D:Phototoxic Dermatitis

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pChart

Disease Term
Synonyms Contact Dermatitides Phototoxic, CONTACT DERMATITIS PHOTOTOXIC, Dermatitides Phototoxic, Dermatitides Phototoxic Contact, Dermatitis Contact Phototoxic, DERMATITIS PHOTOTOXIC CONTACT, Phototoxic Contact Dermatitides, PHOTOTOXIC CONTACT DERMATITIS, Phototoxic Dermatitides, PHOTOTOXICITY
Documents 99
Hot Single Events 45
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Phototoxic Dermatitis. They are ordered first by their relevance to Phototoxic Dermatitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 46.08
2 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37 5.00
3 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12 5.00
4 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07 5.00
5 INT352357 CPZ Positive_regulation of Gene_expression of HLA-DRA 1 0.12 0.13 0.07 5.00
6 INT352358 CD86 Positive_regulation of GOPC 1 0.30 0.13 0.07 5.00
7 INT239466 Ppp2r1a Regulation of Phosphorylation of Akt1 1 0.01 0 0.03 5.00
8 INT354622 CTSB Regulation of PRDX5 1 0.00 0.38 0 5.00
9 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0 5.00
10 INT268445 Olr1 Positive_regulation of Positive_regulation of Lipa 1 0.01 0.87 0 5.00
11 INT268459 Binding of LDLR and Olr1 1 0.00 0.78 0 5.00
12 INT268446 Cdk5 Positive_regulation of Cdk5r1 1 0.02 0.58 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Phototoxic Dermatitis. They are ordered first by their pain relevance and then by number of times they were reported in Phototoxic Dermatitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.98
2 INT167287 Localization of Dock7 1 0.00 0.8 0.09 99.88
3 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.82
4 INT321657 Positive_regulation of Positive_regulation of Fech 1 0.02 0.8 0 99.08
5 INT38834 Positive_regulation of Positive_regulation of PPY 2 0.42 4.18 0.61 98.98
6 INT204175 Localization of Mri1 12 0.60 2.73 2.35 98.92
7 INT321658 Positive_regulation of Fech 1 0.02 0.8 0 98.86
8 INT3180 Positive_regulation of PPY 39 0.63 25.57 10.15 98.82
9 INT76752 Negative_regulation of TOP2B 8 0.42 6.2 0.14 98.16
10 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86 97.88
11 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 97.88
12 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 97.88
13 INT19621 Positive_regulation of CD86 23 0.69 14 2.58 97.88
14 INT209890 Positive_regulation of Gene_expression of CD83 11 0.62 9.04 1.88 97.88
15 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 97.56
16 INT155485 Regulation of Gene_expression of CD86 7 0.61 3.73 0.6 97.56
17 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 97.00
18 INT27293 Regulation of SOD1 21 0.53 15.73 1.55 96.60
19 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91 96.36
20 INT352365 Positive_regulation of Localization of CD86 1 0.50 0.29 0.07 96.08
21 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 95.68
22 INT352366 Localization of CD86 1 0.74 0.29 0.07 95.68
23 INT546 Binding of ALB 311 0.48 85.98 60.14 90.80
24 INT1850 Binding of OXA1L 77 0.48 7.61 15.22 90.80
25 INT52924 Negative_regulation of GSR 49 0.58 28.08 9.28 90.72
26 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 89.76
27 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 86.80
28 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 85.44
29 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72 85.44
30 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66 85.20
31 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 85.12
32 INT19617 Negative_regulation of CD86 12 0.42 3.68 1.77 85.12
33 INT97144 Negative_regulation of CD83 5 0.39 2.28 0.54 85.12
34 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 84.96
35 INT84877 Binding of GRIN2D 2 0.48 2.41 2.99 84.80
36 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 84.12
37 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 83.68
38 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 83.32
39 INT197362 Positive_regulation of Gene_expression of MCAT 2 0.10 2.73 0.19 83.04
40 INT18954 Negative_regulation of OLAH 9 0.09 8.31 3.67 82.80
41 INT197364 Gene_expression of MCAT 18 0.16 24.11 4.27 82.56
42 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 82.32
43 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 82.08
44 INT135264 Positive_regulation of MCAT 4 0.27 2.74 0.19 80.96
45 INT76869 Localization of PAEP 15 0.73 6.57 3.36 80.64
46 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 78.32
47 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 78.08
48 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 77.84
49 INT129231 Gene_expression of Ddx41 29 0.63 9.73 1.52 77.72
50 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 77.72
51 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 77.48
52 INT5489 Localization of CA2 172 0.80 39.46 33.56 77.44
53 INT87406 Gene_expression of GSTP1 16 0.77 11.37 0.35 76.56
54 INT203874 Positive_regulation of Gene_expression of GSTP1 3 0.49 1.91 0 76.56
55 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 75.00
56 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 75.00
57 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 75.00
58 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 75.00
59 INT50618 Gene_expression of Dio1 48 0.74 17.37 15.91 75.00
60 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 75.00
61 INT103272 Positive_regulation of Gene_expression of Dio1 4 0.26 1.66 1.34 75.00
62 INT86446 Protein_catabolism of Lipg 9 0.50 3.52 1.25 74.44
63 INT214355 Binding of Akt1 13 0.36 3.72 2.59 73.88
64 INT197360 Regulation of MCAT 6 0.09 7.86 1.78 73.56
65 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 71.64
66 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36 71.64
67 INT65834 Negative_regulation of ATP2A2 4 0.07 2.39 0.21 70.60
68 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97 70.60
69 INT92632 Gene_expression of Vsig2 48 0.50 19.93 3.04 69.04
70 INT97885 Regulation of LOC500077 7 0.16 2.93 4.33 68.60
71 INT215987 Regulation of Mri1 4 0.30 2.1 1.54 68.60
72 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 67.48
73 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59 67.48
74 INT19393 Gene_expression of Gfm1 31 0.51 18.9 3.2 66.52
75 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15 64.40
76 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 64.40
77 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 63.68
78 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 63.68
79 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 62.88
80 INT204795 Gene_expression of Xiap 9 0.60 15.32 0.7 61.76
81 INT204809 Positive_regulation of Gene_expression of Xiap 1 0.45 1.6 0 61.76
82 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 61.20
83 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65 60.88
84 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 60.56
85 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73 60.40
86 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08 59.36
87 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67 59.36
88 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 58.96
89 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06 58.96
90 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 57.12
91 INT268443 Negative_regulation of Atp6v0c-rs2 1 0.01 0.15 0 55.20
92 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78 54.92
93 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 54.68
94 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 54.68
95 INT8101 Binding of INCENP 42 0.31 16.2 6.68 54.44
96 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 53.28
97 INT186094 Binding of Mri1 14 0.20 7.8 2.35 47.28
98 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 47.04
99 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 46.48
100 INT305470 Regulation of Gene_expression of GSTP1 1 0.06 0.59 0 40.96
101 INT3535 Regulation of CA2 61 0.32 16.48 10.8 40.40
102 INT221083 Localization of CES2 2 0.80 1.48 0.03 38.88
103 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 37.04
104 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 36.52
105 INT116540 Binding of Twist1 35 0.48 16.32 2.85 35.72
106 INT1108 Gene_expression of PPY 58 0.75 36.57 10.76 34.88
107 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08 29.40
108 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 27.00
109 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 26.64
110 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 25.28
111 INT19575 Negative_regulation of Positive_regulation of Abat 14 0.43 2.07 11.05 25.28
112 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 25.00
113 INT5127 Localization of Lhb 488 0.80 50.48 162.66 25.00
114 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 25.00
115 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 25.00
116 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 25.00
117 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 25.00
118 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 25.00
119 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 25.00
120 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 25.00
121 INT17870 Positive_regulation of Gspt2 6 0.39 0 0.43 25.00
122 INT31408 Localization of HCA1 4 0.28 1.4 0.33 24.60
123 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 20.72
124 INT174838 Localization of INCENP 80 0.64 19.05 12.89 20.40
125 INT96579 Negative_regulation of Negative_regulation of MMP9 5 0.40 4.55 1.04 19.64
126 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 14.88
127 INT204805 Regulation of Xiap 3 0.40 3.98 0.17 14.68
128 INT65053 Positive_regulation of Binding of Nfkb1 11 0.65 3.78 2.84 13.88
129 INT109021 Negative_regulation of Binding of Nfkb1 7 0.39 4.13 1.42 13.40
130 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02 13.00
131 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 6.80
132 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
133 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
134 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
135 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
136 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
137 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
138 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
139 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
140 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
141 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
142 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
143 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
144 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
145 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
146 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
147 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
148 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
149 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
150 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
151 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
152 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
153 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
154 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 5.00
155 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73 5.00
156 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05 5.00
157 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
158 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
159 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
160 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 5.00
161 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
162 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
163 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
164 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
165 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
166 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 5.00
167 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
168 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
169 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 5.00
170 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
171 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
172 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 5.00
173 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
174 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
175 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09 5.00
176 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62 5.00
177 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
178 INT45437 Localization of Acot1 84 0.79 17.37 22.18 5.00
179 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 5.00
180 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
181 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
182 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
183 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86 5.00
184 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
185 INT12269 Gene_expression of Chrna9 39 0.73 6.98 18.44 5.00
186 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
187 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 5.00
188 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
189 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
190 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66 5.00
191 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
192 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73 5.00
193 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
194 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61 5.00
195 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47 5.00
196 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
197 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17 5.00
198 INT7786 Positive_regulation of Ptgdr 26 0.47 5.62 14.99 5.00
199 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 5.00
200 INT60044 Gene_expression of Syn1 38 0.78 4.98 14.61 5.00
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