D:Polymyositis

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Disease Term
Synonyms Idiopathic Polymyositides, Idiopathic Polymyositis, Multiple Myositis, MYOSITIDES MULTIPLE, Myositis Multiple, Ossificans Polymyositis, Polymyositides, POLYMYOSITIDES IDIOPATHIC, Polymyositis Idiopathic, Polymyositis Ossificans
Documents 251
Hot Single Events 73
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Polymyositis. They are ordered first by their relevance to Polymyositis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT285205 Binding of VEGFA and SLEB1 1 0.05 5.12 0.38 95.32
2 INT221068 Cd79a Regulation of Gene_expression of IgG 1 0.01 0.93 0.1 54.16
3 INT221067 Cd79a Regulation of IgG 1 0.01 0.93 0.1 54.16
4 INT221066 Cd79a Regulation of Gene_expression of Ighm 1 0.01 0.93 0.1 53.96
5 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 39.28
6 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 39.28
7 INT288003 Binding of COL2A1 and PADI1 1 0.09 0.11 0.06 23.52
8 INT339816 SRP72 Regulation of Binding of SRP72 and UCN2 1 0.16 0.08 0 21.92
9 INT339817 Binding of SRP72 and UCN2 1 0.12 0.08 0 21.92
10 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0 14.36
11 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 5.00
12 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55 5.00
13 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
14 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
15 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56 5.00
16 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56 5.00
17 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56 5.00
18 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48 5.00
19 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 0.02 1.15 0.47 5.00
20 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 5.00
21 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39 5.00
22 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
23 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
24 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33 5.00
25 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29 5.00
26 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 0.05 0.86 0.28 5.00
27 INT300546 Binding of Il23a and Il1 1 0.01 0.5 0.25 5.00
28 INT316769 Binding of H2-K1 and Hspa9 1 0.08 1.02 0.15 5.00
29 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12 5.00
30 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
31 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11 5.00
32 INT339819 SRP72 Regulation of SRP54 1 0.38 0.37 0.08 5.00
33 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
34 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
35 INT339822 SRP68 Positive_regulation of SRP72 1 0.33 0.28 0.05 5.00
36 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03 5.00
37 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0 5.00
38 INT316770 Hsp90b1 Positive_regulation of Ddit3 1 0.12 0.17 0 5.00
39 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
40 INT339823 MAPK1 Negative_regulation of Gene_expression of SRP72 1 0.29 0.55 0 5.00
41 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0 5.00
42 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0 5.00
43 INT339820 MAPK8 Regulation of Phosphorylation of SRP72 1 0.31 0.08 0 5.00
44 INT339821 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of SRP72 1 0.29 0.28 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Polymyositis. They are ordered first by their pain relevance and then by number of times they were reported in Polymyositis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 99.62
2 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 99.44
3 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 99.34
4 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 99.24
5 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 99.20
6 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05 99.20
7 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 99.06
8 INT11709 Positive_regulation of Gene_expression of PIK3C2A 2 0.49 1.88 0.74 99.06
9 INT14888 Gene_expression of PSS 9 0.66 6.9 1.65 98.84
10 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48 98.74
11 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75 98.60
12 INT252171 Gene_expression of Trub1 2 0.01 1.09 0.28 98.60
13 INT11710 Positive_regulation of SERPINC1 6 0.59 6.15 1.47 98.20
14 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 98.20
15 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 97.92
16 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 97.84
17 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22 97.04
18 INT39945 Binding of Dlat 27 0.32 14.95 3.88 96.72
19 INT327486 Binding of Dpa 1 0.02 1.74 0 96.68
20 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 96.56
21 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 96.52
22 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86 96.00
23 INT24741 Positive_regulation of Rf 16 0.17 18.23 4.75 95.92
24 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03 95.64
25 INT49402 Positive_regulation of EDA 6 0.61 4.23 1.43 95.64
26 INT54044 Negative_regulation of EDA 7 0.42 2.54 1.14 95.64
27 INT181001 Regulation of PRTN3 5 0.18 6.07 3.39 95.56
28 INT120664 Positive_regulation of TACC2 3 0.01 7.43 1.08 95.00
29 INT67248 Gene_expression of TACC2 12 0.50 13.51 3.65 95.00
30 INT17646 Gene_expression of HSPA8 8 0.77 6.75 0.64 94.84
31 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 94.40
32 INT143228 Positive_regulation of Amh-rs3 1 0.02 6.36 1.32 93.92
33 INT143227 Gene_expression of Amh-rs3 1 0.03 4.2 0.86 93.92
34 INT143231 Positive_regulation of CRYGD 20 0.49 14.87 3.67 93.92
35 INT143229 Positive_regulation of Positive_regulation of CRYGD 2 0.49 2.49 0.47 93.92
36 INT143226 Positive_regulation of Positive_regulation of Amh-rs3 1 0.02 2.12 0.44 93.92
37 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 93.60
38 INT135408 Transcription of Il17a 8 0.64 10.7 3.39 93.56
39 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 93.52
40 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 93.36
41 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 92.68
42 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 91.24
43 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 90.80
44 INT73927 Gene_expression of FBL 10 0.48 3.55 1.72 90.28
45 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 89.80
46 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95 89.80
47 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 89.16
48 INT6507 Binding of C5 23 0.48 15.35 3.91 88.96
49 INT110210 Negative_regulation of CSRP1 12 0.59 8.96 2.81 88.80
50 INT106508 Positive_regulation of Gene_expression of Ptges 12 0.20 5.37 2.06 88.80
51 INT339853 Phosphorylation of SRP72 1 0.82 5.39 1.3 87.64
52 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 87.64
53 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 86.88
54 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5 86.52
55 INT181097 Regulation of Chka 4 0.13 2.95 0.12 85.80
56 INT171100 Gene_expression of Rrad 7 0.75 6.64 0.85 85.28
57 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 85.28
58 INT71314 Regulation of Ptges3 1 0.13 0.84 1.02 85.28
59 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 84.72
60 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 84.68
61 INT88425 Negative_regulation of DYSF 4 0.57 4.68 0.83 84.00
62 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 83.72
63 INT35380 Binding of Fn1 8 0.35 4.84 2.23 83.04
64 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 83.00
65 INT66423 Binding of ELOVL1 52 0.40 61.63 5.16 82.80
66 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39 81.92
67 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 81.84
68 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 81.68
69 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 81.68
70 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26 81.52
71 INT54041 Binding of Fbgl1 2 0.03 2.15 0.34 81.36
72 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 81.28
73 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 80.56
74 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 80.00
75 INT54043 Transcription of Fn1 3 0.61 1.59 1.1 78.64
76 INT54042 Transcription of Fbgl1 1 0.02 0.4 0.17 78.64
77 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 77.96
78 INT102547 Gene_expression of Cd68 25 0.75 14.47 5.22 77.96
79 INT164171 Gene_expression of Cd163 18 0.49 12.45 4.63 77.96
80 INT10182 Gene_expression of HTLVR 6 0.55 7.82 1.98 75.52
81 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 75.08
82 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 75.00
83 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 75.00
84 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 75.00
85 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 75.00
86 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 75.00
87 INT50928 Negative_regulation of HARS 2 0.38 0.63 0.13 75.00
88 INT143225 Regulation of Amh-rs3 1 0.01 2.11 0.48 74.76
89 INT156850 Binding of VDR 40 0.47 24.86 4.87 72.48
90 INT143925 Negative_regulation of Ptges 18 0.42 10.5 5.18 71.84
91 INT287118 Negative_regulation of Gene_expression of VDR 3 0.36 3.53 0.66 71.60
92 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 71.44
93 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 71.44
94 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 71.00
95 INT166140 Binding of Rrad 2 0.12 3.54 0.6 70.80
96 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 70.56
97 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 70.48
98 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 69.88
99 INT25236 Binding of REG1A 6 0.47 3.69 0.91 69.04
100 INT25237 Binding of NRSN1 4 0.29 2.58 0.53 69.04
101 INT120665 Binding of TACC2 4 0.07 4.33 0.46 67.80
102 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 66.04
103 INT22804 Positive_regulation of ALDOC 8 0.41 8.07 1.02 66.04
104 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 64.56
105 INT68188 Gene_expression of TNNI1 5 0.75 5.17 1.72 64.56
106 INT139353 Regulation of Gene_expression of Ptges 3 0.18 2.05 0.71 64.08
107 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 63.28
108 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 62.96
109 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 62.92
110 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 62.56
111 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 62.56
112 INT50050 Gene_expression of CSRP1 23 0.76 16.84 5.86 61.76
113 INT339863 Positive_regulation of Phosphorylation of SRP72 1 0.69 1.89 0.24 61.28
114 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 60.56
115 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 60.20
116 INT25238 Localization of REG1A 5 0.78 2.93 0.81 59.44
117 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 58.88
118 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 54.96
119 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 54.44
120 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 53.96
121 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 53.60
122 INT149138 Binding of PDX1 27 0.37 32.62 9.33 52.40
123 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 52.16
124 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67 50.00
125 INT62291 Gene_expression of PTGES2 14 0.68 8.34 4.75 50.00
126 INT184410 Gene_expression of ASF1A 6 0.11 5.51 1.94 50.00
127 INT184157 Gene_expression of Ptges3 6 0.45 2.93 0.71 50.00
128 INT252169 Negative_regulation of Gene_expression of Ptges3 1 0.16 0.5 0.21 50.00
129 INT143209 Gene_expression of ALDOC 2 0.18 0.87 0.14 50.00
130 INT252168 Localization of Cd163 1 0.27 0.32 0.13 50.00
131 INT339840 Positive_regulation of Gene_expression of SRP72 1 0.69 2.83 0.27 49.44
132 INT201425 Positive_regulation of Localization of IgG 4 0.08 2.2 0.1 45.88
133 INT72747 Localization of IgG 55 0.53 30.88 4.19 45.36
134 INT192404 Localization of Ighm 15 0.48 5.8 0.85 45.36
135 INT215120 Negative_regulation of Localization of IgG 5 0.16 3.44 0.43 45.36
136 INT339847 Gene_expression of SRP72 1 0.77 3.3 0.65 45.04
137 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 43.76
138 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 42.36
139 INT73925 Regulation of FBL 3 0.22 2.19 0.31 37.96
140 INT201994 Regulation of TACC2 2 0.03 0.21 0.1 37.96
141 INT65474 Positive_regulation of Binding of TNFRSF13C 1 0.41 1.21 0.07 36.64
142 INT65473 Binding of TNFRSF13C 1 0.31 1.2 0.07 36.64
143 INT10373 Gene_expression of ADI1 8 0.25 5.97 0.92 36.28
144 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 32.96
145 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 25.00
146 INT339851 Regulation of Transcription of SRP72 1 0.61 0.34 0.07 24.88
147 INT75648 Negative_regulation of CTD 4 0.07 3.91 0.25 24.80
148 INT339858 Transcription of SRP72 1 0.71 0.34 0.07 24.28
149 INT28647 Binding of CTD 13 0.31 14.2 1.5 22.64
150 INT339849 Localization of SRP72 1 0.75 0.72 0.08 21.92
151 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 21.76
152 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 19.92
153 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 19.92
154 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 18.32
155 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 18.04
156 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 17.96
157 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 17.64
158 INT171099 Positive_regulation of Rrad 2 0.57 1.65 0.23 13.72
159 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 9.88
160 INT202815 Regulation of Dse 1 0.01 0.63 0.12 8.96
161 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
162 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
163 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
164 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
165 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
166 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
167 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
168 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
169 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
170 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
171 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
172 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
173 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
174 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
175 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
176 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
177 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
178 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
179 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
180 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
181 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
182 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
183 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
184 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
185 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
186 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
187 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
188 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
189 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
190 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
191 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
192 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
193 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
194 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
195 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
196 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
197 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
198 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
199 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
200 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
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