D:Pneumoconiosis

Disease Term Synonyms Bagassosis, Black Lung Disease, Coal Workers Pneumoconioses, COAL WORKERS PNEUMOCONIOSIS, PNEUMOCONIOSES, Pneumoconioses Coal Workers, Pneumoconiosis Coal Workers Documents 41 Hot Single Events 5 Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Pneumoconiosis. They are ordered first by their relevance to Pneumoconiosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT230437	Binding of PDX1 and HRCT1	1	0.04	2.45	0.43	77.56
2	INT302421	IFNA1 Positive_regulation of Cxcl10	1	0.02	1.8	0.45	5.00
3	INT302422	IFNA1 Positive_regulation of Cxcl9	1	0.03	1.81	0.45	5.00
4	INT302423	Etohi5 Positive_regulation of IFNA1	1	0.00	1.77	0.44	5.00
5	INT230438	Binding of PDX1 and HAUS7	1	0.02	2.29	0.35	5.00
6	INT333398	CFD Negative_regulation of Gene_expression of Pdgfa	1	0.02	0.64	0.3	5.00
7	INT202422	IL8 Positive_regulation of Localization of ELANE	1	0.02	0.91	0.24	5.00
8	INT333394	CFD Negative_regulation of Gene_expression of Cat	1	0.03	0.79	0.22	5.00
9	INT333397	CFD Negative_regulation of Gene_expression of Nos2	1	0.04	0.8	0.22	5.00
10	INT269994	Binding of Nfkb2 and Tpx2	1	0.04	0.51	0.21	5.00
11	INT269995	Positive_regulation of Binding of Nfkb2 and Tpx2	1	0.05	0.51	0.21	5.00
12	INT333393	CFD Positive_regulation of Gene_expression of Timp1	1	0.07	0.82	0.16	5.00
13	INT333396	CFD Positive_regulation of Bcl2l1	1	0.05	0.98	0.13	5.00
14	INT310727	Binding of DKC1 and TERT	1	0.23	0.91	0.05	5.00
15	INT227072	Binding of LTF and PTPRC	1	0.00	0.51	0.04	5.00
16	INT311144	CAT Positive_regulation of APRT	1	0.01	0	0.03	5.00
17	INT311145	CAT Positive_regulation of Protein_catabolism of APRT	1	0.01	0	0	5.00
18	INT333395	Binding of CFD and Aes	1	0.03	0.24	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Pneumoconiosis. They are ordered first by their pain relevance and then by number of times they were reported in Pneumoconiosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT72060	Positive_regulation of Gene_expression of Ros1	127	0.41	76.76	20.91	90.56
2	INT55344	Gene_expression of Ros1	396	0.54	217.64	59.98	90.16
3	INT69437	Positive_regulation of ROS1	328	0.58	222.83	40.56	88.12
4	INT147607	Binding of TERT	16	0.48	12.36	1.31	83.00
5	INT171060	Gene_expression of PDX1	72	0.75	72.57	17.97	82.48
6	INT69435	Negative_regulation of ROS1	74	0.51	50.38	13.71	79.72
7	INT69436	Negative_regulation of Gene_expression of ROS1	81	0.38	46.58	12.22	79.72
8	INT69440	Gene_expression of ROS1	752	0.78	477.64	103.83	79.12
9	INT311146	Protein_catabolism of APRT	1	0.01	0.39	0.2	78.08
10	INT311147	Positive_regulation of Protein_catabolism of APRT	1	0.01	0.07	0	73.36
11	INT249469	Gene_expression of BMF	1	0.54	1.53	0	70.24
12	INT170854	Gene_expression of CFD	26	0.68	39.77	4.74	59.24
13	INT249471	Binding of BMF	1	0.30	1.3	0	58.00
14	INT15801	Positive_regulation of TFRC	11	0.33	6.35	3.3	57.12
15	INT83332	Regulation of Gene_expression of TFRC	5	0.22	3.03	1.99	51.56
16	INT303885	Negative_regulation of Serpinh1	5	0.05	1.68	0.7	51.28
17	INT15805	Gene_expression of TFRC	35	0.75	17.44	8.52	51.20
18	INT29393	Positive_regulation of APRT	18	0.67	5.28	2.13	50.40
19	INT15798	Positive_regulation of Gene_expression of TFRC	9	0.46	4.99	1.42	45.40
20	INT200072	Gene_expression of APRT	8	0.65	1	0.54	42.32
21	INT92941	Binding of ASAP1	24	0.39	12.38	1.25	35.80
22	INT60974	Gene_expression of Scgb1a1	34	0.71	7.48	0.9	24.08
23	INT187045	Regulation of Scgb1a1	6	0.46	1.42	0.3	16.04
24	INT96778	Positive_regulation of Pdgfa	22	0.46	12.7	5.31	14.44
25	INT44529	Positive_regulation of Pdgfb	11	0.43	7.98	1.36	13.16
26	INT269969	Binding of Scgb1a1	1	0.28	0.4	0.08	12.68
27	INT20856	Binding of APRT	2	0.36	0	0.34	8.84
28	INT6852	Localization of TNF	883	0.81	705.95	270.84	6.80
29	INT6481	Binding of TNF	624	0.48	510.2	214.82	6.80
30	INT53577	Negative_regulation of Localization of TNF	110	0.59	59.28	35.23	6.80
31	INT6478	Negative_regulation of Binding of TNF	36	0.58	30.42	13.31	6.80
32	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	5.00
33	INT9238	Gene_expression of IL6	1575	0.78	1135.66	424.22	5.00
34	INT5235	Negative_regulation of TNF	924	0.59	772.91	331.98	5.00
35	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81	5.00
36	INT10832	Gene_expression of IL8	1050	0.78	698.72	270	5.00
37	INT5972	Gene_expression of IL1B	948	0.78	510.91	263.97	5.00
38	INT68684	Gene_expression of VEGFA	2371	0.78	1742.52	259.2	5.00
39	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210	5.00
40	INT48955	Gene_expression of Nos2	753	0.78	403.87	208.08	5.00
41	INT6488	Gene_expression of Tnf	484	0.78	339.61	191.58	5.00
42	INT867	Gene_expression of IFNA1	930	0.78	594.85	168.03	5.00
43	INT5116	Gene_expression of IL2	670	0.78	291.13	146.69	5.00
44	INT48953	Positive_regulation of Nos2	486	0.70	239.85	131.87	5.00
45	INT9235	Negative_regulation of Gene_expression of TNF	346	0.59	252.98	118.61	5.00
46	INT12339	Localization of IL8	437	0.81	251.87	117.39	5.00
47	INT11051	Positive_regulation of Gene_expression of IL6	415	0.69	319.21	109.3	5.00
48	INT27096	Positive_regulation of Nfkb1	325	0.70	195.11	109.06	5.00
49	INT12082	Localization of IL6	365	0.81	241.78	105.78	5.00
50	INT10838	Positive_regulation of IL8	381	0.70	295.51	101.62	5.00
51	INT11381	Positive_regulation of IL1B	330	0.70	209.31	100.9	5.00
52	INT68682	Positive_regulation of VEGFA	640	0.70	454.14	81.65	5.00
53	INT9236	Regulation of Gene_expression of TNF	204	0.62	162.66	72.99	5.00
54	INT10837	Positive_regulation of Gene_expression of IL8	294	0.70	190.08	70.34	5.00
55	INT6489	Positive_regulation of Gene_expression of Tnf	140	0.70	92.31	67.85	5.00
56	INT6486	Positive_regulation of Tnf	168	0.70	123.47	66.05	5.00
57	INT1425	Gene_expression of Rbm39	143	0.58	51.32	65.44	5.00
58	INT11937	Localization of Il6	228	0.81	139.83	64.39	5.00
59	INT5058	Positive_regulation of IFNA1	356	0.70	245.75	60.52	5.00
60	INT17564	Gene_expression of Gpt	322	0.75	208.51	60.36	5.00
61	INT169926	Positive_regulation of Gopc	416	0.46	157.8	58.67	5.00
62	INT5770	Binding of Rbm39	88	0.41	13.23	55.5	5.00
63	INT20375	Gene_expression of Hand1	213	0.60	148.51	54.53	5.00
64	INT20382	Gene_expression of Hand2	211	0.66	142.26	51.05	5.00
65	INT61619	Gene_expression of IL12A	194	0.77	146.07	41.97	5.00
66	INT48222	Positive_regulation of Localization of IL8	123	0.59	78.04	37.2	5.00
67	INT60710	Gene_expression of Col7a1	217	0.78	113.2	35.2	5.00
68	INT2609	Localization of ELANE	111	0.81	50.22	26.63	5.00
69	INT19856	Gene_expression of CD8A	240	0.75	147.86	26.39	5.00
70	INT72370	Gene_expression of Timp1	82	0.65	57.52	24.16	5.00
71	INT10835	Regulation of IL8	79	0.49	53.04	24.14	5.00
72	INT147792	Gene_expression of COPD	230	0.70	287.13	24.1	5.00
73	INT66758	Binding of Nfkb1	97	0.48	50.65	23.65	5.00
74	INT4465	Gene_expression of CEL	116	0.77	98.35	23.58	5.00
75	INT48081	Localization of Il1b	46	0.80	21.59	22.4	5.00
76	INT14731	Positive_regulation of TGFB1	78	0.67	52.57	22.23	5.00
77	INT8483	Positive_regulation of Positive_regulation of TNF	73	0.67	60.35	22.03	5.00
78	INT84732	Positive_regulation of Hand2	81	0.69	62.07	22	5.00
79	INT74682	Positive_regulation of Mmp2	72	0.69	40.46	21.73	5.00
80	INT5328	Positive_regulation of CD4	191	0.69	133.43	21.31	5.00
81	INT14701	Negative_regulation of IFNA1	118	0.54	84.19	20.08	5.00
82	INT18311	Positive_regulation of CD8A	145	0.69	113.48	19.44	5.00
83	INT19509	Localization of Ifng	55	0.78	28.25	18.67	5.00
84	INT65260	Positive_regulation of Col7a1	95	0.69	61.73	18.42	5.00
85	INT19929	Negative_regulation of Positive_regulation of TNF	52	0.59	38.16	16.51	5.00
86	INT12950	Gene_expression of Cat	85	0.75	35.94	15.76	5.00
87	INT96775	Gene_expression of Pdgfa	42	0.54	29.78	15.46	5.00
88	INT55740	Gene_expression of Timp1	53	0.75	28.63	13.85	5.00
89	INT99780	Positive_regulation of Cxcl10	43	0.69	39.67	13.27	5.00
90	INT61624	Positive_regulation of Gene_expression of IL12A	50	0.56	33.07	13.07	5.00
91	INT36263	Positive_regulation of CEL	53	0.69	34.88	12.87	5.00
92	INT92686	Gene_expression of Ctgf	51	0.77	34.4	11.93	5.00
93	INT36287	Binding of CD4	96	0.47	58.93	11.88	5.00
94	INT69029	Gene_expression of PTPRC	127	0.75	74.26	11.57	5.00
95	INT48956	Negative_regulation of Positive_regulation of Nos2	34	0.46	13.15	11.15	5.00
96	INT48203	Positive_regulation of Tgfb1	67	0.70	41.31	11.07	5.00
97	INT13240	Gene_expression of TF	94	0.76	57.81	10.99	5.00
98	INT94465	Positive_regulation of Gene_expression of Hand1	43	0.38	29.76	10.88	5.00
99	INT94784	Binding of ROS1	113	0.40	71.57	10.26	5.00
100	INT167964	Gene_expression of Aes	30	0.58	25.41	10.16	5.00
101	INT95565	Positive_regulation of IL12A	47	0.56	33.96	10.16	5.00
102	INT32344	Localization of LTF	30	0.80	15.28	10.09	5.00
103	INT57876	Positive_regulation of Egr1	46	0.70	25.6	9.41	5.00
104	INT140224	Localization of Ccl2	32	0.72	26.91	9.39	5.00
105	INT149138	Binding of PDX1	27	0.37	32.62	9.33	5.00
106	INT101105	Positive_regulation of FUT1	62	0.30	55.96	9.28	5.00
107	INT25381	Localization of Csf2	62	0.76	47.48	9.03	5.00
108	INT96068	Positive_regulation of Timp1	30	0.58	23.94	8.17	5.00
109	INT72337	Positive_regulation of Positive_regulation of Nos2	37	0.65	17.02	8.11	5.00
110	INT126478	Gene_expression of Cxcl12	78	0.77	58.69	8.01	5.00
111	INT104387	Positive_regulation of Cxcl9	24	0.67	22.26	7.87	5.00
112	INT121496	Gene_expression of TERT	107	0.78	45.6	7.42	5.00
113	INT58365	Gene_expression of LTF	51	0.78	44.14	7.25	5.00
114	INT138922	Positive_regulation of Stat1	57	0.69	28.35	7.2	5.00
115	INT76120	Gene_expression of Ptprc	102	0.59	30.42	7.02	5.00
116	INT17049	Localization of CD4	57	0.75	35.33	6.89	5.00
117	INT52180	Binding of Aes	38	0.42	23.16	6.7	5.00
118	INT65265	Positive_regulation of Gene_expression of Col7a1	48	0.69	23.81	6.16	5.00
119	INT126481	Gene_expression of Cxcr4	69	0.77	34.99	6	5.00
120	INT15132	Gene_expression of TNFRSF1A	33	0.75	20.09	5.93	5.00
121	INT52904	Positive_regulation of LTF	21	0.67	15.58	5.78	5.00
122	INT35536	Negative_regulation of CAT	26	0.57	14.39	5.38	5.00
123	INT6476	Gene_expression of TNFRSF1B	21	0.67	18.22	5.25	5.00
124	INT22597	Positive_regulation of TF	43	0.68	27.27	5.17	5.00
125	INT143234	Gene_expression of Nfkbia	10	0.62	5.2	5.02	5.00
126	INT161220	Binding of Ccl2	17	0.46	17.63	4.94	5.00
127	INT23245	Positive_regulation of Gene_expression of CEL	19	0.69	14.81	4.92	5.00
128	INT69215	Gene_expression of Col1a1	38	0.68	17.39	4.77	5.00
129	INT26069	Positive_regulation of Positive_regulation of IFNA1	26	0.50	16.61	4.76	5.00
130	INT153269	Binding of Ccl3	10	0.48	8.87	4.69	5.00
131	INT101594	Positive_regulation of Cd40	36	0.69	16.14	4.56	5.00
132	INT18995	Binding of CEL	23	0.47	14.46	4.5	5.00
133	INT55741	Negative_regulation of Timp1	15	0.51	8.12	4.09	5.00
134	INT156137	Gene_expression of Col1a2	28	0.73	13.3	3.99	5.00
135	INT138916	Transcription of Cxcl9	13	0.68	9.88	3.96	5.00
136	INT15724	Negative_regulation of Fn1	15	0.53	5.61	3.87	5.00
137	INT160409	Transcription of Cxcl10	9	0.65	7.95	3.53	5.00
138	INT28528	Gene_expression of MSMB	25	0.65	7.66	3.49	5.00
139	INT92681	Positive_regulation of Ctgf	13	0.69	9.78	3.47	5.00
140	INT133214	Regulation of PDX1	9	0.34	10.26	3.36	5.00
141	INT55002	Gene_expression of ASAP1	46	0.64	22.8	3.2	5.00
142	INT70885	Gene_expression of Pdgfb	48	0.67	42.27	3.19	5.00
143	INT132149	Positive_regulation of Gene_expression of LTF	10	0.70	11.5	3.14	5.00
144	INT66367	Gene_expression of Gsk3b	16	0.45	9.75	3.07	5.00
145	INT130603	Binding of Timp1	9	0.35	8.52	3.04	5.00
146	INT138141	Transcription of Mmp2	10	0.64	6.52	2.99	5.00
147	INT136388	Gene_expression of Cxcl5	13	0.75	21.45	2.98	5.00
148	INT41545	Negative_regulation of APRT	8	0.57	2.99	2.88	5.00
149	INT171058	Negative_regulation of PDX1	5	0.32	9.31	2.72	5.00
150	INT175685	Positive_regulation of Gene_expression of Timp1	11	0.57	8.18	2.58	5.00
151	INT133194	Negative_regulation of TERT	23	0.48	4.01	2.45	5.00
152	INT183468	Localization of TBK1	6	0.32	4.35	2.36	5.00
153	INT38118	Negative_regulation of Positive_regulation of IFNA1	8	0.43	3.95	2.04	5.00
154	INT46332	Binding of Mmp2	10	0.34	5.63	2	5.00
155	INT142461	Positive_regulation of Positive_regulation of Stat1	7	0.54	5.06	1.94	5.00
156	INT146793	Positive_regulation of Tp53	30	0.70	32.93	1.94	5.00
157	INT171059	Localization of PDX1	8	0.56	6.7	1.9	5.00
158	INT133269	Positive_regulation of PDX1	10	0.54	9.77	1.9	5.00
159	INT152155	Positive_regulation of Col1a2	7	0.56	10.18	1.89	5.00
160	INT45167	Positive_regulation of ASAP1	32	0.60	17.09	1.84	5.00
161	INT57875	Positive_regulation of Positive_regulation of Egr1	6	0.49	2.74	1.75	5.00
162	INT37978	Localization of Ripk2	4	0.78	0.57	1.73	5.00
163	INT64378	Gene_expression of DMRT1	9	0.54	1.72	1.71	5.00
164	INT166131	Positive_regulation of Positive_regulation of Col7a1	8	0.46	6.4	1.65	5.00
165	INT120071	Negative_regulation of Positive_regulation of Tgfb1	4	0.16	4.06	1.55	5.00
166	INT139317	Negative_regulation of Col1a2	8	0.41	7.17	1.54	5.00
167	INT153201	Negative_regulation of Gene_expression of Col1a1	7	0.38	6.37	1.52	5.00
168	INT120004	Transcription of Tp53	8	0.72	4.92	1.48	5.00
169	INT147788	Regulation of FUT1	11	0.12	7.72	1.44	5.00
170	INT54593	Positive_regulation of Gene_expression of TF	16	0.68	9.05	1.43	5.00
171	INT170853	Positive_regulation of Gene_expression of CFD	7	0.23	9.89	1.41	5.00
172	INT125980	Binding of CFD	8	0.42	10.96	1.39	5.00
173	INT183065	Positive_regulation of Gene_expression of PDX1	7	0.54	6.58	1.29	5.00
174	INT22403	Regulation of MSMB	10	0.39	2.5	1.28	5.00
175	INT17805	Regulation of Localization of ELANE	7	0.59	1.88	1.08	5.00
176	INT159775	Negative_regulation of Gene_expression of Timp1	9	0.37	4.36	1.08	5.00
177	INT127459	Negative_regulation of PAH	18	0.56	15.15	1.05	5.00
178	INT224722	Binding of Mcpt1	6	0.10	4.82	1.03	5.00
179	INT230440	Gene_expression of HAUS7	1	0.04	4.13	1.02	5.00
180	INT226691	Positive_regulation of Gene_expression of Cxcr4	14	0.57	7.9	0.9	5.00
181	INT143714	Phosphorylation of Nfkbia	4	0.64	2.94	0.87	5.00
182	INT126030	Regulation of CFD	4	0.21	3.92	0.83	5.00
183	INT143720	Negative_regulation of Phosphorylation of Nfkbia	3	0.33	2.68	0.83	5.00
184	INT78706	Positive_regulation of Ksr1	2	0.08	1	0.78	5.00
185	INT248227	Protein_catabolism of CFD	4	0.46	2.48	0.77	5.00
186	INT174553	Localization of Stat1	17	0.80	6.62	0.73	5.00
187	INT5211	Localization of Cd40	6	0.78	1.75	0.71	5.00
188	INT158295	Transcription of CD8A	11	0.53	4.02	0.7	5.00
189	INT76127	Transcription of CEL	5	0.71	2.02	0.7	5.00
190	INT160799	Regulation of IGFALS	11	0.29	9.09	0.7	5.00
191	INT202428	Positive_regulation of Binding of CD4	4	0.37	2.11	0.68	5.00
192	INT302664	Positive_regulation of SMAD2	2	0.49	0.85	0.64	5.00
193	INT108328	Negative_regulation of Gene_expression of CEL	6	0.57	2.56	0.63	5.00
194	INT269997	Regulation of Gene_expression of TNFRSF1B	3	0.44	3.33	0.6	5.00
195	INT269970	Positive_regulation of Positive_regulation of Cd40	2	0.50	1.79	0.57	5.00
196	INT202427	Negative_regulation of Localization of CD4	2	0.32	3.1	0.56	5.00
197	INT28238	Positive_regulation of Hrct1	5	0.38	3.66	0.5	5.00
198	INT224442	Negative_regulation of Gene_expression of Pdgfa	2	0.30	2.48	0.5	5.00
199	INT202426	Transcription of CD4	6	0.69	3.96	0.49	5.00
200	INT168801	Localization of Egr1	4	0.78	0.7	0.48	5.00