D:Mantle-cell Lymphoma

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Disease Term
Synonyms Centrocytic Small Cell Lymphoma, CENTROCYTIC SMALL CELL LYMPHOMAS, DIFFUSE LYMPHOCYTIC LYMPHOMA POORLY DIFFERENTIATED, Lymphocytic Lymphoma Diffuse Poorly Differentiated, LYMPHOMA CENTROCYTIC SMALL CELL, Lymphoma Lymphocytic Diffuse Intermediate Differentiated, Lymphoma Lymphocytic Diffuse Poorly Differentiated, Lymphoma Lymphocytic Intermediate, Lymphoma Mantle Cell, Lymphoma Mantle Zone, Lymphoma Small Cell Centrocytic
Documents 58
Hot Single Events 138
Hot Interactions 14

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mantle-cell Lymphoma. They are ordered first by their relevance to Mantle-cell Lymphoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT276380 Binding of PIM1 and Trp53 1 0.01 0.66 0 98.12
2 INT305632 Binding of BCL6 and MME 1 0.00 1.37 0 95.28
3 INT276374 Skp2 Regulation of Protein_catabolism of CIB1 1 0.00 0.58 0 90.92
4 INT276382 Binding of CIB1 and Skp2 1 0.01 0.57 0 90.92
5 INT276393 Skp2 Regulation of CIB1 1 0.00 0.57 0 90.92
6 INT276336 Skp2 Regulation of Cdkn1b 1 0.00 0.57 0 90.92
7 INT276335 Binding of Cdkn1b and Skp2 1 0.00 0.57 0 90.92
8 INT276302 Binding of SKP2 and CIB1 1 0.03 0.57 0 90.76
9 INT276379 Binding of SKP2 and Cdkn1b 1 0.02 0.57 0 90.76
10 INT276303 Negative_regulation of AKT1 Negative_regulation of CCND1 1 0.01 0.58 0 89.04
11 INT276390 Positive_regulation of CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 88.64
12 INT276378 CD40 Positive_regulation of Gene_expression of Pdcd1 1 0.01 1.06 0 88.64
13 INT345486 PMAIP1 Positive_regulation of Localization of CYC1 1 0.18 0.96 0 87.52
14 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0 85.04
15 INT345483 Binding of MYC and PMAIP1 1 0.16 0.63 0 62.52
16 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0 58.72
17 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0 58.72
18 INT327336 Binding of VEGFA and Elavl1 1 0.06 0.94 0.04 57.20
19 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 56.32
20 INT276301 Binding of CCL21 and CXCL13 1 0.04 1.85 0.18 49.36
21 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03 44.56
22 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03 44.56
23 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03 44.16
24 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0 42.80
25 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0 41.92
26 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 40.80
27 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 38.88
28 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 38.32
29 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0 35.84
30 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
31 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
32 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
33 INT291377 Binding of CX3CR1 and Cx3cl1 2 0.36 3.57 1.02 5.00
34 INT327334 Il10 Negative_regulation of TNF 1 0.02 1.46 0.6 5.00
35 INT327323 Il10 Positive_regulation of Gene_expression of Ttpa 1 0.02 1.43 0.58 5.00
36 INT327339 Gtf3a Positive_regulation of VEGFA 1 0.00 2.34 0.58 5.00
37 INT327332 VEGFA Positive_regulation of Gene_expression of Hgfac 1 0.00 2.02 0.49 5.00
38 INT327333 Binding of TNF and Fxr1 1 0.06 3.74 0.48 5.00
39 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 5.00
40 INT327308 Binding of Elavl1 and Ttpa 1 0.02 1.73 0.34 5.00
41 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
42 INT327328 Binding of Hnrnpd and Elavl1 1 0.06 0.74 0.3 5.00
43 INT327337 MIR29A Negative_regulation of Ttpa 1 0.04 1.14 0.28 5.00
44 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
45 INT327340 Binding of TNF and Hnrnpd 1 0.03 1.02 0.25 5.00
46 INT327300 Binding of Hnrnpd and Myc 1 0.12 1.02 0.25 5.00
47 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24 5.00
48 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24 5.00
49 INT327313 Positive_regulation of Mapk14 Positive_regulation of Phosphorylation of Khsrp 1 0.09 0.24 0.22 5.00
50 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22 5.00
51 INT327315 S100a8 Negative_regulation of Binding of Khsrp 1 0.01 0.55 0.21 5.00
52 INT291348 IL8 Positive_regulation of Phosphorylation of SHC1 1 0.11 1.16 0.2 5.00
53 INT291346 IL8 Positive_regulation of Binding of EGFR and GRB2 1 0.15 1.17 0.2 5.00
54 INT327317 Ttpa Negative_regulation of Elavl1 1 0.02 0.45 0.19 5.00
55 INT327312 Positive_regulation of Ttpa Negative_regulation of Elavl1 1 0.03 0.45 0.19 5.00
56 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
57 INT327327 Ttpa Negative_regulation of Il3 1 0.01 0.4 0.17 5.00
58 INT291354 CXCL12 Positive_regulation of EPHB2 1 0.42 2.02 0.16 5.00
59 INT327310 Binding of Ccnd1 and Elavl1 1 0.04 0.38 0.16 5.00
60 INT327306 Mapk6 Positive_regulation of Mapk14 Positive_regulation of Positive_regulation of IL8 1 0.00 0.3 0.16 5.00
61 INT327325 Binding of Hnrnpd and Ccnd1 1 0.03 0.38 0.16 5.00
62 INT327324 Mapk6 Positive_regulation of Mapk14 1 0.01 0.29 0.15 5.00
63 INT327329 S100a8 Positive_regulation of Mapk14 1 0.00 0.36 0.14 5.00
64 INT327326 Binding of Mapkapk2 and Ttpa 1 0.02 0.34 0.14 5.00
65 INT327309 Il1 Positive_regulation of Mapk14 1 0.01 0.36 0.14 5.00
66 INT327316 Binding of Elavl1 and Khsrp 1 0.12 0.36 0.14 5.00
67 INT327319 Binding of Mapk14 and Ttpa 1 0.01 0.34 0.14 5.00
68 INT291347 Positive_regulation of TXK Positive_regulation of CXCR4 Positive_regulation of EPHB2 1 0.02 0.61 0.13 5.00
69 INT327322 Mapkapk2 Regulation of Il6 1 0.02 0.26 0.13 5.00
70 INT291349 CXCR4 Positive_regulation of EPHB2 1 0.42 1.87 0.13 5.00
71 INT327318 Mapk14 Regulation of Localization of Elavl1 1 0.09 0.42 0.13 5.00
72 INT327330 Mapk14 Regulation of Il1 1 0.01 0.33 0.12 5.00
73 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1 5.00
74 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 5.00
75 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1 5.00
76 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1 5.00
77 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1 5.00
78 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1 5.00
79 INT291358 Binding of CXCL12 and CXCR7 1 0.20 0.11 0.09 5.00
80 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09 5.00
81 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09 5.00
82 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08 5.00
83 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08 5.00
84 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08 5.00
85 INT276384 Binding of Mirlet7a-1 and MIR9-1 1 0.39 1.12 0.08 5.00
86 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
87 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
88 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06 5.00
89 INT327338 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of VEGFA 1 0.05 0.93 0.05 5.00
90 INT276337 Timp1 Positive_regulation of Il10 1 0.01 0.76 0.05 5.00
91 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
92 INT262781 Birc5 Regulation of TEP1 1 0.00 0.49 0.05 5.00
93 INT262780 Birc5 Regulation of CD163L1 1 0.00 0.49 0.05 5.00
94 INT327314 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Ttpa 1 0.02 0.91 0.05 5.00
95 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
96 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04 5.00
97 INT276386 Gtf3a Regulation of PTPN6 1 0.00 0.86 0.04 5.00
98 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
99 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
100 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 5.00
101 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04 5.00
102 INT315803 Binding of FL and Tst 1 0.04 0.66 0.04 5.00
103 INT276392 Timp1 Regulation of PTPN6 1 0.02 0.87 0.04 5.00
104 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04 5.00
105 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
106 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04 5.00
107 INT276377 Binding of Lgals1 and KRT20 1 0.00 1.11 0.03 5.00
108 INT276388 Il22 Positive_regulation of STAT3 1 0.03 1.3 0.03 5.00
109 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03 5.00
110 INT276305 Binding of LGALS1 and KRT20 1 0.01 1.11 0.03 5.00
111 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03 5.00
112 INT312303 Positive_regulation of FLT1 Positive_regulation of VEGFA 1 0.38 0.73 0.03 5.00
113 INT291357 CXCR4 Positive_regulation of AKT1 1 0.08 1.27 0.03 5.00
114 INT276300 TAT Regulation of Gene_expression of VEGFA 1 0.14 1.58 0 5.00
115 INT276387 ALK Positive_regulation of Gene_expression of Il22ra1 1 0.00 1.55 0 5.00
116 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0 5.00
117 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0 5.00
118 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0 5.00
119 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0 5.00
120 INT278041 Binding of VEGFA and HCC 1 0.02 1.64 0 5.00
121 INT234378 MAPK7 Positive_regulation of PPARA 1 0.21 0.05 0 5.00
122 INT262752 IGHA1 Positive_regulation of IGKV2D-19 1 0.00 1.39 0 5.00
123 INT300337 Gene_expression of MITF Negative_regulation of Gene_expression of TSC1 1 0.00 0.65 0 5.00
124 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0 5.00
125 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0 5.00
126 INT355201 Binding of HDAC9 and Gopc 1 0.01 0.06 0 5.00
127 INT315813 Binding of Tst and KRT20 1 0.10 0.35 0 5.00
128 INT276333 Binding of Il10rb and Il22ra1 1 0.00 1.25 0 5.00
129 INT327341 VEGFA Regulation of Elavl1 1 0.08 1.27 0 5.00
130 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0 5.00
131 INT327335 VEGFA Regulation of Binding of Elavl1 1 0.08 1.27 0 5.00
132 INT315814 Tst Positive_regulation of Localization of RTEL1 1 0.02 2.19 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mantle-cell Lymphoma. They are ordered first by their pain relevance and then by number of times they were reported in Mantle-cell Lymphoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT46142 Gene_expression of Chka 18 0.19 16.4 1.84 100.00
2 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.94
3 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 99.94
4 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0 99.84
5 INT105181 Positive_regulation of Hist1h3f 10 0.33 4.06 0.68 99.80
6 INT347628 Positive_regulation of Gene_expression of Hist1h3f 2 0.19 1.26 0 99.80
7 INT276363 Positive_regulation of Gene_expression of PIM1 4 0.15 2.87 0.09 99.78
8 INT121387 Negative_regulation of Gene_expression of CD5 3 0.40 2.6 0.25 99.76
9 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 99.68
10 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53 99.68
11 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 99.68
12 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01 99.66
13 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 99.64
14 INT113989 Regulation of Gene_expression of CCND1 11 0.44 7.57 0.24 99.64
15 INT276346 Regulation of Protein_catabolism of CCND1 1 0.04 0.66 0 99.64
16 INT276362 Protein_catabolism of CCND1 1 0.10 0.66 0 99.64
17 INT315806 Phosphorylation of RTEL1 1 0.04 0.68 0.03 99.64
18 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85 99.60
19 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26 99.52
20 INT39417 Gene_expression of Fcer2a 65 0.76 32.1 7.37 99.48
21 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 99.16
22 INT75498 Positive_regulation of Gene_expression of CCND1 21 0.68 19.4 0.51 99.12
23 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 99.04
24 INT66852 Gene_expression of Fcer2 15 0.14 9.74 1.27 99.04
25 INT130646 Regulation of CXCL12 14 0.47 7.67 3.48 99.00
26 INT113111 Regulation of CXCR4 14 0.61 12.81 1.39 99.00
27 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 98.84
28 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98 98.80
29 INT118952 Gene_expression of Hist1h3f 13 0.21 3.58 1.05 98.68
30 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 98.58
31 INT276344 Positive_regulation of PIM1 3 0.25 1.07 0.17 98.56
32 INT189852 Localization of H2-Q13 4 0.06 4.1 0.47 98.52
33 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 98.44
34 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 98.44
35 INT93003 Binding of CD40 28 0.47 20.25 7.13 98.28
36 INT86503 Negative_regulation of Fcer2 3 0.09 2.49 0.55 98.24
37 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 98.18
38 INT77146 Binding of IL4 23 0.36 13.69 5.39 98.18
39 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 98.16
40 INT35027 Positive_regulation of Gene_expression of Igh-6 6 0.02 4.26 2.24 98.16
41 INT126457 Gene_expression of BCL6 34 0.66 22.45 1.75 98.08
42 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36 98.08
43 INT28359 Gene_expression of Pdcd1 39 0.57 34.09 3.4 98.02
44 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 97.76
45 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58 97.76
46 INT35910 Binding of Mme 8 0.37 4.79 3.16 97.76
47 INT277796 Binding of Bcl6 1 0.17 1.33 0 97.76
48 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 97.24
49 INT231820 Gene_expression of Irf8 2 0.19 5.43 0.19 97.24
50 INT26434 Localization of MME 17 0.81 8.67 2.3 96.72
51 INT70021 Localization of BCL2 23 0.74 21.6 1.09 96.72
52 INT235466 Localization of BCL6 3 0.27 5 0.29 96.72
53 INT94156 Negative_regulation of Crem 1 0.00 1.5 0.15 96.36
54 INT289105 Gene_expression of WNT3 4 0.20 2.02 0.37 95.96
55 INT299899 Gene_expression of WNT10A 2 0.06 1.8 0 95.96
56 INT99291 Transcription of Slc6a4 7 0.46 1.16 3.28 95.72
57 INT207299 Binding of BCL6 6 0.30 3.5 0.41 95.28
58 INT276311 Gene_expression of Irf4 6 0.64 4.95 0.37 95.28
59 INT276314 Gene_expression of Mum1 1 0.16 3.85 0.03 95.16
60 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 94.88
61 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 94.88
62 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 94.88
63 INT94163 Negative_regulation of UCN2 11 0.57 6.86 1.75 94.88
64 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 94.40
65 INT23317 Gene_expression of Spn 20 0.48 14.51 4.01 94.00
66 INT276354 Positive_regulation of Localization of CIB1 1 0.10 0.57 0 94.00
67 INT276350 Positive_regulation of Negative_regulation of CIB1 1 0.11 0.56 0 94.00
68 INT276316 Positive_regulation of Negative_regulation of Cdkn1b 1 0.07 0.56 0 94.00
69 INT276361 Localization of CIB1 1 0.15 0.56 0 94.00
70 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48 94.00
71 INT182339 Gene_expression of Ms4a1 18 0.68 16.6 0.42 93.68
72 INT62031 Gene_expression of Cd19 27 0.65 10.39 0.93 93.44
73 INT179043 Negative_regulation of Cdkn1b 7 0.36 5.99 0.22 93.20
74 INT164585 Regulation of PMAIP1 2 0.20 2.07 0.61 93.10
75 INT190935 Gene_expression of Cd5 2 0.25 3.02 0.04 93.08
76 INT276345 Negative_regulation of CIB1 1 0.09 0.56 0 93.04
77 INT277802 Gene_expression of Rit1 3 0.35 4.59 0.21 92.32
78 INT233867 Negative_regulation of SKP2 3 0.24 2.25 0.13 91.80
79 INT276328 Negative_regulation of Skp2 1 0.04 0.56 0 91.80
80 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 91.64
81 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 91.16
82 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75 90.92
83 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51 90.88
84 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84 90.80
85 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 90.80
86 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 90.80
87 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 90.36
88 INT191018 Positive_regulation of Gene_expression of Cd79a 12 0.26 8.01 1.05 90.36
89 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31 90.08
90 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 89.80
91 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 89.80
92 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01 89.68
93 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 89.64
94 INT91511 Positive_regulation of Localization of CYC1 15 0.67 14.68 3.57 89.60
95 INT276307 Protein_catabolism of Cdkn1b 2 0.45 2.57 0 89.24
96 INT106604 Protein_catabolism of CIB1 4 0.90 1.24 1.98 89.08
97 INT276343 Regulation of Phosphorylation of MDM2 1 0.14 0.85 0 88.80
98 INT276366 Positive_regulation of Phosphorylation of MDM2 1 0.15 0.85 0 88.80
99 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0 88.80
100 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 87.76
101 INT91509 Localization of CYC1 39 0.78 34.74 7.17 87.52
102 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99 87.44
103 INT121388 Positive_regulation of BCL6 2 0.28 2.71 0.32 86.96
104 INT276359 Positive_regulation of Protein_catabolism of MDM2 1 0.15 1.79 0 86.88
105 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87 86.88
106 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 86.84
107 INT88070 Binding of Ema 7 0.18 7.39 0.31 86.40
108 INT101049 Positive_regulation of CD5 6 0.67 5.71 0.68 86.16
109 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 86.00
110 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41 85.76
111 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 85.76
112 INT113112 Negative_regulation of CXCR4 39 0.58 28.28 5.36 85.44
113 INT113110 Negative_regulation of CXCL12 8 0.43 6.01 1.63 85.44
114 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 85.12
115 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 85.12
116 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 85.04
117 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 84.96
118 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 84.96
119 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16 84.44
120 INT96523 Positive_regulation of Chka 5 0.69 3.78 0.19 84.40
121 INT96524 Positive_regulation of Positive_regulation of Chka 2 0.41 2.36 0.12 84.40
122 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 84.40
123 INT276365 Negative_regulation of Protein_catabolism of MDM2 1 0.14 0.86 0 84.32
124 INT276357 Protein_catabolism of MDM2 2 0.32 1.18 0 84.32
125 INT56610 Positive_regulation of Gene_expression of Chka 3 0.10 5.4 0.3 84.00
126 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29 83.60
127 INT305634 Localization of CCND1 1 0.07 2.69 0 83.48
128 INT14201 Localization of Igh-6 9 0.81 3.29 3.36 83.48
129 INT53764 Gene_expression of SPN 5 0.75 5.62 0.38 82.88
130 INT70019 Binding of BCL2 25 0.47 17.55 0.79 82.80
131 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 82.40
132 INT34358 Binding of MME 13 0.37 7.25 5.14 82.24
133 INT276367 Regulation of Gene_expression of TLX1 1 0.10 1.4 0 81.80
134 INT276313 Regulation of Gene_expression of Tlx3 1 0.06 1.4 0 81.80
135 INT276355 Gene_expression of TLX1 1 0.17 3.95 0.03 81.40
136 INT345504 Binding of PMAIP1 1 0.15 1.7 0.1 81.20
137 INT213519 Gene_expression of Tlx3 4 0.70 5.15 0.54 81.00
138 INT81860 Gene_expression of Manba 2 0.26 1.39 0.32 80.72
139 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 79.60
140 INT279383 Negative_regulation of Ttpa 2 0.06 16.02 3.37 79.40
141 INT279378 Negative_regulation of Ddit3 2 0.30 1.35 0.06 78.52
142 INT28572 Regulation of Rit1 4 0.30 3.63 0.48 78.40
143 INT197122 Transcription of CRS 2 0.49 3.09 0.18 78.16
144 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 77.56
145 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 77.56
146 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 77.56
147 INT217804 Negative_regulation of MITF 19 0.01 19.95 0.57 76.24
148 INT279380 Positive_regulation of Ttpa 2 0.07 2.66 0.33 76.00
149 INT244805 Gene_expression of Pax5 2 0.62 1.39 0.04 76.00
150 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 75.80
151 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71 75.68
152 INT276353 Positive_regulation of Gene_expression of TLX1 1 0.10 1.39 0 75.40
153 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 75.40
154 INT94162 Binding of UCN2 3 0.36 1.8 1.18 75.40
155 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 75.16
156 INT128162 Negative_regulation of Positive_regulation of DDIT3 4 0.41 4.54 0.53 73.68
157 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 73.64
158 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91 73.36
159 INT164587 Gene_expression of MCL1 94 0.75 124.05 5.39 72.40
160 INT164583 Negative_regulation of Gene_expression of MCL1 19 0.56 22.45 1.94 72.40
161 INT198052 Positive_regulation of Gene_expression of MCL1 19 0.48 24.19 0.47 72.40
162 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 71.36
163 INT345499 Negative_regulation of Positive_regulation of PMAIP1 1 0.21 1.65 0 70.96
164 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 68.52
165 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 68.52
166 INT279381 Regulation of Ms4a1 1 0.15 2.7 0 68.00
167 INT258317 Localization of Ms4a1 2 0.41 1.77 0.11 68.00
168 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 67.52
169 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 67.12
170 INT166021 Positive_regulation of MCL1 36 0.67 62.97 1.44 66.32
171 INT175388 Localization of Ugcg 22 0.37 13.84 2.24 65.16
172 INT55169 Binding of RELA 40 0.36 4.91 1.74 64.56
173 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 64.40
174 INT193814 Positive_regulation of Positive_regulation of CXCR4 2 0.38 3.08 0.39 64.32
175 INT82795 Binding of MYC 16 0.47 6.1 0.9 62.52
176 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 61.60
177 INT245089 Localization of CXCL12 8 0.65 10.17 1.28 61.44
178 INT164588 Regulation of MCL1 12 0.43 14.09 2.63 60.88
179 INT276329 Binding of Chka 1 0.05 5.74 0 60.40
180 INT276310 Negative_regulation of Gene_expression of Pdcd1 3 0.05 4.18 0.31 59.92
181 INT277799 Binding of Ms4a1 6 0.42 3.59 0 58.44
182 INT202473 Binding of Cd19 3 0.31 2.43 0 58.44
183 INT129164 Binding of Cd22 6 0.19 4.46 0.57 58.44
184 INT133156 Binding of Cd40 77 0.48 45.92 13.77 58.44
185 INT187168 Binding of Cd74 13 0.27 11.2 3.44 58.44
186 INT227772 Binding of Cd80 11 0.29 7.85 2.2 58.44
187 INT29986 Binding of Fcer2a 9 0.27 4.34 1.38 58.44
188 INT279382 Regulation of Cd22 1 0.14 1.22 0 58.44
189 INT259006 Regulation of Cd19 2 0.13 1.39 0 58.44
190 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 56.36
191 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 56.16
192 INT241803 Positive_regulation of GBA 6 0.70 2.41 0.3 55.04
193 INT277795 Regulation of Binding of Ms4a1 2 0.24 0.67 0 54.64
194 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 54.48
195 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 54.48
196 INT73476 Transcription of MYC 18 0.69 12.14 2.13 54.24
197 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 54.24
198 INT61910 Binding of Slc3a2 6 0.01 3 0.7 54.20
199 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 53.96
200 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 53.96
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