D:Natriuresis

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Disease Term
Synonyms Disorder Of Sodium Metabolism, Extracellular Fluid Volume Contraction, EXTRACELLULAR VOLUME EXPANSION, Natriureses, NATRIURETIC, Sodium Balance, SODIUM IMBALANCE
Documents 1202
Hot Single Events 200
Hot Interactions 95

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Natriuresis. They are ordered first by their relevance to Natriuresis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT7296 Binding of HCLS1 and NPPA 1 0.02 1.65 0.15 100.00
2 INT7302 Binding of NPPA and Nppa 1 0.13 1.25 0.11 100.00
3 INT14790 Nppa Regulation of Edn3 1 0.45 0.7 0 100.00
4 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4 100.00
5 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4 100.00
6 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1 100.00
7 INT42154 NPPA Regulation of Gene_expression of TUBA4A 1 0.04 0.68 0.1 100.00
8 INT42153 NPPA Regulation of TUBA4A 1 0.04 0.68 0.1 100.00
9 INT32494 Nppa Negative_regulation of Localization of Avp 1 0.28 1.16 0.18 100.00
10 INT7303 HCLS1 Negative_regulation of Binding of NPPA and Nppa 1 0.01 0.42 0.04 100.00
11 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37 100.00
12 INT25430 Gtf3a Regulation of Nppa 1 0.24 0.57 0.43 100.00
13 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19 100.00
14 INT154356 Binding of Nppc and ITS 1 0.00 0.85 0.35 100.00
15 INT32698 Nppa Regulation of Oxt 1 0.57 0.35 0.35 100.00
16 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35 100.00
17 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07 100.00
18 INT146722 Cnp Positive_regulation of Positive_regulation of Oprl1 1 0.17 0.34 0.07 100.00
19 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14 100.00
20 INT14794 Edn3 Negative_regulation of Gfra1 1 0.06 0.25 0 100.00
21 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22 100.00
22 INT158391 Oxt Positive_regulation of Localization of Nppa 2 0.27 0.64 0.03 100.00
23 INT208937 Nfkb1 Positive_regulation of Gene_expression of Nppa 1 0.04 0.38 0.08 100.00
24 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08 100.00
25 INT25431 Gtf3a Regulation of Sald1 1 0.03 0.2 0.09 100.00
26 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05 100.00
27 INT10906 Agt Regulation of Localization of Nppb 1 0.10 0.19 0.1 100.00
28 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18 100.00
29 INT14792 Edn3 Regulation of Nppa 1 0.17 0.17 0 100.00
30 INT32564 Gtf3a Negative_regulation of Localization of Gnrh1 1 0.05 0.2 0.05 99.98
31 INT16413 Nppa Regulation of Localization of LH 1 0.43 0.76 0.45 99.80
32 INT177676 Binding of Trib3 and Myo1f Positive_regulation of Trib3 1 0.00 0.3 0.1 99.56
33 INT91075 NPTXR Positive_regulation of BHLHE22 1 0.54 0.1 0.6 99.42
34 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33 99.38
35 INT71755 Nppa Regulation of Localization of Alb 1 0.25 1.29 0.11 99.38
36 INT340178 Car2 Positive_regulation of Positive_regulation of Nos3 1 0.01 0.26 0 99.24
37 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24 99.04
38 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27 99.00
39 INT10902 Edn1 Regulation of Avp 1 0.27 0.35 0 98.96
40 INT10905 Edn1 Regulation of Agt 1 0.11 0.35 0 98.96
41 INT82094 Binding of KNG1 and CLPP 1 0.03 0.42 0.21 98.68
42 INT239402 Binding of NPPA and ASAP1 1 0.19 1.24 0.04 98.40
43 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54 97.48
44 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22 97.16
45 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22 97.16
46 INT51719 Nppa Regulation of Regulation of Pomc 1 0.14 0.1 0.07 96.92
47 INT5645 Sult2a1 Positive_regulation of Positive_regulation of IGKV2-29 1 0.00 0.39 0.22 96.80
48 INT5646 Sult2a1 Positive_regulation of IGKV2-29 1 0.00 0.39 0.22 96.80
49 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 96.12
50 INT16355 GH1 Positive_regulation of IGF1 1 0.24 0.25 0 95.48
51 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12 94.96
52 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68 93.20
53 INT16411 Nppb Regulation of Localization of LH 1 0.34 0.49 0.41 91.68
54 INT16414 Nppa Regulation of Nppb 1 0.24 0.26 0.05 91.68
55 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57 90.84
56 INT10903 Apoa2 Positive_regulation of Nppb 1 0.08 0.17 0 90.80
57 INT10910 Apoa2 Positive_regulation of Apoa2 Positive_regulation of Nppb 1 0.02 0.17 0 90.80
58 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 90.48
59 INT11124 Nppa Negative_regulation of Thop1 Positive_regulation of Nppa 1 0.23 0.4 0 90.04
60 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22 89.52
61 INT11122 Nppa Negative_regulation of Thop1 1 0.20 0.4 0 89.40
62 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07 89.36
63 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11 89.20
64 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07 88.76
65 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65 88.72
66 INT79486 Nppa Negative_regulation of NA 1 0.03 1.83 0.41 88.64
67 INT10909 Edn1 Positive_regulation of Nppb 1 0.39 0.16 0 88.64
68 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23 88.24
69 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51 87.32
70 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0 87.16
71 INT146720 Cck Regulation of Cnp 1 0.12 0.43 0.21 86.48
72 INT306921 Ang Positive_regulation of Gene_expression of Ephx2 1 0.15 0.79 0.12 86.48
73 INT107814 Nppa Positive_regulation of Positive_regulation of Sst 1 0.42 0.16 0.55 85.80
74 INT247656 Binding of Tnnc1 and Gdf15 1 0.02 0.94 0.16 85.72
75 INT196627 IL1B Regulation of DNAH8 1 0.00 0.63 0.09 85.28
76 INT196643 IL1B Regulation of NA 1 0.00 0.63 0.09 85.28
77 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12 85.04
78 INT196619 KNG1 Regulation of DNAH8 1 0.00 0.62 0.09 84.92
79 INT196645 KNG1 Regulation of NA 1 0.00 0.62 0.09 84.92
80 INT191497 Binding of REN and NLRP3 1 0.02 0.55 0.27 83.64
81 INT345298 NLRP3 Positive_regulation of Localization of Edn1 1 0.01 0.94 0.03 83.04
82 INT97223 Gm9902 Regulation of Negative_regulation of Mme 1 0.00 0.61 0 83.00
83 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32 82.28
84 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32 82.28
85 INT196605 Binding of DNAH8 and SPANXB1 Positive_regulation of DNAH8 1 0.00 0.08 0.3 82.28
86 INT196604 Binding of DNAH8 and SPANXB1 Positive_regulation of NA 1 0.00 0.08 0.3 82.28
87 INT196613 Binding of KNG1 and NA 1 0.01 0.08 0.27 81.92
88 INT196616 Binding of NA and SPANXB1 1 0.00 0.08 0.27 81.92
89 INT196626 Binding of DNAH8 and KNG1 1 0.00 0.08 0.27 81.72
90 INT196637 Binding of DNAH8 and SPANXB1 1 0.00 0.08 0.27 81.72
91 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23 80.88
92 INT32700 Nppa Negative_regulation of Oxt 1 0.40 0.16 0.19 80.56
93 INT32696 Nppa Negative_regulation of Avp 1 0.45 0.16 0.19 80.56
94 INT32697 Nppa Negative_regulation of Gene_expression of Oxt 1 0.40 0.16 0.19 80.56
95 INT327727 Atp6v0a2 Negative_regulation of Gene_expression of Kit 1 0.05 0.83 0.41 80.40
96 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47 79.60
97 INT32195 Itga7 Negative_regulation of Mbp 1 0.04 0.32 0 79.56
98 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29 78.96
99 INT196612 Binding of KNG1 and Negative_regulation of NA 1 0.01 0.19 0.29 78.96
100 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27 78.64
101 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26 78.64
102 INT340174 Binding of Oxt and Avpr1b 1 0.34 0.13 0 76.56
103 INT340177 Binding of Oxt and Avpr1a 6 0.15 2.24 0.29 76.08
104 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0 75.00
105 INT7295 HCLS1 Positive_regulation of NPPA 1 0.02 0.44 0.09 75.00
106 INT16412 Nppa Negative_regulation of Localization of LH 2 0.41 0.29 0.62 75.00
107 INT30706 Nppa Positive_regulation of Localization of AVP 1 0.78 0.45 0.3 75.00
108 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57 75.00
109 INT98237 Pde2a Negative_regulation of LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0 75.00
110 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0 75.00
111 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42 75.00
112 INT16410 Nppb Negative_regulation of Localization of LH 1 0.37 0.21 0.38 75.00
113 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46 75.00
114 INT9086 Binding of Nppa and Nppb 1 0.35 0.19 0.08 75.00
115 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0 75.00
116 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0 75.00
117 INT139004 Mtpn Regulation of NFKB1 1 0.33 0.55 0 75.00
118 INT107810 Sst Positive_regulation of Localization of Nppa 1 0.42 0.14 0.77 75.00
119 INT30705 Nppa Negative_regulation of Localization of AVP 1 0.48 0.22 0.15 75.00
120 INT10908 Avp Positive_regulation of Localization of Nppb 1 0.42 0.23 0 75.00
121 INT10907 Apoa2 Positive_regulation of Localization of Nppb 1 0.09 0.23 0 75.00
122 INT20587 Nppa Positive_regulation of Gfra1 1 0.02 0.32 0.26 75.00
123 INT26367 POMC Regulation of Localization of NPPA 1 0.28 0.29 0.16 75.00
124 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33 75.00
125 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28 75.00
126 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11 75.00
127 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27 75.00
128 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69 75.00
129 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22 75.00
130 INT5627 Tfpi Positive_regulation of Localization of Nppa 1 0.31 0.07 0.1 75.00
131 INT5626 Tfpi Positive_regulation of Transcription of Nppa 1 0.31 0.07 0.1 75.00
132 INT196640 PTGER2 Negative_regulation of DNAH8 1 0.00 0.46 0.08 74.76
133 INT196611 PTGER2 Negative_regulation of NA 1 0.00 0.46 0.08 74.76
134 INT240129 Binding of Nppb and Crp 1 0.21 1.02 0.32 74.48
135 INT340180 Binding of Avp and Oxt 3 0.17 0.57 0 74.08
136 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12 73.68
137 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34 73.04
138 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09 73.04
139 INT191499 CMA1 Positive_regulation of NLRP3 1 0.02 0.42 0.3 72.68
140 INT191502 Binding of CMA1 and NLRP3 1 0.01 0.42 0.3 72.68
141 INT191504 CPN2 Positive_regulation of NLRP3 1 0.00 0.37 0.27 72.32
142 INT191498 Binding of CTSG and NLRP3 1 0.07 0.37 0.25 71.60
143 INT191496 CTSG Positive_regulation of NLRP3 1 0.09 0.37 0.25 71.60
144 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18 71.04
145 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 71.00
146 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 71.00
147 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55 71.00
148 INT191536 Klk1c2 Positive_regulation of NLRP3 1 0.02 0.36 0.24 70.96
149 INT191537 Binding of Klk1c2 and NLRP3 1 0.02 0.36 0.24 70.96
150 INT171825 Binding of Prkcg and Ncs1 1 0.00 0.07 0.66 69.96
151 INT171824 Binding of Ncs1 and Aspm 1 0.00 0.07 0.65 69.96
152 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68 69.76
153 INT222558 Mzb1 Regulation of Localization of Prl 1 0.13 0.14 0.1 69.64
154 INT171400 Binding of Adcyap1 and Prkcg 1 0.01 0.24 0.08 69.04
155 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23 68.68
156 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32 68.12
157 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 67.60
158 INT245503 SST Regulation of Gene_expression of CSF2 1 0.06 0.67 0.39 67.56
159 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0 67.04
160 INT171399 Binding of Npr1 and Prkcg 1 0.00 0.23 0.04 65.68
161 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04 65.32
162 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 64.16
163 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0 63.44
164 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5 62.72
165 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41 62.28
166 INT100127 ADM Positive_regulation of PRL 1 0.28 0.51 0.08 62.24
167 INT191500 ACE Positive_regulation of Localization of KNG1 1 0.10 0.17 0.24 61.64
168 INT340179 Binding of Oxt and Oxtr 10 0.31 2.53 0.19 61.60
169 INT122710 GUCA2A Positive_regulation of RTCA 1 0.03 0.16 0.05 61.44
170 INT122713 Guca2b Positive_regulation of RTCA 1 0.03 0.16 0.05 61.44
171 INT323623 Binding of Adm and Edn1 1 0.04 0.77 0.03 61.12
172 INT129074 Binding of GRP and TCHP 1 0.00 0.5 0.12 60.12
173 INT129094 Binding of GRP and Pik3r1 1 0.00 0.49 0.12 60.12
174 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12 60.12
175 INT129092 Binding of GRP and Lyn 1 0.00 0.48 0.12 60.12
176 INT222546 Mzb1 Positive_regulation of Localization of Prl 1 0.10 0.17 0.12 59.72
177 INT196621 PTGER2 Negative_regulation of Gene_expression of DNAH8 1 0.00 0.33 0.28 59.72
178 INT196631 PTGER2 Negative_regulation of NFKB1 1 0.00 0.32 0.28 59.72
179 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42 58.96
180 INT354619 AR Positive_regulation of Gene_expression of Nppa 1 0.00 0.38 0 57.48
181 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34 56.56
182 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 56.40
183 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22 56.32
184 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12 55.88
185 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12 55.88
186 INT129093 Binding of Lyn and TCHP 1 0.00 0.49 0.12 55.88
187 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 55.44
188 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09 55.12
189 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11 54.24
190 INT91087 SST Positive_regulation of Positive_regulation of Prkcg 1 0.29 0.05 0.43 53.36
191 INT222477 Mzb1 Positive_regulation of Gene_expression of Prl 1 0.10 0.1 0.03 52.08
192 INT222515 Gnrh1 Positive_regulation of Localization of Gh1 1 0.05 0.21 0 51.92
193 INT196648 PTGER2 Regulation of DNAH8 1 0.00 0.14 0.12 51.84
194 INT196636 PTGER2 Regulation of NA 1 0.00 0.14 0.12 51.84
195 INT345297 Binding of NAGLU and Lcn2 1 0.01 1.24 0.07 51.80
196 INT345292 Binding of Lcn2 and Havcr1 1 0.00 1.17 0.07 50.52
197 INT317566 Car2 Positive_regulation of Camk2a 2 0.19 0.58 0.32 50.00
198 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03 50.00
199 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03 50.00
200 INT317395 Gopc Regulation of Gene_expression of Car2 2 0.10 0 0.03 50.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Natriuresis. They are ordered first by their pain relevance and then by number of times they were reported in Natriuresis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5617 Localization of Nppa 266 0.81 83.51 83.89 100.00
2 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 100.00
3 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 100.00
4 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 100.00
5 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 100.00
6 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96 100.00
7 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 100.00
8 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 100.00
9 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46 100.00
10 INT16356 Regulation of NPPA 33 0.62 13.24 9.53 100.00
11 INT7132 Localization of NPPA 53 0.81 19.79 10.86 100.00
12 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 100.00
13 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 100.00
14 INT6210 Binding of Nppa 39 0.47 14.35 7.21 100.00
15 INT9085 Localization of Nppb 32 0.81 15.1 3.47 100.00
16 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76 100.00
17 INT214 Localization of AVP 370 0.81 208.51 91.09 100.00
18 INT110039 Positive_regulation of Nppb 38 0.53 34.54 2.88 100.00
19 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82 100.00
20 INT159472 Localization of NPPB 32 0.79 33.67 3.59 100.00
21 INT7297 Binding of NPPA 8 0.45 5.33 0.79 100.00
22 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41 100.00
23 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97 100.00
24 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 100.00
25 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98 100.00
26 INT654 Localization of REN 250 0.81 75.12 47.86 100.00
27 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 100.00
28 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 100.00
29 INT11057 Protein_catabolism of Nppa 11 0.94 3.34 1.47 100.00
30 INT5624 Transcription of Nppa 19 0.69 8.52 4.72 100.00
31 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 100.00
32 INT685 Regulation of AVP 124 0.62 34.9 39.91 100.00
33 INT146995 Binding of NPR2 1 0.43 2.14 0.27 100.00
34 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58 100.00
35 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 100.00
36 INT129534 Gene_expression of Nppb 19 0.58 23.68 1.6 100.00
37 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 100.00
38 INT661 Gene_expression of REN 100 0.78 48.21 11.36 100.00
39 INT55034 Positive_regulation of Adm 27 0.61 14.1 6.13 100.00
40 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 100.00
41 INT45159 Regulation of Nppb 16 0.54 13.57 4.46 100.00
42 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 100.00
43 INT2140 Regulation of REN 104 0.62 28.24 24.49 100.00
44 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
45 INT46 Localization of Ren 233 0.81 46.15 62.44 100.00
46 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 100.00
47 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 100.00
48 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
49 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 100.00
50 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
51 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 100.00
52 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39 100.00
53 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32 100.00
54 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66 100.00
55 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21 100.00
56 INT15155 Regulation of Localization of NPPA 8 0.62 2.67 1.65 100.00
57 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 100.00
58 INT11099 Localization of NPR1 5 0.67 1.49 1.21 100.00
59 INT292 Localization of Penk 876 0.81 88.44 669.14 100.00
60 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 100.00
61 INT6195 Transcription of Npr1 9 0.69 3 5.94 100.00
62 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 100.00
63 INT3962 Regulation of AGT 50 0.62 20.96 13.01 100.00
64 INT7293 Negative_regulation of Binding of Nppa 5 0.43 1.4 0.55 100.00
65 INT935 Localization of Gtf3a 124 0.70 35.72 43.3 100.00
66 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 100.00
67 INT20498 Negative_regulation of Positive_regulation of Nppa 9 0.59 4.5 2.43 100.00
68 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77 100.00
69 INT32269 Gene_expression of TUBA4A 4 0.57 1.47 0.39 100.00
70 INT7300 Negative_regulation of Binding of NPPA 1 0.38 0.83 0.07 100.00
71 INT1158 Regulation of Agt 106 0.61 29.4 30.29 100.00
72 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 100.00
73 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 100.00
74 INT11098 Regulation of NPR1 5 0.37 1.39 1.74 100.00
75 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13 100.00
76 INT5621 Positive_regulation of Transcription of Nppa 5 0.50 4.97 0.74 100.00
77 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93 100.00
78 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 100.00
79 INT8989 Binding of Npr1 25 0.36 5.52 14.58 100.00
80 INT109081 Localization of Nppa 9 0.59 2.72 0.61 100.00
81 INT76401 Localization of Nppc 2 0.54 1.09 0.24 100.00
82 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
83 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98 100.00
84 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81 100.00
85 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 100.00
86 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 100.00
87 INT11058 Positive_regulation of Protein_catabolism of Nppa 1 0.37 0.53 0.17 100.00
88 INT155889 Binding of Nps 22 0.42 9.79 2.6 100.00
89 INT159128 Localization of Nps 12 0.69 5.18 1.74 100.00
90 INT105134 Regulation of Ralbp1 1 0.23 1.5 0.26 100.00
91 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 100.00
92 INT81136 Binding of Npr1 6 0.48 1.45 1.15 100.00
93 INT4153 Binding of Insrr 109 0.40 17.99 72.15 100.00
94 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 100.00
95 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 100.00
96 INT15587 Protein_catabolism of NPPA 4 0.71 1.55 0.87 100.00
97 INT65558 Regulation of Nppc 1 0.21 0.79 0.44 100.00
98 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 100.00
99 INT398 Localization of AGT 45 0.78 16.97 11.54 100.00
100 INT76402 Gene_expression of Nppc 2 0.30 1.8 0.17 100.00
101 INT170161 Localization of NPPC 2 0.62 2.06 0.32 100.00
102 INT7134 Localization of KNG1 127 0.79 65.73 67.97 100.00
103 INT116066 Positive_regulation of Nppc 1 0.02 0.44 0.39 100.00
104 INT10168 Positive_regulation of Localization of Gtf3a 16 0.60 3.55 3.75 100.00
105 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82 100.00
106 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57 100.00
107 INT5743 Localization of NA 104 0.59 14.35 35.29 100.00
108 INT25540 Regulation of TGM2 3 0.28 0.33 0.73 100.00
109 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 100.00
110 INT145960 Positive_regulation of GLP1R 19 0.58 7.25 1.19 100.00
111 INT933 Regulation of Localization of Gtf3a 6 0.11 2.3 1.47 100.00
112 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 100.00
113 INT5625 Regulation of Transcription of Nppa 2 0.26 0.29 0.46 100.00
114 INT153077 Positive_regulation of Gene_expression of Nppa 9 0.40 5.07 0.13 100.00
115 INT159473 Regulation of Localization of NPPB 2 0.61 1 0.25 100.00
116 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63 100.00
117 INT82097 Protein_catabolism of CORIN 1 0.23 0.35 0.21 100.00
118 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 100.00
119 INT16358 Positive_regulation of Negative_regulation of NPPA 2 0.41 0.83 0.21 100.00
120 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39 100.00
121 INT323622 Gene_expression of Amh 1 0.01 1.91 0 100.00
122 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 100.00
123 INT51718 Positive_regulation of Negative_regulation of Nppa 3 0.47 0.79 0.57 100.00
124 INT148536 Regulation of Nppb 2 0.19 0.31 0.33 100.00
125 INT32194 Positive_regulation of Itga7 1 0.05 0.38 0.1 100.00
126 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 100.00
127 INT83712 Transcription of Nos3 19 0.69 13.09 6.31 100.00
128 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 100.00
129 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85 100.00
130 INT8718 Regulation of Mcc 1 0.19 0.52 0.66 100.00
131 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68 100.00
132 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 100.00
133 INT11732 Negative_regulation of Gtf3a 25 0.30 15.73 8.5 100.00
134 INT27835 Regulation of Positive_regulation of Ren 10 0.44 2.27 2.38 100.00
135 INT32618 Regulation of Positive_regulation of Agt 2 0.43 0.42 0.52 100.00
136 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33 100.00
137 INT71562 Regulation of Regulation of Fabp6 2 0.04 0.4 0 100.00
138 INT5118 Regulation of SST 97 0.62 34.35 51.74 100.00
139 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 100.00
140 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 100.00
141 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
142 INT2212 Binding of Abat 89 0.48 18.36 63.99 100.00
143 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 100.00
144 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
145 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 100.00
146 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 100.00
147 INT3076 Regulation of KNG1 52 0.60 20.39 27.89 100.00
148 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 100.00
149 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 100.00
150 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61 100.00
151 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5 100.00
152 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89 100.00
153 INT60999 Localization of Nos3 12 0.74 5.28 1.75 100.00
154 INT63959 Regulation of Tnni3 11 0.21 4.69 1.57 100.00
155 INT36588 Protein_catabolism of Calca 7 0.87 1.98 1.31 100.00
156 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 100.00
157 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95 100.00
158 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95 100.00
159 INT15109 Gene_expression of H6PD 9 0.65 7.21 0.93 100.00
160 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88 100.00
161 INT145957 Positive_regulation of Localization of GLP1R 5 0.43 2.12 0.61 100.00
162 INT242986 Positive_regulation of Gene_expression of Nppb 3 0.26 2.77 0.5 100.00
163 INT17158 Regulation of Protein_catabolism of Nppa 1 0.24 0.1 0.28 100.00
164 INT77031 Gene_expression of LIPG 4 0.51 4.32 0.26 100.00
165 INT162634 Positive_regulation of Localization of Nppb 1 0.08 0.93 0.25 100.00
166 INT162633 Localization of Nppb 1 0.12 0.93 0.25 100.00
167 INT92135 Positive_regulation of Transcription of NPPA 1 0.03 1.17 0.2 100.00
168 INT92134 Transcription of NPPA 1 0.04 1.15 0.19 100.00
169 INT118575 Positive_regulation of G6PD 9 0.50 3.35 0.18 100.00
170 INT329791 Negative_regulation of Protein_catabolism of Calca 1 0.21 1.17 0.1 100.00
171 INT118576 Positive_regulation of H6PD 2 0.45 0.49 0.1 100.00
172 INT118574 Positive_regulation of Gene_expression of G6PD 2 0.49 0.33 0.1 100.00
173 INT175695 Positive_regulation of Gene_expression of Nppc 1 0.06 1.06 0.07 100.00
174 INT157584 Negative_regulation of Nppb 2 0.25 0.63 0.05 100.00
175 INT175696 Positive_regulation of Localization of Klk1 1 0.49 0.6 0.04 100.00
176 INT175697 Localization of Klk1 1 0.73 0.59 0.04 100.00
177 INT175698 Positive_regulation of Localization of Nos3 2 0.27 1.19 0.04 100.00
178 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61 99.98
179 INT50929 Positive_regulation of hs 4 0.24 4.5 1.32 99.98
180 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32 99.96
181 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74 99.96
182 INT11157 Binding of EGF 88 0.48 53.73 21.25 99.92
183 INT2036 Localization of EGF 42 0.77 21.5 9.74 99.92
184 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16 99.92
185 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03 99.90
186 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 99.84
187 INT3579 Localization of Oxt 555 0.81 43.35 292.44 99.84
188 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 99.84
189 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 99.84
190 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.84
191 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5 99.84
192 INT154197 Positive_regulation of Prkg1 2 0.44 1.32 1.12 99.84
193 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69 99.82
194 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 99.82
195 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 99.80
196 INT76403 Gene_expression of Cnp 16 0.70 8.36 3.07 99.80
197 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 99.80
198 INT110040 Binding of Nppb 9 0.18 8.91 0.19 99.80
199 INT76404 Localization of Cnp 4 0.68 0.87 0.68 99.80
200 INT139281 Gene_expression of VIPR2 3 0.74 0.88 0.2 99.80
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