D:Newborn Drug Withdrawal Syndrome

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pChart

Disease Term
Synonyms Abstinence Syndrome Neonatal, Abstinence Syndromes Neonatal, Addiction Neonatal Passive, Addictions Neonatal Passive, Crack Baby, NEONATAL ABSTINENCE SYNDROME, Neonatal Abstinence Syndromes, Neonatal Nicotine Withdrawal Syndrome, Neonatal Opiate Withdrawal, Neonatal Paroxetine Withdrawal Syndrome, Neonatal Passive Addiction
Documents 224
Hot Single Events 24
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Newborn Drug Withdrawal Syndrome. They are ordered first by their relevance to Newborn Drug Withdrawal Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33 81.60
2 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 5.00
3 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4 5.00
4 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Newborn Drug Withdrawal Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Newborn Drug Withdrawal Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38 99.98
2 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.78
3 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 99.12
4 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35 98.84
5 INT12318 Negative_regulation of Positive_regulation of Cort 7 0.43 3.89 2.65 98.84
6 INT27868 Positive_regulation of Positive_regulation of Cort 9 0.59 1.13 6.64 98.84
7 INT12316 Negative_regulation of Cort 10 0.38 5.89 6.08 98.84
8 INT12717 Binding of Pck1 85 0.47 12.49 54.81 98.40
9 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 98.16
10 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6 97.88
11 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 95.64
12 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 91.28
13 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 90.36
14 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 89.72
15 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 87.92
16 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 86.96
17 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58 86.96
18 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 86.96
19 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 86.16
20 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 85.84
21 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73 85.68
22 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39 85.68
23 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 83.00
24 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 80.56
25 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96 79.04
26 INT20575 Gene_expression of Akr1d1 48 0.57 6.2 22.5 78.60
27 INT201232 Binding of CEBPZ 7 0.31 1.73 1.7 78.40
28 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 77.24
29 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53 75.40
30 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 75.12
31 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28 75.12
32 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 74.88
33 INT201233 Localization of CEBPZ 4 0.62 0.82 0.77 67.56
34 INT15610 Localization of GOPC 223 0.65 68.26 28.7 67.40
35 INT344929 Localization of AOC2 1 0.31 0.2 0.45 67.40
36 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 66.56
37 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 63.56
38 INT157238 Transcription of PER1 3 0.50 0.21 0.74 63.56
39 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 61.48
40 INT13716 Positive_regulation of TH 33 0.68 19.11 16 56.12
41 INT64748 Regulation of Binding of Pck1 4 0.44 0.45 3.15 53.64
42 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66 51.92
43 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 51.84
44 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 51.84
45 INT7076 Regulation of Serbp1 11 0.45 0.96 8.12 51.84
46 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 51.40
47 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 50.00
48 INT194032 Binding of Rax 3 0.03 0.13 0.14 50.00
49 INT89271 Gene_expression of Serbp1 4 0.52 1.41 4.53 48.60
50 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 43.84
51 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 42.16
52 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73 42.16
53 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 42.16
54 INT5300 Regulation of Insr 54 0.60 11.33 29.26 39.20
55 INT7327 Regulation of Th 164 0.62 29.67 110.14 38.64
56 INT3506 Localization of TH 12 0.81 0.78 6.66 35.68
57 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61 35.68
58 INT15765 Localization of PON1 8 0.75 3.61 2.08 35.68
59 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89 35.68
60 INT193070 Localization of CHAT 3 0.17 1.03 0.86 35.68
61 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 35.40
62 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 34.28
63 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 33.52
64 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 31.60
65 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 25.00
66 INT738 Regulation of POMC 459 0.62 111.19 243.74 25.00
67 INT115391 Gene_expression of Cort 18 0.59 9.43 6.53 25.00
68 INT10085 Regulation of Cort 8 0.39 2.99 2.63 25.00
69 INT177609 Negative_regulation of GREM1 4 0.06 1.73 0.19 8.80
70 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34 6.68
71 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 5.36
72 INT1396 Binding of Penk 355 0.48 22.79 269.65 5.00
73 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 5.00
74 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
75 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
76 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
77 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
78 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
79 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
80 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
81 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 5.00
82 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
83 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
84 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 5.00
85 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04 5.00
86 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
87 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 5.00
88 INT605 Regulation of Acot1 61 0.62 10.7 26.34 5.00
89 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
90 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 5.00
91 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 5.00
92 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
93 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
94 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
95 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
96 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44 5.00
97 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
98 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
99 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
100 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
101 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
102 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
103 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
104 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
105 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
106 INT94784 Binding of ROS1 113 0.40 71.57 10.26 5.00
107 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
108 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
109 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 5.00
110 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 5.00
111 INT69439 Regulation of ROS1 46 0.45 31.22 6.94 5.00
112 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 5.00
113 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
114 INT206950 Positive_regulation of Atf4 14 0.45 7.02 5.71 5.00
115 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 5.00
116 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
117 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29 5.00
118 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83 5.00
119 INT91401 Binding of OGFR 12 0.41 4.1 4.47 5.00
120 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09 5.00
121 INT106972 Gene_expression of MAP2 36 0.75 9.72 3.87 5.00
122 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 5.00
123 INT167446 Regulation of CCNA2 2 0.39 2.01 3.49 5.00
124 INT178631 Phosphorylation of ESR1 21 0.75 9.16 3.36 5.00
125 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33 5.00
126 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 5.00
127 INT274751 Localization of Mpeg1 4 0.05 4.16 2.9 5.00
128 INT241623 Gene_expression of Atf4 12 0.74 8.67 2.85 5.00
129 INT67137 Positive_regulation of Mpeg1 4 0.26 9.67 2.73 5.00
130 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58 5.00
131 INT50558 Negative_regulation of PCNA 31 0.57 13.97 2.3 5.00
132 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27 5.00
133 INT219458 Negative_regulation of CCNA2 9 0.38 1.23 2.21 5.00
134 INT177841 Gene_expression of CCNA2 2 0.50 0.64 1.97 5.00
135 INT65855 Localization of TP53 18 0.76 17.08 1.89 5.00
136 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66 5.00
137 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63 5.00
138 INT149762 Regulation of MAS1 8 0.31 5.34 1.61 5.00
139 INT241672 Positive_regulation of CCNA2 4 0.44 1.56 1.57 5.00
140 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57 5.00
141 INT241668 Negative_regulation of Transcription of CCNA2 1 0.27 0.44 1.5 5.00
142 INT241618 Regulation of Atf4 3 0.43 1.41 1.46 5.00
143 INT241627 Regulation of Positive_regulation of Atf4 1 0.29 0.36 1.4 5.00
144 INT241624 Positive_regulation of Positive_regulation of Atf4 1 0.32 0.72 1.32 5.00
145 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22 5.00
146 INT169618 Localization of OGFR 2 0.72 0.38 1.22 5.00
147 INT274749 Positive_regulation of Localization of Mpeg1 1 0.01 0.06 1.2 5.00
148 INT213465 Transcription of Lep 4 0.68 2.11 1.15 5.00
149 INT58211 Gene_expression of FURIN 7 0.57 0.62 1.15 5.00
150 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12 5.00
151 INT57189 Negative_regulation of Gene_expression of Chat 5 0.56 1.35 1.07 5.00
152 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02 5.00
153 INT15186 Negative_regulation of HRH2 8 0.51 2.26 0.99 5.00
154 INT71906 Regulation of Gene_expression of ESR1 22 0.41 11.01 0.98 5.00
155 INT241665 Transcription of CCNA2 1 0.44 0.38 0.98 5.00
156 INT241619 Phosphorylation of Eif5b 1 0.08 0.61 0.97 5.00
157 INT326601 Gene_expression of SLC18A2 2 0.42 1.31 0.92 5.00
158 INT123712 Gene_expression of SLC22A18 1 0.69 0 0.92 5.00
159 INT241620 Negative_regulation of Positive_regulation of Atf4 1 0.27 0.85 0.88 5.00
160 INT274753 Positive_regulation of Positive_regulation of Mpeg1 1 0.01 0 0.81 5.00
161 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79 5.00
162 INT241664 Negative_regulation of PRB3 1 0.08 0.33 0.77 5.00
163 INT274752 Negative_regulation of Localization of Mpeg1 1 0.01 0 0.76 5.00
164 INT148341 Gene_expression of MAS1 9 0.65 4.19 0.68 5.00
165 INT16022 Gene_expression of Ppia 4 0.66 0.43 0.64 5.00
166 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62 5.00
167 INT202140 Protein_catabolism of ROS1 7 0.28 2.58 0.62 5.00
168 INT181916 Regulation of Binding of ROS1 4 0.28 2.72 0.61 5.00
169 INT274748 Positive_regulation of Gene_expression of Mpeg1 3 0.41 0.59 0.61 5.00
170 INT241673 Phosphorylation of GDNF 2 0.79 1.06 0.61 5.00
171 INT262535 Regulation of NXNL1 1 0.00 0.15 0.59 5.00
172 INT241625 Regulation of Gene_expression of Atf4 2 0.43 0.83 0.59 5.00
173 INT241670 Regulation of Positive_regulation of PRB3 1 0.06 0.12 0.55 5.00
174 INT169957 Transcription of PCNA 7 0.34 0.94 0.55 5.00
175 INT241671 Positive_regulation of PRB3 1 0.07 0.12 0.52 5.00
176 INT241626 Negative_regulation of Regulation of Atf4 1 0.28 0.29 0.48 5.00
177 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48 5.00
178 INT241674 Negative_regulation of Transcription of PCNA 1 0.11 0.33 0.47 5.00
179 INT241617 Positive_regulation of Phosphorylation of Ccna2 1 0.49 0.15 0.45 5.00
180 INT241616 Phosphorylation of Ccna2 1 0.79 0.15 0.45 5.00
181 INT241615 Negative_regulation of Ccna2 1 0.41 0.24 0.44 5.00
182 INT241675 Negative_regulation of Gene_expression of CCNA2 1 0.27 0.22 0.43 5.00
183 INT177858 Positive_regulation of Gene_expression of CCNA2 2 0.44 0.42 0.37 5.00
184 INT241678 Gene_expression of PRB3 2 0.26 1.26 0.37 5.00
185 INT241667 Positive_regulation of Regulation of CCNA2 1 0.32 0 0.35 5.00
186 INT241629 Phosphorylation of Atf4 1 0.52 0.08 0.04 5.00
187 INT313043 Localization of MAS1 1 0.21 0.13 0 5.00
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