D:Migraine Without Aura

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Disease Term
Synonyms COMMON MIGRAINE, Common Migraines, Migraine Common, Migraines Common
Documents 1106
Hot Single Events 200
Hot Interactions 11

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Migraine Without Aura. They are ordered first by their relevance to Migraine Without Aura and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29 99.84
2 INT35201 Trh Regulation of Tshb 1 0.01 0.28 0.39 99.84
3 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26 99.48
4 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98 98.32
5 INT25036 TRH Regulation of Prl 4 0.27 1.75 1.09 95.44
6 INT251730 Binding of CD70 and SUGT1 1 0.01 0.85 0.49 94.32
7 INT251731 Binding of CD70 and SNRNP70 1 0.04 0.84 0.49 92.88
8 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08 86.72
9 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35 86.72
10 INT251729 Binding of FEN1 and EXOSC1 1 0.19 1.13 0.74 85.20
11 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37 84.72
12 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37 78.24
13 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36 62.56
14 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59 53.12
15 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7 26.00
16 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25 5.00
17 INT214411 DNAH8 Regulation of CAPN1 1 0.00 1.01 0.94 5.00
18 INT214408 ATP1A4 Regulation of DNAH8 1 0.04 1.01 0.94 5.00
19 INT214409 ATP1A4 Regulation of CAPN1 1 0.01 1.01 0.93 5.00
20 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5 5.00
21 INT326514 Sugt1 Negative_regulation of MTHFR 1 0.01 0.77 0.42 5.00
22 INT176009 Binding of GRHPR and ZNF677 1 0.00 0.57 0.36 5.00
23 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26 5.00
24 INT214412 CASQ1 Regulation of JUND 1 0.02 0.46 0.24 5.00
25 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Migraine Without Aura. They are ordered first by their pain relevance and then by number of times they were reported in Migraine Without Aura. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 100.00
2 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 100.00
3 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 100.00
4 INT198058 Binding of CACNA1I 1 0.16 1.35 0.71 100.00
5 INT186509 Regulation of MOCOS 1 0.02 0.69 0.29 100.00
6 INT5793 Binding of CTS 110 0.48 63.91 40.62 100.00
7 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81 99.84
8 INT142735 Regulation of RLS 33 0.53 45.83 11.35 99.84
9 INT4535 Localization of PROC 106 0.73 76.24 21.1 99.84
10 INT13790 Binding of HTR1A 52 0.47 18.83 17.59 99.84
11 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.80
12 INT287529 Negative_regulation of Positive_regulation of AKR1B1 2 0.41 2.1 0.63 99.80
13 INT354254 Negative_regulation of Regulation of FBF1 1 0.03 2.25 1.67 99.76
14 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 99.72
15 INT24444 Regulation of FBF1 2 0.12 5.55 5.06 99.58
16 INT5127 Localization of Lhb 488 0.80 50.48 162.66 99.54
17 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 99.52
18 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 99.52
19 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 99.48
20 INT12484 Binding of Drd2 45 0.48 15.17 24.72 99.48
21 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 99.32
22 INT260501 Positive_regulation of AKR1B1 5 0.67 4.31 0.71 99.32
23 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.28
24 INT65149 Positive_regulation of Drb1 4 0.53 2.62 1.99 99.28
25 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38 99.28
26 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 99.28
27 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 99.26
28 INT251733 Binding of CD70 1 0.27 0.76 0.22 99.26
29 INT257966 Regulation of GABRQ 1 0.24 0.7 0.24 99.26
30 INT257963 Regulation of GABRE 1 0.35 0.69 0.24 99.26
31 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.24
32 INT2415 Binding of MAOA 26 0.47 13.26 11.86 99.20
33 INT109095 Binding of Drd4 7 0.40 3.6 3.18 99.20
34 INT99653 Gene_expression of CACNA1I 2 0.29 2.22 1.34 99.20
35 INT123536 Positive_regulation of MTHFR 7 0.57 4.74 1 99.12
36 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.04
37 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 99.04
38 INT11374 Gene_expression of Es2 7 0.67 3.27 2.89 98.96
39 INT39948 Binding of FLNA 45 0.42 58.05 4.27 98.92
40 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 98.92
41 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 98.76
42 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 98.72
43 INT178890 Localization of CHDH 12 0.62 15.76 1.49 98.72
44 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04 98.68
45 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 98.64
46 INT76417 Positive_regulation of Positive_regulation of Il4 3 0.09 0.34 1.7 98.64
47 INT11375 Negative_regulation of Es2 10 0.50 6.52 5.64 98.60
48 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 98.56
49 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 98.56
50 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 98.52
51 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 98.52
52 INT69303 Positive_regulation of Gene_expression of Il4 27 0.68 20.01 14.8 98.52
53 INT76416 Positive_regulation of Gene_expression of Il5 9 0.08 4.16 1.65 98.52
54 INT27170 Gene_expression of Maoa 13 0.67 3.88 7.5 98.32
55 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23 98.32
56 INT93244 Localization of CSAD 2 0.60 1.59 1 98.22
57 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 98.20
58 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 98.20
59 INT135568 Localization of CHM 5 0.65 6.51 1.76 98.20
60 INT66617 Localization of HTR2A 6 0.80 1.35 3.32 98.12
61 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7 98.08
62 INT96779 Regulation of Gene_expression of Il5 2 0.42 2.05 0.52 98.04
63 INT20664 Binding of ACE 60 0.48 35.27 9.16 98.00
64 INT142049 Regulation of Mthfr 6 0.41 4.73 2 97.96
65 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 97.88
66 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 97.80
67 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 97.76
68 INT5166 Binding of Ldlr 14 0.48 11.95 3.32 97.64
69 INT50038 Positive_regulation of Il5 11 0.41 6.89 3.49 97.60
70 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27 97.24
71 INT155639 Regulation of Negative_regulation of Mthfr 1 0.56 0.76 0.66 97.16
72 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 97.12
73 INT191164 Gene_expression of CD70 5 0.66 3.01 0.59 97.12
74 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 96.96
75 INT6481 Binding of TNF 624 0.48 510.2 214.82 96.96
76 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 96.92
77 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14 96.92
78 INT76415 Regulation of Il5 6 0.18 3.56 1.4 96.84
79 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 96.60
80 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 96.56
81 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 96.56
82 INT23366 Positive_regulation of Tshb 10 0.50 4.11 1.79 96.56
83 INT67724 Regulation of Gene_expression of ISYNA1 14 0.51 5.99 3.62 96.56
84 INT101883 Regulation of Gene_expression of Nos3 11 0.52 6.71 2.73 96.56
85 INT186510 Localization of KCNN3 3 0.75 1.6 1.66 96.52
86 INT59 Regulation of Adrb1 25 0.42 8.32 9.78 96.44
87 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88 96.44
88 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 96.40
89 INT109447 Gene_expression of Mir677 1 0.00 0.86 0.86 96.36
90 INT198059 Positive_regulation of CACNA1I 1 0.34 2.46 1.15 96.28
91 INT847 Regulation of Lhb 131 0.61 22.08 46.54 96.20
92 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 96.16
93 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 96.16
94 INT137276 Binding of Acads 3 0.32 1.82 0.84 96.12
95 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 96.00
96 INT619 Positive_regulation of Positive_regulation of Prl 116 0.70 22.69 45.06 96.00
97 INT162 Regulation of Prl 794 0.62 165.01 322.24 95.96
98 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 95.92
99 INT67710 Binding of Sepp1 3 0.41 1.77 1.83 95.80
100 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38 95.72
101 INT15888 Positive_regulation of Nbr1 42 0.69 35.76 10.48 95.52
102 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 95.44
103 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 95.44
104 INT35493 Positive_regulation of Negative_regulation of PPBP 2 0.49 1.5 0.98 95.44
105 INT54969 Binding of Sult1a1 4 0.35 1.4 2.18 95.36
106 INT214418 Negative_regulation of Gene_expression of KCNJ10 1 0.31 0.57 0.38 95.16
107 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01 95.04
108 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55 95.04
109 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 95.00
110 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97 95.00
111 INT11703 Regulation of Es2 7 0.39 3.23 4.91 95.00
112 INT198062 Regulation of CACNA1I 1 0.20 2.94 1.03 94.88
113 INT197360 Regulation of MCAT 6 0.09 7.86 1.78 94.88
114 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 94.88
115 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 94.68
116 INT251734 Localization of CD70 1 0.69 3.93 2.42 94.64
117 INT214416 Gene_expression of KCNJ10 1 0.48 0.57 0.38 94.64
118 INT38963 Binding of Lsd 7 0.41 1.91 4.12 94.60
119 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 94.44
120 INT15092 Positive_regulation of SLC6A4 17 0.67 7.32 6.7 94.36
121 INT67228 Regulation of Gene_expression of Il4 11 0.50 6.67 5.2 94.36
122 INT132153 Transcription of Drb1 1 0.63 0.6 0.55 94.12
123 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 93.96
124 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 93.88
125 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 93.84
126 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 93.80
127 INT23401 Gene_expression of HLA-DOA 91 0.30 38.21 5.52 93.80
128 INT6596 Positive_regulation of HLA-DRB1 33 0.61 27.01 7.26 93.52
129 INT58484 Regulation of Il4 12 0.45 8.67 6.09 93.52
130 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 93.40
131 INT18412 Binding of PLEK 49 0.47 17.82 10.72 93.36
132 INT72535 Binding of Maob 3 0.42 1.98 1.73 93.36
133 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 93.32
134 INT8699 Gene_expression of Nka1 45 0.67 6.41 22.56 93.32
135 INT3840 Negative_regulation of FCGR3B 18 0.59 8.9 5.97 93.08
136 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 92.80
137 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8 92.68
138 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 92.40
139 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 92.16
140 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 92.16
141 INT5711 Positive_regulation of Localization of Lhb 90 0.70 10.92 36.76 91.88
142 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57 91.88
143 INT62916 Gene_expression of HTR1F 12 0.75 3.25 5.24 91.88
144 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 91.76
145 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 91.76
146 INT73594 Positive_regulation of Gene_expression of ISYNA1 61 0.55 31.35 13.45 91.56
147 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99 91.56
148 INT90268 Regulation of Drb1 2 0.41 1.46 1.08 91.44
149 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 91.36
150 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3 91.32
151 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 91.20
152 INT57606 Negative_regulation of Cyb5r1 1 0.03 0.52 0.56 91.12
153 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 91.04
154 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 91.00
155 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41 90.96
156 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 90.92
157 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47 90.84
158 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 90.68
159 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 90.68
160 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 90.44
161 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02 90.32
162 INT138833 Binding of MTHFR 12 0.46 16.08 6.4 90.16
163 INT32117 Binding of us 5 0.23 3.61 3.91 89.88
164 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 89.72
165 INT83035 Binding of INSR 16 0.47 9.29 4.11 89.44
166 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 89.44
167 INT13501 Binding of Drd2 65 0.48 23.76 35.6 89.40
168 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07 89.28
169 INT7232 Regulation of Negative_regulation of Lhb 9 0.45 3.63 3.29 88.96
170 INT17217 Regulation of Negative_regulation of Gnrh1 5 0.31 2.56 3.78 88.96
171 INT738 Regulation of POMC 459 0.62 111.19 243.74 88.96
172 INT68017 Gene_expression of Ea2 4 0.23 3.15 2.11 88.68
173 INT123903 Gene_expression of ATXN3 7 0.75 6.71 1.85 88.68
174 INT144782 Gene_expression of LY6E 2 0.01 1.67 1.12 88.68
175 INT144781 Gene_expression of Etax2 1 0.01 1.68 1.09 88.68
176 INT24445 Gene_expression of FBF1 2 0.35 2.73 3.63 88.48
177 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 88.40
178 INT257960 Gene_expression of GABRQ 1 0.40 0.81 0.36 88.28
179 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 88.28
180 INT1530 Regulation of Gh 382 0.61 115.96 112.47 88.28
181 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8 88.24
182 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 87.68
183 INT5118 Regulation of SST 97 0.62 34.35 51.74 87.68
184 INT78626 Regulation of Gdnf 7 0.45 3.3 4.64 87.68
185 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 87.60
186 INT10888 Binding of Vwf 32 0.46 22.87 5.21 87.60
187 INT158 Localization of Prl 2431 0.81 378.96 952.2 87.36
188 INT3830 Positive_regulation of FCGR3B 27 0.67 15.18 10.49 87.16
189 INT49774 Binding of DRD2 48 0.48 17.42 20.73 86.76
190 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 86.72
191 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 86.52
192 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9 86.52
193 INT198060 Localization of CACNA1I 1 0.37 0.71 0.32 86.16
194 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 86.08
195 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 86.08
196 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 85.24
197 INT251735 Binding of FEN1 1 0.17 1.13 0.74 85.20
198 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 85.08
199 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54 85.00
200 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 84.88
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