D:Optic Nerve Injuries

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Disease Term
Synonyms Avulsion Optic Nerve, Avulsions Optic Nerve, Contusion Optic Nerve, CONTUSIONS OPTIC NERVE, Cranial Nerve Ii Injuries, INJURIES OPTIC NERVE, Injury Optic Nerve, Nerve Avulsion Optic, Nerve Avulsions Optic, Nerve Contusion Optic, Nerve Contusions Optic
Documents 60
Hot Single Events 97
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Optic Nerve Injuries. They are ordered first by their relevance to Optic Nerve Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287387 Olfml1 Positive_regulation of Negative_regulation of Rgc32 1 0.00 0.54 0 100.00
2 INT155318 Binding of Calb1 and Fos 1 0.40 0.36 0.14 75.00
3 INT235775 Binding of Tnfrsf1a and Tradd 3 0.31 3 0.12 68.96
4 INT235774 Binding of Tradd and Tnfrsf12a 1 0.10 1.21 0 68.96
5 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
6 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4 5.00
7 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13 5.00
8 INT318620 Mog Regulation of Mbp 1 0.05 0.85 0.23 5.00
9 INT241451 Mag Positive_regulation of Ngfr 1 0.09 0.1 0.21 5.00
10 INT241462 Binding of OMG and Ngfr 1 0.11 0.15 0.15 5.00
11 INT241457 Binding of Mag and Ngfr 1 0.09 0.15 0.15 5.00
12 INT241453 Binding of Ngfr and Rtn4r 1 0.03 0.15 0.15 5.00
13 INT241465 Binding of OMG and Rtn4r 1 0.04 0.15 0.14 5.00
14 INT241458 Binding of Mag and Rtn4r 1 0.03 0.15 0.14 5.00
15 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13 5.00
16 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12 5.00
17 INT241444 Binding of Tnfrsf19 and Lingo1 1 0.08 0.49 0.06 5.00
18 INT241447 Binding of Tnfrsf19 and Rtn4r 1 0.04 0.49 0.06 5.00
19 INT241461 Binding of TNF and Tnfrsf19 1 0.17 0.49 0.06 5.00
20 INT329015 Binding of APCS and SRGN 1 0.08 1.14 0.04 5.00
21 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 0.09 0 0.03 5.00
22 INT241460 Rock1 Positive_regulation of Phosphorylation of MLC1 1 0.38 0.63 0.03 5.00
23 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03 5.00
24 INT241459 Gart Positive_regulation of Racgap1 1 0.01 0 0.03 5.00
25 INT241464 Binding of TNF and Lingo1 1 0.13 0.43 0.03 5.00
26 INT241463 Binding of TNF and Rtn4r 1 0.06 0.43 0.03 5.00
27 INT200761 Binding of Tfam and Gopc 1 0.01 0.1 0 5.00
28 INT241456 Tgtp1 Positive_regulation of Rock1 1 0.01 0 0 5.00
29 INT241448 Binding of Rock1 and Tgtp1 1 0.01 0 0 5.00
30 INT299232 Onc1 Regulation of Gene_expression of Aqp4 1 0.01 0.43 0 5.00
31 INT241443 Binding of Tgtp1 and Cacna1d 1 0.00 0 0 5.00
32 INT299234 Onc1 Negative_regulation of Thy1 1 0.02 0.16 0 5.00
33 INT299233 Onc1 Regulation of Gene_expression of Aqp9 1 0.01 0.19 0 5.00
34 INT241433 Binding of Tgtp1 and Cacna1d Positive_regulation of Rock1 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Optic Nerve Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Optic Nerve Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT287384 Positive_regulation of Olfml1 1 0.01 0.45 0 100.00
2 INT185649 Regulation of ERG 17 0.20 10.14 1.49 99.96
3 INT287385 Negative_regulation of Nstr2 1 0.09 3.33 0 99.92
4 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 99.92
5 INT200753 Gene_expression of Ocm 2 0.15 1.6 0.24 99.88
6 INT12148 Positive_regulation of IGKV1-5 24 0.57 3.13 1.25 99.84
7 INT235751 Regulation of Nbn 1 0.18 1.21 0.09 99.72
8 INT116824 Negative_regulation of Rgc32 21 0.31 21.62 2.46 99.66
9 INT24519 Negative_regulation of ERG 15 0.38 6.98 1.33 99.62
10 INT287383 Regulation of Nstr2 1 0.06 3.24 0.13 99.54
11 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 99.52
12 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 99.52
13 INT190479 Positive_regulation of 1190002H23Rik 6 0.07 5.64 0.53 98.82
14 INT49129 Positive_regulation of GFAP 35 0.69 28.78 10.38 98.80
15 INT20992 Regulation of ITGB2 11 0.37 9.04 1.73 98.76
16 INT164116 Negative_regulation of 1190002H23Rik 33 0.51 18.73 2.71 98.66
17 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7 98.56
18 INT209419 Regulation of GPSM2 5 0.21 3.03 0.33 98.52
19 INT22270 Regulation of IGKV1-5 13 0.39 3.56 3.54 98.52
20 INT10919 Positive_regulation of ITGB2 25 0.67 13.75 5.45 98.24
21 INT286266 Positive_regulation of Regulation of ITGB2 1 0.07 1.33 0.1 98.24
22 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4 98.24
23 INT287386 Negative_regulation of Strs1 1 0.09 0.74 0.1 98.20
24 INT87931 Binding of IGKV1-5 13 0.06 2.03 0.65 98.20
25 INT224164 Binding of GPSM2 5 0.17 1.14 0.46 97.92
26 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 97.90
27 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 97.44
28 INT235746 Positive_regulation of Casp2 2 0.04 2.67 0.67 97.40
29 INT65576 Positive_regulation of Regulation of GFAP 2 0.45 1.25 0.91 97.20
30 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 97.04
31 INT44027 Positive_regulation of Lif 7 0.40 2.76 1.9 97.04
32 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18 97.04
33 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 97.00
34 INT218919 Negative_regulation of Xiap 4 0.32 4.61 0.46 96.80
35 INT65578 Regulation of GFAP 8 0.26 6.81 2.2 96.64
36 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73 96.56
37 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 96.32
38 INT82140 Negative_regulation of Raf1 3 0.14 1.7 1.38 96.12
39 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0 95.84
40 INT203489 Positive_regulation of Gene_expression of Pou4f1 3 0.49 2.33 0.84 95.62
41 INT235748 Negative_regulation of Yy1 1 0.27 1.34 0.1 95.60
42 INT203473 Gene_expression of Pou4f1 69 0.76 25.94 11.36 95.34
43 INT35946 Positive_regulation of Clu 12 0.69 4.92 2.73 94.92
44 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 94.64
45 INT138786 Positive_regulation of Lcn2 7 0.51 3.41 1.59 94.48
46 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45 94.32
47 INT105215 Negative_regulation of Pou4f1 16 0.53 9.42 5.97 94.16
48 INT289490 Negative_regulation of Negative_regulation of Pou4f1 1 0.32 0.09 0.06 94.16
49 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 94.00
50 INT112267 Positive_regulation of Rgc32 10 0.39 8.1 2.09 94.00
51 INT211489 Gene_expression of ARHGAP4 6 0.65 2.88 0.61 93.92
52 INT235753 Gene_expression of Tradd 3 0.62 5.41 0.48 93.72
53 INT200750 Gene_expression of Rho 19 0.65 6.52 0.69 93.32
54 INT99508 Regulation of Bcl2l1 12 0.61 10.44 2.71 92.80
55 INT79981 Positive_regulation of Gene_expression of Gdnf 27 0.70 12.49 10.77 92.68
56 INT77793 Positive_regulation of Gdnf 54 0.70 23.76 25.08 92.68
57 INT198124 Regulation of Aqp9 6 0.61 3.62 0.1 92.56
58 INT8027 Regulation of Gene_expression of Ngf 34 0.62 26.32 31.16 92.04
59 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 91.84
60 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 91.48
61 INT56769 Gene_expression of Ntrk1 36 0.77 15.79 20.75 91.48
62 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 90.56
63 INT120550 Negative_regulation of Rock1 27 0.42 18.38 5.66 90.20
64 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 90.04
65 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 89.60
66 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 89.60
67 INT145929 Regulation of Bax 20 0.60 18.12 5.35 89.12
68 INT353250 Localization of Rgc32 1 0.04 0.69 0 89.12
69 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 89.08
70 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93 89.00
71 INT138784 Positive_regulation of Gene_expression of Lcn2 3 0.49 4.44 1.13 89.00
72 INT94233 Positive_regulation of Gene_expression of Clu 3 0.69 2.64 0.71 89.00
73 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 88.72
74 INT115890 Gene_expression of Nefh 28 0.68 11.55 3.84 88.72
75 INT58986 Gene_expression of Clu 17 0.77 8.35 9.61 88.52
76 INT138785 Gene_expression of Lcn2 9 0.56 9.88 2.41 87.96
77 INT112372 Positive_regulation of GPSM2 8 0.41 5.49 1.94 87.92
78 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13 87.48
79 INT252212 Negative_regulation of Gene_expression of Lgals3 5 0.43 4.82 0.88 87.40
80 INT8422 Binding of Cntf 8 0.37 4.54 1.72 87.28
81 INT219218 Positive_regulation of Negative_regulation of Rgc32 3 0.06 2.96 0.03 87.20
82 INT272414 Positive_regulation of Positive_regulation of NARFL 9 0.37 12.88 0.84 86.60
83 INT116625 Phosphorylation of Nefh 13 0.79 5.94 1.4 86.24
84 INT256397 Binding of Nefh 3 0.09 1.31 0 85.76
85 INT318610 Positive_regulation of Binding of Lif 1 0.28 0.67 0.19 85.12
86 INT299519 Binding of Lif 2 0.21 0.67 0.29 85.12
87 INT140089 Positive_regulation of Stat1 5 0.68 3.42 1.58 84.96
88 INT204860 Positive_regulation of Litaf 2 0.67 1.83 0.51 84.32
89 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 84.28
90 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 83.76
91 INT156676 Gene_expression of Rtn4 14 0.65 5.78 3.16 83.08
92 INT152308 Binding of Lgals3 13 0.40 6.39 1.44 82.96
93 INT289493 Regulation of Narfl 1 0.03 1.61 0 82.92
94 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 82.20
95 INT24371 Positive_regulation of Sphk1 2 0.41 2.37 0.46 81.48
96 INT35903 Positive_regulation of Sgpl1 2 0.39 1.87 0.3 81.48
97 INT235754 Positive_regulation of Casp4 2 0.42 2.47 0.22 81.04
98 INT131116 Localization of IGKV1-5 10 0.36 2.13 1.06 79.76
99 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 79.56
100 INT181268 Localization of GPSM2 3 0.35 2.49 0.44 79.48
101 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 79.36
102 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 79.04
103 INT317734 Positive_regulation of Binding of Lgals3 1 0.44 0.89 0.15 79.04
104 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95 78.72
105 INT99506 Negative_regulation of Bcl2l1 25 0.58 15.7 6.09 77.92
106 INT216030 Positive_regulation of Rtn4r 5 0.50 2.78 0.49 77.60
107 INT132191 Regulation of Cabin1 6 0.45 2.96 1.28 77.56
108 INT299215 Gene_expression of Kcnj1 1 0.08 1.94 0.09 77.12
109 INT12150 Negative_regulation of IGKV1-5 24 0.55 1.91 1.17 77.04
110 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 76.88
111 INT50392 Regulation of Ret 6 0.54 3.51 2.22 76.52
112 INT20586 Regulation of Gfra1 20 0.51 9.43 3.41 76.52
113 INT85844 Regulation of Gdnf 18 0.50 11.08 10.43 76.52
114 INT219219 Gene_expression of Rgc32 9 0.13 7.29 0.85 76.24
115 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 75.68
116 INT299196 Transcription of Thy1 1 0.66 1.98 0 75.28
117 INT2924 Positive_regulation of sch 11 0.50 4.09 3.82 75.00
118 INT15096 Positive_regulation of Pitpnm1 11 0.21 7.14 2.43 75.00
119 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 75.00
120 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54 75.00
121 INT195080 Positive_regulation of Tnc 4 0.45 26.67 2.34 75.00
122 INT78193 Regulation of Tnc 2 0.19 0.31 0.31 75.00
123 INT71689 Localization of Ntf3 23 0.73 11.1 7.91 74.60
124 INT3034 Localization of Ngf 126 0.81 50.81 72.84 74.60
125 INT68582 Localization of CNTF 4 0.73 2.02 1.68 74.60
126 INT235743 Regulation of Tradd 1 0.49 2.14 0.06 73.60
127 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53 73.04
128 INT116622 Positive_regulation of Nefh 17 0.39 11.98 3.86 71.80
129 INT164117 Positive_regulation of Negative_regulation of 1190002H23Rik 3 0.40 2.16 0.27 71.12
130 INT181266 Gene_expression of GPSM2 18 0.32 0.54 1.64 71.08
131 INT286265 Negative_regulation of GPSM2 3 0.20 1.06 0.31 71.08
132 INT73354 Gene_expression of Gap43 36 0.77 13.74 7.47 70.24
133 INT215661 Positive_regulation of Gene_expression of Gap43 2 0.64 1.8 0.3 70.24
134 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92 70.16
135 INT216034 Gene_expression of Rtn4r 8 0.78 4.14 0.98 69.36
136 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 69.20
137 INT69396 Gene_expression of H2-K1 72 0.65 38.16 4.56 68.92
138 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 68.92
139 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 68.20
140 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 68.20
141 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29 67.88
142 INT98478 Negative_regulation of Lif 3 0.42 1.29 0.84 67.88
143 INT120603 Negative_regulation of Cntf 6 0.35 3.57 0.78 67.88
144 INT216035 Binding of Rtn4r 9 0.48 5.21 1.13 66.28
145 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 64.80
146 INT54938 Regulation of Rb1 6 0.44 4.41 2.69 64.48
147 INT235755 Regulation of Ppm1b 1 0.20 1.4 0.15 64.48
148 INT235752 Regulation of Rassf4 1 0.11 1.28 0.06 64.48
149 INT235742 Regulation of Smad4 1 0.04 1.66 0.06 64.48
150 INT235745 Regulation of Rad9 1 0.16 1.28 0.06 64.48
151 INT71559 Gene_expression of Ccng1 3 0.09 2.58 0.3 63.68
152 INT235744 Regulation of Gene_expression of Ccng1 1 0.06 1.14 0.11 63.68
153 INT235747 Regulation of Ccng1 1 0.04 1.14 0.11 63.68
154 INT144918 Gene_expression of Thy1 5 0.62 4.39 0.06 60.48
155 INT252211 Negative_regulation of Lgals3 6 0.43 4.82 0.48 58.64
156 INT247871 Negative_regulation of Thy1 8 0.54 7.23 0.03 58.40
157 INT266875 Positive_regulation of Narfl 37 0.05 38.43 3.73 58.08
158 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 56.76
159 INT315354 Gene_expression of Etv5 2 0.37 1.02 0.21 56.36
160 INT289494 Regulation of 1190002H23Rik 1 0.04 1.64 0 55.84
161 INT226977 Positive_regulation of Gene_expression of Rtn4 1 0.51 1.1 0.19 55.72
162 INT299228 Regulation of Gene_expression of Thy1 1 0.22 1.47 0.03 50.72
163 INT77795 Localization of Gdnf 26 0.81 6.29 8.55 50.00
164 INT77794 Binding of Gdnf 15 0.48 8.38 8.22 50.00
165 INT14384 Gene_expression of Prf1 9 0.60 3.03 2.22 50.00
166 INT235758 Positive_regulation of Gene_expression of Tradd 2 0.49 2.16 0.17 50.00
167 INT235749 Regulation of Eef2k 1 0.19 0.4 0.03 50.00
168 INT235756 Positive_regulation of Tradd 1 0.40 1.04 0 50.00
169 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 49.96
170 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 49.76
171 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 49.60
172 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 49.48
173 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 49.48
174 INT289500 Negative_regulation of Regulation of ERG 1 0.02 0.92 0 44.08
175 INT168640 Positive_regulation of Gene_expression of Iba1 9 0.33 8.3 4.55 42.76
176 INT292050 Positive_regulation of Iba1 4 0.25 3.17 0.84 42.76
177 INT168641 Gene_expression of Iba1 24 0.63 12.21 6.7 41.92
178 INT289497 Binding of Narfl 1 0.03 2.23 0 41.20
179 INT198121 Gene_expression of Aqp9 19 0.77 5.67 0.12 39.68
180 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 38.76
181 INT6866 Regulation of Gfap 51 0.61 19.6 23.56 38.32
182 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 36.24
183 INT6864 Positive_regulation of Gene_expression of Gfap 110 0.70 59.01 47.07 36.24
184 INT204838 Binding of Iba1 10 0.29 1.61 0.98 36.00
185 INT136304 Negative_regulation of Aqp4 54 0.59 48.42 7.4 33.64
186 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52 32.48
187 INT329016 Regulation of Gene_expression of GON4L 1 0.06 1.12 0.05 32.48
188 INT329020 Regulation of GON4L 1 0.06 1.12 0.05 32.48
189 INT180095 Gene_expression of Rock1 22 0.55 4.9 1.14 32.24
190 INT109536 Negative_regulation of Vegfa 15 0.46 10.35 1.39 31.72
191 INT299194 Transcription of Aqp9 1 0.67 1.48 0 31.36
192 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 30.40
193 INT227780 Gene_expression of GON4L 2 0.13 2.72 0.05 30.08
194 INT186623 Negative_regulation of Mag 13 0.42 12.22 6.48 24.16
195 INT141536 Negative_regulation of Rtn4r 8 0.43 4.71 0.98 24.16
196 INT226978 Negative_regulation of Omg 1 0.16 0.41 0 24.16
197 INT179213 Gene_expression of Aqp3 10 0.63 5.13 0.77 23.84
198 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 23.48
199 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 23.48
200 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 23.00
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