D:Endometroid Carcinoma

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Disease Term
Synonyms Adenocarcinoma Endometrioid, ADENOCARCINOMAS ENDOMETRIOID, Carcinoma Endometrioid, CARCINOMAS ENDOMETRIOID, Endometrioid Adenocarcinoma, Endometrioid Adenocarcinomas, Endometrioid Carcinoma, Endometrioid Carcinomas
Documents 90
Hot Single Events 120
Hot Interactions 10

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Endometroid Carcinoma. They are ordered first by their relevance to Endometroid Carcinoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0 94.04
2 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03 91.24
3 INT269213 Binding of SNAI1 and Positive_regulation of Gene_expression of CDH1 1 0.37 1.03 0 90.16
4 INT321642 Binding of Cd3e and Spn 1 0.00 1.08 0 89.20
5 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0 86.32
6 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0 86.32
7 INT304019 Binding of AKT1 and TP53 1 0.27 0.72 0 86.32
8 INT304017 Regulation of Binding of AKT1 and TP53 1 0.32 0.73 0 86.32
9 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34 82.56
10 INT269209 SNAI1 Regulation of Gene_expression of LOXL2 1 0.07 1.14 0 81.12
11 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31 75.36
12 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28 73.20
13 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0 72.24
14 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0 72.24
15 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0 72.24
16 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0 71.44
17 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0 71.44
18 INT304024 Binding of AKT1 and PTEN 1 0.33 1.08 0 71.44
19 INT304027 Negative_regulation of PTEN Positive_regulation of Positive_regulation of AKT1 1 0.32 1.86 0 50.04
20 INT305350 Pten Regulation of Phosphorylation of Akt1 1 0.05 0.95 0 45.12
21 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39 33.32
22 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0 29.44
23 INT304016 SFRP4 Regulation of Binding of MSI1 1 0.04 1.78 0 29.44
24 INT304014 Binding of MSI1 and SGCG 1 0.00 1.92 0 9.64
25 INT257745 SAGE1 Positive_regulation of AXL 1 0.07 1.96 0.69 5.00
26 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35 5.00
27 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35 5.00
28 INT187603 Binding of Ptgis and Ppara 1 0.00 0.26 0.31 5.00
29 INT257735 GAS6 Positive_regulation of Gene_expression of SAGE1 1 0.04 0.98 0.31 5.00
30 INT257739 SAGE1 Positive_regulation of DDR1 1 0.00 0.91 0.31 5.00
31 INT257740 SAGE1 Positive_regulation of Gene_expression of AXL 1 0.07 0.72 0.27 5.00
32 INT269210 CDH1 Positive_regulation of Positive_regulation of ITK 1 0.06 0.84 0.06 5.00
33 INT187602 Binding of Ppara and Rxrb 1 0.00 0 0.05 5.00
34 INT269214 SNAI1 Positive_regulation of Positive_regulation of CDH1 1 0.35 0.71 0.04 5.00
35 INT269211 SNAI1 Positive_regulation of Gene_expression of CDH1 1 0.40 0.73 0.04 5.00
36 INT187621 Gnrh1 Regulation of Gene_expression of Pparg 1 0.00 0.09 0 5.00
37 INT304020 AR Regulation of TP53 1 0.24 1.11 0 5.00
38 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0 5.00
39 INT187623 Lhb Regulation of Gene_expression of Pparg 1 0.02 0.09 0 5.00
40 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Endometroid Carcinoma. They are ordered first by their pain relevance and then by number of times they were reported in Endometroid Carcinoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 99.98
2 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 99.98
3 INT130705 Gene_expression of TFAM 50 0.77 38.85 2.79 99.84
4 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 99.84
5 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 99.84
6 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 99.84
7 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51 99.68
8 INT305347 Negative_regulation of Gene_expression of Msh6 1 0.25 2.22 0 99.68
9 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.56
10 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 99.44
11 INT305349 Gene_expression of Msh6 1 0.46 2.21 0 99.44
12 INT204345 Negative_regulation of Gene_expression of TFAM 3 0.42 1.48 0 99.16
13 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26 99.12
14 INT269222 Regulation of Gene_expression of SNAI1 2 0.27 2.24 0 99.12
15 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 98.96
16 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 98.96
17 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 98.56
18 INT61117 Gene_expression of Ppara 158 0.68 69.3 15.98 98.24
19 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 98.08
20 INT95655 Negative_regulation of Gene_expression of MKI67 5 0.41 3.66 0.36 98.08
21 INT95654 Negative_regulation of Gene_expression of SKI 1 0.31 1.32 0.36 98.08
22 INT305296 Regulation of Gene_expression of TFAM 1 0.45 2.68 0 97.92
23 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75 97.92
24 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 97.80
25 INT54912 Gene_expression of SKI 3 0.57 2.81 0.82 97.80
26 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 97.76
27 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15 97.64
28 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 97.64
29 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 97.56
30 INT204343 Positive_regulation of Gene_expression of TFAM 7 0.50 3.87 0 97.56
31 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 97.56
32 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 97.52
33 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22 97.52
34 INT305295 Regulation of Binding of TP53 1 0.39 1.09 0 97.44
35 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 97.12
36 INT8103 Binding of TP53 46 0.44 40.2 2.96 97.12
37 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 97.04
38 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 97.04
39 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 97.04
40 INT68781 Negative_regulation of TFAM 15 0.58 10.01 2.42 96.76
41 INT59768 Regulation of TFAM 7 0.45 4.64 1.08 96.76
42 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 96.76
43 INT201846 Positive_regulation of SFRP4 4 0.37 2.74 0.54 96.76
44 INT201858 Gene_expression of SFRP4 3 0.48 4.91 0.51 96.76
45 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 96.64
46 INT190022 Positive_regulation of Mlh1 2 0.38 3.16 0.03 96.56
47 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63 96.48
48 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05 96.48
49 INT319136 Binding of Mad2l1 1 0.04 1.24 0 96.40
50 INT304053 Gene_expression of KIAA1324 1 0.18 0.98 0 96.20
51 INT304064 Positive_regulation of KIAA1324 1 0.14 0.98 0 96.20
52 INT206869 Gene_expression of ALDH1A2 3 0.38 2.51 0.16 95.88
53 INT304063 Positive_regulation of ALDH1A2 1 0.29 0.97 0 95.88
54 INT319140 Binding of ZIC2 1 0.36 1.24 0 95.76
55 INT269225 Negative_regulation of Gene_expression of SNAI1 4 0.58 9.11 0.28 95.52
56 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 95.36
57 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 95.36
58 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 95.12
59 INT8669 Positive_regulation of Afp 66 0.70 58.21 7.67 94.76
60 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03 94.16
61 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0 94.16
62 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 93.76
63 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 92.92
64 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62 92.80
65 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04 92.80
66 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41 92.80
67 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 92.76
68 INT179885 Regulation of PTEN 8 0.26 11.88 2.18 92.76
69 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19 92.76
70 INT50268 Gene_expression of FBN1 13 0.65 10.73 2.72 92.32
71 INT164178 Gene_expression of ADCY10 9 0.65 2.72 0.39 92.32
72 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 92.12
73 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87 92.08
74 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32 91.84
75 INT163289 Phosphorylation of CCND1 7 0.36 4.81 0.81 91.68
76 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 91.48
77 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 91.28
78 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 91.08
79 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 91.04
80 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 91.04
81 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8 90.56
82 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 90.48
83 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 90.48
84 INT269228 Binding of SNAI1 1 0.47 2.28 0.18 90.16
85 INT268686 Gene_expression of JAZF1 2 0.68 9.33 0 89.80
86 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0 89.56
87 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19 89.44
88 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68 89.36
89 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 89.36
90 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 89.20
91 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 89.20
92 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 89.20
93 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 88.88
94 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 88.40
95 INT304052 Binding of MSI1 8 0.05 12.19 0 88.28
96 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 88.24
97 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 88.16
98 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 87.84
99 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 86.88
100 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 86.88
101 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 86.36
102 INT4228 Gene_expression of CAT 50 0.75 20.62 7.18 86.04
103 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 85.92
104 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 85.44
105 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 83.52
106 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 83.28
107 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75 82.96
108 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74 82.64
109 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 82.64
110 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 82.44
111 INT111298 Gene_expression of ACTN4 12 0.70 9.42 2.6 82.04
112 INT257754 Positive_regulation of Gene_expression of ACTN4 1 0.45 4.58 1.7 82.04
113 INT304078 Regulation of Phosphorylation of KRT20 1 0.00 1 0 81.40
114 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12 81.32
115 INT22455 Binding of Nbr1 8 0.21 10.57 0.93 81.16
116 INT269227 Gene_expression of LOXL2 2 0.42 1.86 0.03 81.12
117 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 80.92
118 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 80.84
119 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 80.72
120 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 80.32
121 INT172329 Binding of MRC1 8 0.36 3.88 0.03 79.92
122 INT101902 Negative_regulation of Mki67 12 0.39 7.92 0.34 79.36
123 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 79.00
124 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 77.44
125 INT147517 Negative_regulation of Gene_expression of Ppara 12 0.37 3.46 2.55 77.12
126 INT304074 Binding of MSH5 1 0.14 1.11 0 76.76
127 INT6884 Negative_regulation of pr 20 0.42 13.18 7.97 76.64
128 INT304071 Binding of MSH6 1 0.28 1.11 0 76.36
129 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 76.08
130 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 75.64
131 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 75.60
132 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 75.00
133 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 75.00
134 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 75.00
135 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 75.00
136 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37 71.68
137 INT282953 Regulation of MSI1 2 0.03 1.63 0.03 71.68
138 INT236621 Regulation of KRAS 7 0.53 6.16 0 71.68
139 INT198037 Regulation of PIK3CA 2 0.28 2.63 0 71.68
140 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 71.44
141 INT126454 Gene_expression of Msln 15 0.55 11.82 2.63 71.20
142 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21 71.20
143 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 71.20
144 INT254053 Gene_expression of CDH6 1 0.02 1.48 0 71.20
145 INT254054 Gene_expression of Crabp2 1 0.08 0.29 0 71.20
146 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 69.76
147 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 69.44
148 INT211581 Binding of Pms2 2 0.32 2.49 0.04 67.44
149 INT170922 Binding of Ppara 59 0.45 28.45 6.7 66.84
150 INT190035 Binding of Msh6 2 0.28 2.72 0 66.64
151 INT78320 Gene_expression of EPCAM 57 0.75 50.34 7.53 66.48
152 INT92142 Binding of MSH2 5 0.46 5.64 0.75 66.08
153 INT39000 Regulation of pr 24 0.44 12.51 4.36 65.92
154 INT190038 Binding of Mlh1 2 0.28 3.11 0 65.52
155 INT8545 Negative_regulation of MUC16 19 0.57 15.96 2.81 65.12
156 INT147522 Positive_regulation of Gene_expression of Ppara 28 0.47 15.82 3.18 64.40
157 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 62.96
158 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 62.96
159 INT11157 Binding of EGF 88 0.48 53.73 21.25 62.44
160 INT59784 Binding of DES 22 0.47 19.48 2.27 60.96
161 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 60.20
162 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 60.00
163 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 60.00
164 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 59.88
165 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37 59.36
166 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1 59.36
167 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 57.12
168 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 57.12
169 INT190014 Regulation of Pten 8 0.62 6.03 1.2 55.92
170 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 53.12
171 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 53.12
172 INT319141 Regulation of MTUS1 1 0.00 1.56 0 52.88
173 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 52.00
174 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06 52.00
175 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 51.84
176 INT135556 Localization of AKT1 38 0.69 12.78 1.17 51.60
177 INT207233 Transcription of KRAS 3 0.48 1.56 0.03 50.76
178 INT82913 Regulation of Ppara 15 0.61 10.66 3.03 48.40
179 INT304058 Positive_regulation of MSI1 1 0.07 2.74 0 48.00
180 INT78877 Gene_expression of EWSR1 10 0.75 11.16 0.97 47.84
181 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 47.48
182 INT258435 Binding of Serpinb1c 3 0.24 2.43 0.07 47.28
183 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 46.08
184 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 45.12
185 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 41.92
186 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 40.16
187 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 38.72
188 INT187618 Localization of Ppara 13 0.70 6.91 3.09 37.92
189 INT170927 Negative_regulation of Ppara 27 0.54 13.58 5.12 37.84
190 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 36.64
191 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 36.64
192 INT304048 Negative_regulation of Gene_expression of SFRP4 1 0.34 0.97 0 36.64
193 INT192676 Binding of PTEN 14 0.46 10.58 3.06 34.44
194 INT187590 Gene_expression of Brca1 12 0.65 4.94 0.11 33.68
195 INT187589 Positive_regulation of Gene_expression of Brca1 2 0.55 1.93 0.03 33.68
196 INT187580 Positive_regulation of Brca1 1 0.10 1.17 0 33.68
197 INT236108 Positive_regulation of Positive_regulation of Pten 3 0.39 2.3 0.04 32.48
198 INT257765 Localization of ACTN4 1 0.63 1.02 0.38 32.32
199 INT187615 Regulation of Binding of Ppara 3 0.15 2.09 0.43 31.60
200 INT36286 Binding of Cd3e 33 0.36 10.11 3.21 28.20
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