D:Neck Pain

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Disease Term
Synonyms Ache Neck, Aches Neck, Anterior Cervical Pain, Anterior Cervical Pains, Anterior Neck Pain, Anterior Neck Pains, Cervical Pain, Cervical Pain Anterior, Cervical Pain Posterior, Cervical Pains, Cervical Pains Anterior
Documents 3692
Hot Single Events 145
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neck Pain. They are ordered first by their relevance to Neck Pain and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5 100.00
2 INT165305 CSF2 Positive_regulation of Localization of CCBE1 1 0.06 1.34 0.35 96.56
3 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 84.32
4 INT164249 Binding of MPZ and Mpz 1 0.06 2.13 0.24 83.20
5 INT326438 Binding of HFE and TAPVR1 1 0.01 0.48 0.29 76.96
6 INT117419 Binding of AVPR2 and TSKU 1 0.39 0.21 0 71.08
7 INT281733 LTK Regulation of IgG 1 0.00 1.37 0.03 5.80
8 INT245572 Binding of AVPR2 and SPECC1 1 0.10 0.75 0.75 5.00
9 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64 5.00
10 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57 5.00
11 INT239573 Binding of DPF1 and AIS 1 0.02 0.74 0.31 5.00
12 INT268236 Binding of TNF and fc 1 0.04 0.2 0.29 5.00
13 INT239570 Binding of PDGFC and AIS 1 0.04 0.9 0.26 5.00
14 INT239572 DPF1 Positive_regulation of AIS 1 0.02 0.71 0.24 5.00
15 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24 5.00
16 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
17 INT195424 SNRNP70 Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
18 INT239571 Binding of PDGFC and IGSF10 1 0.00 0.34 0.08 5.00
19 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 5.00
20 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 5.00
21 INT197761 Binding of KRT5 and C4a 1 0.02 2.29 0 5.00
22 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0 5.00
23 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0 5.00
24 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
25 INT262413 Binding of EPHB1 and ADHD1 1 0.17 0.1 0 5.00
26 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neck Pain. They are ordered first by their pain relevance and then by number of times they were reported in Neck Pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT253864 Negative_regulation of PNP 13 0.26 6.84 6.67 100.00
2 INT174232 Gene_expression of PNP 36 0.30 8.74 3.17 100.00
3 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 100.00
4 INT311241 Transcription of Myo5a 1 0.50 1.61 1.37 100.00
5 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 100.00
6 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 100.00
7 INT64700 Binding of Nf1 14 0.45 15.24 2.29 100.00
8 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 100.00
9 INT209122 Binding of KCNK9 1 0.36 0.3 0.2 100.00
10 INT105824 Regulation of Casq1 4 0.07 2.66 2.1 99.96
11 INT263074 Positive_regulation of TAPVR1 2 0.43 2.73 1.97 99.92
12 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 99.90
13 INT232316 Regulation of CNTN3 1 0.26 0.28 0.28 99.86
14 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 99.82
15 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 99.82
16 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 99.80
17 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 99.80
18 INT232323 Regulation of SMCP 1 0.23 3.07 3.06 99.80
19 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 99.78
20 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 99.60
21 INT148389 Regulation of Localization of Csda 1 0.26 0.63 0.52 99.56
22 INT148388 Localization of Csda 1 0.47 0.63 0.52 99.56
23 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.48
24 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.48
25 INT232318 Regulation of C12orf39 1 0.04 0.28 0.28 99.46
26 INT118883 Positive_regulation of LRMP 1 0.45 1.49 1.81 99.40
27 INT210886 Localization of TNS3 2 0.62 1.26 2.1 99.16
28 INT212358 Regulation of Localization of TNS3 1 0.37 0.98 0.91 99.16
29 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42 99.12
30 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.92
31 INT221762 Regulation of Gene_expression of Adrm1 4 0.07 4.45 2.42 98.76
32 INT221763 Regulation of Gene_expression of TSKU 1 0.14 3.03 1.85 98.76
33 INT125980 Binding of CFD 8 0.42 10.96 1.39 98.68
34 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 98.56
35 INT143494 Binding of DCPS 24 0.29 24.41 3.67 98.44
36 INT240681 Positive_regulation of AVPR2 3 0.41 0.87 0.29 98.44
37 INT113916 Localization of C2 4 0.60 1.88 0.32 98.24
38 INT8794 Negative_regulation of Ppt1 35 0.57 6.44 14.52 98.20
39 INT53316 Localization of Ppt1 5 0.65 1.59 1.32 98.20
40 INT134106 Positive_regulation of SPECC1 14 0.68 9.44 8.09 98.16
41 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 98.08
42 INT71760 Binding of CSE 9 0.48 2.84 5.42 97.84
43 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 97.72
44 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 97.68
45 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 97.68
46 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 97.68
47 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 97.68
48 INT130428 Gene_expression of TSKU 11 0.65 8.02 4.81 97.60
49 INT212563 Gene_expression of Adrm1 26 0.13 11.46 3.58 97.60
50 INT91648 Binding of SPECC1 7 0.48 22.42 19.36 97.52
51 INT22738 Negative_regulation of DYNLL1 17 0.57 6.68 2.06 97.36
52 INT14690 Localization of CSF2 124 0.80 85.17 27.26 97.12
53 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 97.08
54 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 97.08
55 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 97.08
56 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 97.08
57 INT68188 Gene_expression of TNNI1 5 0.75 5.17 1.72 97.08
58 INT169171 Transcription of PSMA7 1 0.67 0.49 0.13 96.68
59 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 96.64
60 INT165306 Localization of CCBE1 1 0.09 1.34 0.35 96.56
61 INT2541 Binding of Calca 200 0.48 67.14 134.62 96.24
62 INT71418 Binding of CES1 42 0.40 29.78 5.01 96.20
63 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 96.16
64 INT155225 Negative_regulation of MYRIP 1 0.42 0.71 0.31 95.80
65 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 95.20
66 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 94.92
67 INT94629 Negative_regulation of ZNRF1 6 0.36 3.08 1.34 94.84
68 INT27627 Binding of Rac1 41 0.41 22.88 13.68 94.04
69 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 93.80
70 INT425 Localization of PRL 455 0.81 189.64 144.8 93.36
71 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 93.28
72 INT97885 Regulation of LOC500077 7 0.16 2.93 4.33 93.16
73 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 93.08
74 INT145970 Negative_regulation of MSD 11 0.50 4.7 2.26 93.00
75 INT186094 Binding of Mri1 14 0.20 7.8 2.35 92.96
76 INT215987 Regulation of Mri1 4 0.30 2.1 1.54 92.96
77 INT118884 Gene_expression of IRF1 5 0.66 2.71 2 92.88
78 INT118882 Positive_regulation of Gene_expression of IRF1 1 0.49 1.35 1.92 92.88
79 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 92.76
80 INT107074 Gene_expression of C5 14 0.75 9.87 3.64 92.56
81 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 92.20
82 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 91.76
83 INT1721 Negative_regulation of HP 148 0.42 86.82 16.89 91.68
84 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 91.60
85 INT14857 Negative_regulation of Gene_expression of Ppt1 7 0.42 1.16 3.3 91.56
86 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 91.44
87 INT3364 Binding of SGCG 87 0.47 31.93 17.24 91.28
88 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 91.20
89 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83 90.40
90 INT21167 Regulation of NCF1 3 0.15 0.75 1.24 90.40
91 INT152616 Gene_expression of SPECC1 8 0.66 8.43 4.32 90.28
92 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 90.08
93 INT263073 Gene_expression of TAPVR1 6 0.58 4.66 2.61 90.04
94 INT232317 Gene_expression of C12orf39 4 0.75 2.21 2.16 89.88
95 INT195205 Positive_regulation of PEX1 1 0.06 1.18 0.2 89.60
96 INT6481 Binding of TNF 624 0.48 510.2 214.82 89.60
97 INT68216 Binding of NF1 40 0.48 51.24 4.59 89.32
98 INT223837 Gene_expression of Nid1 2 0.03 0.68 0.35 89.32
99 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 89.16
100 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62 89.16
101 INT92426 Gene_expression of Ts1 10 0.58 6.14 0.59 89.12
102 INT134974 Negative_regulation of Gene_expression of Ts1 2 0.31 1.34 0.09 89.12
103 INT6507 Binding of C5 23 0.48 15.35 3.91 88.64
104 INT131066 Binding of C6 4 0.31 1.81 0.86 88.64
105 INT118583 Positive_regulation of IRF1 10 0.68 3.75 3.91 88.56
106 INT112326 Binding of Aqp2 3 0.11 1.01 0.69 88.52
107 INT101941 Positive_regulation of PNMA2 2 0.41 0.99 1.18 88.48
108 INT107653 Gene_expression of ACAT1 9 0.60 4.74 1.03 87.64
109 INT107652 Gene_expression of C7 4 0.60 2.06 0.56 87.64
110 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 87.56
111 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 87.56
112 INT168234 Negative_regulation of Col4a3bp 1 0.28 0.24 0.21 87.32
113 INT162295 Positive_regulation of EPHX2 1 0.70 2.53 0.52 86.88
114 INT202716 Gene_expression of NMS 4 0.49 4.56 0.57 86.48
115 INT31341 Positive_regulation of CSE 15 0.60 11.57 12.29 86.40
116 INT105722 Binding of Kctd1 4 0.35 4.4 0.43 86.32
117 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 86.28
118 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 85.64
119 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99 85.52
120 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.28
121 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 85.24
122 INT53493 Negative_regulation of C6 3 0.53 2.68 1.77 85.16
123 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24 85.12
124 INT263075 Negative_regulation of TAPVR1 3 0.22 1.41 1 84.96
125 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 84.92
126 INT18007 Positive_regulation of C6orf25 23 0.66 14.98 1.95 84.80
127 INT4395 Positive_regulation of CSH1 20 0.50 6.27 1.52 84.52
128 INT262366 Localization of Adh4 1 0.78 1.88 1 84.32
129 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 84.08
130 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 83.68
131 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 83.60
132 INT161599 Binding of Saa 11 0.41 8.61 2.34 83.40
133 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 83.32
134 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 83.32
135 INT114330 Binding of MPZ 21 0.32 25.58 2.14 83.20
136 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08 83.08
137 INT168231 Negative_regulation of Transcription of Nfib 1 0.42 0.23 0.2 83.08
138 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 82.88
139 INT76584 Gene_expression of GCA 1 0.58 1.29 0.24 82.88
140 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 82.08
141 INT107540 Gene_expression of MSD 8 0.58 2.54 1.23 81.60
142 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67 81.44
143 INT17807 Positive_regulation of PDGFC 4 0.06 3.28 0.86 81.12
144 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22 80.80
145 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 80.52
146 INT79442 Negative_regulation of XCL1 2 0.19 0.95 1.89 79.92
147 INT168232 Positive_regulation of Transcription of Nfib 1 0.45 0.22 0.2 79.68
148 INT168235 Transcription of Nfib 1 0.52 0.22 0.2 79.68
149 INT129353 Negative_regulation of ADCK2 1 0.57 0.16 0 79.20
150 INT14516 Positive_regulation of CRTAC1 14 0.37 4.6 6.01 78.36
151 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 78.16
152 INT211271 Regulation of Igh-VS107 1 0.01 1.96 0.44 78.04
153 INT164248 Positive_regulation of MPZ 18 0.67 24.54 2.16 77.68
154 INT44619 Negative_regulation of Msln 1 0.14 1.09 0.71 77.48
155 INT114911 Positive_regulation of Mpz 3 0.23 1.46 0.8 77.28
156 INT81043 Negative_regulation of Kctd1 9 0.57 7.68 1.06 76.96
157 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 76.64
158 INT349080 Binding of Rtn1 1 0.32 5.68 3.21 76.04
159 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 75.48
160 INT212152 Gene_expression of Cts8 1 0.58 0.31 0.35 75.32
161 INT15508 Negative_regulation of nt 8 0.36 3.4 2.26 75.00
162 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 75.00
163 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 75.00
164 INT142404 Gene_expression of THPO 18 0.77 4.39 0.56 75.00
165 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 74.52
166 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 74.36
167 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 74.04
168 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 73.44
169 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 73.32
170 INT124191 Localization of SDHB 3 0.74 2.4 0.32 72.96
171 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 72.88
172 INT71763 Gene_expression of Mri1 33 0.58 12.56 8.6 72.52
173 INT48473 Binding of Smcp 5 0.31 5.14 0.24 71.36
174 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 70.16
175 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 69.52
176 INT38698 Positive_regulation of COP 9 0.59 2.05 4.48 69.32
177 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 68.44
178 INT167007 Positive_regulation of Binding of LCO 1 0.37 0.31 0.31 68.20
179 INT22679 Binding of SERPINE1 25 0.36 17.33 2.36 68.16
180 INT320170 Negative_regulation of YES1 1 0.37 0.17 0.15 68.08
181 INT167005 Binding of LCO 1 0.27 0.31 0.31 67.68
182 INT202715 Binding of NMS 3 0.27 6.92 0.65 67.56
183 INT132453 Binding of TF 31 0.36 12.98 1.22 67.36
184 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83 66.56
185 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 66.52
186 INT183712 Binding of EMG1 2 0.29 0.27 0.19 66.52
187 INT87942 Positive_regulation of LOC500077 12 0.68 3.98 4.55 64.24
188 INT97886 Negative_regulation of Positive_regulation of LOC500077 1 0.28 0.67 0.14 64.24
189 INT62763 Binding of GFER 3 0.48 0.66 0.06 63.52
190 INT111958 Regulation of Thim 4 0.16 3.34 1.67 63.36
191 INT162666 Gene_expression of ST3 5 0.67 5.66 1.73 63.20
192 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95 63.16
193 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 61.84
194 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 61.28
195 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 61.16
196 INT110076 Regulation of C6 2 0.22 1.14 0.96 59.76
197 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 59.20
198 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 59.04
199 INT167006 Localization of LCO 1 0.55 0.53 0.56 57.20
200 INT167004 Localization of Clta 1 0.13 0.53 0.56 57.20
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