D:Neurosis

Disease Term Synonyms DISORDER NEUROTIC, Disorders Neurotic, NEUROSES, Neurotic, Neurotic Disorder, Neurotic Disorders, Neuroticism, Nonpsychotic Mental Disorder, PSYCHONEUROSES, UNSPECIFIED NEUROTIC DISORDER Documents 943 Hot Single Events 49 Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Neurosis. They are ordered first by their relevance to Neurosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT277192	SUGT1 Positive_regulation of Gene_expression of SLC6A4	1	0.01	0.86	1.04	88.40
2	INT311616	Binding of MET and Comt	1	0.01	0.2	0.37	75.84
3	INT262370	Binding of GAD1 and GNPTAB	1	0.00	1.36	0	35.56
4	INT235709	Binding of NA and SSR1	1	0.07	0.72	1.08	5.00
5	INT38936	Binding of Avp and Crh	7	0.40	0.82	1.04	5.00
6	INT311612	Binding of Drd2 and Sert1	1	0.12	0.65	0.86	5.00
7	INT304575	Creb1 Regulation of Gene_expression of Bdnf	1	0.04	1	0.84	5.00
8	INT304576	Binding of Arntl and Clock	6	0.37	0.43	0.5	5.00
9	INT304578	Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf	1	0.06	0.9	0.49	5.00
10	INT304577	Binding of Arntl and Clock Regulation of Gene_expression of Maoa	1	0.01	0.3	0.44	5.00
11	INT267644	Binding of Das and RLS	1	0.06	1.04	0.35	5.00
12	INT247949	Cdk5r1 Positive_regulation of Cdk5	1	0.26	1.12	0.28	5.00
13	INT272618	Positive_regulation of Binding of GAD1 and CEBPZ	1	0.14	0.91	0.25	5.00
14	INT272619	Binding of GAD1 and CEBPZ	1	0.10	0.91	0.25	5.00
15	INT311613	Binding of Slc6a4 and Pten	1	0.24	0.32	0.21	5.00
16	INT342647	Negative_regulation of Binding of Avp and Crh	1	0.37	0.64	0.18	5.00
17	INT247948	Positive_regulation of Cdk5r1 Positive_regulation of Cdk5	1	0.26	0.16	0.07	5.00
18	INT288099	Binding of APP and App	1	0.01	1.04	0.05	5.00
19	INT340502	Agtr1a Negative_regulation of Phosphorylation of Jak2	1	0.12	2.32	0	5.00
20	INT340504	Agtr1a Negative_regulation of Phosphorylation of Pik3cb	1	0.06	1.16	0	5.00
21	INT204927	Binding of LGMN and IL33	1	0.00	0.52	0	5.00
22	INT299889	Binding of MAT1A and MPP6	1	0.03	0.39	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Neurosis. They are ordered first by their pain relevance and then by number of times they were reported in Neurosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT42980	Gene_expression of GAD1	139	0.69	94.77	45.11	99.62
2	INT11458	Binding of Tap2	3	0.39	2.51	0.57	99.36
3	INT19	Regulation of Gnrhr	131	0.62	36.4	55.66	99.36
4	INT1360	Negative_regulation of Regulation of Gnrhr	5	0.43	0.77	2.86	99.36
5	INT88868	Binding of MCS	45	0.40	37.43	7.98	99.34
6	INT1361	Negative_regulation of Gnrhr	118	0.58	57.77	35.54	98.76
7	INT9973	Binding of MMVP1	14	0.48	22.66	1.79	98.52
8	INT3002	Binding of SUGT1	62	0.24	55.9	14.91	98.48
9	INT4851	Positive_regulation of Chat	53	0.70	9.21	15.11	97.44
10	INT11377	Positive_regulation of Ngf	331	0.70	206.5	238	97.44
11	INT38480	Positive_regulation of Cym	1	0.35	0.52	0.16	95.20
12	INT62630	Positive_regulation of CNR1	86	0.70	40.34	51.51	94.68
13	INT921	Regulation of GH1	172	0.60	52.88	51.04	93.84
14	INT92669	Gene_expression of Bdnf	309	0.78	178.26	116.68	93.60
15	INT106556	Negative_regulation of Gene_expression of Bdnf	42	0.59	34.71	17.64	93.60
16	INT224814	Regulation of EGOT	2	0.17	0.79	0.39	92.96
17	INT1752	Negative_regulation of Ache	109	0.59	42.05	15.73	92.36
18	INT15089	Regulation of SLC6A4	48	0.62	17.87	25.6	91.20
19	INT1215	Negative_regulation of PGE	19	0.47	4.6	1.52	90.72
20	INT756	Gene_expression of C3	138	0.75	100.6	19.2	90.64
21	INT66040	Positive_regulation of Bdnf	114	0.69	67.67	51.81	89.96
22	INT4297	Negative_regulation of CFP	21	0.42	12.7	10.29	88.48
23	INT15091	Gene_expression of SLC6A4	101	0.78	29.91	53.64	88.40
24	INT140670	Negative_regulation of Gene_expression of SLC6A4	4	0.51	2.7	3.88	88.40
25	INT101140	Negative_regulation of Tap1	7	0.50	9.08	17.46	87.76
26	INT189506	Gene_expression of Anxty	32	0.55	45.92	9.11	87.20
27	INT197512	Gene_expression of ABCA4	19	0.75	7.08	0.57	87.12
28	INT205634	Localization of TAS2R20	3	0.21	0.37	0.04	86.80
29	INT13735	Negative_regulation of Regulation of GH1	14	0.42	4.35	5.39	86.60
30	INT249	Localization of GHRH	215	0.80	78.02	51.87	86.36
31	INT254	Regulation of Localization of GHRH	30	0.60	5.17	11.46	86.36
32	INT134346	Binding of PCS	51	0.37	22.27	5.67	85.92
33	INT154358	Transcription of RLS	3	0.59	2.99	0.58	85.52
34	INT52179	Regulation of Lbp	39	0.61	25.4	18.32	84.48
35	INT7581	Binding of ADHD1	132	0.46	135.1	19.73	84.16
36	INT145425	Positive_regulation of NLRP1	19	0.47	6.93	12.09	84.08
37	INT7538	Negative_regulation of IL2	95	0.57	47.31	31.7	83.36
38	INT100427	Binding of SERPINA1	9	0.36	9.63	2.51	83.28
39	INT91991	Negative_regulation of IGKV1-22	2	0.57	2.55	1.67	83.24
40	INT1767	Positive_regulation of PROC	83	0.67	54.14	17	81.96
41	INT91106	Negative_regulation of LTF	9	0.51	5.73	1.09	81.48
42	INT16236	Negative_regulation of CFH	31	0.57	19.59	3.36	80.88
43	INT11381	Positive_regulation of IL1B	330	0.70	209.31	100.9	80.80
44	INT36054	Transcription of IL1B	53	0.72	32.64	17.31	80.80
45	INT36055	Positive_regulation of Transcription of IL1B	9	0.49	6.24	2.21	80.80
46	INT54368	Positive_regulation of VTA1	13	0.59	3.81	8.13	80.48
47	INT252	Localization of GH1	529	0.80	227.4	122.05	80.08
48	INT248	Positive_regulation of Localization of GH1	137	0.69	49.25	32.92	80.08
49	INT984	Positive_regulation of Localization of GHRH	58	0.70	12.66	16.51	80.08
50	INT914	Positive_regulation of GH1	292	0.69	100.7	84.91	79.36
51	INT16234	Positive_regulation of CFH	25	0.50	26.05	3.33	79.32
52	INT957	Positive_regulation of GHRH	136	0.70	36.84	40.52	78.96
53	INT235711	Negative_regulation of Positive_regulation of GNPTAB	1	0.02	0.59	0.15	77.44
54	INT3467	Positive_regulation of Ptger1	28	0.54	10.59	8.93	76.96
55	INT42826	Positive_regulation of Positive_regulation of Ptger1	2	0.28	0.41	0.14	76.96
56	INT57734	Binding of SLC6A4	36	0.48	11.94	15.42	76.84
57	INT53929	Positive_regulation of GNPTAB	12	0.32	6.66	1.4	76.56
58	INT6894	Gene_expression of CNR1	168	0.78	74.07	62.84	74.96
59	INT10444	Positive_regulation of Gene_expression of CNR1	18	0.69	8.69	7.84	74.96
60	INT47681	Regulation of Ntrk2	17	0.62	3.61	6.31	72.96
61	INT3589	Positive_regulation of SCN5A	101	0.57	46.01	21.73	70.48
62	INT8776	Negative_regulation of Positive_regulation of Ache	2	0.43	1.17	0.36	68.76
63	INT101429	Positive_regulation of PST	10	0.40	2.14	0.6	67.60
64	INT8777	Positive_regulation of Ache	25	0.68	7.77	3.18	67.36
65	INT161394	Binding of Mks1	2	0.02	1.52	0.62	66.72
66	INT124126	Regulation of Bas	3	0.23	1.68	1.29	65.52
67	INT42391	Positive_regulation of BCR	7	0.49	4.93	1.44	64.40
68	INT16281	Negative_regulation of Anxty	20	0.48	17.23	4.06	60.48
69	INT62509	Gene_expression of MCS	58	0.67	21.46	6.57	59.40
70	INT109095	Binding of Drd4	7	0.40	3.6	3.18	58.40
71	INT54701	Localization of Ptafr	19	0.49	18.68	3.82	57.92
72	INT200098	Localization of CAPRIN2	2	0.19	0.47	0.05	57.92
73	INT198027	Localization of MCL1	5	0.72	7.46	0.51	57.44
74	INT171476	Negative_regulation of Regulation of HTR1A	1	0.42	1.05	0.52	56.52
75	INT14131	Regulation of HTR1A	34	0.60	9.61	14.74	56.20
76	INT290177	Positive_regulation of Gene_expression of HAL	1	0.11	0.49	0	55.68
77	INT320170	Negative_regulation of YES1	1	0.37	0.17	0.15	54.40
78	INT1829	Gene_expression of CFH	71	0.75	64.24	2.49	54.16
79	INT108710	Gene_expression of HAL	36	0.58	14.75	2.16	54.16
80	INT97984	Negative_regulation of SLC6A4	45	0.59	15.43	18.09	54.04
81	INT148564	Localization of HAL	8	0.68	2.46	0.62	50.96
82	INT290176	Positive_regulation of Localization of HAL	1	0.11	0.55	0	50.96
83	INT19689	Regulation of Tes	5	0.24	1.01	2.76	50.00
84	INT45014	Regulation of IL1RL1	12	0.14	1.87	2.67	49.60
85	INT75742	Binding of RLS	86	0.42	95.27	19.04	44.40
86	INT720	Positive_regulation of POMC	807	0.70	237.37	353.83	43.76
87	INT30041	Binding of HAL	8	0.35	2.36	0.95	43.20
88	INT290178	Negative_regulation of Binding of HAL	1	0.09	0.5	0	43.20
89	INT11303	Gene_expression of Avp	116	0.78	39.23	23.88	41.36
90	INT115600	Positive_regulation of Bas	5	0.49	1.89	0.46	37.92
91	INT269798	Regulation of Gene_expression of Anxty	1	0.03	2.05	0.37	36.52
92	INT36148	Binding of GAD1	10	0.41	7.91	1.47	34.48
93	INT205635	Gene_expression of TAS2R20	8	0.19	0.16	0	33.72
94	INT161098	Regulation of Positive_regulation of CNR1	3	0.45	2.22	1.87	30.56
95	INT66039	Positive_regulation of Ntrk2	53	0.69	15.87	17.23	28.72
96	INT278527	Gene_expression of NEO1	1	0.04	1.51	0.13	25.60
97	INT5454	Localization of CRH	124	0.79	79.18	41.53	24.44
98	INT10142	Gene_expression of ANXA3	4	0.35	3.1	0.54	24.20
99	INT6782	Gene_expression of SCN5A	156	0.78	33.13	17.88	24.08
100	INT56053	Negative_regulation of Bdnf	77	0.58	64.4	26.83	23.64
101	INT278526	Positive_regulation of Gene_expression of ANXA3	1	0.08	0.52	0	20.64
102	INT18311	Positive_regulation of CD8A	145	0.69	113.48	19.44	17.44
103	INT36778	Positive_regulation of Anxty	14	0.48	12.85	5.08	15.20
104	INT269797	Positive_regulation of Negative_regulation of Anxty	1	0.03	2.07	0.48	15.20
105	INT166021	Positive_regulation of MCL1	36	0.67	62.97	1.44	14.04
106	INT3364	Binding of SGCG	87	0.47	31.93	17.24	8.84
107	INT2542	Localization of Calca	2008	0.81	518.3	1408.65	5.00
108	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	5.00
109	INT7114	Positive_regulation of Ltp	1192	0.62	290.76	755.77	5.00
110	INT1912	Gene_expression of Calca	1152	0.78	453.25	739.84	5.00
111	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81	5.00
112	INT5680	Gene_expression of Ngf	530	0.78	264.29	310.56	5.00
113	INT6852	Localization of TNF	883	0.81	705.95	270.84	5.00
114	INT2909	Positive_regulation of Abat	334	0.70	62.1	256.43	5.00
115	INT738	Regulation of POMC	459	0.62	111.19	243.74	5.00
116	INT9987	Gene_expression of Abat	296	0.78	95.46	226.34	5.00
117	INT1308	Localization of Pomc	457	0.81	66.83	217.5	5.00
118	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210	5.00
119	INT9132	Negative_regulation of Prkcg	279	0.59	88.05	203.47	5.00
120	INT438	Gene_expression of Crh	376	0.78	159.11	169.17	5.00
121	INT1114	Localization of Ins1	748	0.80	192.95	165.48	5.00
122	INT7628	Gene_expression of Ltp	273	0.77	70.21	147.87	5.00
123	INT1273	Gene_expression of Avp	356	0.78	90.56	138.7	5.00
124	INT4658	Binding of OPRM1	188	0.48	25.96	136.24	5.00
125	INT5497	Positive_regulation of Crh	299	0.70	125.54	131.14	5.00
126	INT65600	Positive_regulation of Casp3	376	0.70	198.44	128.03	5.00
127	INT65054	Positive_regulation of Nfkb1	285	0.70	149.33	126.73	5.00
128	INT1026	Binding of Lbp	207	0.48	150.96	119.16	5.00
129	INT1438	Localization of Pomc	360	0.81	101.26	116.47	5.00
130	INT4207	Regulation of Avp	267	0.62	63.72	115.33	5.00
131	INT47243	Gene_expression of Prkcg	195	0.78	58.05	108.44	5.00
132	INT60526	Gene_expression of IL10	449	0.78	292.71	107.84	5.00
133	INT1898	Regulation of Crh	220	0.62	61.33	102.64	5.00
134	INT65500	Gene_expression of App	605	0.78	429.94	98.31	5.00
135	INT3537	Positive_regulation of Car2	413	0.56	103.51	94.35	5.00
136	INT12763	Phosphorylation of Prkcg	167	0.82	38.91	89.63	5.00
137	INT1472	Positive_regulation of Ins1	349	0.69	146.2	86.36	5.00
138	INT16254	Positive_regulation of Gene_expression of Ngf	144	0.70	80.61	82.08	5.00
139	INT7528	Regulation of OPRM1	100	0.62	20.63	80.57	5.00
140	INT19771	Positive_regulation of PAG1	69	0.61	75.61	76.88	5.00
141	INT3657	Gene_expression of Ins1	514	0.78	321.69	75.76	5.00
142	INT12536	Localization of Prkcg	101	0.80	36.37	73.81	5.00
143	INT3034	Localization of Ngf	126	0.81	50.81	72.84	5.00
144	INT5861	Gene_expression of Egr1	203	0.78	49.35	68.13	5.00
145	INT7134	Localization of KNG1	127	0.79	65.73	67.97	5.00
146	INT13286	Gene_expression of Ca2	317	0.67	71.58	65.01	5.00
147	INT18981	Gene_expression of ABAT	78	0.68	38.35	61.36	5.00
148	INT546	Binding of ALB	311	0.48	85.98	60.14	5.00
149	INT102020	Gene_expression of Creb1	190	0.78	57.31	59.77	5.00
150	INT6623	Gene_expression of NA	231	0.78	45.78	59.36	5.00
151	INT1307	Positive_regulation of Localization of Pomc	120	0.70	24.58	58.48	5.00
152	INT82055	Positive_regulation of Creb1	176	0.70	60.2	58.39	5.00
153	INT9408	Positive_regulation of Crp	296	0.69	242.27	57.35	5.00
154	INT1200	Negative_regulation of Ins1	274	0.58	155.17	56.14	5.00
155	INT2276	Regulation of Ins1	234	0.61	103.78	54.05	5.00
156	INT4345	Gene_expression of Gtf3a	157	0.67	80.75	48.47	5.00
157	INT375	Positive_regulation of REN	293	0.70	152.46	47.55	5.00
158	INT1028	Positive_regulation of Lbp	102	0.69	67.86	46.05	5.00
159	INT2275	Negative_regulation of Localization of Ins1	183	0.59	51.02	44.94	5.00
160	INT49105	Gene_expression of Vcam1	157	0.78	157.27	43.01	5.00
161	INT613	Gene_expression of Alb	268	0.78	149.84	42.78	5.00
162	INT27798	Gene_expression of Ntrk2	111	0.78	56.08	42.68	5.00
163	INT12228	Positive_regulation of Gene_expression of Abat	44	0.65	17.51	40.55	5.00
164	INT30817	Gene_expression of Th	142	0.76	33.56	38.12	5.00
165	INT4449	Positive_regulation of NA	179	0.55	40.26	37.82	5.00
166	INT56870	Gene_expression of CYP2D6	87	0.78	8.83	37.53	5.00
167	INT6417	Negative_regulation of ABAT	49	0.51	19.6	36.81	5.00
168	INT2416	Negative_regulation of MAOA	92	0.59	42.24	36.5	5.00
169	INT18893	Positive_regulation of CPP	81	0.69	38.03	34.33	5.00
170	INT16960	Gene_expression of Crp	166	0.76	116.21	34.07	5.00
171	INT65536	Negative_regulation of Positive_regulation of Nfkb1	77	0.59	38.86	33.33	5.00
172	INT7082	Gene_expression of CRH	180	0.78	64.66	31.74	5.00
173	INT11087	Positive_regulation of Drd2	54	0.69	12.4	31.43	5.00
174	INT29743	Negative_regulation of App	91	0.59	65.56	31.26	5.00
175	INT106554	Positive_regulation of Gene_expression of Bdnf	73	0.70	42.58	30.77	5.00
176	INT1179	Negative_regulation of Ace	157	0.59	67.03	30.46	5.00
177	INT1158	Regulation of Agt	106	0.61	29.4	30.29	5.00
178	INT660	Negative_regulation of REN	194	0.59	82.06	29.46	5.00
179	INT169180	Binding of SNRNP70	204	0.47	119.1	29.3	5.00
180	INT4868	Gene_expression of GAL	75	0.78	22.23	29.02	5.00
181	INT47712	Positive_regulation of App	135	0.69	101.38	28.94	5.00
182	INT9199	Positive_regulation of CEBPZ	111	0.67	30.99	28.45	5.00
183	INT91775	Gene_expression of Slc6a4	102	0.78	26.45	28.23	5.00
184	INT74726	Negative_regulation of Slc6a4	61	0.59	21.01	27.84	5.00
185	INT2408	Regulation of CCK	37	0.61	10.01	26.66	5.00
186	INT70048	Positive_regulation of Gene_expression of IL10	90	0.55	71.34	25.66	5.00
187	INT5622	Gene_expression of Nppa	101	0.78	49.46	25.31	5.00
188	INT57192	Binding of Ltp	43	0.41	17.48	24.96	5.00
189	INT12484	Binding of Drd2	45	0.48	15.17	24.72	5.00
190	INT151758	Gene_expression of PYCARD	91	0.63	14.54	24.27	5.00
191	INT147792	Gene_expression of COPD	230	0.70	287.13	24.1	5.00
192	INT13838	Positive_regulation of Drd1a	48	0.70	9.83	23.42	5.00
193	INT102021	Positive_regulation of Gene_expression of Creb1	66	0.70	24.04	23.28	5.00
194	INT18894	Gene_expression of CPP	44	0.77	23.05	23.05	5.00
195	INT7383	Localization of VIP	53	0.81	17.7	22.65	5.00
196	INT7678	Localization of Alb	142	0.81	80.93	22.49	5.00
197	INT127435	Gene_expression of Per1	89	0.77	13.94	22.31	5.00
198	INT3299	Positive_regulation of AGT	126	0.68	79.45	21.91	5.00
199	INT74682	Positive_regulation of Mmp2	72	0.69	40.46	21.73	5.00
200	INT16396	Negative_regulation of CEBPZ	76	0.48	30.03	21.6	5.00