D:Neglected Diseases

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Disease Term
Synonyms DISEASE NEGLECTED, DISEASES NEGLECTED, Neglected Disease
Documents 55
Hot Single Events 4
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neglected Diseases. They are ordered first by their relevance to Neglected Diseases and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
2 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21 5.00
3 INT197095 IL1B Regulation of Positive_regulation of TNF 1 0.01 0.64 0.19 5.00
4 INT175727 IL1B Regulation of VEGFA 2 0.04 0.7 0.19 5.00
5 INT197093 TNF Regulation of Positive_regulation of IL1B 1 0.01 0.64 0.19 5.00
6 INT197097 IL1B Regulation of FLT4 1 0.03 0.66 0.19 5.00
7 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
8 INT197098 TNF Regulation of FLT4 1 0.14 0.66 0.19 5.00
9 INT329324 KNG1 Positive_regulation of Localization of ecs 1 0.00 1.16 0.17 5.00
10 INT329317 ACE Regulation of Positive_regulation of KNG1 1 0.02 1.05 0.12 5.00
11 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12 5.00
12 INT275896 IFN1@ Positive_regulation of Gene_expression of TH1L 1 0.09 0.37 0.08 5.00
13 INT331271 KRT28 Regulation of Localization of KRT39 1 0.27 0.29 0 5.00
14 INT236071 Binding of pf and Pv 1 0.02 2.4 0 5.00
15 INT331269 Binding of KRT26 and KRT39 1 0.12 0.47 0 5.00
16 INT331274 Binding of PHGDH and KRT28 1 0.26 0.46 0 5.00
17 INT197096 VEGFA Positive_regulation of FLT4 1 0.04 1.43 0 5.00
18 INT197099 Negative_regulation of Binding of FLT4 and VEGFA 1 0.04 1.04 0 5.00
19 INT331273 Binding of KRT28 and KRT39 1 0.19 2.72 0 5.00
20 INT331272 Binding of PHGDH and KRT26 1 0.16 0.46 0 5.00
21 INT331270 Binding of KRT28 and KRT26 1 0.10 0.46 0 5.00
22 INT229629 Binding of BCR and PAEP 1 0.04 0.37 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neglected Diseases. They are ordered first by their pain relevance and then by number of times they were reported in Neglected Diseases. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT189063 Regulation of NDS9 1 0.01 0.8 0 100.00
2 INT189062 Negative_regulation of NDS9 1 0.01 0.93 0 100.00
3 INT341511 Regulation of Regulation of HAT1 1 0.15 1.63 0 85.64
4 INT172625 Regulation of HAT1 9 0.35 9.21 0.28 85.32
5 INT147113 Binding of LTF 14 0.29 18.24 0.98 75.00
6 INT172617 Positive_regulation of HAT1 7 0.33 5.47 0.54 73.20
7 INT191731 Gene_expression of Lmrq1 31 0.43 14.46 0.34 68.80
8 INT207890 Regulation of Gene_expression of Lmrq1 3 0.28 2.87 0.07 68.80
9 INT207891 Positive_regulation of Gene_expression of Lmrq1 5 0.28 3.87 0.05 61.64
10 INT219359 Localization of SMARCB1 7 0.66 4.17 0.09 57.28
11 INT331290 Localization of KRT28 3 0.46 1.64 0.05 56.96
12 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 54.68
13 INT139527 Positive_regulation of Gene_expression of PAEP 16 0.43 4.66 0.98 54.68
14 INT191732 Regulation of Lmrq1 7 0.28 3.6 0.08 54.16
15 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 50.60
16 INT181790 Gene_expression of FLT4 13 0.72 11.73 0.56 39.04
17 INT266506 Positive_regulation of rsm1 3 0.48 1.3 0 35.32
18 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 27.76
19 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08 27.76
20 INT173090 Regulation of INCENP 24 0.09 9.45 2.16 25.00
21 INT175109 Gene_expression of MAP3K8 3 0.45 1.31 0 25.00
22 INT173537 Binding of CCL16 18 0.40 13.02 7.36 17.44
23 INT351707 Localization of HAT1 1 0.06 0.67 0 16.48
24 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
25 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
26 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
27 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
28 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
29 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
30 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
31 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
32 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
33 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
34 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
35 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
36 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
37 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
38 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
39 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
40 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
41 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
42 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
43 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
44 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
45 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
46 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
47 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
48 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
49 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
50 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
51 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
52 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
53 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
54 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
55 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
56 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
57 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
58 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
59 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
60 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
61 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
62 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
63 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
64 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
65 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
66 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
67 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
68 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
69 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
70 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52 5.00
71 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 5.00
72 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
73 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
74 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 5.00
75 INT14043 Binding of HP 52 0.30 26.56 7.76 5.00
76 INT91667 Localization of IL12A 39 0.74 25.51 7.36 5.00
77 INT35584 Binding of ACLY 22 0.35 31.78 7.17 5.00
78 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 5.00
79 INT50255 Regulation of Cd4 39 0.49 29.73 6.77 5.00
80 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 5.00
81 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 5.00
82 INT78913 Positive_regulation of Gene_expression of ABCC1 22 0.67 5.95 5.82 5.00
83 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 5.00
84 INT32389 Regulation of ecs 11 0.49 7.23 5.43 5.00
85 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
86 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 5.00
87 INT104549 Localization of Il18 16 0.78 13.01 4.64 5.00
88 INT2836 Positive_regulation of PAEP 51 0.67 26.69 4.57 5.00
89 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 5.00
90 INT182898 Regulation of Gene_expression of IFN1@ 18 0.44 9.49 4.46 5.00
91 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
92 INT10053 Localization of Paf 15 0.80 9.14 3.64 5.00
93 INT176386 Positive_regulation of Gene_expression of TH1L 14 0.32 9.17 3.4 5.00
94 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 5.00
95 INT192676 Binding of PTEN 14 0.46 10.58 3.06 5.00
96 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94 5.00
97 INT185407 Binding of PER1 13 0.42 9.32 2.6 5.00
98 INT33243 Localization of HP 17 0.12 9.7 2.2 5.00
99 INT123705 Gene_expression of SMARCB1 40 0.73 19.47 2.2 5.00
100 INT39453 Negative_regulation of TCN2 12 0.59 3.98 2.13 5.00
101 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
102 INT68496 Binding of PGR 26 0.48 16.36 2.09 5.00
103 INT15580 Gene_expression of TCN2 16 0.44 7.59 1.97 5.00
104 INT48722 Negative_regulation of Gene_expression of SERPINE1 12 0.43 7.66 1.85 5.00
105 INT192563 Gene_expression of HAT1 8 0.38 4.47 1.71 5.00
106 INT117014 Binding of TCN2 11 0.13 1.6 1.38 5.00
107 INT213965 Gene_expression of rsm1 7 0.54 4.18 1.29 5.00
108 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 5.00
109 INT287436 Positive_regulation of HTs 9 0.60 2.27 1.14 5.00
110 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12 5.00
111 INT155156 Gene_expression of TCN1 13 0.58 3.25 0.99 5.00
112 INT156326 Positive_regulation of SMARCB1 20 0.67 8.77 0.97 5.00
113 INT10303 Regulation of STH 16 0.60 16.14 0.95 5.00
114 INT183362 Regulation of AQP1 3 0.23 1.49 0.92 5.00
115 INT197105 Negative_regulation of FLT4 13 0.42 11.48 0.92 5.00
116 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
117 INT228154 Gene_expression of DNAAF1 9 0.57 1.23 0.82 5.00
118 INT221129 Gene_expression of IGKV1-22 5 0.22 1.73 0.78 5.00
119 INT4471 Negative_regulation of Gprasp1 5 0.36 1.92 0.75 5.00
120 INT132281 Binding of TCN1 2 0.33 0.95 0.74 5.00
121 INT80939 Positive_regulation of PDR 8 0.55 5.43 0.67 5.00
122 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67 5.00
123 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 5.00
124 INT180029 Regulation of rsm1 3 0.02 2.38 0.55 5.00
125 INT139780 Binding of AQP1 7 0.32 4.62 0.54 5.00
126 INT242110 Regulation of IGKV1-22 2 0.06 2.02 0.52 5.00
127 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 5.00
128 INT189176 Positive_regulation of Localization of TH1L 5 0.23 2.93 0.42 5.00
129 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42 5.00
130 INT324886 Transcription of Ece1 2 0.37 1.95 0.4 5.00
131 INT164328 Negative_regulation of SMARCB1 8 0.24 4.04 0.4 5.00
132 INT119001 Regulation of ACLY 5 0.44 4.83 0.36 5.00
133 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33 5.00
134 INT41689 Gene_expression of PHGDH 11 0.75 6.61 0.28 5.00
135 INT196006 Regulation of FLT4 2 0.25 2.24 0.27 5.00
136 INT207896 Gene_expression of TLR8 3 0.36 2.82 0.26 5.00
137 INT275900 Regulation of Localization of TH1L 2 0.26 0.99 0.26 5.00
138 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24 5.00
139 INT165643 Regulation of TCN1 4 0.39 0.56 0.22 5.00
140 INT322282 Localization of PSMD2 2 0.20 1.42 0.22 5.00
141 INT242111 Binding of IGKV1-22 2 0.06 1.47 0.2 5.00
142 INT227872 Positive_regulation of MLL 7 0.01 2.44 0.19 5.00
143 INT197104 Positive_regulation of Gene_expression of FLT4 1 0.56 3.45 0.19 5.00
144 INT197102 Localization of FLT4 4 0.65 2.89 0.17 5.00
145 INT246513 Regulation of IL4I1 2 0.10 2.06 0.15 5.00
146 INT17904 Positive_regulation of Hts 9 0.39 2.91 0.15 5.00
147 INT217052 Localization of Lmrq1 6 0.44 3.36 0.15 5.00
148 INT197103 Binding of FLT4 2 0.29 3.08 0.14 5.00
149 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 5.00
150 INT282803 Regulation of PMCH 1 0.01 0.36 0.11 5.00
151 INT285203 Gene_expression of Hts 7 0.55 0.64 0.1 5.00
152 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1 5.00
153 INT207888 Negative_regulation of Lmrq1 5 0.11 2.95 0.09 5.00
154 INT5361 Positive_regulation of CPM 4 0.60 1.61 0.09 5.00
155 INT329321 Positive_regulation of Positive_regulation of Tbxa2r 1 0.26 1.76 0.07 5.00
156 INT275899 Positive_regulation of Localization of Lmrq1 3 0.09 1.5 0.07 5.00
157 INT197101 Positive_regulation of Localization of FLT4 1 0.38 0.77 0.06 5.00
158 INT207894 Positive_regulation of Lmrq1 4 0.28 2.66 0.05 5.00
159 INT285204 Binding of Hts 1 0.04 0.05 0.03 5.00
160 INT326411 Gene_expression of H2afy 1 0.05 0.8 0.03 5.00
161 INT236072 Binding of DARC 8 0.03 6.01 0.03 5.00
162 INT331277 Transcription of KRT39 1 0.51 0.14 0 5.00
163 INT331275 Regulation of KRT28 1 0.17 0.34 0 5.00
164 INT275898 Regulation of Localization of Lmrq1 1 0.07 0.48 0 5.00
165 INT331278 Regulation of KRT26 1 0.11 0.22 0 5.00
166 INT248744 Negative_regulation of STH 2 0.41 1.02 0 5.00
167 INT331284 Transcription of KRT26 1 0.27 0.14 0 5.00
168 INT202814 Binding of CEACAM5 1 0.17 1.14 0 5.00
169 INT266508 Binding of rsm1 2 0.25 0.89 0 5.00
170 INT331294 Positive_regulation of Localization of KRT39 1 0.42 0.29 0 5.00
171 INT236068 Binding of Pv 1 0.22 2.25 0 5.00
172 INT331293 Gene_expression of KRT39 1 0.49 1.39 0 5.00
173 INT331289 Negative_regulation of Binding of KRT28 1 0.26 0.51 0 5.00
174 INT207893 Gene_expression of Sgpp1 1 0.03 1.36 0 5.00
175 INT331286 Positive_regulation of Localization of SMARCB1 1 0.11 0.44 0 5.00
176 INT348070 Regulation of EML1 1 0.03 0.13 0 5.00
177 INT331279 Binding of KRT26 1 0.15 0.46 0 5.00
178 INT331283 Regulation of KRT39 1 0.20 0.22 0 5.00
179 INT207895 Positive_regulation of Gene_expression of Sgpp1 1 0.02 1.47 0 5.00
180 INT331287 Gene_expression of KRT26 1 0.26 0.91 0 5.00
181 INT331282 Binding of KRT28 1 0.23 2.08 0 5.00
182 INT326413 Positive_regulation of H2afy 1 0.03 0.11 0 5.00
183 INT351697 Positive_regulation of Gene_expression of MAP3K8 1 0.03 0 0 5.00
184 INT236074 Gene_expression of DARC 9 0.28 11.4 0 5.00
185 INT207889 Regulation of Gene_expression of Sgpp1 1 0.02 1.36 0 5.00
186 INT188758 Negative_regulation of CPM 2 0.05 0.89 0 5.00
187 INT331291 Binding of KRT39 1 0.35 0.99 0 5.00
188 INT331288 Transcription of KRT28 1 0.43 0.14 0 5.00
189 INT331285 Localization of KRT39 1 0.63 0.29 0 5.00
190 INT331276 Positive_regulation of KRT39 1 0.39 0.8 0 5.00
191 INT331281 Positive_regulation of KRT28 1 0.33 1.52 0 5.00
192 INT331280 Negative_regulation of KRT28 1 0.26 1.02 0 5.00
193 INT236069 Gene_expression of Pv 1 0.30 0.74 0 5.00
194 INT326412 Positive_regulation of Gene_expression of H2afy 1 0.03 0.67 0 5.00
195 INT331292 Positive_regulation of Gene_expression of PHGDH 1 0.49 0.49 0 5.00
196 INT246512 Positive_regulation of IL4I1 2 0.26 1.05 0 5.00
197 INT326414 Gene_expression of PRAC 1 0.01 0.26 0 5.00
198 INT354103 Gene_expression of Gprasp1 1 0.22 0.45 0 5.00
199 INT236073 Positive_regulation of DARC 1 0.02 1.38 0 5.00
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