D:Leber Hereditary Optic Atrophy

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pChart

Disease Term
Synonyms Leber Hereditary Optic Neuropathy, Leber Optic Atrophy, Leber S Hereditary Optic Atrophy, Leber S Hereditary Optic Neuropathy, Leber S Optic Atrophy, LEBERS OPTIC ATROPHY, Optic Atrophy Leber, OPTIC ATROPHY LEBER HEREDITARY, Optic Atrophy Leber S
Documents 20
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Leber Hereditary Optic Atrophy. They are ordered first by their relevance to Leber Hereditary Optic Atrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 55.48
2 INT298688 Binding of OPA1 and MFN1 1 0.52 2.09 0 14.56
3 INT298687 Binding of OPA1 and PARL 1 0.50 2.09 0 14.56
4 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leber Hereditary Optic Atrophy. They are ordered first by their pain relevance and then by number of times they were reported in Leber Hereditary Optic Atrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79575 Binding of NDUFA1 2 0.02 0.77 0.03 100.00
2 INT116622 Positive_regulation of Nefh 17 0.39 11.98 3.86 99.64
3 INT115890 Gene_expression of Nefh 28 0.68 11.55 3.84 99.64
4 INT154095 Positive_regulation of Gene_expression of Nefh 6 0.58 5.35 1.01 99.64
5 INT308323 Regulation of APOBR 1 0.01 1.91 0 99.00
6 INT308322 Regulation of ATP6 1 0.25 1.84 0 99.00
7 INT145514 Localization of Nefh 5 0.32 2.23 0.72 98.68
8 INT256399 Positive_regulation of ND4 1 0.01 1.36 0 98.56
9 INT256397 Binding of Nefh 3 0.09 1.31 0 98.56
10 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 98.28
11 INT256396 Regulation of Nefh 1 0.03 0.57 0 95.20
12 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 90.96
13 INT290205 Negative_regulation of Protein_catabolism of AAVS1 2 0.20 0.7 0 90.12
14 INT37950 Regulation of PDSS1 3 0.44 1.24 0.91 89.96
15 INT290207 Protein_catabolism of AAVS1 2 0.35 0.69 0 89.48
16 INT157959 Binding of AQP4 32 0.48 43.44 7.44 88.68
17 INT89546 Phosphorylation of NEFH 10 0.76 3.49 5.08 88.20
18 INT102696 Binding of MRP63 4 0.46 3.68 0.27 86.24
19 INT203710 Positive_regulation of AKR7A2 1 0.01 0.39 0 77.52
20 INT17470 Negative_regulation of NDUFC1 3 0.05 3.43 0.75 77.12
21 INT234572 Regulation of MRP63 1 0.09 0.08 0 76.32
22 INT265514 Negative_regulation of COX1 1 0.42 0.82 0 68.04
23 INT105669 Positive_regulation of Gene_expression of AAVS1 20 0.49 9.02 2.06 65.52
24 INT290206 Positive_regulation of Positive_regulation of AAVS1 1 0.17 0.24 0 65.52
25 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 65.08
26 INT190418 Positive_regulation of AAVS1 15 0.49 4.71 0.98 65.08
27 INT194332 Localization of MFN2 2 0.74 1.45 0.15 64.20
28 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 58.16
29 INT234575 Gene_expression of MRP63 1 0.16 0.62 0 50.64
30 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 39.16
31 INT302703 Binding of PLAA 1 0.13 0.87 0.15 34.08
32 INT234573 Gene_expression of TRNL1 1 0.03 0 0 24.68
33 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 14.84
34 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 14.32
35 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 11.96
36 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
37 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
38 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
39 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
40 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36 5.00
41 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
42 INT33854 Localization of OPA1 19 0.65 10.55 5.04 5.00
43 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
44 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
45 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
46 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 5.00
47 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 5.00
48 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
49 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
50 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 5.00
51 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 5.00
52 INT237247 Regulation of Mri1 6 0.27 4.64 1.2 5.00
53 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 5.00
54 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 5.00
55 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 5.00
56 INT161807 Phosphorylation of ROS1 10 0.43 4.86 0.62 5.00
57 INT211489 Gene_expression of ARHGAP4 6 0.65 2.88 0.61 5.00
58 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 5.00
59 INT293957 Localization of PION 1 0.55 2 0.53 5.00
60 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 5.00
61 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 5.00
62 INT224340 Localization of TYMP 3 0.62 2.86 0.3 5.00
63 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 5.00
64 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 5.00
65 INT232628 Gene_expression of Opa1 10 0.78 17.01 0.26 5.00
66 INT240051 Regulation of Regulation of Jun 2 0.26 1.25 0.18 5.00
67 INT302682 Localization of POLG2 1 0.67 1 0.11 5.00
68 INT302693 Localization of C10orf2 1 0.59 1 0.11 5.00
69 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 5.00
70 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 5.00
71 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 5.00
72 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 5.00
73 INT302692 Localization of POLG 1 0.69 0.99 0.1 5.00
74 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 5.00
75 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 5.00
76 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 5.00
77 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 5.00
78 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 5.00
79 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 5.00
80 INT302700 Localization of TK2 1 0.65 0.65 0.07 5.00
81 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 5.00
82 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 5.00
83 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 5.00
84 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 5.00
85 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 5.00
86 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 5.00
87 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 5.00
88 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 5.00
89 INT302685 Localization of MPV17 1 0.65 0.67 0.07 5.00
90 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 5.00
91 INT293958 Gene_expression of PION 1 0.49 1.69 0.06 5.00
92 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
93 INT265513 Binding of Opa1 2 0.48 5.75 0 5.00
94 INT232634 Localization of Opa1 2 0.75 1.11 0 5.00
95 INT302688 Transcription of OPA1 1 0.68 0.3 0 5.00
96 INT234577 Positive_regulation of Gene_expression of MRP63 1 0.10 0.58 0 5.00
97 INT302687 Regulation of PLAA 1 0.19 0.24 0 5.00
98 INT234574 Negative_regulation of POLRMT 1 0.21 0 0 5.00
99 INT252235 Gene_expression of C5orf34 1 0.01 0 0 5.00
100 INT146667 Regulation of OPA3 1 0.26 0.13 0 5.00
101 INT234576 Negative_regulation of MRP63 1 0.09 0 0 5.00
102 INT170471 Localization of THY1 7 0.37 0.75 0 5.00
103 INT146666 Regulation of Opa1 1 0.27 0.13 0 5.00
104 INT232633 Regulation of Gene_expression of Opa1 2 0.27 2.6 0 5.00
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