D:Osteitis

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Disease Term
Synonyms BONE INFLAMMATION, INFLAMMATION BONE
Documents 354
Hot Single Events 19
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Osteitis. They are ordered first by their relevance to Osteitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 83.04
2 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 70.92
3 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 66.24
4 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 64.80
5 INT206088 IL6 Positive_regulation of JAK1 1 0.18 0.05 0 46.36
6 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
7 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
8 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
9 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
10 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
11 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
12 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
13 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
14 INT206089 Negative_regulation of FOSB Negative_regulation of Gene_expression of PTGS2 1 0.00 0.97 0.19 5.00
15 INT206081 IL6ST Negative_regulation of IL6 1 0.11 0.81 0.17 5.00
16 INT206059 IL6 Positive_regulation of INS 1 0.02 1.16 0.16 5.00
17 INT206070 ANG Positive_regulation of Transcription of IL6 1 0.05 1.5 0.15 5.00
18 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12 5.00
19 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1 5.00
20 INT206042 Negative_regulation of FDPS Negative_regulation of Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
21 INT206054 RAC1 Positive_regulation of STAT3 1 0.07 0.11 0.09 5.00
22 INT206075 Negative_regulation of FDPS Negative_regulation of Binding of GGPS1 1 0.01 0 0.09 5.00
23 INT206078 Binding of FDPS and GGPS1 1 0.00 0 0.09 5.00
24 INT206072 ANG Positive_regulation of IL6 1 0.05 0.5 0.08 5.00
25 INT206080 ANG Regulation of Gene_expression of IL6 1 0.03 0.4 0.07 5.00
26 INT206063 ANG Positive_regulation of Gene_expression of KRT20 1 0.00 1.01 0.07 5.00
27 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05 5.00
28 INT206087 RAC1 Positive_regulation of Gene_expression of STAT3 1 0.08 0.05 0.05 5.00
29 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05 5.00
30 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05 5.00
31 INT206083 LDLR Positive_regulation of Binding of STAT3 1 0.02 0.53 0.04 5.00
32 INT206073 Negative_regulation of RAC1 Positive_regulation of IL6 1 0.14 0.06 0.04 5.00
33 INT206067 Gene_expression of RAC1 Positive_regulation of Positive_regulation of IL6 1 0.16 0.07 0.04 5.00
34 INT206068 RAC1 Positive_regulation of IL6 1 0.16 0.06 0.04 5.00
35 INT206066 LDLR Positive_regulation of Phosphorylation of STAT3 1 0.02 0.52 0.04 5.00
36 INT206071 IRF6 Positive_regulation of Positive_regulation of IL1B 1 0.00 0.58 0.03 5.00
37 INT206076 IL6 Positive_regulation of Positive_regulation of STAT3 1 0.19 0.3 0.03 5.00
38 INT206061 RAC1 Positive_regulation of Positive_regulation of STAT3 1 0.07 0.43 0.03 5.00
39 INT206085 FDPS Positive_regulation of AGFG1 1 0.00 0.4 0 5.00
40 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0 5.00
41 INT206079 ANG Regulation of KRT20 1 0.00 0.54 0 5.00
42 INT206069 ANG Positive_regulation of Gene_expression of IL6 1 0.05 0.51 0 5.00
43 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0 5.00
44 INT206086 LDLR Positive_regulation of Localization of IL6 1 0.03 0.42 0 5.00
45 INT206060 FDPS Positive_regulation of AKT1 1 0.00 0.4 0 5.00
46 INT206055 F2 Positive_regulation of Gene_expression of IL6 1 0.01 1.24 0 5.00
47 INT206082 IL6 Positive_regulation of Gene_expression of CCL2 1 0.07 0.3 0 5.00
48 INT206180 Foxm1 Positive_regulation of Transcription of Olr1 1 0.00 0.48 0 5.00
49 INT206077 RAC1 Positive_regulation of Phosphorylation of STAT3 1 0.07 0.35 0 5.00
50 INT206181 FDPS Positive_regulation of ras 1 0.00 0.4 0 5.00
51 INT206084 EGF Negative_regulation of Gene_expression of IL6 1 0.05 0.61 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Osteitis. They are ordered first by their pain relevance and then by number of times they were reported in Osteitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 97.40
2 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 97.24
3 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 97.24
4 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 97.04
5 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 96.72
6 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 96.68
7 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.32
8 INT4097 Localization of Pth 66 0.81 47.17 4.36 96.20
9 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 90.28
10 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 89.92
11 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 89.48
12 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 89.16
13 INT202701 Regulation of CNO 1 0.27 1.26 0.21 87.68
14 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 83.64
15 INT85388 Positive_regulation of Bmc1 8 0.25 3.74 0.56 83.32
16 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 81.96
17 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 80.96
18 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 80.56
19 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 80.40
20 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 79.44
21 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 78.92
22 INT67589 Gene_expression of MT1E 8 0.51 7.52 1.09 76.68
23 INT2544 Localization of PTH 39 0.81 30.55 2.22 76.32
24 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 75.00
25 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 75.00
26 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 74.88
27 INT114159 Binding of PHPT1 1 0.30 1.21 0.14 74.20
28 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 74.08
29 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 72.44
30 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 70.92
31 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 70.64
32 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 70.60
33 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 69.60
34 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 69.60
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 66.92
36 INT2649 Regulation of Calca 433 0.62 146.05 330.95 66.88
37 INT86437 Binding of IL6 154 0.48 121.22 29.3 64.80
38 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 64.16
39 INT133422 Binding of IL6ST 10 0.40 4.9 1.49 63.20
40 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 59.20
41 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98 59.16
42 INT174029 Protein_catabolism of BSG 5 0.01 2.5 0.95 58.92
43 INT177584 Gene_expression of MR1 80 0.58 46.48 5.48 56.44
44 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78 56.16
45 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47 56.16
46 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32 55.64
47 INT206143 Positive_regulation of Transcription of STAT3 1 0.21 0.34 0.06 54.84
48 INT206148 Positive_regulation of Transcription of STAT1 2 0.21 0.72 0.06 54.84
49 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 54.76
50 INT121347 Binding of GNAS 8 0.13 3.99 1.47 54.52
51 INT128424 Transcription of STAT1 5 0.37 3.28 0.9 54.28
52 INT144038 Transcription of STAT3 4 0.56 0.99 0.25 54.28
53 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 52.88
54 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 48.64
55 INT3343 Regulation of PTH 24 0.62 11.18 1.62 47.44
56 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29 45.40
57 INT206156 Positive_regulation of Phosphorylation of IL6ST 1 0.14 0.05 0 45.40
58 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 42.48
59 INT206153 Phosphorylation of IL6ST 1 0.22 0.05 0 42.44
60 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 37.64
61 INT6481 Binding of TNF 624 0.48 510.2 214.82 35.32
62 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 28.64
63 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 27.92
64 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 25.76
65 INT49986 Transcription of Tnf 25 0.72 18.3 16.22 25.00
66 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 25.00
67 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 24.48
68 INT71303 Binding of FOSB 3 0.29 3.94 0.26 22.48
69 INT60198 Binding of JUN 54 0.48 11.56 10.27 21.64
70 INT60196 Binding of FOS 33 0.47 13.11 6.95 18.16
71 INT85138 Binding of GDNF 6 0.37 2.01 0.58 17.84
72 INT55952 Transcription of TP53 16 0.61 12.14 2.36 17.12
73 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0 17.12
74 INT9321 Transcription of Igf1 25 0.69 10.2 6.08 15.32
75 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25 15.28
76 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 15.12
77 INT95512 Transcription of Ghr 24 0.69 3.1 4.12 14.40
78 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 11.80
79 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 9.76
80 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 9.76
81 INT61626 Transcription of IL6 73 0.72 42.04 17.86 6.08
82 INT110180 Phosphorylation of JUN 23 0.80 11.21 3.83 5.28
83 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
84 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
85 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
86 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
87 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
88 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
89 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
90 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
91 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
92 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
93 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
94 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
95 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
96 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
97 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
98 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
99 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
100 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
101 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
102 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
103 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
104 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
105 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
106 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
107 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
108 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
109 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
110 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
111 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
112 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
113 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
114 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
115 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
116 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
117 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
118 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
119 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
120 INT13354 Transcription of TNF 108 0.72 85.81 42.32 5.00
121 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
122 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
123 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
124 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
125 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
126 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
127 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
128 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
129 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
130 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
131 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 5.00
132 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
133 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
134 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
135 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 5.00
136 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
137 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
138 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
139 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
140 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
141 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
142 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 5.00
143 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
144 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
145 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69 5.00
146 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
147 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
148 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
149 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2 5.00
150 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
151 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
152 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
153 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
154 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
155 INT250 Regulation of GHRH 65 0.61 17.46 23.19 5.00
156 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 5.00
157 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 5.00
158 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
159 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
160 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
161 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
162 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
163 INT17848 Binding of PTGS2 70 0.46 32.1 20.6 5.00
164 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
165 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
166 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
167 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 5.00
168 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 5.00
169 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 5.00
170 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
171 INT36054 Transcription of IL1B 53 0.72 32.64 17.31 5.00
172 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
173 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
174 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
175 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
176 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
177 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
178 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
179 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
180 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
181 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
182 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
183 INT55168 Binding of NFKB1 55 0.48 22.94 13.15 5.00
184 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
185 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
186 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 5.00
187 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34 5.00
188 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
189 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
190 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
191 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86 5.00
192 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
193 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 5.00
194 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 5.00
195 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
196 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06 5.00
197 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
198 INT66213 Localization of RELA 63 0.78 14.71 8.77 5.00
199 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
200 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
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