D:Drug-induced Liver Injury

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Disease Term
Synonyms Disease Drug Induced Liver, DISEASES DRUG INDUCED LIVER, Drug Induced Hepatitides, DRUG INDUCED HEPATITIS, DRUG INDUCED LIVER DISEASE, Drug Induced Liver Diseases, Drug Induced Liver Injuries, DRUG INDUCED LIVER INJURY, HEPATITIDES DRUG INDUCED, Hepatitides Toxic, Hepatitis Drug Induced
Documents 76
Hot Single Events 42
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Drug-induced Liver Injury. They are ordered first by their relevance to Drug-induced Liver Injury and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7 95.52
2 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55 80.80
3 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36 66.24
4 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11 62.60
5 INT56278 Binding of CYP2B6 and TACC2 1 0.40 0.32 0.06 60.16
6 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1 58.68
7 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09 53.72
8 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22 5.00
9 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17 5.00
10 INT185997 Binding of FANCB and fc 2 0.01 2.51 0.63 5.00
11 INT225065 Binding of ETF1 and FANCB 1 0.01 2.07 0.59 5.00
12 INT225083 Binding of ETF1 and fc 1 0.00 2.13 0.57 5.00
13 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
14 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
15 INT227137 Binding of HBS1L and BDNF-AS 1 0.00 1.32 0.08 5.00
16 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
17 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07 5.00
18 INT225081 Binding of FCAR and fc 1 0.00 0.27 0.07 5.00
19 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07 5.00
20 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 5.00
21 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0 5.00
22 INT353189 Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0 5.00
23 INT225084 IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
24 INT353197 ARNTL Regulation of Hlf 1 0.29 0.33 0 5.00
25 INT353188 Ggh Regulation of Cux2 1 0.11 0.08 0 5.00
26 INT353191 Renbp Regulation of Gene_expression of Yif1 1 0.00 0.55 0 5.00
27 INT353195 ARNTL Regulation of Gene_expression of Tef 1 0.22 0.33 0 5.00
28 INT353199 Cux2 Regulation of Plxna3 Negative_regulation of Cyp4a8 1 0.01 0.35 0 5.00
29 INT353187 Ggh Regulation of Hoxa2 1 0.01 0.08 0 5.00
30 INT353196 ARNTL Regulation of Tef 1 0.36 0.32 0 5.00
31 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0 5.00
32 INT225080 Positive_regulation of IGHG3 Negative_regulation of fc 1 0.01 0.24 0 5.00
33 INT353198 ARNTL Regulation of Dbp 1 0.32 0.32 0 5.00
34 INT353194 ARNTL Regulation of Localization of Ahr 1 0.27 0.32 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Drug-induced Liver Injury. They are ordered first by their pain relevance and then by number of times they were reported in Drug-induced Liver Injury. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 99.40
2 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43 99.32
3 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36 98.44
4 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32 98.44
5 INT3882 Positive_regulation of SARNP 2 0.31 1.46 0.82 98.04
6 INT182667 Binding of DLAT 11 0.31 40.75 2.8 97.96
7 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 97.76
8 INT4208 Regulation of Got1 23 0.44 6.72 6.62 96.76
9 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 96.56
10 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02 96.36
11 INT53574 Regulation of Tnf 45 0.62 40.68 19.71 95.96
12 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 94.04
13 INT167424 Positive_regulation of Pak1 1 0.14 1.43 0.83 94.04
14 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 93.80
15 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 91.12
16 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 91.04
17 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05 90.60
18 INT28060 Positive_regulation of Hdlcl1 48 0.66 37.31 3.79 89.56
19 INT282824 Regulation of PML 3 0.44 2.66 0.09 89.20
20 INT15772 Negative_regulation of Hdlcl1 17 0.41 15.77 1.45 89.00
21 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 86.96
22 INT17425 Regulation of Gene_expression of Ins1 23 0.45 18.99 5.61 86.96
23 INT18515 Gene_expression of Lipg 18 0.66 9.3 3.72 86.96
24 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 86.24
25 INT130188 Positive_regulation of Negative_regulation of Cat 5 0.45 2.26 0.86 86.24
26 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 86.24
27 INT12952 Negative_regulation of Gene_expression of Cat 16 0.57 7.44 1.14 86.24
28 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 86.24
29 INT36287 Binding of CD4 96 0.47 58.93 11.88 85.20
30 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 84.40
31 INT224245 Binding of Sla 1 0.03 1.07 0.13 82.52
32 INT70201 Negative_regulation of ESCO2 4 0.37 1.46 1.01 82.44
33 INT120665 Binding of TACC2 4 0.07 4.33 0.46 82.44
34 INT34589 Gene_expression of PNPLA4 2 0.13 1.5 0.11 82.20
35 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 81.84
36 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 81.84
37 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 81.48
38 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 80.80
39 INT59165 Binding of fc 67 0.36 37.51 8.68 80.60
40 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09 80.48
41 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 80.04
42 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 80.04
43 INT10166 Localization of Tnf 237 0.81 153.95 88.64 75.00
44 INT224246 Binding of Rbm45 1 0.09 2.57 0.34 74.80
45 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 73.52
46 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 72.80
47 INT97062 Binding of PML 10 0.41 11.63 1.65 72.40
48 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 71.48
49 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 66.24
50 INT265 Negative_regulation of Por 4 0.59 0.34 0.41 66.08
51 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 64.40
52 INT45717 Gene_expression of Yif1 3 0.52 3.22 0.27 62.08
53 INT22214 Positive_regulation of Localization of Gpt 14 0.62 8.42 7.89 60.72
54 INT22213 Localization of Gpt 52 0.78 34.05 12.94 60.24
55 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 57.08
56 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 53.72
57 INT174106 Binding of Renbp 18 0.24 15.82 0.58 52.56
58 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 50.00
59 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33 50.00
60 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 50.00
61 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 48.96
62 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16 48.64
63 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 48.60
64 INT227416 Positive_regulation of DLAT 4 0.45 17.02 1.11 44.68
65 INT64953 Negative_regulation of HLA-DRB1 9 0.58 5.15 0.56 43.16
66 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 40.08
67 INT225069 Localization of NKRF 1 0.31 0.66 0 39.44
68 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 33.12
69 INT153329 Gene_expression of Cm9 6 0.67 4.35 0.95 33.12
70 INT227402 Positive_regulation of Negative_regulation of Trbv26 1 0.49 2.04 0.11 26.64
71 INT227403 Positive_regulation of Negative_regulation of Tcrb 1 0.06 2.04 0.11 26.64
72 INT227404 Negative_regulation of Trbv26 1 0.41 2.03 0.11 25.36
73 INT135273 Negative_regulation of Tcrb 3 0.05 2.71 0.14 23.44
74 INT197143 Positive_regulation of Renbp 15 0.33 9.41 1.31 6.56
75 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 5.00
76 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
77 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
78 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
79 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54 5.00
80 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
81 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
82 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 5.00
83 INT1000 Localization of Ggh 31 0.75 2.74 16.41 5.00
84 INT61117 Gene_expression of Ppara 158 0.68 69.3 15.98 5.00
85 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
86 INT2758 Binding of Dbp 36 0.44 8.3 14.47 5.00
87 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
88 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 5.00
89 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 5.00
90 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
91 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
92 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62 5.00
93 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 5.00
94 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 5.00
95 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79 5.00
96 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
97 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
98 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 5.00
99 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
100 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
101 INT19449 Binding of FANCB 22 0.47 7.4 4.27 5.00
102 INT32705 Gene_expression of Cyp2c12 7 0.65 0.62 4.11 5.00
103 INT149623 Negative_regulation of fc 17 0.12 10.56 4.05 5.00
104 INT72936 Gene_expression of Pparg 39 0.77 19.01 4.02 5.00
105 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84 5.00
106 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84 5.00
107 INT168677 Negative_regulation of ACOT1 14 0.27 6.29 3.52 5.00
108 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78 5.00
109 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
110 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 5.00
111 INT40647 Gene_expression of Ggh 5 0.59 0.24 2.03 5.00
112 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 5.00
113 INT119018 Gene_expression of TREH 22 0.65 12.44 1.95 5.00
114 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 5.00
115 INT31815 Gene_expression of Arntl 4 0.75 1.51 1.8 5.00
116 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
117 INT99234 Binding of FCGR2A 1 0.01 1.77 1.68 5.00
118 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
119 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 5.00
120 INT3816 Gene_expression of Ahr 13 0.65 7.51 1.31 5.00
121 INT49013 Gene_expression of Por 6 0.75 2.19 1.22 5.00
122 INT21756 Regulation of Alb 15 0.43 8.21 1.19 5.00
123 INT15896 Gene_expression of FANCB 18 0.65 6.44 1.18 5.00
124 INT53285 Gene_expression of Cyp2c11 20 0.76 5.43 1.17 5.00
125 INT205618 Gene_expression of Renbp 15 0.26 9.26 1.04 5.00
126 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 5.00
127 INT38558 Positive_regulation of DBT 9 0.31 1.59 0.86 5.00
128 INT70027 Positive_regulation of Gene_expression of C6orf25 10 0.62 7.21 0.83 5.00
129 INT101693 Gene_expression of Ggt1 2 0.65 4.92 0.81 5.00
130 INT262726 Localization of PML 6 0.57 7.13 0.72 5.00
131 INT208371 Localization of Ahr 2 0.50 1.9 0.66 5.00
132 INT69283 Gene_expression of PHEX 25 0.75 7.81 0.64 5.00
133 INT225072 Binding of ETF1 1 0.02 2.55 0.63 5.00
134 INT49770 Binding of FCAR 7 0.26 0.86 0.62 5.00
135 INT94826 Positive_regulation of HBS1L 13 0.40 4.62 0.61 5.00
136 INT219793 Negative_regulation of Renbp 5 0.13 3.42 0.61 5.00
137 INT248682 Gene_expression of Rxrb 8 0.60 1.41 0.58 5.00
138 INT205619 Regulation of Renbp 6 0.17 1.91 0.55 5.00
139 INT175759 Gene_expression of ARNTL 9 0.75 0.8 0.44 5.00
140 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41 5.00
141 INT69282 Binding of PHEX 4 0.15 1.43 0.41 5.00
142 INT15588 Regulation of PHEX 4 0.26 1.48 0.39 5.00
143 INT129302 Positive_regulation of Gene_expression of TREH 4 0.49 1.28 0.37 5.00
144 INT158730 Gene_expression of Plxna3 4 0.65 1.82 0.29 5.00
145 INT75006 Gene_expression of Gstm1 6 0.45 2.19 0.29 5.00
146 INT227415 Regulation of DLAT 2 0.29 2.93 0.28 5.00
147 INT166755 Localization of PHEX 2 0.73 1.16 0.28 5.00
148 INT227417 Protein_catabolism of DLAT 1 0.44 1.51 0.27 5.00
149 INT220699 Positive_regulation of CHRNE 5 0.32 2.26 0.26 5.00
150 INT227414 Localization of DLAT 2 0.49 5.14 0.26 5.00
151 INT225076 Positive_regulation of Binding of IGHG3 2 0.50 0.92 0.26 5.00
152 INT225077 Positive_regulation of Binding of ETF1 1 0.03 0.82 0.21 5.00
153 INT206946 Gene_expression of Rxra 4 0.60 2.2 0.17 5.00
154 INT180332 Gene_expression of Sla 6 0.17 9.77 0.16 5.00
155 INT227405 Localization of Pdc 4 0.32 2.87 0.15 5.00
156 INT342932 Positive_regulation of Gene_expression of Renbp 2 0.10 1.09 0.15 5.00
157 INT227406 Regulation of Bcl2l10 2 0.03 2.99 0.13 5.00
158 INT227401 Gene_expression of Nup210 2 0.51 1.26 0.12 5.00
159 INT37103 Gene_expression of CHRNE 5 0.67 4.32 0.12 5.00
160 INT227411 Negative_regulation of Positive_regulation of HCC 1 0.02 1.35 0.11 5.00
161 INT224248 Positive_regulation of Gene_expression of Sla 1 0.03 0.86 0.1 5.00
162 INT220702 Protein_catabolism of CHRNE 1 0.64 1.22 0.08 5.00
163 INT220704 Protein_catabolism of ACOT1 1 0.02 1.19 0.08 5.00
164 INT342933 Negative_regulation of Gene_expression of Renbp 4 0.09 2.42 0.08 5.00
165 INT220700 Gene_expression of MUSK 3 0.75 6.67 0.07 5.00
166 INT206945 Gene_expression of Nr1i2 8 0.63 2.03 0.04 5.00
167 INT224247 Transcription of Sla 1 0.04 1.19 0.04 5.00
168 INT225075 Positive_regulation of Gene_expression of NKRF 1 0.18 0.26 0.04 5.00
169 INT225074 Gene_expression of NKRF 1 0.24 0.26 0.04 5.00
170 INT353183 Regulation of Cyp4a8 1 0.20 0.7 0 5.00
171 INT353172 Negative_regulation of Plxna3 1 0.01 0.14 0 5.00
172 INT227412 Transcription of DLAT 1 0.34 1.4 0 5.00
173 INT353182 Binding of Cux2 1 0.29 0.15 0 5.00
174 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0 5.00
175 INT224249 Gene_expression of Asgr1 1 0.03 0.96 0 5.00
176 INT353178 Gene_expression of Cyp4a8 1 0.51 0.35 0 5.00
177 INT353175 Gene_expression of Mup5 1 0.50 0 0 5.00
178 INT219794 Regulation of Gene_expression of Renbp 2 0.08 0.2 0 5.00
179 INT353169 Negative_regulation of Gene_expression of Ggh 1 0.08 0 0 5.00
180 INT353186 Positive_regulation of Gene_expression of Igf2 1 0.37 0.08 0 5.00
181 INT353181 Gene_expression of Ids 1 0.26 0.61 0 5.00
182 INT353177 Binding of Tef 1 0.26 0.6 0 5.00
183 INT140498 Gene_expression of Tef 2 0.56 1.58 0 5.00
184 INT353180 Transcription of Renbp 1 0.12 0 0 5.00
185 INT220703 Regulation of MUSK 1 0.34 1.48 0 5.00
186 INT353174 Gene_expression of Stat5b 1 0.48 0 0 5.00
187 INT353170 Gene_expression of Hlf 1 0.35 0.44 0 5.00
188 INT353171 Regulation of Gene_expression of Yif1 1 0.01 0 0 5.00
189 INT353184 Regulation of Gene_expression of Ggh 1 0.09 0 0 5.00
190 INT352264 Gene_expression of Degs1 2 0.46 0.6 0 5.00
191 INT206698 Regulation of HBS1L 4 0.09 3.06 0 5.00
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