D:Nevus

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Disease Term
Synonyms Mole Skin, Moles Skin, Nevi, Skin Mole, SKIN MOLES
Documents 162
Hot Single Events 68
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nevus. They are ordered first by their relevance to Nevus and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34 100.00
2 INT276228 Nrtim1 Positive_regulation of PPARG 1 0.01 2.18 0.14 99.48
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76 97.92
4 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57 91.76
5 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3 72.48
6 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09 65.24
7 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02 29.76
8 INT266839 Fgf23 Negative_regulation of Slc34a1 1 0.21 0.88 0 29.36
9 INT290475 POU3F2 Negative_regulation of Mitf 1 0.43 1.14 0 17.12
10 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
11 INT75057 Binding of POMC and Msx1 2 0.39 0.6 0.2 5.00
12 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
13 INT290444 S100A4 Regulation of TIMP1 1 0.00 1.3 0.14 5.00
14 INT290443 Gene_expression of TIMP2 Negative_regulation of MMP2 1 0.06 1.56 0.13 5.00
15 INT274715 TBL1XR1 Positive_regulation of TIMP1 1 0.00 0.26 0.04 5.00
16 INT290477 POU3F2 Negative_regulation of Gene_expression of Mitf 1 0.43 0.36 0 5.00
17 INT290474 MAPK1 Regulation of Mitf 1 0.04 0.15 0 5.00
18 INT290482 GPR143 Regulation of Gene_expression of Mitf 1 0.36 0.64 0 5.00
19 INT332136 POGLUT1 Negative_regulation of HJURP 1 0.00 0.06 0 5.00
20 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0 5.00
21 INT274716 TBL1XR1 Positive_regulation of Gene_expression of MMP1 1 0.02 0.45 0 5.00
22 INT324053 Binding of Banf1 and Lemd3 1 0.20 0.15 0 5.00
23 INT332135 POGLUT1 Negative_regulation of NLRP5 1 0.00 0.06 0 5.00
24 INT290483 RAB27A Regulation of Gene_expression of Mitf 1 0.25 0.64 0 5.00
25 INT332069 POGLUT1 Negative_regulation of fd 1 0.00 0.06 0 5.00
26 INT266837 Dmp1 Negative_regulation of Gene_expression of Fgf23 1 0.48 2.41 0 5.00
27 INT266835 Pth Regulation of Slc34a3 1 0.19 0.07 0 5.00
28 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0 5.00
29 INT354789 Tnc Regulation of HSPG2 1 0.02 1.38 0 5.00
30 INT276759 ABCB1 Regulation of TOP2A 1 0.04 0.61 0 5.00
31 INT266836 Pth Regulation of Slc34a1 1 0.09 0.07 0 5.00
32 INT266834 Pth Negative_regulation of Positive_regulation of Grxcr1 1 0.04 0.51 0 5.00
33 INT290480 MLANA Regulation of Gene_expression of Mitf 1 0.27 0.64 0 5.00
34 INT266833 Phex Regulation of Gene_expression of Fgf23 1 0.23 0.46 0 5.00
35 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0 5.00
36 INT266838 Fgf23 Regulation of Slc34a1 1 0.13 0.3 0 5.00
37 INT290476 Mitf Regulation of Gene_expression of CD200 1 0.34 0.2 0 5.00
38 INT290481 MLANA Regulation of Mitf 1 0.16 0.2 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nevus. They are ordered first by their pain relevance and then by number of times they were reported in Nevus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42 99.96
2 INT73626 Positive_regulation of Gene_expression of PPARG 22 0.70 18.82 4.4 99.96
3 INT191678 Gene_expression of Xiap 60 0.71 57.25 1.37 99.88
4 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 99.80
5 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 99.80
6 INT326013 Gene_expression of UBR4 1 0.08 0.85 0 99.80
7 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 99.76
8 INT4756 Positive_regulation of Nrtim1 37 0.33 14.6 24.12 99.76
9 INT159618 Transcription of Trpm1 8 0.69 11.42 1.21 99.60
10 INT159614 Gene_expression of Trpm1 13 0.77 9.47 1.25 99.60
11 INT159620 Gene_expression of TRPM1 7 0.75 7.96 1.65 99.60
12 INT159621 Transcription of TRPM1 1 0.52 2.49 0.39 99.60
13 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47 99.46
14 INT203256 Regulation of Gene_expression of Xiap 1 0.57 2.82 0 99.28
15 INT193102 Positive_regulation of Gene_expression of Xiap 9 0.64 10.62 0.15 99.24
16 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 99.20
17 INT5481 Binding of TYR 26 0.47 1.3 7.95 99.20
18 INT338169 Binding of MTAP 1 0.36 0.76 0.37 99.20
19 INT159615 Negative_regulation of Trpm1 1 0.43 1.68 0.13 98.20
20 INT159616 Negative_regulation of Transcription of Trpm1 1 0.31 1.74 0.13 98.16
21 INT92075 Regulation of GSTM1 12 0.50 16.18 2.27 98.16
22 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09 97.64
23 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 97.44
24 INT69700 Transcription of MC1R 15 0.71 4.32 5.62 97.40
25 INT58755 Binding of PAM 6 0.34 3.09 0.97 97.20
26 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 96.88
27 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 96.64
28 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 96.16
29 INT179300 Negative_regulation of TGFB1I1 1 0.06 1.92 0 96.16
30 INT159617 Negative_regulation of Gene_expression of Trpm1 1 0.31 1.74 0.12 95.96
31 INT159619 Negative_regulation of Gene_expression of Trpm3 1 0.00 1.71 0 95.44
32 INT159613 Gene_expression of Trpm3 8 0.57 2.31 0.5 95.12
33 INT79692 Negative_regulation of PPARG 24 0.59 16 4.31 94.72
34 INT79690 Negative_regulation of Gene_expression of PPARG 10 0.59 10.48 1.55 94.72
35 INT118373 Gene_expression of Fgf23 16 0.77 29.62 1.04 93.52
36 INT51137 Negative_regulation of GSTM1 39 0.43 14.74 6.5 93.40
37 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55 93.36
38 INT54897 Negative_regulation of HSPA9 3 0.41 5.08 1.19 93.12
39 INT161378 Binding of BRAF 1 0.08 2.24 0.48 91.76
40 INT178027 Negative_regulation of Xiap 14 0.54 11.62 0.24 91.64
41 INT299153 Negative_regulation of Tnc 2 0.42 8.14 0.98 91.08
42 INT203253 Protein_catabolism of Xiap 1 0.92 20.16 0.43 90.76
43 INT191671 Positive_regulation of Xiap 5 0.67 4.63 0.49 90.56
44 INT203264 Binding of Xiap 5 0.39 5.3 0.03 90.48
45 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 90.00
46 INT166312 Negative_regulation of Vim 7 0.22 5.9 0.46 90.00
47 INT76931 Positive_regulation of MLANA 2 0.45 1.35 0.08 88.88
48 INT168708 Negative_regulation of MLANA 2 0.41 1.42 0.08 88.88
49 INT21737 Binding of MC1R 129 0.48 45.45 56.54 87.80
50 INT203254 Positive_regulation of Protein_catabolism of Xiap 1 0.64 7.46 0.12 87.52
51 INT75382 Negative_regulation of HSPG2 20 0.57 15.18 7.03 86.40
52 INT174195 Negative_regulation of HLA-E 31 0.42 11.98 3.88 86.40
53 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 85.72
54 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 85.60
55 INT203252 Localization of Xiap 1 0.69 2.15 0 85.40
56 INT324041 Localization of Mro 1 0.33 1.48 0 85.08
57 INT140296 Negative_regulation of XIAP 9 0.45 13.61 1.37 84.76
58 INT266830 Regulation of Slc34a3 1 0.42 1.85 0 83.96
59 INT276227 Gene_expression of UBL4A 9 0.20 7.12 0.64 83.84
60 INT14916 Binding of RASA1 15 0.37 13.64 1.44 83.48
61 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 83.36
62 INT266831 Positive_regulation of Slc34a3 1 0.47 1.79 0 82.68
63 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 82.36
64 INT240359 Binding of Tnc 2 0.35 11.67 1.48 81.52
65 INT301355 Binding of Ext1 2 0.37 4.07 0.03 81.20
66 INT324047 Binding of Lemd3 1 0.48 3.18 0 80.84
67 INT64450 Gene_expression of Mc1r 13 0.77 9.22 5.43 80.56
68 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4 80.08
69 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 78.68
70 INT55566 Gene_expression of Dct 5 0.36 1.13 0.94 77.68
71 INT203260 Negative_regulation of Gene_expression of Xiap 4 0.54 4.54 0.1 75.84
72 INT70019 Binding of BCL2 25 0.47 17.55 0.79 75.76
73 INT67612 Binding of PPARG 38 0.48 22.67 8.94 75.04
74 INT178399 Regulation of Positive_regulation of Mapk8 4 0.44 3.4 0.23 74.92
75 INT70654 Gene_expression of Actg2 27 0.67 18.62 4.79 74.64
76 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 74.60
77 INT102336 Gene_expression of Krit1 3 0.69 2.54 0.49 74.56
78 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 73.80
79 INT203265 Regulation of Xiap 1 0.41 7.93 0 73.52
80 INT324046 Gene_expression of Lemd3 1 0.67 1.69 0.1 73.40
81 INT102337 Gene_expression of RAP1A 4 0.58 1.83 0.17 72.24
82 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 71.44
83 INT29636 Localization of PAM 5 0.73 2.1 0.87 70.32
84 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 70.08
85 INT68652 Regulation of Positive_regulation of JUN 4 0.54 4.95 1.26 66.96
86 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 66.96
87 INT110925 Positive_regulation of Positive_regulation of JUN 14 0.49 6.22 1.98 66.96
88 INT13063 Binding of RHCE 16 0.38 6.54 1.22 64.64
89 INT135299 Binding of PTCH1 10 0.48 12.16 0.84 63.08
90 INT113564 Regulation of PLAUR 3 0.48 5.15 0.41 61.92
91 INT75497 Regulation of JUN 28 0.61 11.04 7.09 61.12
92 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05 60.72
93 INT22413 Positive_regulation of Cyp39a1 2 0.08 2.49 0.09 59.48
94 INT86000 Gene_expression of VN1R5 1 0.04 0.58 0.09 58.08
95 INT290473 Positive_regulation of Regulation of PLAUR 1 0.24 1.71 0 58.08
96 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62 56.52
97 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 55.64
98 INT173159 Localization of PPARA 96 0.74 64.55 10.26 55.64
99 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42 54.96
100 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32 54.96
101 INT203251 Positive_regulation of Positive_regulation of Casp2 1 0.06 0.49 0 54.72
102 INT203262 Positive_regulation of Casp2 1 0.06 0.49 0 54.72
103 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 54.36
104 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 54.36
105 INT27882 Gene_expression of HSP90B2P 52 0.75 36.51 9.59 52.64
106 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83 51.80
107 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22 48.16
108 INT70021 Localization of BCL2 23 0.74 21.6 1.09 46.32
109 INT213794 Phosphorylation of Mitf 2 0.42 2.56 0.15 45.92
110 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 45.72
111 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32 45.24
112 INT139549 Positive_regulation of Mc1r 2 0.17 0.7 0.94 45.08
113 INT100275 Gene_expression of TBL1XR1 19 0.25 6.99 1.33 41.40
114 INT131612 Negative_regulation of Mitf 3 0.56 3.91 0.23 39.88
115 INT355897 Localization of Brca2 1 0.11 1.32 0 38.72
116 INT84701 Binding of HSP90B2P 8 0.47 7.37 1.29 38.56
117 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 37.92
118 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 37.04
119 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 36.56
120 INT97450 Gene_expression of Mitf 36 0.75 17.22 0.39 35.96
121 INT266819 Regulation of Localization of Grxcr1 2 0.06 1.28 0 25.64
122 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 25.52
123 INT79016 Gene_expression of Gstt1 4 0.44 0.59 0.7 25.52
124 INT266818 Localization of Grxcr1 7 0.12 3.9 0 25.28
125 INT69875 Negative_regulation of Binding of MC1R 2 0.39 0.37 1.26 24.88
126 INT70263 Negative_regulation of Cyp39a1 2 0.05 0.96 0 24.48
127 INT203258 Negative_regulation of Protein_catabolism of Xiap 1 0.39 1.02 0 24.36
128 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 23.68
129 INT276766 Negative_regulation of ATP8A1 1 0.01 1.76 0.16 22.92
130 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 19.60
131 INT266823 Regulation of Grxcr1 3 0.06 1.4 0.03 19.04
132 INT290461 Regulation of Gene_expression of Mitf 3 0.59 3.13 0 18.52
133 INT180885 Positive_regulation of Gene_expression of VCAN 10 0.35 12.52 0.18 13.92
134 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84 12.96
135 INT266828 Negative_regulation of Fgf23 3 0.42 5.63 0.04 12.88
136 INT165361 Positive_regulation of APAF1 4 0.39 4.8 0.16 12.40
137 INT97449 Transcription of Mitf 4 0.69 4.28 0.09 11.80
138 INT290464 Transcription of POU3F2 1 0.64 1.08 0 11.44
139 INT79691 Regulation of Gene_expression of PPARG 10 0.50 10.44 1.62 11.24
140 INT79689 Regulation of PPARG 10 0.62 8.04 1.07 11.24
141 INT203266 Positive_regulation of Protein_catabolism of Casp2 1 0.08 1.03 0 10.44
142 INT203267 Protein_catabolism of Casp2 1 0.11 0.97 0 9.44
143 INT276224 Binding of Nrtim1 1 0.01 1.3 0.23 7.52
144 INT118372 Regulation of Fgf23 4 0.55 3.31 0.15 7.32
145 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46 7.28
146 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85 7.04
147 INT173911 Regulation of CD69 3 0.22 2.95 0.25 6.08
148 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
149 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
150 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
151 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
152 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
153 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
154 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
155 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
156 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
157 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
158 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
159 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
160 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
161 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
162 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
163 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
164 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
165 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
166 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
167 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
168 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
169 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
170 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
171 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
172 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
173 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
174 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
175 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
176 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 5.00
177 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52 5.00
178 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
179 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
180 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
181 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
182 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 5.00
183 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 5.00
184 INT11508 Positive_regulation of TGFBI 24 0.70 19.81 15.78 5.00
185 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
186 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
187 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
188 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
189 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
190 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
191 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
192 INT107033 Gene_expression of Slc37a4 66 0.62 27.34 12.35 5.00
193 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18 5.00
194 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
195 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
196 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
197 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
198 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 5.00
199 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89 5.00
200 INT13010 Gene_expression of TYR 38 0.65 14.81 8.84 5.00
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