 1 0.01 0 0 50.00
73 INT69749 Binding of Tacr3 3 0.06 2.2 0.81 48.40
74 INT48877 Binding of Tacr1 16 0.43 5.26 8.04 47.92
75 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 47.68
76 INT115964 Negative_regulation of ITGAL 7 0.34 3.76 0.86 47.68
77 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74 47.68
78 INT267145 Negative_regulation of Binding of ICAM1 5 0.57 4.12 0.33 47.68
79 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 47.20
80 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 46.96
81 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 46.52
82 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 46.00
83 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 44.84
84 INT77947 Regulation of Gene_expression of IL12A 6 0.24 5.23 0.94 44.84
85 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 44.52
86 INT190229 Gene_expression of Cd55 7 0.64 5 0.64 42.24
87 INT205637 Positive_regulation of Gene_expression of TAS2R20 1 0.14 0 0 41.88
88 INT205635 Gene_expression of TAS2R20 8 0.19 0.16 0 41.88
89 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 41.68
90 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49 41.68
91 INT226854 Gene_expression of S100a13 2 0.36 0.84 0.1 41.44
92 INT124092 Gene_expression of Myo1b 3 0.41 1.22 0.82 40.72
93 INT180095 Gene_expression of Rock1 22 0.55 4.9 1.14 38.72
94 INT222019 Gene_expression of Wisp2 2 0.62 0.14 0.03 38.16
95 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96 32.64
96 INT63356 Regulation of CD44 6 0.23 6.29 0.61 32.64
97 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14 32.08
98 INT226869 Negative_regulation of Lcn5 1 0.23 0.33 0.03 31.24
99 INT226879 Negative_regulation of Slc16a7 1 0.21 0.33 0.03 31.24
100 INT226871 Negative_regulation of Smarcc1 1 0.22 0.33 0.03 31.24
101 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23 29.24
102 INT226885 Regulation of Regulation of Mmp2 1 0.17 0.32 0.03 28.84
103 INT123551 Regulation of Mmp2 17 0.57 11.6 6 28.20
104 INT226863 Regulation of Mmp15 1 0.24 0.32 0.03 28.20
105 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 27.76
106 INT82795 Binding of MYC 16 0.47 6.1 0.9 25.76
107 INT63067 Localization of MYC 13 0.78 6.93 0.19 25.76
108 INT226864 Gene_expression of Gbp2 1 0.49 0.15 0 25.52
109 INT226859 Positive_regulation of Gene_expression of Gbp2 1 0.32 0.15 0 25.52
110 INT133538 Gene_expression of Rhoq 2 0.05 0.07 0 25.52
111 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 25.00
112 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05 23.84
113 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48 23.84
114 INT204971 Gene_expression of Pink1 42 0.77 23.95 4.75 22.12
115 INT100548 Regulation of SELP 8 0.29 8.56 1.17 21.84
116 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4 21.76
117 INT289615 Gene_expression of MXD1 1 0.34 0.2 0 20.28
118 INT289619 Transcription of MXD1 1 0.36 0.42 0 15.76
119 INT209020 Negative_regulation of Gene_expression of Slc11a1 3 0.16 0.78 0.49 15.04
120 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2 14.72
121 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 12.96
122 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 12.96
123 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 9.92
124 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 9.44
125 INT170308 Gene_expression of Ido1 159 0.75 69.51 15.98 6.40
126 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 6.40
127 INT224807 Gene_expression of Gria4 35 0.78 4.63 4.02 6.40
128 INT226878 Gene_expression of Mast2 1 0.33 0.27 0.09 6.40
129 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
130 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
131 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
132 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
133 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
134 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
135 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
136 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
137 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
138 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
139 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
140 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
141 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
142 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
143 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
144 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
145 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
146 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
147 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
148 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
149 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
150 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
151 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
152 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
153 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
154 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 5.00
155 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
156 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
157 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
158 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
159 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
160 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
161 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
162 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
163 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
164 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
165 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
166 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 5.00
167 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
168 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
169 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 5.00
170 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
171 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
172 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 5.00
173 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
174 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
175 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
176 INT104392 Gene_expression of Cxcl10 113 0.75 106.86 34.12 5.00
177 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
178 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
179 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
180 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
181 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
182 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
183 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
184 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
185 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
186 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
187 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 5.00
188 INT14884 Positive_regulation of Gene_expression of SFTPA1 32 0.25 20.37 26.09 5.00
189 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
190 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
191 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
192 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
193 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 5.00
194 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
195 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
196 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
197 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
198 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
199 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
200 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
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