D:Otitis

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Disease Term
Synonyms EAR INFLAMMATION, Ear Inflammations, Inflammation Ear, INFLAMMATIONS EAR, OTITIDES
Documents 202
Hot Single Events 31
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Otitis. They are ordered first by their relevance to Otitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT248147 PLAT Positive_regulation of Gene_expression of CPOX 1 0.00 0.51 0.15 92.84
2 INT58633 Negative_regulation of Il1f5 Negative_regulation of Mpo 1 0.15 0.98 0.48 75.00
3 INT58634 Negative_regulation of Il1 Negative_regulation of Mpo 1 0.20 0.98 0.47 75.00
4 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54 5.00
5 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11 5.00
6 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1 5.00
7 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71 5.00
8 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 5.00
9 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54 5.00
10 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5 5.00
11 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4 5.00
12 INT267585 TNF Regulation of IL6 2 0.16 2.44 0.37 5.00
13 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36 5.00
14 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34 5.00
15 INT267628 IL4 Positive_regulation of IgG 1 0.00 1.42 0.27 5.00
16 INT267586 IL4 Positive_regulation of IGHE 1 0.00 1.42 0.27 5.00
17 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25 5.00
18 INT267624 Klk1 Positive_regulation of KNG1 1 0.05 0.52 0.25 5.00
19 INT267584 TNF Positive_regulation of Gene_expression of PLA2G6 1 0.08 0.87 0.25 5.00
20 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25 5.00
21 INT267596 KNG1 Positive_regulation of Gene_expression of PLA2G6 1 0.01 0.87 0.25 5.00
22 INT267591 CYSLTR1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.87 0.25 5.00
23 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24 5.00
24 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18 5.00
25 INT267627 Il1 Positive_regulation of Gene_expression of TNF 1 0.02 0.45 0.17 5.00
26 INT293867 Binding of COL2A1 and MEFV 1 0.01 0.52 0.14 5.00
27 INT267587 PTAFR Positive_regulation of Localization of PTPRC 1 0.00 2.04 0.09 5.00
28 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09 5.00
29 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09 5.00
30 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07 5.00
31 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06 5.00
32 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0 5.00
33 INT293869 Binding of COL2A1 and GREM1 1 0.00 1.11 0 5.00
34 INT293868 Binding of GREM1 and OCM 1 0.00 1.11 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Otitis. They are ordered first by their pain relevance and then by number of times they were reported in Otitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT272057 Phosphorylation of COPD 2 0.54 4.15 0.22 99.90
2 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66 99.84
3 INT250505 Positive_regulation of Negative_regulation of COL2A1 1 0.41 0.57 0.05 99.84
4 INT38036 Gene_expression of Rac2 4 0.57 3.74 0.95 98.62
5 INT129686 Gene_expression of FSCN1 46 0.15 18.91 34.47 97.82
6 INT6852 Localization of TNF 883 0.81 705.95 270.84 97.60
7 INT104527 Binding of FSCN1 18 0.23 14.75 19.6 97.26
8 INT152730 Positive_regulation of S100a8 48 0.68 47.67 15.4 97.12
9 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 93.92
10 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 93.92
11 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 93.92
12 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 93.64
13 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 93.44
14 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 93.44
15 INT38038 Negative_regulation of Rac2 1 0.36 0.79 0.55 93.32
16 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 93.24
17 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 92.84
18 INT38037 Regulation of Rac2 2 0.38 0.79 0.57 92.60
19 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 92.44
20 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 91.68
21 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31 91.28
22 INT227751 Negative_regulation of Positive_regulation of Plat 1 0.19 0.63 0.28 91.28
23 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83 91.20
24 INT14506 Regulation of Sst 46 0.62 15.02 22.66 88.80
25 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 87.28
26 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48 86.88
27 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 83.28
28 INT129685 Negative_regulation of FSCN1 7 0.05 3.44 5.69 83.24
29 INT72565 Localization of IL1RN 45 0.80 23.59 13.17 82.72
30 INT9732 Regulation of COL2A1 9 0.58 6.93 0.44 82.32
31 INT6574 Negative_regulation of Pla2g1b 35 0.59 11.4 10.44 80.64
32 INT81194 Binding of CPOX 40 0.29 23.7 18.95 79.68
33 INT5008 Localization of Calca 204 0.81 80.35 125.16 79.52
34 INT293873 Negative_regulation of OCM 1 0.04 0.65 0 78.20
35 INT250504 Negative_regulation of URI1 1 0.10 0.71 0.03 78.04
36 INT221135 Regulation of Binding of NEU1 1 0.17 0.61 0.06 77.08
37 INT14450 Binding of NEU1 7 0.14 5.1 0.5 76.68
38 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02 76.44
39 INT59465 Negative_regulation of ISYNA1 41 0.49 21.9 9.46 76.12
40 INT6993 Negative_regulation of Mpo 72 0.59 61.83 19.51 75.00
41 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 75.00
42 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 75.00
43 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 75.00
44 INT19775 Localization of Il1 183 0.78 145.5 50.91 75.00
45 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24 75.00
46 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68 75.00
47 INT25609 Localization of Il1f5 17 0.80 10.66 6.71 75.00
48 INT53572 Negative_regulation of Localization of Il1 18 0.40 12.78 6.7 75.00
49 INT58632 Negative_regulation of Il1f5 3 0.13 3.5 0.96 75.00
50 INT58631 Negative_regulation of Localization of Il1f5 2 0.13 1.8 0.89 75.00
51 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81 73.60
52 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 73.08
53 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 71.04
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 69.24
55 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 69.24
56 INT45878 Gene_expression of NEU1 14 0.65 7.28 0.47 69.12
57 INT293874 Positive_regulation of OCM 1 0.05 2 0 67.52
58 INT107247 Regulation of Plat 10 0.44 7.21 5.14 67.08
59 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 64.32
60 INT11063 Negative_regulation of CES1 16 0.53 6.92 1.11 62.16
61 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 62.08
62 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 60.92
63 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 60.48
64 INT130199 Negative_regulation of Binding of CPOX 4 0.30 1.89 2.1 60.40
65 INT64176 Transcription of CPOX 35 0.41 15.1 5.5 60.28
66 INT221134 Positive_regulation of NEU1 1 0.19 2.51 0.11 59.92
67 INT293877 Binding of OCM 1 0.03 1.68 0.08 52.40
68 INT2606 Localization of NEU1 10 0.41 4.6 1.82 52.12
69 INT45208 Regulation of NEU1 2 0.10 3.79 0.58 52.12
70 INT10605 Positive_regulation of Ltc4s 21 0.68 17.22 4.8 51.28
71 INT20229 Negative_regulation of Positive_regulation of Ltc4s 2 0.23 0.87 0.29 51.28
72 INT117147 Negative_regulation of Gene_expression of Cxcl2 19 0.55 15.33 6.57 50.84
73 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 50.04
74 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 49.72
75 INT313395 Gene_expression of OPN1MW 2 0.18 1.46 0.81 47.88
76 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 47.52
77 INT23257 Regulation of CRP 127 0.62 100.05 21.87 45.60
78 INT279349 Localization of IDUA 7 0.76 4.97 0.07 44.40
79 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 43.28
80 INT116605 Binding of Nos2 28 0.37 16.88 8.18 40.64
81 INT227750 Positive_regulation of Binding of Nos2 1 0.18 0.8 0.23 40.64
82 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 40.00
83 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 39.88
84 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 38.44
85 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12 37.52
86 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75 37.52
87 INT3165 Gene_expression of LYZ 25 0.65 16.72 5.16 35.24
88 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 25.00
89 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 24.16
90 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71 22.64
91 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 19.80
92 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 18.96
93 INT174838 Localization of INCENP 80 0.64 19.05 12.89 14.60
94 INT155590 Gene_expression of ARIH1 8 0.58 10.76 0.24 14.08
95 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 12.60
96 INT221131 Localization of Tlr2 17 0.80 13.82 1.28 12.20
97 INT12339 Localization of IL8 437 0.81 251.87 117.39 10.92
98 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 8.40
99 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 7.64
100 INT90674 Negative_regulation of LOX 56 0.57 38.01 8.58 7.60
101 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07 5.72
102 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
103 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
104 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
105 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
106 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
107 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
108 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
109 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
110 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
111 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
112 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
113 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
114 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
115 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
116 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
117 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
118 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
119 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
120 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
121 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
122 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
123 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
124 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
125 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
126 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
127 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
128 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
129 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
130 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
131 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
132 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
133 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
134 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
135 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
136 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
137 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
138 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
139 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 5.00
140 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
141 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
142 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
143 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
144 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
145 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
146 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 5.00
147 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
148 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
149 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
150 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
151 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
152 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
153 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
154 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
155 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
156 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
157 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
158 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
159 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 5.00
160 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
161 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
162 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
163 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
164 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
165 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
166 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
167 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
168 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
169 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 5.00
170 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 5.00
171 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
172 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 5.00
173 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
174 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
175 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
176 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
177 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
178 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
179 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
180 INT8518 Localization of Ifng 53 0.81 36.68 24.13 5.00
181 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
182 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
183 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
184 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
185 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
186 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
187 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
188 INT20129 Regulation of Il1 53 0.53 44.14 19.89 5.00
189 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
190 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
191 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
192 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 5.00
193 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 5.00
194 INT101988 Positive_regulation of GDF15 71 0.69 51.03 18.56 5.00
195 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
196 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 5.00
197 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
198 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95 5.00
199 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
200 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
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